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CDI NextGen Proteomics

1 Order Completed
Mayaguez, PR

About CDI NextGen Proteomics

CDI, the result of intensive efforts and advances developed by the High-Throughput Biology Center at Johns Hopkins University, is a privately owned research and discovery company in the field of proteomics.

The company was created by scientists for scientists, addressing the critical needs required in order... Show more »

CDI, the result of intensive efforts and advances developed by the High-Throughput Biology Center at Johns Hopkins University, is a privately owned research and discovery company in the field of proteomics.

The company was created by scientists for scientists, addressing the critical needs required in order to accelerate research, advance discoveries and translate these discoveries into novel products and services that improve human health.

The company applies its accelerating platforms to internal, collaborative, and client programs.

Service and technology dissemination provide immediate revenue.
Internal programs create a pipeline of proprietary biomarker panels and soon-to-be diagnostic and predictive tools in the fields of autoimmunity, oncology, therapeutic outcome and toxicity prediction.

Recent Publications

  • Li H et al. (2016) Penetrance of Congenital Heart Disease in a Mouse Model of Down Syndrome Depends on a Trisomic Potentiator of a Disomic Modifier. Genetics 2016 Mar 30. pii: genetics.116.188045.
  • Yang L et al. (2016) Identification of serum biomarkers for gastric cancer diagnosis using a human proteome microarray. Mol Cell Proteomics 15 (2):614-23. doi: 10.1074/mcp.M115.051250. Epub 2015 Nov 23
  • Syed P et al.(2016) Autoantibody Profiling of Glioma Serum Samples to Identify Biomarkers Using Human Proteome Arrays Sci Rep 2015 Sep 15;5:13895. doi: 10.1038/srep13895.
  • Zhang HN et al. (2015) Systematic identification of arsenic-binding proteins reveals that hexokinase-2 is inhibited by arsenic. Proc Natl Acad Sci USA 112(49):15084-9.
  • Hu J et al. (2015) Systematic Prediction of Scaffold Proteins Reveals New Design Principles in Scaffold-Mediated Signal Transduction. Comput Biol 112(9): e1004508.
  • Cox E et al. (2015) Identification of SUMO E3 ligase-specific substrates using the HuProt human proteome microarray. Methods Mol Biol 1295:455-63.
  • Hu C et al. (2015) Autoantibody Profiling on Human Proteome Microarray for Biomarker Discovery in Cerebrospinal Fluid and Sera of Neuropsychiatric Lupus. PLoS One 10:e0126643.
  • Liu S et al. (2014) Characterization of monoclonal antibody's binding kinetics using oblique-incidence reflectivity difference approach. MAbs 7:110-119.
  • Jung JG et al. (2014) Notch3 interactome analysis identified WWP2 as a negative regulator of Notch3 signaling in ovarian cancer. PLos Genet 10:e1004751.
  • Fan Q et al. (2014) Identification of proteins that interact with alpha A-crystallin using a human proteome microarray. Mol Vis 20:117–124.
  • Deng RP et al. (2014) Global Identification of O-GlcNAc Transferase (OGT) Interactors by a Human Proteome Microarray and the Construction of an OGT Interactome. Proteomics 14(9): 1020-30. doi: 10.1002/pmic.201300144. Epub 2014 Mar 25.0.
  • Ma TM et al. (2014) Serine Racemase Regulated by Binding to Stargazin and PSD-95: Potential NMDA-AMPA Glutamate Neurotransmission Cross-talk. J Biol Chem pii: jbc.M114.571604
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Our Services (18)


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Clinical Biomarkers

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HuProt™ Human Proteome Array

Price on request

The HuProt™ Human Proteome Microarray contains the worlds largest number of unique, individually-purified human proteins. That’s more than double the not-so-close second.

The comprehensive content of the HuProt™ microarray allows thousands of interactions to be profiled in high-throughput:

-Autoantibody/Biomarker... Show more »

The HuProt™ Human Proteome Microarray contains the worlds largest number of unique, individually-purified human proteins. That’s more than double the not-so-close second.

The comprehensive content of the HuProt™ microarray allows thousands of interactions to be profiled in high-throughput:

-Autoantibody/Biomarker Profiling
-Antibody Specificity
-DNA/RNA Binding
-Protein Binding
-Small Molecule Binding
-Enzyme Substrate ID

The HuProt™ v3.0 Human Proteome Protein Microarray contains >19,000 unique, newly resequenced and individually purified human proteins encompassing >15,000 genes (~75% of the human proteome) and 124 unique mouse gene symbols. Recombinant proteins are expressed in yeast (S. cerevisiae), purified and printed on nitrocellulose-coated glass slides in duplicate, along with control proteins.

CDI now uses the Arrayjet Ultra Marathon II non-contact piezoelectric (inkjet) printer for the manufacture of all microarrays with significant performance advantages over contact print methods:
• precise spot morphology
• reduced inter- and intra-array variability
• greater data reproducibility
• large batch sizes for large cohort analysis
• rapid production of custom configured arrays

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HuProt Human Mouse Immunology Oncology Alzheimers Disease Parkinson's disease (PD) Autoimmune disease Microarray Biology Vaccines Large molecules/Biologics Small molecules Show 13 more tags Show less

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Biomarker Discovery

Price on request

Circulating disease related autoantibodies - or disease biomarkers are invaluable for screening patients for pathologies such as cancer, autoimmune disorders, infectious diseases and also to monitor the effectiveness of subsequent treatments.

The CDI HuProt microarray contains nearly 75% of the human proteome on a single glass... Show more »

Circulating disease related autoantibodies - or disease biomarkers are invaluable for screening patients for pathologies such as cancer, autoimmune disorders, infectious diseases and also to monitor the effectiveness of subsequent treatments.

The CDI HuProt microarray contains nearly 75% of the human proteome on a single glass slide, a unique and powerful tool for high-throughput serum profiling and biomarker discovery.

In addition to analysis using the full HuProt microarray, CDI can custom print microarrays containing up to 14 separate subarrays -each containing only proteins of interest as determined during the discovery phase. In this configuration, 14 individual samples can be run on a single microarray - a substantial cost savings.

Clinical Applications

  • Biomarkers for predicting clinical outcome of immunotherapy-treated patients
  • Identify new, reliable diagnostic biomarkers
  • Monitor development and progression or recovery of disease
  • Assess vaccine development; assay for the presence of off-target immune responses that could lead to autoimmune mediated issues

HuProt Microarray Characteristics

  • Recombinant proteins encompassing more than 15,000 unique human genes
  • N-terminal GST- and His6-tagged proteins are purified and printed on glass slides in duplicate, along with control proteins (GST, BSA, Histones, IgG, etc.)
  • Proteome coverage ~ 75%
  • Yeast expression system (S. cerevisiae)
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Genepix 4000B Scanner Molecular Devices HuProt Human Mouse Humanized Mouse Immunology Oncology Autoimmune disease Microarray biomarker Biomarker discovery Autoimmune Profiling Immune Profiling Protein microarray Human protein microarray Biomarker analysis Serum Blood Stool Biofluids Plasma Biology Drug Discovery biomarker HuProt Vaccines Large molecules/Biologics Small molecules Show 28 more tags Show less

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Monoclonal Antibody (mAb) Production

Price on request

Fast-MAb is CDI's microarray-powered custom monoclonal antibody development and specificity validation service with access to -20,000 antigens.

Fast-MAb addresses the urgent need for monoclonal antibodies with unprecedented specificity to native human proteins with delivery in 8 weeks.

CDI utilizes its HuProt™ Human Proteome... Show more »

Fast-MAb is CDI's microarray-powered custom monoclonal antibody development and specificity validation service with access to -20,000 antigens.

Fast-MAb addresses the urgent need for monoclonal antibodies with unprecedented specificity to native human proteins with delivery in 8 weeks.

CDI utilizes its HuProt™ Human Proteome Microarray for validating the final product – therefore your antibody will be screened for cross-reactivity against thousands of human proteins - - 75% of the human proteome.

Be Specific. Whether you are grant-writing, publishing or manufacturing... make CDI Fast-MAb part of your discovery and development success.

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Human Mouse monoclonal antibody mab monoclonal antibodies antibodies Biology monospecific immunogen epitope protein peptide Show 12 more tags Show less

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Antibody Services

Price on request

Antibody Cross-Reactivity Testing

CDI will specificity-test your antibody against over 19,000 human recombinant proteins - native & denatured - and at 2 working concentrations.

High-Spec Cross-Reactivity Testing leverages the power of the HuProt™ microarray to help pharmaceutical companies assess their therapeutic antibody... Show more »

Antibody Cross-Reactivity Testing

CDI will specificity-test your antibody against over 19,000 human recombinant proteins - native & denatured - and at 2 working concentrations.

High-Spec Cross-Reactivity Testing leverages the power of the HuProt™ microarray to help pharmaceutical companies assess their therapeutic antibody pipeline quickly and cost-effectively, thus increasing the number of new treatments discovered, and identifying losers earlier.

Research reagent companies developing commercial antibodies can realize a tremendous quality advantage by offering products with unmatched levels of specificity that can bolster academic research programs at all stages – from grant application to publication. Be Specific.

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HuProt Human Mouse HuProt Protein Microarray Microarray Protein microarray Human protein microarray HuProt Biology HuProt Show 11 more tags Show less

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Biochemistry & Molecular Biology

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Clinical Chemistry

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Omics

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Biomarkers

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Biology

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Antibody/Antigen Detection Based Testing

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Protein Arrays

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Clinical Research

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Clinical Laboratory Services

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Proteomics

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Pharmacology & Toxicology

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Protein Services

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Bioanalysis

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Scott Paschke

Vice President

FileType/PDF Created with Sketch. CDI_FastMAb.pdf

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FileType/PDF Created with Sketch. CDI_HighSpec.pdf

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FileType/PDF Created with Sketch. CDI_ImmuneProfiler_Brochure.pdf

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