Located in the San Francisco Bay Area – a center of excellence in Biotechnology, CELLTHEON Corporation offers customized solution for expression of a wide variety of recombinant proteins, including monoclonal antibodies for preclinical studies to the biotechnology and pharmaceutical industries.
Celltheon is dedicated to the development of SMART technologies™ and services that significantly reduce the time, and costs associated with developing biotherapeutics.
Celltheon has a team of scientists that have many years of experience in the use of molecular biology techniques resulting in the cloning and construction of novel genes and antibodies for use in the generation of unique reagents and recombinant mammalian cells for biopharmaceutical production. Our team of highly- trained experts is available to deliver quality molecular biology services.
Celltheon can take your cell line development project from DNA to clone selection and stability. Celltheon’s services enable you to maximize protein yield and establish economical production processes. We have expertise with a number of cell lines including CHO, HEK293, NSO, K562, PC12, NIH3T3 etc. We have cloned and generated >100 stable cell lines: intracellular, secreted and surface expressed, some very hard to express proteins.
Celltheon has developed the SMART expression platform that has unique elements for expressing recombinant proteins to monoclonal antibodies. Celltheon's SMART expression platform has been licensed by several institutions and companies 90% of the of Novel and Biosimilar Monoclonal antibodies express at >1.0gm/L at both pool stage and single clones. Our clones and pools show stability for >30-60 generations.
Celltheon has developed purification processes and specific analytical tools to support client production process. Celltheon has well established scale up methodologies in place for scaling up to 10-100L using stir tanks, perfusion and WAVE biorectors. We also purify and deliver low endotoxin material for animal studies.
Celltheon has robust glycan optimization technology which results in very precise control of the resulting N-glycan profile for several proteins.
Celltheon SMART expression platform has been developed and optimized for expression of various recombinant proteins, with added unique elements ( patent pending) that generate stable high expressing clones.
Celltheon's integrated suite of technologies is available for development of a stable cell line. Our capabilities encompass:
Celltheon has successfully developed several stable NS0 cell lines, expressing therapeutic proteins. Celltheon has also developed the accompanying upstream processes to improve the expression of these cell lines by several fold.
Bulk Transient Transfection
Transient transfection of mammalian cells has become increasingly important to produce milligram quantities of a recombinant protein in a short duration for characterization and preclinical studies.
We can assist you with:
Celltheon can scale up from 10-100L scale in various stir tank, perfusion or WAVE bioreactors to generate animal study material.
We can develop customized purification process based on your scale, quantity and quality of your protein.
Includes: N-glycan analysis, Reverse Phase assays, Protein A titer quantification, etc.
Celltheon will take your current cell lines and further optimize the expression using Celltheon's SMART process optimization technology involving media development.
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