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Champions Oncology

19 Orders Completed
Hackensack, New Jersey, US

About Champions Oncology

Founded: 1985 Size: 51-200 employees

Champions Oncology delivers innovative solutions to oncology drug development, accelerating the journey from the research bench to the clinic – decreasing timelines, lowering costs, and ultimately saving patient lives.


With the industry’s most highly characterized tumor bank of relevant clinical and molecular data, our models enable researchers to evaluate therapeutics alongside standards of care to facilitate therapeutic discovery with the goal of realizing predictive, efficacious results in patients.


Champions Oncology provides an end-to-end range of research and development solutions to deliver greater certainty in the fight against cancer. Our deep expertise includes screens using commercially-available and custom cell lines, to studies leveraging syngeneic or traditional patient-derived xenograft (PDX) models, and modeling treatment response in the clinic. Champions Oncology is your partner in meeting today’s needs and innovating for tomorrow’s challenges.

 

Our Services (13)


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Ex Vivo Models and Assays

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Oncology Cancer Immuno-Oncology

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Clinical Flow Cytometry

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Cancer Immunology Good Laboratory Practice Good Clinical Practice

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Patient-Derived Xenograft (PDX)

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As our understanding of the complex mechanisms underlying cancer grows, so does the need for extensive translational research. In an era of targeted molecular therapy, the remarkably wide range and heterogeneous expression of genetic modifications in cancer further underscores the need for large cohorts of highly-characterized, clinically relevant PDX models to guide drug development strategies.

Champions Oncology is the solution. Champions TumorGraft technology — based on a platform that replicates human tumors in immunodeficient and humanized mice plaforms, known as patient-derived xenografts (PDX) — provide models for robust, rigorous translational research that helps shorten development timelines while controlling costs.

We have a bank of over 1000 highly-characterized, clinically relevant models, a flexible environment, global footprint and forward-thinking vision position Champions Oncology as the ideal partner for your oncology drug development program. Please see our online database of available models and associated data at https://database.championsoncology.com

We are a US-based CRO with operations in Rockville MD and Headquartered in Hackensack NJ.

Mouse Humanized Mouse Oncology

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Leukemia Patient Derived Xenograft (PDX)

Price on request

Champions has a unique bank of primary leukapheresed AML and ALL patient samples which engraft in NOG and NOG-EXL mice. These PDX models are never passaged through animals and replicate systemic disease (with bone marrow, peripheral blood and spleen involvement).

Models reflect the heterogenous nature of these diseases and studies are followed by flow cytometry and IHC to assess tumor burden over time.

Our Haem-onc models have extensive clinical characterization information, in addition to engraftment validation and molecular characterization through the TruSight Myeloid Targeted Sequencing Panel.

Oncology Immuno-Oncology Humanized Mouse Mouse

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Humanized Mouse Models

Price on request

Utilizing Taconic's NOG and NOG-EXL mice we have the capability to generate humanized immune system animals utilizing CD34+ Hematopoetic stem cell donors.

Coupled together with our unique, clinically relevant and well characterized PDX models our ImmunoGraft platform is suitable for testing of I/O therapies alone or in synergy.

We can also run PBMC derived humanized animals for I/O studies

We have the capability to run human cell lines in either of these platforms.

Oncology Immuno-Oncology Humanized Mouse Mouse cell lines

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Human Tumor Xenograft Models

Price on request

In addition to our PDX models, we have an ever expanding cohort of human cell line xenografts available for in vivo studies. We can run any commercially available human tumor cell line.

We also have the unique ability to accept custom cell lines (client generated) to run in vivo studies.

Oncology Immuno-Oncology cell lines Mouse Humanized Mouse

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Syngeneic (Allograft) Tumor Models

Price on request

In addition to our PDX models, we have a panel of syngeneic models available for study including 4T-1 (Breast), MC38 (CRC), LLC (Lung), CT26 (CRC), B16F10 (Melanoma), EMT6 (Breast), RENCA (Renal), KLN205 (Lung) and A20 (Lymphoma).

We also have the unique ability to accept custom cell lines (client generated) to run in vivo studies.

Oncology Immuno-Oncology Mouse

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Flow Cytometry

Price on request

We have in-house flow cytometry capabilities using MACSQuant® Analyzers by Miltenyi Biotec.

For more complex flow analysis we outsource to reputable and industry leading FACS service providers

Tumor tissue Human tissue Primary Cells Bone marrow Blood Human Mouse Humanized Mouse Show 8 more tags Show less

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Immunohistochemistry (IHC)

Price on request

We can validate or run pre-validated antibody IHC analysis on samples generated from our models. We can also outsource to reputable and industry leading IHC service providers

Oncology Immuno-Oncology immunohistochemistry IHC antibodies Human tissue Tumor tissue Primary Cells Bone marrow Humanized Mouse Mouse Human Show 12 more tags Show less

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Xenograft Models

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Cytometry

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Tissue Microarrays

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Oncology Animal Models

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FileType/PDF Created with Sketch. Champions - Breast Cancer Models.pdf

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FileType/PDF Created with Sketch. Champions - Colorectal Models Brochure.pdf

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FileType/PDF Created with Sketch. Champions - NSCLC Models Brochure.pdf

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FileType/PDF Created with Sketch. Champions - Ovarian Models.pdf

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FileType/PDF Created with Sketch. Champions - Sarcoma Models.pdf

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FileType/PDF Created with Sketch. Champions Oncology - ImmunoGraft Sheet.pdf

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FileType/PDF Created with Sketch. Champions Oncology - PDX Model Overview Sheet.pdf

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FileType/PDF Created with Sketch. Champions Oncology - Study Overview Sheet.pdf

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FileType/PDF Created with Sketch. HER2 Gene Modeling Sell Sheet_FINAL.pdf

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FileType/PDF Created with Sketch. ImmunoGraft Sheet.pdf

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FileType/PDF Created with Sketch. Ovarian Models.pdf

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FileType/PDF Created with Sketch. Sarcoma Models.pdf

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FileType/PDF Created with Sketch. Study Overview Sheet.pdf

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FileType/PDF Created with Sketch. Study Series - Biomarker Discovery.pdf

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FileType/PDF Created with Sketch. Study Series - Clinical Trial Simulation.pdf

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FileType/PDF Created with Sketch. Study Series - Combination Study.pdf

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FileType/PDF Created with Sketch. Study Series - Efficacy 1.pdf

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FileType/PDF Created with Sketch. Study Series - Efficacy 2.pdf

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FileType/PDF Created with Sketch. Study Series - Indication Screen.pdf

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FileType/PDF Created with Sketch. Study Series - Pipeline Screen.pdf

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FileType/PDF Created with Sketch. Study Series - Proof of Concept.pdf

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