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CBSET

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Lexington, Massachusetts, US

About CBSET

Founded: 2006 Type: Nonprofit Size: 51-200 employees

CBSET is a state-of-the-art biomedical research institute located in Lexington MA.

Our mission is to advance biomedical research through innovative, high-quality services. We combine top-tier research with operational expertise. Since our inception, CBSET has continued to develop technical and scientific... Show more »

CBSET is a state-of-the-art biomedical research institute located in Lexington MA.

Our mission is to advance biomedical research through innovative, high-quality services. We combine top-tier research with operational expertise. Since our inception, CBSET has continued to develop technical and scientific acumen through collaborative projects in the medical device, pharmaceutical and academic communities. Our 40,000 square foot, GLP-compliant, AAALAC-accredited facility includes vivaria, procedure rooms, catheterization / imaging labs, surgical and necropsy suites, histopathology, SEM, and a range of other technologies.

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Our Services (34)


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Animal Models and Studies

Price on request
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Medical Device Testing

Price on request

Extensive Experience in the Evaluation of Medical Devices

Our expertise ranges from early device iteration, optimization, and mechanistic studies aimed at driving differentiation in the marketplace, to large-scale GLP safety assessments for regulatory submissions.

State-of-the-art medical device testing

We profile the... Show more »

Extensive Experience in the Evaluation of Medical Devices

Our expertise ranges from early device iteration, optimization, and mechanistic studies aimed at driving differentiation in the marketplace, to large-scale GLP safety assessments for regulatory submissions.

State-of-the-art medical device testing

We profile the safety and efficacy of implanted devices and combination products, and develop novel testing and assessment procedures with multiple regulatory compliances.

  • Open paradigm of collaboration as a non-profit (501(c)(3)) institute
  • Operational compliance and accreditation - GLP, OLAW, AAALAC
  • Animal sciences expertise - full-time ACLAM-certified DVMs
  • Experts in safety - full-time boarded DACVPs
  • Full histology suite for all phases of embedding, sectioning, staining and imaging
  • Customizable mechanical testing of both biomaterials and biological tissues
  • Leaders in computational modeling of combination drug and energy delivery devices

Fully-equipped operating suites

We enable complex surgical procedures in our state-of-the-art facilities.

  • Extensive surgical expertise in small and large animal models
  • Multiple, fully-equipped ORs with anesthesia machines, ventilators, hemodynamic and airway gas monitoring systems
  • Multiple surgery tables and hospital-grade fluoroscopy systems, including dedicated prep and recovery rooms for each suite
  • Catheterization lab
  • Adjoining conference facilities with 2-way video and audio

GLP-compliant imaging modalities

  • Laparoscopic/Endoscopic Olympus towers
  • OEC® Digital Fluoroscopy
  • GE Innova System/3-D Angiography
  • Computed Tomography (CT) and Optical Coherence Tomography (OCT)
  • EP Mapping and Electrophysiology
  • Ultrasound in a wide range of clinical applications, including Intravascular (IVUS), Transthoracic (TTE), Trans-esophageal (TEE), and Intra-cardiac (ICE) procedures
  • Faxitron: Bench-top x-ray enables high resolution imaging of specimens and devices ex vivo
  • Scanning Electron Microscopy (SEM)
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3D Modeling

Three Dimensional Modeling
Price on request

Integrate lab animal sciences with physical modeling and pathology...

CBSET's multi-disciplinary approach can integrate computational modeling of drug release, absorption, and local tissue distribution. We pair the complexities of anatomic and surgical methods with a deep understanding of drug kinetics to meet your needs in a... Show more »

Integrate lab animal sciences with physical modeling and pathology...

CBSET's multi-disciplinary approach can integrate computational modeling of drug release, absorption, and local tissue distribution. We pair the complexities of anatomic and surgical methods with a deep understanding of drug kinetics to meet your needs in a variety of applications, including:

  • Pharmacokinetics (PK) / bio-distribution
  • Drug-material interactions and formulation
  • Computational and 3D modeling
  • Controlled-release therapeutics
  • Combination drug-device products
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Drug Formulation Evaluation

Price on request

Integrate lab animal sciences with physical modeling and pathology...

CBSET's multi-disciplinary approach can integrate computational modeling of drug release, absorption, and local tissue distribution. We pair the complexities of anatomic and surgical methods with a deep understanding of drug kinetics to meet your needs in a... Show more »

Integrate lab animal sciences with physical modeling and pathology...

CBSET's multi-disciplinary approach can integrate computational modeling of drug release, absorption, and local tissue distribution. We pair the complexities of anatomic and surgical methods with a deep understanding of drug kinetics to meet your needs in a variety of applications, including:

  • Pharmacokinetics (PK) / bio-distribution
  • Drug-material interactions and formulation
  • Computational and 3D modeling
  • Controlled-release therapeutics
  • Combination drug-device products
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Biodistribution Studies

Price on request

Integrate lab animal sciences with physical modeling and pathology...

CBSET's multi-disciplinary approach can integrate computational modeling of drug release, absorption, and local tissue distribution. We pair the complexities of anatomic and surgical methods with a deep understanding of drug kinetics to meet your needs in a... Show more »

Integrate lab animal sciences with physical modeling and pathology...

CBSET's multi-disciplinary approach can integrate computational modeling of drug release, absorption, and local tissue distribution. We pair the complexities of anatomic and surgical methods with a deep understanding of drug kinetics to meet your needs in a variety of applications, including:

  • Pharmacokinetics (PK) / bio-distribution
  • Drug-material interactions and formulation
  • Computational and 3D modeling
  • Controlled-release therapeutics
  • Combination drug-device products
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Histology and Pathology Services

Price on request

Supporting the Research Continuum, from Pilot to Regulatory Submission

As a multidisciplinary not-for-profit research institute, CBSET supports a range of applications in therapeutic and device development, with AAALAC-accredited animal research facilities and GLP-compliant analyses. Histology is a critical endpoint for the... Show more »

Supporting the Research Continuum, from Pilot to Regulatory Submission

As a multidisciplinary not-for-profit research institute, CBSET supports a range of applications in therapeutic and device development, with AAALAC-accredited animal research facilities and GLP-compliant analyses. Histology is a critical endpoint for the non-clinical evaluation of medical devices, drugs, biologics and biomaterials.

CBSET’s Comprehensive Histopathology Suite

Our histopathology suite and ACVP boarded pathologists provide flexible support and active collaboration for all facets of sample processing, staining, imaging and analysis, pairing it with expert interpretation and reporting. We will devise the right histopathology protocol for your aims and apply the optimal staining paradigm to satisfy your scientific endpoints.

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Computational Modeling

Price on request

Integrate lab animal sciences with physical modeling and pathology...

CBSET's multi-disciplinary approach can integrate computational modeling of drug release, absorption, and local tissue distribution. We pair the complexities of anatomic and surgical methods with a deep understanding of drug kinetics to meet your needs in a... Show more »

Integrate lab animal sciences with physical modeling and pathology...

CBSET's multi-disciplinary approach can integrate computational modeling of drug release, absorption, and local tissue distribution. We pair the complexities of anatomic and surgical methods with a deep understanding of drug kinetics to meet your needs in a variety of applications, including:

  • Pharmacokinetics (PK) / bio-distribution
  • Drug-material interactions and formulation
  • Computational and 3D modeling
  • Controlled-release therapeutics
  • Combination drug-device products
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Histological Staining

Price on request

Staining Paradigms Selected to Elucidate Disease, Injury or Toxic Effect in Tissue

Primary staining provides rapid, low-cost visualization of any tissue type for robust qualitative assessments of histological changes. Common primary stain paradigms include:

  • Cytology – e.g., Wright-Giemsa
  • Histology

Staining Paradigms Selected to Elucidate Disease, Injury or Toxic Effect in Tissue

Primary staining provides rapid, low-cost visualization of any tissue type for robust qualitative assessments of histological changes. Common primary stain paradigms include:

  • Cytology – e.g., Wright-Giemsa
  • Histology
    • Fibrosis/ repair – e.g., Masson’s trichrome
    • Bone/ collagen – e.g., von Kossa, Goldner’s trichrome, safranin O
    • Vascular – e.g., Movat’s pentachrome, van Gieson elastin

Secondary staining (IHC, IFA, ISH) is used for pinpoint contrast and quantitative analysis. Immunohistochemistry (IHC) and Immunofluorescence (IFA) use antibodies targeting cellular biomarkers, coupled to chromogenic enzymes or fluorophores, for improved dynamic range and sensitivity. In Situ Hybridization (ISH) detects expression of RNA in sections via oligonucleotide hybridization to target RNA sequences.

  • Neurologic – e.g., neurofilament (NF), tyrosine hydroxylase (TH), calcitonin gene related peptide (CGRP)
  • Connective tissue/vascular – e.g., collagen I, collagen III, von Willebrand factor, actin
  • Inflammation – e.g., CD3, CD79a, C18, CD68
  • Cell death and proliferation – e.g., TUNEL, proliferating cell nuclear antigen (PCNA)
  • Gene expression (custom oligonucleotide probes directed to mRNA targets)
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Biomarker Analysis

Price on request

Tissue biomarker analysis can include:

  • Method development
  • Secondary probe strategies for optimized signal detection and amplification
  • A wide range of fluorophores, or fluorophore-conjugated secondary antibodies
  • Multiplexing for simultaneous visualization of multiple markers
  • Quantitative analysis/ scoring of localization and intensity of signals

Tissue biomarker analysis can include:

  • Method development
  • Secondary probe strategies for optimized signal detection and amplification
  • A wide range of fluorophores, or fluorophore-conjugated secondary antibodies
  • Multiplexing for simultaneous visualization of multiple markers
  • Quantitative analysis/ scoring of localization and intensity of signals
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Histopathological Examination

Price on request

CBSET’s Comprehensive Histopathology Suite

Our histopathology suite and ACVP boarded pathologists provide flexible support and active collaboration for all facets of sample processing, staining, imaging and analysis, pairing it with expert interpretation and reporting. We will devise the right histopathology protocol for your... Show more »

CBSET’s Comprehensive Histopathology Suite

Our histopathology suite and ACVP boarded pathologists provide flexible support and active collaboration for all facets of sample processing, staining, imaging and analysis, pairing it with expert interpretation and reporting. We will devise the right histopathology protocol for your aims and apply the optimal staining paradigm to satisfy your scientific endpoints.

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Tissue Slide Preparation

Price on request

Slide preparation capabilities include:

  • Tissue trimming and fixation
  • Paraffin and plastic resin processing
  • Embedding, sectioning and staining
  • Microtomy and EXAKT micro-grinding

Slide preparation capabilities include:

  • Tissue trimming and fixation
  • Paraffin and plastic resin processing
  • Embedding, sectioning and staining
  • Microtomy and EXAKT micro-grinding
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Tissue Preparation

Price on request

Tissue Preparation Services

Tissue Preparation Services

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Tissue Processing

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Tissue Processing Services

Tissue Processing Services

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Biospecimens

Price on request

Biospecimens Services

Biospecimens Services

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Clinical and Anatomic Pathology

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Clinical and Anatomic Pathology Services

Clinical and Anatomic Pathology Services

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Clinical Laboratory Services

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Clinical Laboratory Services

Clinical Laboratory Services

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Clinical Research

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Clinical Research Services

Clinical Research Services

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Microscopy

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Biology

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Electron Microscopy

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In vitro Disease Models

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Imaging & Spectroscopy

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Cells and Tissues

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Scanning Transmission Electron Microscopy (STEM)

Scanning transmission electron microscopy
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Transmission Electron Microscopy (TEM)

Transmission Electron Microscopy services
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Biomarkers

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Biomarkers Services

Biomarkers Services

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Bioanalysis

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Bioanalysis Services

Bioanalysis Services

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Pharmacology

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Pharmacology Services

Pharmacology Services

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Pharmacology & Toxicology

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Pharmacology & Toxicology Services

Pharmacology & Toxicology Services

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Drug Discovery & Development

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Drug Discovery & Development Services

Drug Discovery & Development Services

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ADME/DMPK Studies

Drug Metabolism and Pharmacokinetics
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ADME/DMPK Studies Services

ADME/DMPK Studies Services

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In vivo ADME/DMPK Studies

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In vivo ADME/DMPK Studies Services

In vivo ADME/DMPK Studies Services

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Formulation Services

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Formulation Services

Formulation Services

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Medical Devices & Diagnostics

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Medical Devices & Diagnostics Services

Medical Devices & Diagnostics Services

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Michael Naimark

Director of Business Development

CBSET has not received any reviews.

CBSET has not received any endorsements.