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Center for Drug Discovery

Washington, District of Columbia, US

The CDD is a strategic and bold move by the Georgetown Medical Center to engage the future of drug discovery. Historically problematic areas for academia include pace of drug discovery, the funding of this type of endeavor, development of sufficient infrastructure and aligning strategic partnerships. We anticipate that the CDD and its partners will have a key role in successfully translating our basic science discoveries towards the clinic by providing focused efforts and resources in these key areas.

The mission of the CDD is to discover new drug treatments and diagnostic tools using integrated sciences to improve the health care of our patients. The CDD will focus on 1) identifying and synthesizing candidate drug compounds for selected molecular targets, 2) validating targets/ compounds in cell models and pre-clinical studies, and 3) providing supporting experiments, large scale synthesis and consultation for... Show more »

The CDD is a strategic and bold move by the Georgetown Medical Center to engage the future of drug discovery. Historically problematic areas for academia include pace of drug discovery, the funding of this type of endeavor, development of sufficient infrastructure and aligning strategic partnerships. We anticipate that the CDD and its partners will have a key role in successfully translating our basic science discoveries towards the clinic by providing focused efforts and resources in these key areas.

The mission of the CDD is to discover new drug treatments and diagnostic tools using integrated sciences to improve the health care of our patients. The CDD will focus on 1) identifying and synthesizing candidate drug compounds for selected molecular targets, 2) validating targets/ compounds in cell models and pre-clinical studies, and 3) providing supporting experiments, large scale synthesis and consultation for each candidate molecule for submission of an investigational new drug (IND) application. Together with strong strategic partnerships with industry and governmental agencies, we look forward to a successful future.

Publications

Recent Publications Citing the Center for Drug Discovery (formerly known as the Drug Discovery Program):

  • Hou, S.; Yi, Y. W.; Kang, H. J.; Zhang, L.; Kim, H. J.; Kong, Y.; Liu, Y.; Wang, K.; Kong, H.; Grindrod, S.; Bae, I.; Brown, M. L., Novel Carbazole Inhibits Phospho-STAT3 Through Induction of Protein Tyrosine Phosphatase PTPN6. J Med Chem 2014. [Epub ahead of print]
  • Paige, M.; Wang, K.; Burdick, M.; Park, S.; Cha, J.; Jeffery, E.; Sherman, N.; Shim, Y. M., Role of leukotriene A4 hydrolase aminopeptidase in the pathogenesis of emphysema. J Immunol 2014, 192 (11), 5059-68.
  • Assefnia, S.; Dakshanamurthy, S.; Auvil, J. M.; Hampel, C.; Anastasiadis, P. Z.; Kallakury, B.; Uren, A.; Foley, D. W.; Brown, M. L.; Shapiro, L.; Brenner, M.; Haigh, D.; Byers, S. W., Cadherin-11 in poor prognosis malignancies and rheumatoid arthritis: common target, common therapies. Oncotarget 2014, 5 (6), 1458-74.
  • Liu, Y.; Paige, M.; Olson, T. T.; Al-Muhtasib, N.; Xie, T.; Hou, S.; White, M. P.; Cordova, A.; Guo, J. L.; Kellar, K. J.; Xiao, Y.; Brown, M. L.; Synthesis and Pharmacological Characterization of New Neuronal Nicotinic Acetylcholine Receptor Ligands Derived from Sazetidine-A. Bioorg Med Chem Lett 2014, 24 (13) 2954-56
  • Donahue, T. J.; Hillhouse, T. M.; Webster, K. a; Young, R.; De Oliveira, E. O.; Porter, J. H. (S)-Amisulpride as a Discriminative Stimulus in C57BL/6 Mice and Its Comparison to the Stimulus Effects of Typical and Atypical Antipsychotics. Eur. J. Pharmacol. 2014, 734C, 15–22.
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