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Celsion Labs

Huntsville, Alabama, US

Celsion Labs is a contract research organization with over 20 years of experience in the development of nucleic-acid based therapeutics.

Celsion Labs offers a wide range of analytical and preclinical services to clients developing biologics and small molecule drugs. We are highly specialized in providing preclinical research and development services to companies developing DNA – and RNA-based medicines. With over 20 years of bench to bedside experience in drug development, we understand the value of high quality preclinical research, its timely completion and need for cost control, and we identify with clients who value a pro-customer service attitude.

Our research services range from early lead identification using our throughput screening in relevant cell-based systems to IND-enabling pharmacodynamics, pharmacology/ toxicology, pharmacokinetics, and bio-analytical services. Our services portfolio is supported... Show more »

Celsion Labs is a contract research organization with over 20 years of experience in the development of nucleic-acid based therapeutics.

Celsion Labs offers a wide range of analytical and preclinical services to clients developing biologics and small molecule drugs. We are highly specialized in providing preclinical research and development services to companies developing DNA – and RNA-based medicines. With over 20 years of bench to bedside experience in drug development, we understand the value of high quality preclinical research, its timely completion and need for cost control, and we identify with clients who value a pro-customer service attitude.

Our research services range from early lead identification using our throughput screening in relevant cell-based systems to IND-enabling pharmacodynamics, pharmacology/ toxicology, pharmacokinetics, and bio-analytical services. Our services portfolio is supported by a state-of-the-art facility designed for synthetic chemistry, cell culture, biological assays, formulation and in vivo animal studies.

A key differentiating feature of Celsion Labs’ approach to preclinical services is our proprietary nucleic acid delivery technology that we can provide to our customers as a tool to assess their DNA & RNA drug candidates both in vitro and in animal models. Our proprietary delivery systems include functionalized polymers, lipopolymers, and lipids, and are designed, synthesized, and functionally characterized in-house. These delivery systems provide some of the essential tools to efficiently screen compounds for lead identification, optimization, and demonstration of preclinical proof of concept leading up to IND-enabling studies.Celsion Labs is uniquely positioned to be your research partner at the earliest stages of discovery research.

Recent Publications

  • Up-regulation of the mammalian target of rapamycin complex 1 subunit raptor by aldosterone induces abnormal pulmonary artery smooth muscle cell survival patterns to promote pulmonary arterial hypertension. Aghamohammadzadeh R, Zhang YY, Stephens TE, et al. FASEB J. 2016;30(7):2511-2527. doi:10.1096/fj.201500042.
  • Lipid nanoparticle delivery of a microRNA-145 inhibitor improves experimental pulmonary hypertension. McLendon JM, Joshi SR, Sparks J, et al. J Control Release. 2015;210:67-75.
  • Synthetic tumor networks for screening drug delivery systems. Prabhakarpandian B, Shen MC, Nichols JB, et al. J Control Release. 2015;201:49-55.
  • Genetic and hypoxic alterations of the microRNA-210-ISCU1/2 axis promote iron-sulfur deficiency and pulmonary hypertension. White K, Lu Y, Annis S, et al. EMBO Mol Med. 2015;7(6):695-713.
  • Versatile cationic lipids for siRNA delivery. Sparks J, Slobodkin G, Matar M, et al. J Control Release. 2012;158(2):269-276.
  • Delivery of siRNA to the mouse lung via a functionalized lipopolyamine. Polach KJ, Matar M, Rice J, et al. Mol Ther. 2012;20(1):91-100.
  • A phase II trial of intraperitoneal EGEN-001, an IL-12 plasmid formulated with PEG-PEI-cholesterol lipopolymer in the treatment of persistent or recurrent epithelial ovarian, fallopian tube or primary peritoneal cancer: a Gynecologic Oncology Group study. Alvarez RD, Sill MW, Davidson SA, et al. Gynecol Oncol. 2014;133(3):433-438.
  • Phase I trial of a formulated IL-12 plasmid in combination with carboplatin and docetaxel chemotherapy in the treatment of platinum-sensitive recurrent ovarian cancer. Anwer K, Kelly FJ, Chu C, Fewell JG, Lewis D, Alvarez RD. Gynecol Oncol. 2013;131(1):169-173.
  • Versatile cationic lipids for siRNA delivery. Sparks J, Slobodkin G, Matar M, et al. J Control Release. 2012;158(2):269-276.
  • Delivery of siRNA to the mouse lung via a functionalized lipopolyamine. Polach KJ, Matar M, Rice J, et al. Mol Ther. 2012;20(1):91-100.
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