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Caprion Biosciences, Inc.

5 Orders Completed
Montréal, Quebec, CA

About Caprion Biosciences, Inc.

Founded: 2000

Founded in 2000, Caprion Biosciences, is a leading specialty clinical research organization (CRO) laboratory providing state-of-the-art integrated platforms in proteomics and immune monitoring services to the pharmaceutical and biotechnology industry.

Located in Montreal, Canada and in Gosselies, Belgium,... Show more »

Founded in 2000, Caprion Biosciences, is a leading specialty clinical research organization (CRO) laboratory providing state-of-the-art integrated platforms in proteomics and immune monitoring services to the pharmaceutical and biotechnology industry.

Located in Montreal, Canada and in Gosselies, Belgium, Caprion has been partnering with some of the largest pharmaceutical and most prominent biotech companies for more than 15 years. Caprion Biosciences, a privately-held company, is majority owned by Global Healthcare Opportunities, or GHO Capital Partners LLP.

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Our Services (37)


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Flow Cytometry

Price on request

The immune system is comprised of many cellular subsets. Flow cytometry has become a very powerful tool to precisely quantify and characterize the phenotype of innate and adaptive cellular subsets. Flow cytometry distinguishes a subpopulation from a heterogeneous mixture and evaluates the impact of an agent (antigen, drug) on a... Show more »

The immune system is comprised of many cellular subsets. Flow cytometry has become a very powerful tool to precisely quantify and characterize the phenotype of innate and adaptive cellular subsets. Flow cytometry distinguishes a subpopulation from a heterogeneous mixture and evaluates the impact of an agent (antigen, drug) on a particular immune subset.

ImmuneCarta offers state-of-the-art flow cytometry based assays to characterize immune cell subpopulations and the relationship between phenotypic and functional attributes.

Benefits and Applications

  • Use of qualified backbone panels for identifying major cell lineages of the innate and adaptive arms of the immune system in different specimen types: Whole blood, PBMC (peripheral blood mononuclear cells), Tissue.
    • T cell lineage and memory/activation markers (CD3+, CD4+/-, CD8+/-, HLA-DR+/-, CD38+/-)
      • Naïve (CD45RA+, CD27+, CCR7+)
      • Central memory (CD45RA-, CD27+, CCR7+)
      • Transitional memory (CD45RA-, CD27+, CCR7-)
      • Effector memory (CD45RA-, CD27-, CCR7-)
      • Late-differentiated effectors (CD45RA+, CD27-, CCR7-)
    • B cell lineage and memory/activation markers (CD3-, CD19+, CD27+/-, IgD+/-, CD24+/-, CD38+)
    • Regulatory T cells and memory activation markers (CD3+, CD4+, CCR4+, CD25+, CD127+, CD45RO+/-, HLA-DR)
    • T helper subsets and memory/activation markers (CD3+, CD4+, CD45RA, CD38, HLA-DR)
      • Th1 (CXCR3+, CCR6-)
      • Th2 (CXCR3-, CCR6-)
      • Th17 (CXCR3-, CCR6+)
    • NK cells (CD3-, CD19-, CD14-, CD20-, CD16+, CD56+/-)
    • Monocytes (CD3-, CD19-, CD14+, CD16+/-)
    • Dendritic cells (DCs) (CD3-, CD19-, CD14-, CD20-, HLA-DR+)
      • Myeloid Dendritic cells (CD11c+)
      • Plasmacytoid DCs (CD123+)
    • Optional customization for multiplexing biomarkers of choice (see below)
    • Detection of Antigen-Specific Responses using HLA-restricted multimers
      • Involved in the MHC multimer proficiency testing program

ImmuneCarta offers optional customization for multiplexing biomarkers of choice identifying major cell lineages of the innate and adaptive arms of the immune system.

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Intracellular Cytokine Staining

Price on request

ImmuneCarta provides detailed information on the immune status by combining ICS (Intracellular Cytokine Staining) with cell surface markers and HLA class I multimers to detect Antigen-Specific Responses.

After a short in vitro stimulation with proteins, peptides, or antigen-presenting cells, responsive subsets are analyzed within... Show more »

ImmuneCarta provides detailed information on the immune status by combining ICS (Intracellular Cytokine Staining) with cell surface markers and HLA class I multimers to detect Antigen-Specific Responses.

After a short in vitro stimulation with proteins, peptides, or antigen-presenting cells, responsive subsets are analyzed within this cellular mixture to determine the distribution of functional subsets and ultimately signatures of immune competence.

Benefits and Applications

  • Obtain phenotypic and functional data in a single sample
    Identify the frequency of reactive antigen-specific cells in various matrices
  • Determine precise phenotyping of the responding cell populations with a highly multiparametric read-out (up to 18 parameters)
  • Analyze the relative distribution of functional subsets through multiplexing functions
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Phospho Flow Cytometry

Price on request

Phospho Flow Cytometry is a rapidly developing flow cytometry technology that detects multiple intracellular signaling molecules in immune cells at the single-cell level. Abnormal kinase activity has been associated with disease, including cancer and autoimmunity.

ImmuneCarta uses multiparametric flow cytometry to analyze the... Show more »

Phospho Flow Cytometry is a rapidly developing flow cytometry technology that detects multiple intracellular signaling molecules in immune cells at the single-cell level. Abnormal kinase activity has been associated with disease, including cancer and autoimmunity.

ImmuneCarta uses multiparametric flow cytometry to analyze the phosphorylation state of targeted kinase(s), both in vitro and ex vivo, with and without stimulation. Application of our expertise to understand cell signaling alterations under normal and pathological conditions is critical for the development of novel kinase inhibitors for cancer and autoimmunity.

Benefits and Applications

  • Determine activation status of multiple signaling pathways in specific cellular subsets at the single cell level in several matrices: whole blood, PBMC (peripheral blood mononuclear cells), tissues
  • Multiplex multiple phosphorylated targets to gain insights to membrane proximal and distal signaling events in distinct cellular subsets
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Basophil Activation Test (BAT)

Price on request

The Basophil Activation Test (BAT) assay is performed on whole blood and uses flow cytometry to measure CD63 expression, a degranulation marker, following basophil activation in vitro.

ImmuneCarta uses the Basophil Activation Test (BAT) to identify the fraction of HLA-DR-CD123+ basophils which degranulate following exposure to... Show more »

The Basophil Activation Test (BAT) assay is performed on whole blood and uses flow cytometry to measure CD63 expression, a degranulation marker, following basophil activation in vitro.

ImmuneCarta uses the Basophil Activation Test (BAT) to identify the fraction of HLA-DR-CD123+ basophils which degranulate following exposure to allergens or IgE receptor crosslinking agents.

Benefits and Applications

  • Screen compounds in vitro for their effect on degranulation by using the high throughput BAT assay
  • Measure potency of inhibitors on the degranulation of basophils by using BAT as a pharmacodynamic assay
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ELISpot Assays

Enzyme-Linked ImmunoSpot Assays
Price on request

ELISpot (Enzyme-Linked Immunosorbent Spot) is a widely used technology to assess adaptive immune responses in humans and animals. It’s commonly used to characterize pre-existing immune responses and to monitor the immunogenicity of vaccines and other immune-modulating therapies.

The frequency of antigen-specific cells in response... Show more »

ELISpot (Enzyme-Linked Immunosorbent Spot) is a widely used technology to assess adaptive immune responses in humans and animals. It’s commonly used to characterize pre-existing immune responses and to monitor the immunogenicity of vaccines and other immune-modulating therapies.

The frequency of antigen-specific cells in response to a variety of stimulations can be quantified. PBMC (peripheral blood mononuclear cells) are stimulated in vitro and analyzed for secretion of analytes such as IFNγ, IL-2 and IL-17.

ImmuneCarta offers customizable ELISpot assays to meet specific needs suited for multi-centric clinical studies. Our team participates in ELISpot proficiency testing programs to ensure harmonization of our assays.

Benefits and Applications

  • Screen large numbers of peptide libraries to identify breadth, magnitude and specificity of an immune response
  • Obtain information for large scale epitope mapping studies
  • Identify peptide-reactive cells that can be further analyzed for phenotype and function using ICS (Intracellular Cytokine Staining)
  • Monitor immunogenicity of vaccines and immune modulating therapies
  • Identify peptide-specific HLA-class I restriction
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Procurement

Price on request

Caprion Biosciences provides procurement services for a broad variety of biological specimens.

With our extensive network of clinical and academic collaborators affiliated to major teaching hospitals, Caprion Biosciences has access to:

  • Freshly collected samples (peripheral blood and tissues)
  • Clinical data and pathology... Show more »

Caprion Biosciences provides procurement services for a broad variety of biological specimens.

With our extensive network of clinical and academic collaborators affiliated to major teaching hospitals, Caprion Biosciences has access to:

  • Freshly collected samples (peripheral blood and tissues)
  • Clinical data and pathology reports
  • PBMC (peripheral blood mononuclear cells) obtained by Leukapheresis
  • Biobank of cryopreserved PBMC obtained by leukapheresis. These cells are used for assay development, validation and performance monitoring.

Caprion Biosciences provides all the documentation for ethics approval (informed consent and study protocol).

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Cytometric Bead Array (CBA)

Price on request

ImmuneCarta uses the CBA (Cytokine Bead Array) technology to quantify multiple soluble and intracellular proteins simultaneously, such as cytokines, chemokines, growth factors, adhesion molecules, and phosphorylated proteins in biological fluids or cell culture supernatants. CBA is a flow cytometry-based technique that uses... Show more »

ImmuneCarta uses the CBA (Cytokine Bead Array) technology to quantify multiple soluble and intracellular proteins simultaneously, such as cytokines, chemokines, growth factors, adhesion molecules, and phosphorylated proteins in biological fluids or cell culture supernatants. CBA is a flow cytometry-based technique that uses antibody-coated beads with unique fluorescent intensities that react with particular analytes. Beads that react with different analytes can be mixed and run simultaneously in a single tube.

  • Bead-based assay
  • Multiplexing up to 30 analytes for simultaneous quantification

Sample types include cell culture supernatants and biological fluids from:

  • PBMC (peripheral blood mononuclear cells)
  • Whole blood
  • Tissues
  • Cell lines
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ELISA

Enzyme-linked immunosorbent assay
Price on request

ImmuneCarta uses the Enzyme-Linked Immunosorbent Assay (ELISA) to measure the concentration of analytes such as cytokines and the titer of antibodies in biological fluids (serum and plasma) or cell culture supernatants.

ImmuneCarta uses the Enzyme-Linked Immunosorbent Assay (ELISA) to measure the concentration of analytes such as cytokines and the titer of antibodies in biological fluids (serum and plasma) or cell culture supernatants.

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Cell Surface Protein Profiling

Starting at $500.00 per sample

By combining the industry's largest panel of cell surface antibodies with high level multi-parameter staining panels, a new ability is created that can define novel cell types, gain unprecedented insight into cellular differentiation, and identify potential disease biomarkers.

By combining the industry's largest panel of cell surface antibodies with high level multi-parameter staining panels, a new ability is created that can define novel cell types, gain unprecedented insight into cellular differentiation, and identify potential disease biomarkers.

  • Analyze over 400 cell surface proteins
    • Growth factor, cytokine, and chemokine receptors
    • Adhesion and cell-cell interaction molecules
    • Antigen presentation and processing
    • Stem cell markers
    • Cancer markers
    • T cell, B cell, NK cell activation
    • Toll-like receptors
  • Analyze cell lines, primary cells, blood samples
  • Discover new biomarkers
  • Automated sample processing for maximum reproducibility
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BD FacsCantoII/LSRII Automated liquid handler Human Mouse Non-human primates (NHP) High Throughput Screening Show 6 more tags Show less

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Multiple Reaction Monitoring (MRM) Assay Panels

Price on request

Caprion has extensive expertise in development of targeted biomarker assays using Multiple Reaction Monitoring (MRM) mass spectrometry. MRM, which was selected by Nature Methods as Method of the Year for 2012, facilitates rapid development of highly specific, antibody-free assays for quantitation of up to 100s of target proteins.... Show more »

Caprion has extensive expertise in development of targeted biomarker assays using Multiple Reaction Monitoring (MRM) mass spectrometry. MRM, which was selected by Nature Methods as Method of the Year for 2012, facilitates rapid development of highly specific, antibody-free assays for quantitation of up to 100s of target proteins. Caprion uses stable isotope labeled peptides for each target peptide to facilitate robust quantitation and enhance reproducibility. Proteins for MRM assays can be selected from multiple sources, including proteomics, transcriptomics, literature, or pathway analyses.

Caprion offers both custom and off-the-shelf MRM assays to facilitate rapid screening and verification of candidate biomarkers. Once the most robust biomarkers have been selected, MRM assays can be further developed as fit-for-purpose assays to meet regulatory requirements.

Applications

Caprion’s MRM-based approach facilitates rapid development of highly specific, multiplexed assays for biomarker discovery and development

  • Custom assays for rapid assessment of 100s of candidate biomarkers from literature, proteomics, transcriptomics, and other discovery platforms
  • Off-the-shelf panels for CNS, preclinical safety, diabetes and tuberculosis
  • Verification and refinement of multiplexed biomarker panels for diagnostics, patient stratification, efficacy etc.
  • Elucidation of underlying biology and mechanism of action
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In vivo PK/PD Studies

Price on request

Target Pharmacodynamics. Primity’s deep domain expertise in intracellular analysis of of signaling proteins allows target function to be measured directly in whole blood. This approach assesses the function of the target protein directly in diseased cells instead of measuring downstream biological events in other cells or in... Show more »

Target Pharmacodynamics. Primity’s deep domain expertise in intracellular analysis of of signaling proteins allows target function to be measured directly in whole blood. This approach assesses the function of the target protein directly in diseased cells instead of measuring downstream biological events in other cells or in serum. By getting directly to the source, potentially confounding conditions acting downstream of the target are eliminated and drug activity can be accurately assessed.

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Drug Discovery

Price on request

Proteomics Meet Dose Response..Primity’s technology platforms are empowered by proprietary sample processing techniques that are designed to dramatically reduce sample variability and speed data acquisition. By miniaturizing the reaction volumes and automating the sample processing, high-content data can be delivered in a fraction... Show more »

Proteomics Meet Dose Response..Primity’s technology platforms are empowered by proprietary sample processing techniques that are designed to dramatically reduce sample variability and speed data acquisition. By miniaturizing the reaction volumes and automating the sample processing, high-content data can be delivered in a fraction of the time and cost of traditional systems. This allows variables to be explored and dose responses to be compared quantitatively and reproducibly.

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Immunophenotyping

Price on request
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Mass Cytometry/CyToF

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Cell Services

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Biomarker Discovery

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Pharmacodynamic Biomarkers Discovery

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Biomarkers

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Imaging & Spectroscopy

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Imaging & Spectroscopy Services

Imaging & Spectroscopy Services

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Spectroscopy

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Spectroscopy Services

Spectroscopy Services

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Bioanalysis

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Mass Spectrometry

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Mass Spectrometry Services

Mass Spectrometry Services

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Tandem Mass Spectrometry Methods

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Tandem Mass Spectrometry Methods Services

Tandem Mass Spectrometry Methods Services

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Biology

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Biology Services

Biology Services

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Biochemistry & Molecular Biology

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Biochemistry & Molecular Biology Services

Biochemistry & Molecular Biology Services

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Protein Services

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Protein Services

Protein Services

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Protein Quantification

Price on request

Protein Quantification Services

Protein Quantification Services

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Cells and Tissues

Price on request

Cells and Tissues Services

Cells and Tissues Services

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Cytometry

Price on request

Cytometry Services

Cytometry Services

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Business Development, Marketing & Operations

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Business Development, Marketing & Operations Services

Business Development, Marketing & Operations Services

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Business Operations and Logistics Support

Price on request

Business Operations and Logistics Support Services

Business Operations and Logistics Support Services

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Drug Discovery & Development

Price on request

Drug Discovery & Development Services

Drug Discovery & Development Services

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Pharmacology

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Pharmacology Services

Pharmacology Services

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Bioanalytical Assays

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Bioanalytical Assays Services

Bioanalytical Assays Services

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Immunoassays

Price on request

Immunoassays Services

Immunoassays Services

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Pharmacology & Toxicology

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ADME/DMPK Studies

Drug Metabolism and Pharmacokinetics
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Primity Bio

Cytometry Team
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Bob Fritzen

Senior Director, Business Development
  • Positive review for Cell Surface Protein Profiling:

    December 2018

    "PrimityBio provided the good service efficiently and the staffs are knowledgeable for scientific communication."

  • Positive review for Flow Cytometry:

    November 2017

    "PrimityBio delivered results in good quality and their team works really efficiently to our request."

  • Positive review for Flow Cytometry:

    November 2017

    "PrimityBio staff not only provide good quality of results, but also communicate and update with us throughout the study. We definitely would like to collaborate with them again in the future."

Caprion Biosciences, Inc. has not received any endorsements.