Centre for Cellular and Molecular Platforms (C-CAMP), is a Dept. of Biotechnology (Govt. of India) initiative and a not for profit organisation, that also forms an important part of the Bangalore Bio-cluster. We are acting as an enabler of bioscience research and entrepreneurship by providing research, development, training and service in state of the art technology platforms.
Biologics Characterization Facility
As a mandate from Dept. Of Biotechnology (DBT), Govt. of India, C-CAMP has set up a comprehensive physicochemical characterization facility for biologics and biosimilars using state-of-the-art instrumentation and standard operating protocols (SOPs).Biological entities, unlike small molecule based pharmaceuticals are very complex in nature. Biopharmaceuticals, can exhibit tremendous heterogeneity in terms of posttranslational modifications (PTMs) such as glycosylation, oxidation, deamidation, phosphorylation etc. and structural modifications. In addition to this, changes in upstream and downstream processes during recombinant production of biologics also influence structural heterogeneity. Therefore, comprehensive characterization of biologics is necessary to ensure safety and efficacy.
Imaging Stations available at C-CAMP
LSM 5 LIVE Duo Scan Confocal Microscope- Carl ZEISS
LSM 510 meta confocal microscope with multiphoton laser-Carl ZEISS
LSM 510 meta confocal microscope with 405 laser-Carl ZEISS
FV1000 Confocal Microscope with Simultaneous Scanner-Olympus
Yokagawa Spinning Disc Confocal Microscope-Andor & Olympus
FV1000 Confocal Microscope-Olympus
Zoom Stereo Microscope SZX16-Olympus
Macro Zoom Microscope MVX10-Olympus
With the state-of-the-art facility, we offer Drosophila stock maintenance services. A dedicated team of stock keepers under the guidance of skilled Fly Stock Curator maintains the fly stocks with high standards of fly husbandry.
Injection of DNA into the embryos, raising the survived larvae to adulthood and crossing the G0 flies (>100 individual crosses). Identification and collection of transformants; the collected transformant flies (at least 3 independent lines) are sent to the customer
Flow Cytometers available at C-CAMP
Offered services include design and development of HTS assays, HTS imaging and reading, automated data analysis, and interpretation of hits.
Currently, the following services are offered from this facility:
Molecular mass measurement of intact proteins and peptides
Identification of 1 D and 2 D gel separated proteins
In-solution digestion and characterization of proteins
De novo sequencing of peptides
The facility specializes in the production of pure, functional proteins for structural(15N, 15N 13C, 15N 13C 2H and specific labelling), biophysical, and biochemical studies.
Roche 454 - GS FLX Titanium
We have a Tecnai G2 Spirit BioTWIN - 20 -120kv Transmission Electron Microscopy (TEM)
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