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CARE Research, LLC

3 Orders Completed
Fort Collins, Colorado, US

About CARE Research, LLC

CARE Research, LLC is a preclinical contract research organization (CRO) serving the biomedical research, pharmaceutical, and device and drug development industries. We provide excellent-quality in-vivo laboratory services over a wide variety of species, large and small. Our facilities provide the best... Show more »

CARE Research, LLC is a preclinical contract research organization (CRO) serving the biomedical research, pharmaceutical, and device and drug development industries. We provide excellent-quality in-vivo laboratory services over a wide variety of species, large and small. Our facilities provide the best possible living environment for our research animals. *CARE Research advantages include:* - Protocol development & Regulatory Guidance - Variety of animal models for preclinical trials - Multispecies pharmacokinetics (PK) & toxicokinetics (TK) - Toxicology, Feed, Nutrition & Range finding studies - GLP and GCP Studies - Surgery Suite (ideal for surgical devices & implants) - Specialty Surgical and Diagnostic Equipment - Extensive Experience with FDA, USDA, and EPA - Competitive Pricing - Expeditious Turnaround Time *A humane and compassionate preclinical research lab:* We conduct our research in a manner that emphasizes patient quality of life. Our facilities are fully compliant with USDA and OLAW regulatory requirements. Most vivarium facilities also meet the European Union animal welfare recommendations.

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Certifications & Qualifications

GLP

Diversity Certificates

Minority owned business Small business Woman owned business

Our Services (39)


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Veterinary Research & Diagnostics

Price on request

CARE Research, LLC is a preclinical contract research organization (CRO) serving the biomedical research, pharmaceutical, and device and drug development industries. We provide excellent-quality in-vivo laboratory services over a wide variety of species, large and small. Our facilities provide the best possible living environment for our research animals.

CARE Research, LLC is a preclinical contract research organization (CRO) serving the biomedical research, pharmaceutical, and device and drug development industries. We provide excellent-quality in-vivo laboratory services over a wide variety of species, large and small. Our facilities provide the best possible living environment for our research animals.

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Quantitative Histology

Price on request
Request a quote for more information about this service.

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Animal Behavior Studies

Price on request
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Rheumatoid Arthritis Animal Models

Price on request
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In vivo PK/PD Studies

Price on request

Pharmacokinetic (PK) and Toxicokinetic (TK) studies to support the early stages of the drug discovery process. Routes can be IV, oral gavage, tail vein, infusion, inhalation, IT and more, and conducted in rodents and non-rodents. Eye injection with aqueous humor, vitreous humor, chorion, and retina PK/TK sampling. TK/PK studies... Show more »

Pharmacokinetic (PK) and Toxicokinetic (TK) studies to support the early stages of the drug discovery process. Routes can be IV, oral gavage, tail vein, infusion, inhalation, IT and more, and conducted in rodents and non-rodents. Eye injection with aqueous humor, vitreous humor, chorion, and retina PK/TK sampling. TK/PK studies are often single-dose, but can be repeat-dose.

We provide the following benefits to customers seeking PK screening:

  • Ability to meet aggressive timelines for outsourced PK programs
  • Short lead time for study initiation
  • Rapid turnaround times
  • Flexible scheduling to allow last-minute changes to study protocol
  • Standardized, abbreviated protocols and reporting methods
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Medical Device Development

Price on request

Our surgical facilities are designed for major surgery and medical device testing in small and large animals and can accommodate groups. Clinical pathology assays may be performed in-house for rapid analytical results.

We offer experimental surgeries including:

  • acute or survival procedures
  • cardiovascular models
    -... Show more »

Our surgical facilities are designed for major surgery and medical device testing in small and large animals and can accommodate groups. Clinical pathology assays may be performed in-house for rapid analytical results.

We offer experimental surgeries including:

  • acute or survival procedures
  • cardiovascular models
  • laparoscopic surgical procedures
  • surgeon training programs
  • animal model development
  • thoracic, abdominal, vascular or orthopedic surgery models in pigs, dogs and sheep
  • osteoarthritis models in the dog, rabbit, and guinea pig
  • dermal hypersensitivity and dermal absorption/PK testing in pigs
  • metabolism studies
  • infusion models
  • atherosclerosis models
  • biomaterial and chemotherapy implants
  • small-animal cerebrovascular models including focal ischemia, global ischemia, and cranial window — and more.

Through our working relationship with the College of Veterinary Medicine at Colorado State University, we have access to equipment and facilities for the most complex studies:

  • Top diagnostic imaging including radiography, ultrasound and color flow Doppler imaging, fluoroscopy, CT scanning, MRI, and dual energy x-ray absorptiometry (DEXA)
  • Heart/lung bypass machine
  • Intra-operative radiation therapy
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Animal Surgery

Price on request

Our surgical facilities are designed for major surgery and medical device testing in small and large animals and can accommodate groups. Clinical pathology assays may be performed in-house for rapid analytical results.

We offer experimental surgeries including:

  • acute or survival procedures
  • cardiovascular models
    -... Show more »

Our surgical facilities are designed for major surgery and medical device testing in small and large animals and can accommodate groups. Clinical pathology assays may be performed in-house for rapid analytical results.

We offer experimental surgeries including:

  • acute or survival procedures
  • cardiovascular models
  • laparoscopic surgical procedures
  • surgeon training programs
  • animal model development
  • thoracic, abdominal, vascular or orthopedic surgery models in pigs, dogs and sheep
  • osteoarthritis models in the dog, rabbit, and guinea pig
  • dermal hypersensitivity and dermal absorption/PK testing in pigs
  • metabolism studies
  • infusion models
  • atherosclerosis models
  • biomaterial and chemotherapy implants
  • small-animal cerebrovascular models including focal ischemia, global ischemia, and cranial window — and more.

Through our working relationship with the College of Veterinary Medicine at Colorado State University, we have access to equipment and facilities for the most complex studies:

  • Top diagnostic imaging including radiography, ultrasound and color flow Doppler imaging, fluoroscopy, CT scanning, MRI, and dual energy x-ray absorptiometry (DEXA)
  • Heart/lung bypass machine
  • Intra-operative radiation therapy
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Toxicology

Price on request

Acute Toxicity (GLP or Non-GLP) and Chronic Toxicity (GLP or Non-GLP)

For several decades CARE’s exceptional team of scientists including toxicologists, pathologists, veterinary surgeons, regulatory specialists, and support personnel has designed and performed safety programs ranging from acute through chronic toxicity.... Show more »

Acute Toxicity (GLP or Non-GLP) and Chronic Toxicity (GLP or Non-GLP)

For several decades CARE’s exceptional team of scientists including toxicologists, pathologists, veterinary surgeons, regulatory specialists, and support personnel has designed and performed safety programs ranging from acute through chronic toxicity.

Acute toxicity describes the adverse effects of a substance which result either from a single exposure or from multiple exposures in a short period of time (usually less than 24 hours). To be described as acute toxicity, the adverse effects should occur within 14 days of the administration of the substance. Our evaluation of acute toxicity data includes the relationship between the exposure of animals to the test substance and the incidence and severity of all abnormalities, including behavioral and clinical abnormalities, the reversibility of observed abnormalities, gross lesions, body weight changes, effects on mortality, clinical pathology, histopathology, and any other toxic effects as required by the client. Our data from acute studies in rodent and non-rodents are used in conjunction with future repeat-dose data to aid in the determination of doses, routes, formulations, and regimens to be used in potential clinical studies. Non-GLP acute studies use a minimum number of animals and end-points and are intended to provide data used to make a go/no-go decision with respect to more a GLP study or more definitive studies. Species available include mice, rats, hamsters, guinea pigs, rabbits, canine, swine, sheep, poultry, and large farm animals.

Our chronic toxicity studies provide a thorough examination of the dose effect of a given substance on homeostasis, bodily function, induced diseases, and the effect on lifespan. These provide the bulk of the preclinical information used for assessing safety and risk. The study is conducted in rodent and non-rodent models, in both sexes, and over a regimen that approaches the lifespan of the animal. There are often multiple intermediate evaluations, including daily observations, weekly food and water consumption, and body weight determinations, pharmacokinetic satellite plasma collection, interim necropsies, clinical pathology, and more. At the termination of the study all animals are subjected clinical pathology and to a full necropsy with full tissue collection followed by histopathology. We recommend group sizes in GLP studies sufficient in number to assure enough animals survive to provide statistical significant data. Non-GLP chronic studies use a minimum number of animals and end-points and are intended to provide data used to make a go/no-go decision with respect to the GLP chronic study in the animal model chosen. In some cases a chronic study could provide data needed to evaluate the cancer potential of a certain substance and is usually designed to mimic the route of human exposure. Species available include mice, rats, rabbits, canine, and other small and large species.

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Safety Pharmacology

Price on request

The purpose of the safety pharmacology core battery is to investigate the effects of a test substance on vital functions. In this regard, the cardiovascular, respiratory, and central nervous systems are usually considered the vital organ systems that should be studied in the core battery.

At CARE we offer studies in the... Show more »

The purpose of the safety pharmacology core battery is to investigate the effects of a test substance on vital functions. In this regard, the cardiovascular, respiratory, and central nervous systems are usually considered the vital organ systems that should be studied in the core battery.

At CARE we offer studies in the following areas:

  1. Central Nervous System
  • Effects of the test substance on the central nervous system should be assessed appropriately. Motor activity, behavioral changes, coordination, sensory/motor reflex responses and body temperature should be evaluated. For example, a functional observation battery (FOB), modified Irwin’s, or other appropriate test can be used.
  • Cardiovascular System
    • Effects of the test substance on the cardiovascular system should be assessed appropriately. Blood pressure, heart rate, and the electrocardiogram should be evaluated. In vivo including methods for repolarization and conductance abnormalities, should also be considered
  • Respiratory System
    • Effects of the test substance on the respiratory system should be assessed appropriately. Respiratory rate and other measures of respiratory function (e.g., tidal volume or hemoglobin oxygen saturation) should be evaluated. Clinical observation of animals is generally not adequate to assess respiratory function, and thus these parameters should be quantified by using appropriate methodologies
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Maximum Tolerated Dose (MTD) Studies

Price on request

Non-GLP

We offer range-finding studies, usually 5 to 14 day repeat-dose studies conducted using a minimum number of animals to provide preliminary identification of the target organs of toxicity as well as to select doses for future more definitive studies that are intended to support the clinical trials.

Species available... Show more »

Non-GLP

We offer range-finding studies, usually 5 to 14 day repeat-dose studies conducted using a minimum number of animals to provide preliminary identification of the target organs of toxicity as well as to select doses for future more definitive studies that are intended to support the clinical trials.

Species available include mice, rats, hamsters, guinea pigs, rabbits, canine, swine, sheep, poultry, and large farm animals.

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WET Testing

Whole Effluent Toxicity Testing
Price on request

For several decades CARE’s exceptional team of scientists including toxicologists, pathologists, veterinary surgeons, regulatory specialists, and support personnel has designed and performed safety programs ranging from acute through chronic toxicity.

Our chronic toxicity studies provide a thorough examination of the dose... Show more »

For several decades CARE’s exceptional team of scientists including toxicologists, pathologists, veterinary surgeons, regulatory specialists, and support personnel has designed and performed safety programs ranging from acute through chronic toxicity.

Our chronic toxicity studies provide a thorough examination of the dose effect of a given substance on homeostasis, bodily function, induced diseases, and the effect on lifespan. These provide the bulk of the preclinical information used for assessing safety and risk.

The study is conducted in rodent and non-rodent models, in both sexes, and over a regimen that approaches the lifespan of the animal. There are often multiple intermediate evaluations, including daily observations, weekly food and water consumption, and body weight determinations, pharmacokinetic satellite plasma collection, interim necropsies, clinical pathology, and more. At the termination of the study all animals are subjected clinical pathology and to a full necropsy with full tissue collection followed by histopathology.

We recommend group sizes in GLP studies sufficient in number to assure enough animals survive to provide statistical significant data. Non-GLP chronic studies use a minimum number of animals and end-points and are intended to provide data used to make a go/no-go decision with respect to the GLP chronic study in the animal model chosen. In some cases a chronic study could provide data needed to evaluate the cancer potential of a certain substance and is usually designed to mimic the route of human exposure.

Species available include mice, rats, rabbits, canine, and poultry.

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In vivo Acute Toxicity Studies

Price on request

For several decades CARE’s exceptional team of scientists including toxicologists, pathologists, veterinary surgeons, regulatory specialists, and support personnel has designed and performed safety programs ranging from acute through chronic toxicity.

Acute toxicity describes the adverse effects of a substance which result... Show more »

For several decades CARE’s exceptional team of scientists including toxicologists, pathologists, veterinary surgeons, regulatory specialists, and support personnel has designed and performed safety programs ranging from acute through chronic toxicity.

Acute toxicity describes the adverse effects of a substance which result either from a single exposure or from multiple exposures in a short period of time (usually less than 24 hours). To be described as acute toxicity, the adverse effects should occur within 14 days of the administration of the substance.

Our evaluation of acute toxicity data includes the relationship between the exposure of animals to the test substance and the incidence and severity of all abnormalities, including behavioral and clinical abnormalities, the reversibility of observed abnormalities, gross lesions, body weight changes, effects on mortality, clinical pathology, histopathology, and any other toxic effects as required by the client.

Our data from acute studies in rodent and non-rodents are used in conjunction with future repeat-dose data to aid in the determination of doses, routes, formulations, and regimens to be used in potential clinical studies. Non-GLP acute studies use a minimum number of animals and end-points and are intended to provide data used to make a go/no-go decision with respect to more a GLP study or more definitive studies.

Species available include mice, rats, hamsters, guinea pigs, rabbits, canine, swine, sheep, poultry, and large farm animals.

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Toxicity Animal Models

Price on request

We offer subchronic toxicity studies that are repeat-dose studies usually ranging from 5 days to 6 months.

Our clients use the results of these studies to predict appropriate doses of the test substance for more definitive repeat-dose studies, or chronic toxicity studies, and to help them determine the MTD and NOELs for... Show more »

We offer subchronic toxicity studies that are repeat-dose studies usually ranging from 5 days to 6 months.

Our clients use the results of these studies to predict appropriate doses of the test substance for more definitive repeat-dose studies, or chronic toxicity studies, and to help them determine the MTD and NOELs for selected toxicology endpoints including target organs.

Our study data from subchronic studies in rodent and non-rodents is used to aid in the determination of doses, routes, formulations, and regimens to be used in potential clinical studies. Non-GLP subchronic studies use a minimum number of animals and end-points and are intended to provide data used to make a go/no-go decision with respect to more a GLP study or more definitive studies.

We offer species including mice, rats, hamsters, guinea pigs, rabbits, canine, swine, sheep, poultry, and large farm animals.

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Clinical and Anatomic Pathology

Price on request

CARE Research possesses the capability to run a full-range of clinical pathology testing for health monitoring and verification.

  • Hematology
  • Clinical Chemistry
  • Coagulation Analysis
  • Electrolyte

CARE Research possesses the capability to run a full-range of clinical pathology testing for health monitoring and verification.

  • Hematology
  • Clinical Chemistry
  • Coagulation Analysis
  • Electrolyte
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In vivo ADME/DMPK Studies

Price on request

ADME (Absorption, Distribution, Metabolism, and Excretion) studies are conducted in rodents and non-rodents housed in metabolism cages and usually conducted in the early stages of the drug discovery process. At CARE we offer custom-designed ADME studies in multiple species of lab animals.

The data collected from these... Show more »

ADME (Absorption, Distribution, Metabolism, and Excretion) studies are conducted in rodents and non-rodents housed in metabolism cages and usually conducted in the early stages of the drug discovery process. At CARE we offer custom-designed ADME studies in multiple species of lab animals.

The data collected from these studies are necessary to determine if the compound is a good candidate to move forward, as well as obtaining ADME data necessary to proceed to clinical trials.

In our non-GLP ADME studies we use a minimum number of animals and the data are often used to screen test articles or provide information necessary to proceed to a more definitive ADME study.

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Pharmaceutical Formulation

Price on request

CARE Research has fully-equipped and separate areas dedicated for sample processing and drug formulation.

  • All equipment maintained in accordance with GLPs

CARE Research has fully-equipped and separate areas dedicated for sample processing and drug formulation.

  • All equipment maintained in accordance with GLPs
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Dose Range Finding (DRF) Studies

Price on request

We offer range-finding studies, usually 5 to 14 day repeat-dose studies conducted using a minimum number of animals to provide preliminary identification of the target organs of toxicity as well as to select doses for future more definitive studies that are intended to support the clinical trials.

Species available include... Show more »

We offer range-finding studies, usually 5 to 14 day repeat-dose studies conducted using a minimum number of animals to provide preliminary identification of the target organs of toxicity as well as to select doses for future more definitive studies that are intended to support the clinical trials.

Species available include mice, rats, hamsters, guinea pigs, rabbits, canine, swine, sheep, poultry, and large farm animals.

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In vivo Drug Efficacy Testing

Price on request
Request a quote for more information about this service.

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Animal Necropsy Services

Price on request

A fully-equipped necropsy suite is also available on-site to support toxicology and terminal harvest projects.

  • Licensed Veterinary Surgeon
  • Sterile Environment Designed With Aseptic Technique in Mind
  • Anesthesia and Monitoring Equipment
  • Target Organ or Tissue Collection
  • Terminal Blood Collection for Clinical Pathology or PK/TK

A fully-equipped necropsy suite is also available on-site to support toxicology and terminal harvest projects.

  • Licensed Veterinary Surgeon
  • Sterile Environment Designed With Aseptic Technique in Mind
  • Anesthesia and Monitoring Equipment
  • Target Organ or Tissue Collection
  • Terminal Blood Collection for Clinical Pathology or PK/TK
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PK/PD Data Analysis

Price on request

Pharmacokinetic (PK) and Toxicokinetic (TK) studies to support the early stages of the drug discovery process. Routes are often I.V. AND the proposed clinical route and conducted in rodents and non-rodents. TK/PK studies are often single-dose, but can be repeat-dose.

We provide the following benefits to customers seeking PK... Show more »

Pharmacokinetic (PK) and Toxicokinetic (TK) studies to support the early stages of the drug discovery process. Routes are often I.V. AND the proposed clinical route and conducted in rodents and non-rodents. TK/PK studies are often single-dose, but can be repeat-dose.

We provide the following benefits to customers seeking PK screening:

  • Ability to meet aggressive timelines for outsourced PK programs
  • Short lead time for study initiation
  • Rapid turnaround times
  • Flexible scheduling to allow last-minute changes to study protocol
  • Standardized, abbreviated protocols and reporting methods
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DART Studies

Developmental and Reproductive Toxicology Studies
Price on request

At CARE we conduct reproductive toxicity studies designed to investigate the affect of a test article on male and female fertility and reproductive performance, estrous, spermatogenesis, implantation, embryo-fetal survival and development, gestation length, parturition, lactation, pup survival and development (including potential... Show more »

At CARE we conduct reproductive toxicity studies designed to investigate the affect of a test article on male and female fertility and reproductive performance, estrous, spermatogenesis, implantation, embryo-fetal survival and development, gestation length, parturition, lactation, pup survival and development (including potential functional and behavioral effects), and the ability of offspring from the exposed parental generation to reproduce normally.

We conduct non-GLP pilot studies to provide data needed to determine dose levels for definitive studies. Pilot and embryo-fetal development studies are usually conducted in rats and rabbits.

We usually conduct fertility and reproductive performance studies and pre and postnatal development studies in rats or mice. Mice or dogs can also be used when necessary for embryo-fetal development studies.

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Discovery Pathology

Price on request

Care Research has been providing world class clinical pathology globally for almost 20 years.
 Our board-certified veterinary clinical pathologists and technologists provide laboratory results in a timely, efficient and thoughtful manner; supporting research, clinicians, referring veterinarians, and students in the diagnosis and treatment of many animal species

Care Research has been providing world class clinical pathology globally for almost 20 years.
 Our board-certified veterinary clinical pathologists and technologists provide laboratory results in a timely, efficient and thoughtful manner; supporting research, clinicians, referring veterinarians, and students in the diagnosis and treatment of many animal species

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Animal Models and Studies

Price on request

Our preclinical studies comprise a wide range of capabilities including: PK/ MTD, DART, toxicology, IND/NDA enabling studies, biomedical devices and tissue implantation.

 

We offer a wide variety of animal models, including rodent, rabbit, guinea pig, farm pigs, mini pigs, dogs, sheep and goats at a very... Show more »

Our preclinical studies comprise a wide range of capabilities including: PK/ MTD, DART, toxicology, IND/NDA enabling studies, biomedical devices and tissue implantation.

 

We offer a wide variety of animal models, including rodent, rabbit, guinea pig, farm pigs, mini pigs, dogs, sheep and goats at a very competitive price.  Our in-house histopathology, clinical chemistry and hematology capabilities afford a single point of control.

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Pharmacology & Toxicology

Price on request

We provide Pharmacokinetic (PK) and Toxicokinetic (TK) studies to support the early stages of the drug discovery process. Routes are often I.V. AND the proposed clinical route are conducted in rodents and non-rodents. TK/PK studies are often single-dose, but can be repeat-dose.
We provide the following benefits to... Show more »

We provide Pharmacokinetic (PK) and Toxicokinetic (TK) studies to support the early stages of the drug discovery process. Routes are often I.V. AND the proposed clinical route are conducted in rodents and non-rodents. TK/PK studies are often single-dose, but can be repeat-dose.
We provide the following benefits to customers seeking PK screening:
Ability to meet aggressive timelines for outsourced PK programs, short lead time for study initiation, rapid turnaround times, flexible scheduling to allow last-minute changes to study protocol, standardize and abbreviated protocols, along with reporting methods

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In vivo Toxicity Testing

Price on request

For several decades CARE’s exceptional team of scientists including toxicologists, pathologists, veterinary surgeons, regulatory specialists, and support personnel has designed and performed safety programs ranging from acute to chronic toxicity. Our chronic toxicity studies provide a thorough examination of the dose... Show more »

For several decades CARE’s exceptional team of scientists including toxicologists, pathologists, veterinary surgeons, regulatory specialists, and support personnel has designed and performed safety programs ranging from acute to chronic toxicity. Our chronic toxicity studies provide a thorough examination of the dose effect of a given substance on homeostasis, bodily function, induced diseases, and the effect on lifespan. These provide the bulk of the preclinical information used for assessing safety and risk.

Non-GLP chronic studies use a minimum number of animals and end-points and are intended to provide data used to make a go/no-go decision with respect to the GLP chronic study in the animal model chosen. In some cases a chronic study could provide data needed to evaluate the cancer potential of a certain substance and is usually designed to mimic the route of human exposure.

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Animal Model in vivo Analyses

Price on request
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Clinical Research

Price on request
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Medical Devices & Diagnostics

Price on request
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In vitro Toxicity Testing

Price on request
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Environmental Science

Price on request
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Formulation Services

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Cells and Tissues

Price on request
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Animal Physiology Analyses

Price on request
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ADME/DMPK Studies

Drug Metabolism and Pharmacokinetics
Price on request
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Biology

Price on request
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Solid Dosage Formulation

Price on request
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Animal Microdialysis

Price on request
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Pharmacology

Price on request

Pharmacology Services

Pharmacology Services

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Drug Discovery & Development

Price on request

Drug Discovery & Development Services

Drug Discovery & Development Services

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