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Champions Oncology

Hackensack, New Jersey, US

Champions Oncology, Inc., a US-based CRO, is engaged in the development of advanced technology solutions and services to personalize the development and use of oncology drugs. The Champions TumorGraft® (CTG) platform utilizes the implantation of primary human tumors in immune-deficient mice followed by propagation of the resulting engraftments, or patient-derived xenografts (PDX) models, in a manner that preserves the biological characteristics of the original human tumor.

Champions has shown that our PDX models closely reflect human cancer biology and that their response to drugs is more predictive of clinical outcomes in cancer patients. Champions is building its CTG platform through the procurement, development and characterization of TumorGrafts within multiple cancer types.

Champions TumorGraft® PDX models are procured through agreements with a number of institutions in the U.S. and overseas, as well as... Show more »

Champions Oncology, Inc., a US-based CRO, is engaged in the development of advanced technology solutions and services to personalize the development and use of oncology drugs. The Champions TumorGraft® (CTG) platform utilizes the implantation of primary human tumors in immune-deficient mice followed by propagation of the resulting engraftments, or patient-derived xenografts (PDX) models, in a manner that preserves the biological characteristics of the original human tumor.

Champions has shown that our PDX models closely reflect human cancer biology and that their response to drugs is more predictive of clinical outcomes in cancer patients. Champions is building its CTG platform through the procurement, development and characterization of TumorGrafts within multiple cancer types.

Champions TumorGraft® PDX models are procured through agreements with a number of institutions in the U.S. and overseas, as well as through the company’s Personalized Oncology Solutions business. All models have informed patient consent for research use.

As a result we have generated a bank of over 1000 unique and clinically relevant solid and liquid tumor PDX models. These models are well characterized with patient clinical and treatment histories, PDX drug response data, model growth kinetics and NGS data (WES and RNASeq). Additionally, we have samples (FFPE sections, including TMAs and snap frozen fragments) available for target validation. Data and samples are available at no cost for model selection on studies.

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Champions Oncology has not listed any services.

Patient-Derived Xenograft (PDX)
Price on request

As our understanding of the complex mechanisms underlying cancer grows, so does the need for extensive translational research. In an era of targeted molecular therapy, the remarkably wide range and heterogeneous expression of genetic modifications in cancer further underscores the need for large cohorts of highly-characterized,... Show more »

As our understanding of the complex mechanisms underlying cancer grows, so does the need for extensive translational research. In an era of targeted molecular therapy, the remarkably wide range and heterogeneous expression of genetic modifications in cancer further underscores the need for large cohorts of highly-characterized, clinically relevant PDX models to guide drug development strategies.

Champions Oncology is the solution. Champions TumorGraft technology — based on a platform that replicates human tumors in immunodeficient and humanized mice plaforms, known as patient-derived xenografts (PDX) — provide models for robust, rigorous translational research that helps shorten development timelines while controlling costs.

We have a bank of over 1000 highly-characterized, clinically relevant models, a flexible environment, global footprint and forward-thinking vision position Champions Oncology as the ideal partner for your oncology drug development program. Please see our online database of available models and associated data at https://database.championsoncology.com

We are a US-based CRO with operations in Rockville MD and Headquartered in Hackensack NJ.

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Mouse
Oncology
Humanized mouse
Leukemia Patient Derived Xenograft (PDX)
Price on request

Champions has a unique bank of primary leukapheresed AML and ALL patient samples which engraft in NOG and NOG-EXL mice. These PDX models are never passaged through animals and replicate systemic disease (with bone marrow, peripheral blood and spleen involvement).

Models reflect the heterogenous nature of these diseases and... Show more »

Champions has a unique bank of primary leukapheresed AML and ALL patient samples which engraft in NOG and NOG-EXL mice. These PDX models are never passaged through animals and replicate systemic disease (with bone marrow, peripheral blood and spleen involvement).

Models reflect the heterogenous nature of these diseases and studies are followed by flow cytometry and IHC to assess tumor burden over time.

Our Haem-onc models have extensive clinical characterization information, in addition to engraftment validation and molecular characterization through the TruSight Myeloid Targeted Sequencing Panel.

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Mouse
Humanized mouse
Oncology
Immunooncology
Humanized Mouse Models
Price on request

Utilizing Taconic's NOG and NOG-EXL mice we have the capability to generate humanized immune system animals utilizing CD34+ Hematopoetic stem cell donors.

Coupled together with our unique, clinically relevant and well characterized PDX models our ImmunoGraft platform is suitable for testing of I/O therapies alone or in... Show more »

Utilizing Taconic's NOG and NOG-EXL mice we have the capability to generate humanized immune system animals utilizing CD34+ Hematopoetic stem cell donors.

Coupled together with our unique, clinically relevant and well characterized PDX models our ImmunoGraft platform is suitable for testing of I/O therapies alone or in synergy.

We can also run PBMC derived humanized animals for I/O studies

We have the capability to run human cell lines in either of these platforms.

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Mouse
Humanized mouse
cell lines
Oncology
Immunooncology
Human Tumor Xenograft Models
Price on request

In addition to our PDX models, we have an ever expanding cohort of human cell line xenografts available for in vivo studies. We can run any commercially available human tumor cell line.

We also have the unique ability to accept custom cell lines (client generated) to run in vivo studies.

In addition to our PDX models, we have an ever expanding cohort of human cell line xenografts available for in vivo studies. We can run any commercially available human tumor cell line.

We also have the unique ability to accept custom cell lines (client generated) to run in vivo studies.

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Mouse
Humanized mouse
cell lines
Oncology
Immunooncology
Syngeneic (Allograft) Tumor Models
Price on request

In addition to our PDX models, we have a panel of syngeneic models available for study including 4T-1 (Breast), MC38 (CRC), LLC (Lung), CT26 (CRC), B16F10 (Melanoma), EMT6 (Breast), RENCA (Renal), KLN205 (Lung) and A20 (Lymphoma).

We also have the unique ability to accept custom cell lines (client generated) to run in vivo studies.

In addition to our PDX models, we have a panel of syngeneic models available for study including 4T-1 (Breast), MC38 (CRC), LLC (Lung), CT26 (CRC), B16F10 (Melanoma), EMT6 (Breast), RENCA (Renal), KLN205 (Lung) and A20 (Lymphoma).

We also have the unique ability to accept custom cell lines (client generated) to run in vivo studies.

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Mouse
Oncology
Immunooncology
Flow Cytometry
Price on request

We have in-house flow cytometry capabilities using MACSQuant® Analyzers by Miltenyi Biotec.

For more complex flow analysis we outsource to reputable and industry leading FACS service providers

We have in-house flow cytometry capabilities using MACSQuant® Analyzers by Miltenyi Biotec.

For more complex flow analysis we outsource to reputable and industry leading FACS service providers

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Human
Mouse
Humanized mouse
Whole blood
Human tumor
Tumor cells
Blood
bone marrow
Spleen
cells
Fresh Tumors
Peripheral Blood
Solid tumor
Immunohistochemistry (IHC)
Price on request

We can validate or run pre-validated antibody IHC analysis on samples generated from our models. We can also outsource to reputable and industry leading IHC service providers

We can validate or run pre-validated antibody IHC analysis on samples generated from our models. We can also outsource to reputable and industry leading IHC service providers

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Human
Mouse
Humanized mouse
Human tumor
immunohistochemistry
Tumor cells
IHC
Oncology
Immunooncology
antibodies
bone marrow
Spleen
tumor
Xenograft Models
Price on request
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Cytometry
Price on request
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Tissue Microarrays
Price on request
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Oncology Animal Models
Price on request
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