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Center for Drug Discovery and Innovation

Tampa, Florida

The Center for Drug Discovery and Innovation (CDDI) is a Florida Center of Excellence serving the research community at USF and south Florida. From concept to clinical trials there are significant challenges in the successful development of new pharmaceuticals. It is the mission of CDDI to assist research groups at USF in overcoming some of the critical bottlenecks in early phase drug discovery.

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NMR Laboratory

Tampa, Florida
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The NMR facility provides state-of-the-art ultra-high field (14 and 18 Tesla) instruments that enable researchers to characterize protein structure at atomic resolution (along with the characterization of small molecules). Technical support and training are available for all aspects of... Show more »

The NMR facility provides state-of-the-art ultra-high field (14 and 18 Tesla) instruments that enable researchers to characterize protein structure at atomic resolution (along with the characterization of small molecules). Technical support and training are available for all aspects of project development. Experiments include structure elucidation of small molecules (e.g. synthetic molecules, natural products, and small peptides etc.) to studying advanced protein-ligand interactions.

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The Mass Spectrometry, Biological Applications and High-Throughput Proteomics Facility is dedicated to the identification and quantification of components associated with complex biological matrices. The main goal of our lab is to produce high quality data related to any biological or... Show more »

The Mass Spectrometry, Biological Applications and High-Throughput Proteomics Facility is dedicated to the identification and quantification of components associated with complex biological matrices. The main goal of our lab is to produce high quality data related to any biological or environmental sample, i.e. cancer, Alzheimer’s, diabetes, cardiovascular disease, and parasitology, to name a few. To see a full list of facility activity, please visit our listed website.

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Chemodiversity Laboratory

Tampa, Florida
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  • 1 Project Completed
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The chemodiversity core facility offers a library of natural product-derived crude extracts, fractions and pure compounds for screening. Gas chromatography high-resolution mass spectrometry (MS) analysis, liquid chromatography MS targeted separation and high throughput screening... Show more »

The chemodiversity core facility offers a library of natural product-derived crude extracts, fractions and pure compounds for screening. Gas chromatography high-resolution mass spectrometry (MS) analysis, liquid chromatography MS targeted separation and high throughput screening (targeting solid tumor cell lines, anti-microbial activity, permeability and drug solubility determination) are provided. The services also include general chromatography (MPLC, HPLC) and spectrometric characterization (UV, IR) as well as microbiology workspace (biosafety cabinets), synthesis activities and training.

Our facility offers advanced instrumentation (GC/MS Q-TOF, IR, UV, MPLCs, HPLCs, liquid handling robots, biosafety cabinets, and other essential lab equipment), consultation and services for sample isolation and analysis, derivatization and scale-up. Sample preparation and safety training are also available for commercial and USF clients using our chromatographic and analytical instrumentation.

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Protein production can be a significant bottleneck during early phase drug discovery. Our production facilities are fully equipped and staffed to help researchers produce proteins in bacteria, yeast or insect cells. Whether the protein is hopelessly insoluble or difficult to produce... Show more »

Protein production can be a significant bottleneck during early phase drug discovery. Our production facilities are fully equipped and staffed to help researchers produce proteins in bacteria, yeast or insect cells. Whether the protein is hopelessly insoluble or difficult to produce in quantity, the core staff is ready to work with individuals to turn failure into success.

The Cell Biology facility provides researchers access to cell sorting and analysis for target characterization and validation. The BD FACS Aria II sorter is BSL2 capable permitting levels of safety in cell sorting not available in most flow cores. A second BD Canto II flow cytometer provides automated sampling for analytical flow cytometry. Fully automated Zeiss Axiovert 100 deconvolution and Lecia DM 6000 (laser microcapture) microscopes provide tools for cell imaging and content analyses.

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