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Cayman Chemical

3 Orders Completed
Ann Arbor, Michigan, US

About Cayman Chemical

Cayman Contract Services provides discovery and pre-clinical development services to the global pharmaceutical, biotechnology, and academic research markets. Our diverse suite of services leverages a team of over 150 highly skilled scientists with expertise in medicinal chemistry, structure-based drug... Show more »

Cayman Contract Services provides discovery and pre-clinical development services to the global pharmaceutical, biotechnology, and academic research markets. Our diverse suite of services leverages a team of over 150 highly skilled scientists with expertise in medicinal chemistry, structure-based drug design, complex multi-step organic synthesis, analytical chemistry, sample analysis, and custom assay development. We offer a personalized, flexible approach that enables our clients to accelerate their drug discovery and development through a single-source partner, from novel drug design and synthesis to target identification and validation.

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Our Services (33)


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Functional & Cell Type Specific Assays

Price on request

Activity Screening

We perform activity screening using your compounds, or our libraries, in biochemical or functional assays. Leverage our expertise to custom build a screening assay on a variety of enzyme activity and cell-based platforms or choose from our catalog of more than 200 well-characterized assays.

Activity Screening

We perform activity screening using your compounds, or our libraries, in biochemical or functional assays. Leverage our expertise to custom build a screening assay on a variety of enzyme activity and cell-based platforms or choose from our catalog of more than 200 well-characterized assays.

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Chemical Reference Standards

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Compound Libraries

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Drug Discovery & Development

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Our team of experts can help develop a fit-for-purpose method for discovery, pharmacokinetic, and formulation applications. Supporting services include drug property determination (log D, solubility), and drug metabolism and stability. We continuously expand our LC-MS/MS capabilities for the detection and quantification of drugs, metabolites, and biomarkers in biological samples.

Our team of experts can help develop a fit-for-purpose method for discovery, pharmacokinetic, and formulation applications. Supporting services include drug property determination (log D, solubility), and drug metabolism and stability. We continuously expand our LC-MS/MS capabilities for the detection and quantification of drugs, metabolites, and biomarkers in biological samples.

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Protein Crystallization Screening and Optimization

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Robust protein crystal screening and optimization is performed in a temperature-controlled environment using an Opentrons OT-One S Pro liquid handler.

Robust protein crystal screening and optimization is performed in a temperature-controlled environment using an Opentrons OT-One S Pro liquid handler.

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X-ray Crystallography

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We solve and deliver macromolecular and protein-complex structures using X-ray data collected via access to 3 beamlines at LS-CAT 21-ID, APS, Argonne National Laboratory.

We solve and deliver macromolecular and protein-complex structures using X-ray data collected via access to 3 beamlines at LS-CAT 21-ID, APS, Argonne National Laboratory.

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SAR Analysis

Price on request

Identify, prioritize, and optimize lead candidates leveraging our expertise in Structural Biology, organic synthesis, and activity screening. Identify key interactions, model pharmacophores, enumerate hits, and predict binding, physicochemical, and ADME/tox properties.

Identify, prioritize, and optimize lead candidates leveraging our expertise in Structural Biology, organic synthesis, and activity screening. Identify key interactions, model pharmacophores, enumerate hits, and predict binding, physicochemical, and ADME/tox properties.

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Antibody Production

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Protein Production

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Mass Spectrometry Method Development

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Immunoassay Development

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Lipidomics

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Discovery Lipidomics (Untargeted Profiling)
Through untargeted approaches we analyze hundreds to thousands of lipid species from biological samples to create a detailed lipid profile. After using general liquid-liquid methods for extraction of most lipids within a sample, they are separated... Show more »

Discovery Lipidomics (Untargeted Profiling)
Through untargeted approaches we analyze hundreds to thousands of lipid species from biological samples to create a detailed lipid profile. After using general liquid-liquid methods for extraction of most lipids within a sample, they are separated chromatographically using HPLC or UPLC in order to simultaneously detect individual molecular species and identify changes in these lipids between samples. Detection and identification of lipid species is achieved using high-resolution mass spectrometry (HRMS) and tandem mass spectrometry (MS/MS).

Identification and relative quantitation of candidate lipid species is facilitated by the use of data-processing software and publicly available databases. When molecular identification is provided based on the LC-MS/MS data available, Cayman adheres to the recommendations issued by the Lipid Maps® consortium and the Lipidomics Standards Initiative. Data is reported as tables of mass-to-charge ratios (m/z), with ion intensity peak areas normalized to internal standards, and they can be visualized using powerful plotting and graphing tools. Statistical analysis can also be applied to sort out significant changes within complex lipid profiles.

This 2D feature plot (m/z versus retention time) generated using the Lipostar lipidomics software package represents positively identified molecular species, corresponding to different lipid classes, in adipose tissue. The color of each dot indicates the lipid class (see legend at top left corner), and its size correlates with its relative concentration in the sample.

Untargeted Analysis
Identify profile changes across all major lipid classes or within a single lipid class.

  • Fatty Acyls
  • Glycerolipids
  • Glycerophospholipids
  • Sphingolipids
  • Sterol Lipids

Targeted Lipidomics and Absolute Quantitation
Targeted lipidomics enables the focused analysis of a known collection of lipids. Precise method development allows for the inclusion of equal amounts of isotope-labeled or odd-chain internal standards selected from customizable lipid panels. Lipids from each sample are extracted using standardized protocols and analyzed by LC-MS/MS using analyte-specific collision-induced mass transitions from the molecular ion (or, in some cases, from a known adduct) to a characteristic fragment ion. Analyte concentrations are determined from calibration curves prepared from authentic standards, when available, or surrogate standards when necessary. This approach is especially useful for quantifying lipids present at low levels in samples, such as endogenous bioactive lipids (e.g., prostaglandins, leukotrienes, or endocannabinoids). Standard statistical analysis tools can reveal changing trends in lipid species among experimental groups, which can be visualized with a heat map or other available graphical tools.

 

Targeted Lipid Panels
Maximize data from precious samples with established targeted lipid panels offering the sensitivity, efficiency, and specificity needed to identify and quantify biologically relevant lipids.

  • Eicosanoids and Oxylipins
  • Sphingolipids
  • Endocannabinoids and Endocannabinoid-like Lipids
  • Urinary Lipid Metabolites
  • Cholesterol Esters
  • Short-Chain Fatty Acids
  • Phospholipids
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Biomarker Assay Development

Price on request

Our biomarker profiling group performs pre-clinical bioanalytical screening projects for drug discovery using multiple platforms. We offer scalable assays (catalog or custom), single- or multi-analyte studies, and automation capabilities. Browse our catalog of ELISA and detection assays or contact us to discuss a custom project.

Our biomarker profiling group performs pre-clinical bioanalytical screening projects for drug discovery using multiple platforms. We offer scalable assays (catalog or custom), single- or multi-analyte studies, and automation capabilities. Browse our catalog of ELISA and detection assays or contact us to discuss a custom project.

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Cellular Health & Metabolism Assays

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Mitochondrial Stress Tests

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Cellular Bioenergetics

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Cellular Metabolism and Bionergetics Analysis

Cayman’s cellular metabolism screening services will generate a full profile of mitochondrial function and cellular bioenergetics for pre-clinical compounds. Our scientists are experts in the design of biochemically relevant experimental models and the... Show more »

Cellular Metabolism and Bionergetics Analysis

Cayman’s cellular metabolism screening services will generate a full profile of mitochondrial function and cellular bioenergetics for pre-clinical compounds. Our scientists are experts in the design of biochemically relevant experimental models and the execution of complex mitochondrial assays. With Cayman, you have access to a progressive set of primary screens that determine mitochondrial function in intact cells, functional assays that can be used to screen potential effectors of the electron transport chain (ETC), mitochondrial inner membrane permeability, mitochondrial release of ATP or reactive oxygen species generation, and an assay that measures citrate synthase activity to assess mitochondrial content.

  • Fuel flexibility determination
  • Metabolic phenotype analysis
  • Agilent Seahorse XFe96 analysis with cellular normalization
  • OCR/ECAR analysis at a concentration 10-fold higher than the Cmax
  • Mitochondrial H2O2 measurements
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Agilent Seahorse XF Analyzer BioTek Cytation 5 Miltenyi MacsQuant

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Cellular Metabolism Assays

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Agilent Seahorse XF Analyzer BioTek Cytation 5 Miltenyi MacsQuant

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Neoantigen Identification

Price on request

Immunopeptidome Profiling Services

We provide a complete package for clients’ neoantigen discovery needs, from cell culture and transfection of single HLA alleles to immunoprecipitation of MHC from multiple species and from LC-MS/MS analysis to transcriptome sequencing.

Identification of... Show more »

Immunopeptidome Profiling Services

We provide a complete package for clients’ neoantigen discovery needs, from cell culture and transfection of single HLA alleles to immunoprecipitation of MHC from multiple species and from LC-MS/MS analysis to transcriptome sequencing.

Identification of thousands of MHC-associated peptides
Optimized workflow for MHC Class I and II (human or mouse)
Allele-specific studies matched to your specifications
Suitable for cells or tumor tissue
Analysis using Orbitrap MS and unbiased, deep sequencing of the MHC peptidome
Customized antibody production, cell culture, and bioanalysis services can be tailored to your specific project needs
MHC Class I and MHC Class II Neoantigen Discovery Neoantigen ID
Genetic mutations in cancer cells can give rise to novel peptide sequences (neoantigens) that can be presented via the MHC-I pathway and potentially recognized by the immune system as foreign. Profiling (IDing) the immunopeptidome of established tumor cell lines or tumor tissue holds potential for the development of personalized antitumor immunotherapies designed to stimulate a patient’s immune response to neoantigen-derived epitopes.

MAPPs
MHC class II associated peptide proteomics (MAPPs) is of growing importance as a drug development tool for biological therapeutics, as repeated administration can lead to immune-mediated neutralization and reduced long-term efficacy of recombinant protein and engineered antibody-based drugs. Cayman has optimized methods to enhance uptake of biologics by APCs, which, combined with specific MHC class II immunoprecipitation, results in improved efficiency in identifying potentially immunogenic epitopes in allele-specific patient subsets.

 

MHC Class I and MHC Class II Neoantigen Discovery Neoantigen ID
Genetic mutations in cancer cells can give rise to novel peptide sequences (neoantigens) that can be presented via the MHC-I pathway and potentially recognized by the immune system as foreign. Profiling (IDing) the immunopeptidome of established tumor cell lines or tumor tissue holds potential for the development of personalized antitumor immunotherapies designed to stimulate a patient’s immune response to neoantigen-derived epitopes.

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Immunology Oncology Immuno-Oncology

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Formulation Services

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Bioanalysis

Price on request

Our scientists perform sample analysis, compound screening, and assay development. Choose from our catalog of well-characterized Cayman assays or other commercially available assays qualified by our scientists. Our experts can also develop and qualify an assay that suits your specific requirements. Our team has decades of... Show more »

Our scientists perform sample analysis, compound screening, and assay development. Choose from our catalog of well-characterized Cayman assays or other commercially available assays qualified by our scientists. Our experts can also develop and qualify an assay that suits your specific requirements. Our team has decades of experience developing plate-based, mass spectrometry-based, cell-based, and flow cytometry assays. We consult with you continuously throughout the project—from experimental design to data analysis and reporting—ensuring we meet your objectives.

  • Sample Analysis
  • Biomarker profiling
  • Activity screening
  • Lipidomics
  • Immunopeptidome profiling
  • Proteomic and PTM analysis
  • Cellular metabolism and bioenergetics analysis
  • Custom assay development


 

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Structure-Based Drug Design

Price on request

The Medicinal Chemistry and Structural Biology groups at Cayman have successfully delivered on a wide range of external drug development programs and driven independent and collaborative external and internal programs. This service offers a fully integrated multidisciplinary approach from design and synthesis to screening and... Show more »

The Medicinal Chemistry and Structural Biology groups at Cayman have successfully delivered on a wide range of external drug development programs and driven independent and collaborative external and internal programs. This service offers a fully integrated multidisciplinary approach from design and synthesis to screening and optimization. Scale-up and process/GMP development are also offered. Whether it’s lead generation or optimization, route and methods development, screening, or scale-up, Cayman’s experienced medicinal and organic chemists, structural biologists, and biochemists possess the competencies to augment your pre-clinical drug discovery and development needs.

Drug Design, SAR, & Process Scaling

  • In silico drug design and selectivity assessment
  • Parallel library generation
  • Structure-activity relationship studies
  • Lead optimization and development
  • Route development and scale-up
  • Pre-GMP process development

Structural Biology

  • Recombinant protein production and characterization
  • Biophysical characterization and optimization
  • Protein crystallization
  • Structure determination by X-ray crystallography
  • In silico docking and homology modeling
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Schrodinger Maestro 11

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Medicinal Chemistry

Price on request

The Medicinal Chemistry and Structural Biology groups at Cayman have successfully delivered on a wide range of external drug development programs and driven independent and collaborative external and internal programs. This service offers a fully integrated multidisciplinary approach from design and synthesis to screening and... Show more »

The Medicinal Chemistry and Structural Biology groups at Cayman have successfully delivered on a wide range of external drug development programs and driven independent and collaborative external and internal programs. This service offers a fully integrated multidisciplinary approach from design and synthesis to screening and optimization. Scale-up and process/GMP development are also offered. Whether it’s lead generation or optimization, route and methods development, screening, or scale-up, Cayman’s experienced medicinal and organic chemists, structural biologists, and biochemists possess the competencies to augment your pre-clinical drug discovery and development needs.

Drug Design, SAR, & Process Scaling

  • In silico drug design and selectivity assessment
  • Parallel library generation
  • Structure-activity relationship studies
  • Lead optimization and development
  • Route development and scale-up
  • Pre-GMP process development

Structual Biology

  • Recombinant protein production and characterization
  • Biophysical characterization and optimization
  • Protein crystallization
  • Structure determination by X-ray crystallography
  • In silico docking and homology modeling
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Analytical Chemistry Services

Price on request

Our scientists perform routine quality control testing on thousands of compounds each year, giving Cayman unparalleled expertise in the development and validation of methods to analyze, quantify, and purify small molecules. Employing multiple chemical testing methods customized to each project’s unique requirements, we... Show more »

Our scientists perform routine quality control testing on thousands of compounds each year, giving Cayman unparalleled expertise in the development and validation of methods to analyze, quantify, and purify small molecules. Employing multiple chemical testing methods customized to each project’s unique requirements, we perform qualitative and quantitative analysis, purification, and characterization of chemical entities such as bioactive lipids, natural products, synthetic compounds, cosmetics, pharmaceuticals, and drugs of abuse in organic and biological matrices.

  • Lipid Purification and Analysis
  • Drug Discovery

  • Custom Analytical Chemistry Services

    • Chromatography method development

    • Purification and isolation

    • Unknown identification by multidimensional NMR, high-resolution MS/MS

    • Property determination and specification testing

    • Product reverse engineering and troubleshooting

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Assay Development

Price on request

Choose from our catalog of well-characterized Cayman assays or other commercially available assays qualified by our scientists. Our experts can also develop and qualify an assay that suits your specific requirements. Our team has decades of experience developing plate-based, mass spectrometry-based, cell-based, and flow... Show more »

Choose from our catalog of well-characterized Cayman assays or other commercially available assays qualified by our scientists. Our experts can also develop and qualify an assay that suits your specific requirements. Our team has decades of experience developing plate-based, mass spectrometry-based, cell-based, and flow cytometry assays.

  • Immunoassays
  • Mass spectrometry-based assays
  • Enzyme activity assays
  • Cell-based assays
  • Reporter assays
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Chemical Synthesis

Price on request

Our team of synthetic organic and medicinal chemists brings decades of academic and pharmaceutical experience to perform complex, multi-step organic syntheses. Supported by our Medicinal Chemistry & Structure-Based Drug Design and GMP & Process Development Services, our growing team of more than 70 highly... Show more »

Our team of synthetic organic and medicinal chemists brings decades of academic and pharmaceutical experience to perform complex, multi-step organic syntheses. Supported by our Medicinal Chemistry & Structure-Based Drug Design and GMP & Process Development Services, our growing team of more than 70 highly skilled organic chemists has added broad synthetic proficiencies to our traditional core expertise in lipid, bioconjugate, and stable isotope labeling chemistry. We are ready to take on your next challenging project!

Synthesis, Purification, and Characterization

  • Complex fatty acid metabolites, glycerophospholipids, sphingolipids, and sterols
  • Small molecule, drug-like heterocyclic compounds
  • Classic and emerging drugs of abuse including PEDs, LSD, amphetamines, benzodiazepines, synthetic cannabinoids, opioids, and more
  • Stable isotope-labeled target standards

Development of Analytical Grade Standards

  • Analytical Standards
  • Reference Materials
  • Certified Reference Materials

Small Molecule Analog Synthesis/SAR, Parallel Medicinal Chemistry, and Compound Library Generation

  • Hit-to-Lead: design, synthesis, and screening
  • Lead optimization and scale-up

Specialized Syntheses

  • Bioconjugation
  • Fluorescent dye design, development, and synthesis
  • Selective, stable isotopic labeling
  • Natural Product Chemistry: extraction from biological sources and total synthesis

GMP and Process Development

  • Chemical route exploration, development, and optimization
  • Pre-clinical/clinical API synthesis and method validation
  • Commercial GMP-API manufacturing
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Biochemical Assays

Price on request

Our scientists perform sample analysis, compound screening, and assay development. Choose from our catalog of well-characterized Cayman assays or other commercially available assays qualified by our scientists. Our experts can also develop and qualify an assay that suits your specific requirements. Our team has decades of... Show more »

Our scientists perform sample analysis, compound screening, and assay development. Choose from our catalog of well-characterized Cayman assays or other commercially available assays qualified by our scientists. Our experts can also develop and qualify an assay that suits your specific requirements. Our team has decades of experience developing plate-based, mass spectrometry-based, cell-based, and flow cytometry assays. We consult with you continuously throughout the project—from experimental design to data analysis and reporting—ensuring we meet your objectives.

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Biochemistry & Molecular Biology

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Project Management

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Enzyme Assays

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Synthetic Chemistry

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Chemistry and Materials

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Biochemical Assay Development

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Our scientists perform sample analysis, compound screening, and assay development. Choose from our catalog of well-characterized Cayman assays or other commercially available assays qualified by our scientists. Our experts can also develop and qualify an assay that suits your specific requirements. Our team has decades of... Show more »

Our scientists perform sample analysis, compound screening, and assay development. Choose from our catalog of well-characterized Cayman assays or other commercially available assays qualified by our scientists. Our experts can also develop and qualify an assay that suits your specific requirements. Our team has decades of experience developing plate-based, mass spectrometry-based, cell-based, and flow cytometry assays. We consult with you continuously throughout the project—from experimental design to data analysis and reporting—ensuring we meet your objectives.

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Cell-Based Assays

Price on request

Our scientists perform sample analysis, compound screening, and assay development. Choose from our catalog of well-characterized Cayman assays or other commercially available assays qualified by our scientists. Our experts can also develop and qualify an assay that suits your specific requirements. Our team has decades of... Show more »

Our scientists perform sample analysis, compound screening, and assay development. Choose from our catalog of well-characterized Cayman assays or other commercially available assays qualified by our scientists. Our experts can also develop and qualify an assay that suits your specific requirements. Our team has decades of experience developing plate-based, mass spectrometry-based, cell-based, and flow cytometry assays. We consult with you continuously throughout the project—from experimental design to data analysis and reporting—ensuring we meet your objectives.

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Karin Dunbar

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Business Development Manager, Contract Services

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