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Cerebrasol Ltd

Ville St-Laurent, Québec

CerebraSol Ltd is a contract research organisation (CRO) which was established to provide high quality highly specialised translational neuroscience research services to the biopharmaceutical industry. Our global clientele ranges from small, “start-up” biotechnology companies to major, multinational pharmaceutical establishments.

CerebraSol Ltd. specialises in the design and delivery of focussed preclinical research packages, using electrophysiological recording techniques for nervous system indications such as pain, neurodegeneration (Alzheimer’s and Parkinson’s disease), psychiatric disorders, movement disorders and obesity.

We prepare your compounds for clinical development by providing a flexible, highly skilled service with fast turnaround tailored to our clients’ needs, delivering key proof-of-concept, drug efficacy, mechanism of action data and more.

Selected Publications

α7 nAChR agonist... Show more »

CerebraSol Ltd is a contract research organisation (CRO) which was established to provide high quality highly specialised translational neuroscience research services to the biopharmaceutical industry. Our global clientele ranges from small, “start-up” biotechnology companies to major, multinational pharmaceutical establishments.

CerebraSol Ltd. specialises in the design and delivery of focussed preclinical research packages, using electrophysiological recording techniques for nervous system indications such as pain, neurodegeneration (Alzheimer’s and Parkinson’s disease), psychiatric disorders, movement disorders and obesity.

We prepare your compounds for clinical development by providing a flexible, highly skilled service with fast turnaround tailored to our clients’ needs, delivering key proof-of-concept, drug efficacy, mechanism of action data and more.

Selected Publications

α7 nAChR agonist enhances neural plasticity in the hippocampus via a GABAergic circuit.
Townsend M, Whyment A, Walczak JS, Jeggo R, van den Top M, Flood DG, Leventhal L, Patzke H, Koenig G.
J Neurophysiol. 2016

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Cerebrasol Ltd has not listed any services.

Neuropathic Pain Animal Models
Price on request
Request a quote for more information about this service.
Electrophysiology
Price on request

In vitro and/or in vivo electrophysiology

Therapeutic areas:

  • Pain
  • Parkinson’s Disease
  • Multiple Sclerosis
  • Huntington’s Disease
  • Schizophrenia
  • Depression
  • Anxiety
  • Psychosis

Whole-cell patch clamp recordings from juvenile and adult acute brain and spinal cord slice tissue

Cerebrasol’ expert... Show more »

In vitro and/or in vivo electrophysiology

Therapeutic areas:

  • Pain
  • Parkinson’s Disease
  • Multiple Sclerosis
  • Huntington’s Disease
  • Schizophrenia
  • Depression
  • Anxiety
  • Psychosis

Whole-cell patch clamp recordings from juvenile and adult acute brain and spinal cord slice tissue

Cerebrasol’ expert electrophysiologists can provide important preclinical translational information on:

Mechanism of action
Site of action
Potency
MED

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Guinea pig
Mouse
Rat
Obesity & Diabetes
Neuroscience
Molecular Devices Amplifiers
pClamp
Pain
Neuropathic Pain
Alzheimers
Extracellular Recording
Price on request
  • Field excitatory post-synaptic potentials (fEPSPs)
  • Population spikes (PS)
  • Long-Term Potentiation (LTP)
  • Long-Term Depression (LTD)
  • Schaffer-collateral CA1 pathway
  • Medial/lateral perforant dentate gyrus pathway
  • Dentate gyrus CA3 ‘Mossy Fibre’ pathway
  • Transgenic capability
  • Field excitatory post-synaptic potentials (fEPSPs)
  • Population spikes (PS)
  • Long-Term Potentiation (LTP)
  • Long-Term Depression (LTD)
  • Schaffer-collateral CA1 pathway
  • Medial/lateral perforant dentate gyrus pathway
  • Dentate gyrus CA3 ‘Mossy Fibre’ pathway
  • Transgenic capability
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Electrophysiology Animal Models
Price on request

Therapeutic areas:

  • Alzheimer’s Disease
  • Parkinson’s Disease
  • Multiple Sclerosis
  • Huntington’s Disease
  • Schizophrenia
  • Depression
  • Anxiety
  • Psychosis

Therapeutic areas:

  • Alzheimer’s Disease
  • Parkinson’s Disease
  • Multiple Sclerosis
  • Huntington’s Disease
  • Schizophrenia
  • Depression
  • Anxiety
  • Psychosis
« Show less
Custom Pain Animal Models
Price on request

Pain Categories:

  • Neuropathic pain (nerve injury, diabetic neuropathy, chemotherapy, fracture, etc.)
  • Inflammatory pain
  • Migraine
  • Visceral pain
  • Surgical pain
  • Chemotherapy pain

Pain Categories:

  • Neuropathic pain (nerve injury, diabetic neuropathy, chemotherapy, fracture, etc.)
  • Inflammatory pain
  • Migraine
  • Visceral pain
  • Surgical pain
  • Chemotherapy pain
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Animal Behavior Studies
Price on request

Combined with electrophysiological experiments, Cerebrasol scientists can offer behavioural test to quantify effects of lead compounds on behavioual endpoints

Combined with electrophysiological experiments, Cerebrasol scientists can offer behavioural test to quantify effects of lead compounds on behavioual endpoints

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Cellular Ion Channel Assays
Price on request

Due to the recent development of successful new screening technologies, there has been a dramatic increase in interest in ion channels as drug targets. The proliferation of ion channel screening programmes requires electrophysiology support for hit validation, potency determination, selectivity profiling and lead optimization.... Show more »

Due to the recent development of successful new screening technologies, there has been a dramatic increase in interest in ion channels as drug targets. The proliferation of ion channel screening programmes requires electrophysiology support for hit validation, potency determination, selectivity profiling and lead optimization. Cerebrasol Ltd. aims to provide vital world class electrophysiological support for ion channel drug discovery programmes.

Ion Channel Analysis at Cerebrasol Ltd. includes:

  • Whole-cell patch clamp recordings and single channel recordings from cell lines stably expressing ligand or voltage-gated channels.
  • Whole-cell patch clamp recordings and single channel recordings from freshly dissociated and primary cultured neurones
  • Perforated patch and intracellular recordings for G-protein coupled receptors and signal transduction pathways

Cerebrasol’ expert ion channel pharmacologists can provide important information on compound potency, mechanism of action and selectivity:

  • Mechanism of action
  • State-dependence
  • Kinetics of modulation
  • Site of compound interaction
  • Single channel analysis
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Neurodegeneration Animal Models
Price on request

Behavioural correlates of neurodegenerative disease:

  • Alternating Lever Cyclic Ratio (ALCR)
  • Delayed (non-) Match to Position (DMTP/DNMTP)
  • Anxiety conflict model, predator/stress
  • Barnes maze, Y maze, NOR

Behavioural correlates of neurodegenerative disease:

  • Alternating Lever Cyclic Ratio (ALCR)
  • Delayed (non-) Match to Position (DMTP/DNMTP)
  • Anxiety conflict model, predator/stress
  • Barnes maze, Y maze, NOR
« Show less
In vitro Neurodegeneration Models
Price on request
Request a quote for more information about this service.
Animal Learning, Memory, and Behavior Tests
Price on request
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Animal Models of Disease
Price on request
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Cells and Tissues
Price on request
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Animal Model in vivo Analyses
Price on request
Request a quote for more information about this service.
Animal Cognition & Behavior Tests
Price on request
Request a quote for more information about this service.
CNS/Neurology Animal Models
Price on request
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Animal Models and Studies
Price on request
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Biology
Price on request
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In vitro Disease Models
Price on request
Request a quote for more information about this service.
Pain/Neuropathy Animal Models
Price on request
Request a quote for more information about this service.
Cell-Based Assays
Price on request
Request a quote for more information about this service.
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