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Cambridge Research Biochemicals (CRB)

Billingham, GB

Cambridge Research Biochemicals (CRB), founded in 1980, is the second oldest company in the world to offer custom-made peptides and antibodies to the Medical Research community. CRB specialises in everything from design to synthesis, modification and labelling.

At CRB, we place our customers at the heart of everything we do. Clear, open and regular communication with customers is as important to our success as our in-depth scientific knowledge.

We recognise that each customer has a different need, a different question, a different problem. And we address these on an individual basis. We do not sell ‘off-the-shelf’ solutions. We work with, rather than for, our customers, to provide a highly personal level of support, help and advice. This flexibility means we can adapt to customers’ needs as their projects progress.

As the world’s second oldest peptide manufacturer, CRB enjoys long–standing customer loyalty... Show more »

Cambridge Research Biochemicals (CRB), founded in 1980, is the second oldest company in the world to offer custom-made peptides and antibodies to the Medical Research community. CRB specialises in everything from design to synthesis, modification and labelling.

At CRB, we place our customers at the heart of everything we do. Clear, open and regular communication with customers is as important to our success as our in-depth scientific knowledge.

We recognise that each customer has a different need, a different question, a different problem. And we address these on an individual basis. We do not sell ‘off-the-shelf’ solutions. We work with, rather than for, our customers, to provide a highly personal level of support, help and advice. This flexibility means we can adapt to customers’ needs as their projects progress.

As the world’s second oldest peptide manufacturer, CRB enjoys long–standing customer loyalty from some of the largest international pharmaceutical companies. We welcome opportunities to form strong partnerships with other pharmaceutical, biotechnology and research institutes.

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PNA Synthesis
Peptide Nucleic Acid Synthesis
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PNAs are synthetic analogues of DNA based upon an N-(2-aminoethyl)glycine pseudopeptide backbone. The bases (corresponding to A,G,C,T) are attached to the backbone via a methylene carbonyl linker and the resulting PNA oligomers are able to form very stable complexes with complementary DNA and RNA. They also have the great... Show more »

PNAs are synthetic analogues of DNA based upon an N-(2-aminoethyl)glycine pseudopeptide backbone. The bases (corresponding to A,G,C,T) are attached to the backbone via a methylene carbonyl linker and the resulting PNA oligomers are able to form very stable complexes with complementary DNA and RNA. They also have the great advantage of being resistant to nucleases (and proteases) which makes them potentially ideal reagants for antisense and antigene applications. Labelled PNAs also have applications in molecular diagnostics and as probes in microarrays.

Through an agreement with Panagene Inc, CRB can offer high purity custom PNA oligomers in quantities ranging from 50 nmole to grams to the UK market. PNAs are synthesized on solid phase using Panagene’s patented BTS chemistry and Panagene has the worldwide exclusive license obtained from the Copenhagen Inventor Group (CIG), the inventors¹ for custom PNA. CRB can also offer custom PNA labelled with a variety of reporter molecules such as fluorescent dyes and Biotin.

Although PNAs work well in cell free systems, poor cellular uptake can limit their use in the regulation of gene expression in cell culture and in vivo. The conjugation of PNA to peptides, to lipophilic molecules and to cell-specific receptor ligands offers new ways to surmount this problem. CRB are ideally placed to advise on and supply such conjugates.

As UK distributor for Panagene Inc (South Korea) CRB can offer the following products and services:

  • PNA Telomere FISH probes
  • Fmoc PNA Monomers
  • PNA Probes for Globin Reduction
  • PAN Arrays
  • miRNA Inhibitors
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Peptide Derivatives
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Peptide Conjugation

Cambridge Research Biochemicals is proud to announce the new addition of a custom synthesis service for conjugates of synthetic peptides and oligonucleotides such as Peptide-PMO and Peptide-PNA conjugates for cell screening and in vivo studies.

Cell-penetrating peptides (CPPs) or a peptide of choice can... Show more »

Peptide Conjugation

Cambridge Research Biochemicals is proud to announce the new addition of a custom synthesis service for conjugates of synthetic peptides and oligonucleotides such as Peptide-PMO and Peptide-PNA conjugates for cell screening and in vivo studies.

Cell-penetrating peptides (CPPs) or a peptide of choice can be conjugated to a cargo such as Peptide, PMO (Phosphorodiamidate Morpholino Oligonucleotide) or PNA (Peptide Nucleic Acid) to identify the optimum peptide choice for drug carrier and delivery.

Peptide Conjugate (Peptide-PMO) Libraries can now be synthesised via SELPEPCON™ (SELection of PEPtide CONjugates) a novel and patentable method for parallel assembly of a large number of peptide-therapeutic cargo combinations recently licenced to Cambridge Research Biochemicals by MRC Technology on behalf of the Medical Research Council – Laboratory for Molecular Biology.

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Therapeutic Monoclonal Antibody (mAb) Development
Price on request

Cambridge Research Biochemicals (CRB) has been generating custom-made antibodies since 1985. It is the company’s belief that the maximum capacity for antibodies is not a finite number. Due to the way CRB operates as an antibody manufacturer, and the nature of the way antibody requests come in, small and large volume orders can... Show more »

Cambridge Research Biochemicals (CRB) has been generating custom-made antibodies since 1985. It is the company’s belief that the maximum capacity for antibodies is not a finite number. Due to the way CRB operates as an antibody manufacturer, and the nature of the way antibody requests come in, small and large volume orders can both be successfully managed. CRB operates the following processes to produce an antibody:

  • Antigenic prediction – CRB can either use customer’s own protein or assist in selecting the best peptides which it has been doing successfully for over 25 years
  • Peptide synthesis — peptides are manufactured at CRB’s own premises to highest quality
  • Conjugation to carrier proteins — completed in-house, small or large batches can be completed in one weekly operation
  • Antibody production — Immunisations are carried out using optimised protocols in all available species. CRB produces a timetable of the programme of events (immunisations & bleed cycles) for each antibody project and this is posted to my account allowing end-users to track the progress of their custom antibody online. Screening — ELISA analysis is performed in-house and the results posted to my account within 5 working days of the bleed being taken.
  • Screening — ELISA analysis is performed in-house and the results posted to my account within 5 working days of the bleed being taken
  • Purification — Affinity purifications are completed in-house and the results posted to my account
  • Additional services — CRB offers labelling of antibodies and characterisation of antibodies (including western blotting) as required by its customers
  • CRB offers a range of antibody service categories to suit all budget levels and custom antibody variations. Choose your antibody type from the listing below and follow our advice.
  • TARGET™ Antibodies — the optimised managed custom polyclonal antibody service
  • INFINITY™ Antibodies — our managed monoclonal antibody service
  • Peptide Immunisation — Our basic polyclonal antibody package for low budgets or antibody re-runs
  • Protein Immunisation - Polyclonal antibody production using customer’s own antigen
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Peptide Synthesis
Price on request

Cambridge Research Biochemicals (CRB) has been making custom peptides since 1980. Every peptide is custom-made to order and usually despatched in 2-3 weeks. All peptides are supplied with purity by HPLC and identification by mass spectrometry. CRB offers a range of custom peptide service categories providing every type of peptide... Show more »

Cambridge Research Biochemicals (CRB) has been making custom peptides since 1980. Every peptide is custom-made to order and usually despatched in 2-3 weeks. All peptides are supplied with purity by HPLC and identification by mass spectrometry. CRB offers a range of custom peptide service categories providing every type of peptide production request possible for the production of custom peptides. Choose your peptide type from the listing below and follow our advice.

  • PURE™ Peptides — the simplest peptide range we offer including standard and modified sequences
  • SPECTRUM™ Peptides — fluorescent dye labelled peptides for FRET and other fluorescence-based applications
  • PEAK™ Peptides — stable isotope labelled peptides for mass spectrometry & NMR studies
  • PEPARRAY™ — large, cost-effective sets of peptides for screening purposes
  • PIQUANT™ Peptides — radioactively labelled peptides
  • TRANSPORTER™ Peptides — cell-penetrating peptides
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Synthetic Chemistry
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Protein Conjugation
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Biology
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Antibody Services
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Protein Services
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Nucleic Acid Services
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PNA
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Chemistry and Materials
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Biochemistry & Molecular Biology
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