CBSET is a state-of-the-art biomedical research institute located in Lexington MA. Our mission is to advance biomedical research through innovative, high-quality services. We combine top-tier research with operational expertise. Since our inception, CBSET has continued to develop technical and scientific acumen through collaborative projects in the medical device, pharmaceutical and academic communities. Our 40,000 square foot, GLP-compliant, AAALAC-accredited facility includes vivaria, procedure rooms, catheterization / imaging labs, surgical and necropsy suites, histopathology, SEM, and a range of other technologies.
Extensive Experience in the Evaluation of Medical Devices
Our expertise ranges from early device iteration, optimization, and mechanistic studies aimed at driving differentiation in the marketplace, to large-scale GLP safety assessments for regulatory submissions.
State-of-the-art medical device testing
We profile the safety and efficacy of implanted devices and combination products, and develop novel testing and assessment procedures with multiple regulatory compliances.
Fully-equipped operating suites
We enable complex surgical procedures in our state-of-the-art facilities.
GLP-compliant imaging modalities
Integrate lab animal sciences with physical modeling and pathology...
CBSET's multi-disciplinary approach can integrate computational modeling of drug release, absorption, and local tissue distribution. We pair the complexities of anatomic and surgical methods with a deep understanding of drug kinetics to meet your needs in a variety of applications, including:
Integrate lab animal sciences with physical modeling and pathology...
CBSET's multi-disciplinary approach can integrate computational modeling of drug release, absorption, and local tissue distribution. We pair the complexities of anatomic and surgical methods with a deep understanding of drug kinetics to meet your needs in a variety of applications, including:
Supporting the Research Continuum, from Pilot to Regulatory Submission
As a multidisciplinary not-for-profit research institute, CBSET supports a range of applications in therapeutic and device development, with AAALAC-accredited animal research facilities and GLP-compliant analyses. Histology is a critical endpoint for the non-clinical evaluation of medical devices, drugs, biologics and biomaterials.
CBSET’s Comprehensive Histopathology Suite
Our histopathology suite and ACVP boarded pathologists provide flexible support and active collaboration for all facets of sample processing, staining, imaging and analysis, pairing it with expert interpretation and reporting. We will devise the right histopathology protocol for your aims and apply the optimal staining paradigm to satisfy your scientific endpoints.
Integrate lab animal sciences with physical modeling and pathology...
CBSET's multi-disciplinary approach can integrate computational modeling of drug release, absorption, and local tissue distribution. We pair the complexities of anatomic and surgical methods with a deep understanding of drug kinetics to meet your needs in a variety of applications, including:
Staining Paradigms Selected to Elucidate Disease, Injury or Toxic Effect in Tissue
Primary staining provides rapid, low-cost visualization of any tissue type for robust qualitative assessments of histological changes. Common primary stain paradigms include:
Secondary staining (IHC, IFA, ISH) is used for pinpoint contrast and quantitative analysis. Immunohistochemistry (IHC) and Immunofluorescence (IFA) use antibodies targeting cellular biomarkers, coupled to chromogenic enzymes or fluorophores, for improved dynamic range and sensitivity. In Situ Hybridization (ISH) detects expression of RNA in sections via oligonucleotide hybridization to target RNA sequences.
Tissue biomarker analysis can include:
CBSET’s Comprehensive Histopathology Suite
Our histopathology suite and ACVP boarded pathologists provide flexible support and active collaboration for all facets of sample processing, staining, imaging and analysis, pairing it with expert interpretation and reporting. We will devise the right histopathology protocol for your aims and apply the optimal staining paradigm to satisfy your scientific endpoints.
Slide preparation capabilities include:
Tissue Preparation Services
Tissue Processing Services
Clinical and Anatomic Pathology Services
Clinical Laboratory Services
Biomarkers Services
Bioanalysis Services
Pharmacology Services
Pharmacology & Toxicology Services
Drug Discovery & Development Services
Medical Devices & Diagnostics Services
In vivo ADME/DMPK Studies Services
ADME/DMPK Studies Services
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CBSET has not received any endorsements.