Ppqsfglmq4gffjisroft screen shot 2015 01 21 at 3.35.42 pm

Cambridge Biomedical Inc.

Boston, Massachusetts, US

Since its establishment in 1997, Cambridge Biomedical has supported sponsors and CRO’s developing customized assays for small and large molecules, biomarkers, diagnostics, and medical devices. Our team has expertise and extensive experience in technology transfer, assay development, optimization, and validation. We are positioned to work with you at preclinical, clinical, and post market stages of drug or device development.

Cambridge Biomedical employs senior scientists at the PhD, MD, and MD/PhD level. Our accomplished staff are experts in complex and custom assay development and validation. Given our technical experience and scientific expertise, Cambridge Biomedical is able to perform across a broad range of therapeutic areas.

Since inception, Cambridge Biomedical has developed, qualified, and validated over 150 assays, with an average of 15-20 additional assays per year. We provide sample analysis on over... Show more »

Since its establishment in 1997, Cambridge Biomedical has supported sponsors and CRO’s developing customized assays for small and large molecules, biomarkers, diagnostics, and medical devices. Our team has expertise and extensive experience in technology transfer, assay development, optimization, and validation. We are positioned to work with you at preclinical, clinical, and post market stages of drug or device development.

Cambridge Biomedical employs senior scientists at the PhD, MD, and MD/PhD level. Our accomplished staff are experts in complex and custom assay development and validation. Given our technical experience and scientific expertise, Cambridge Biomedical is able to perform across a broad range of therapeutic areas.

Since inception, Cambridge Biomedical has developed, qualified, and validated over 150 assays, with an average of 15-20 additional assays per year. We provide sample analysis on over 100,000 samples annually.

Certifications: GLP Compliance, CLIA certified, CAP Accredited

Publications:

"Lab Developed Tests" by Dr. John Reddington Ph.D. D.V.M.

"Luminex Assay Validation" by Dr. Archana Kapoor Ph.D.
"Collaborative Assay Development" by Dr. James Lederer Ph.D.

"A High-Throughput Multiplexed Assay For Super Family-Wide Profiling of Enzyme Activity" by Dr. Dan Bachovchin Ph.D.

« Show less

Cambridge Biomedical Inc. has not listed any services.

Ask A Question Find what you're looking for? If not, you can ask this lab a question:
Clinical Biomarkers
Price on request
Request a quote for more information about this service.
MSD Assays
Price on request
Request a quote for more information about this service.
FACS
Fluorescence Activated Cell Sorting
Price on request
Request a quote for more information about this service.
Immunohistochemistry (IHC)
Price on request
Request a quote for more information about this service.
qPCR
Quantitative PCR
Price on request

Cambridge Biomedical has developed numerous PCR, qPCR, and RT-PCR assays utilizing our fully equipped and dedicated PCR suite with the latest generation of PCR equipment including Applied Biosystems ViiA 7 (96 wells, 384 wells, fast cycle), Taqman Low Density Arrays (TLDA), and the Applied Biosystems Prism 7000.

Our scientific... Show more »

Cambridge Biomedical has developed numerous PCR, qPCR, and RT-PCR assays utilizing our fully equipped and dedicated PCR suite with the latest generation of PCR equipment including Applied Biosystems ViiA 7 (96 wells, 384 wells, fast cycle), Taqman Low Density Arrays (TLDA), and the Applied Biosystems Prism 7000.

Our scientific team brings a wide range of experience in developing, validating and optimizing PCR assays.

« Show less
Electrochemiluminescence
Price on request

Electrochemiluminescence or electrogenerated chemiluminescence (ECL) is a type of luminescence produced during electrochemical reactions in solution. Cambridge Biomedical uses the MesoScale Discovery (MSD) platform allowing the detection of biomarkers in single and multiplex formats in microplate wells.

Typical applications of... Show more »

Electrochemiluminescence or electrogenerated chemiluminescence (ECL) is a type of luminescence produced during electrochemical reactions in solution. Cambridge Biomedical uses the MesoScale Discovery (MSD) platform allowing the detection of biomarkers in single and multiplex formats in microplate wells.

Typical applications of electrochemiluminescence:

• Cytokines and chemokines
• Cell signaling pathways
• Angiogenesis and hypoxia markers
• Growth and vascular factors
• Metabolic markers
• Immunogenicity
• Cell based assays
• Vaccine/bioproduction

Advantages of ECL over conventional ELISA:

• High sensitivity and low background because the stimulation mechanism (electrical)
is decoupled from the detection signal (light)
• Emission read at 620 nm, eliminates issues revolving around color quenching
• Improved precision from non-separation-based ("no-wash") immunoassays due to the
proximity-based nature of signal generation, where only labels near surfaces of
electrodes are stimulated
• A large assay dynamic range of five logs
• Carbon electrode plate surface has a 10X greater binding capacity than
conventional ELISA microplates
• Multiple analytes can be run in a single well, reducing required sample volume

« Show less
Custom Cell-Based Assays
Price on request

Cell based assays offer a more accurate representation of a real life model since live cells are used. They also offer the possibility of a dynamic experiment through monitoring the numbers or behavior of live cells. We can recommend strategies and provide contract services for:

• Cell-based assays
• Measuring... Show more »

Cell based assays offer a more accurate representation of a real life model since live cells are used. They also offer the possibility of a dynamic experiment through monitoring the numbers or behavior of live cells. We can recommend strategies and provide contract services for:

• Cell-based assays
• Measuring neutralizing antibodies
• Tissue culture
• Cell culture optimization
• Bioassays including stem cells and protein expression
• systems for large-scale tissue culture

Cambridge Biomedical offers a number of different cell based assay experiments, including assays that measure:

• Cell proliferation
• Toxicity
• Motility
• Production of a measurable product
• Morphology

« Show less
Flow Cytometry
Price on request

Flow Cytometry is a powerful technique for rapidly analyzing large numbers of cells individually using light-scattering, fluorescence, and absorbance measurements. The use of multiple markers in polychromatic Flow Cytometry has a host of applications in basic research, drug discovery, and the clinical laboratory.

Cambridge... Show more »

Flow Cytometry is a powerful technique for rapidly analyzing large numbers of cells individually using light-scattering, fluorescence, and absorbance measurements. The use of multiple markers in polychromatic Flow Cytometry has a host of applications in basic research, drug discovery, and the clinical laboratory.

Cambridge Biomedical is positioned to assist you with specialized Flow Cytomtery or Fluorescence-Activated Cell Sorting (FACS) assay development, validation, optimization, and sample analysis needs. Our facility operates multiple FACS Canto II systems.

The advantages and applications of Flow Cytometry include:

• Capability to simultaneously analyze multiple parameters for a given cell population
• High throughput cell and particle based screening and analyses
• In depth analysis of complex cellular processes such as oncogenesis, cell cycle regulation,
autophagy, apoptosis, necrosis, senescence, cell proliferation, and functional studies
within phenotypically defined populations, such as calcium flux and phosphorylated proteins
• Intracellular and cytoplasmic antigen analysis, and organelle analysis
• DNA and RNA analysis
• Translocation assays
• Screening for ploidy, immunophenotyping, oncological, and disease-associated
biomarker analysis and monitoring
• Whole cell and receptor binding assays, cell counting, functional G-protein-coupled
receptor screening
• In vitro toxicology, antibody screening, and rare event analysis, such as in dendritic cells,
and stem/progenitor cells

« Show less
Biomarker Analysis
Price on request

Luminex®/Quantigene® is a fluorescence covalent microbead immunosorbent assay. Up to 500 analytes can be multiplexed in a single well, the most commonly used Luminex® x-MAP technology is a flexible, open architecture design that can be configured to perform a wide range of bio-assays.

The Cambridge Biomedical laboratory operates two Luminex® FLEXMAP 3D systems with xPonent software.

Luminex®/Quantigene® is a fluorescence covalent microbead immunosorbent assay. Up to 500 analytes can be multiplexed in a single well, the most commonly used Luminex® x-MAP technology is a flexible, open architecture design that can be configured to perform a wide range of bio-assays.

The Cambridge Biomedical laboratory operates two Luminex® FLEXMAP 3D systems with xPonent software.

« Show less
Luminex
NAb Assays
Neutralizing Antibody Assays
Price on request
Request a quote for more information about this service.
ELISA
Enzyme-linked immunosorbent assay
Price on request

ELISA assays in multiple formats, including—colorimetric, fluorescence, electrochemiluminescence.

ELISA assays in multiple formats, including—colorimetric, fluorescence, electrochemiluminescence.

« Show less
Metabolite Profiling
Price on request

In support of your discovery work or clinical trials, we bring extensive experience studying metabolic processes and analysis of the metabolites. We can recommend strategies and provide contract services as follows:

• HPLC with UV or fluorescence detectors
• Kinetic and/or end-point enzymatic assays
• Enzyme... Show more »

In support of your discovery work or clinical trials, we bring extensive experience studying metabolic processes and analysis of the metabolites. We can recommend strategies and provide contract services as follows:

• HPLC with UV or fluorescence detectors
• Kinetic and/or end-point enzymatic assays
• Enzyme inhibition studies

Methods and Technologies:
We seamlessly adapt to your needs, bringing experience with technologies including colorometric and fluorescent testing and HPLC.

« Show less
Western Blot
Price on request
Request a quote for more information about this service.
In vivo Immunogenicity Assays
Price on request

Immunogenicity testing evaluates drug safety, and as such, these tests are essential components in the development of biotherapeutic drugs.

Cambridge Biomedical has developed and validated many different immunogenicity assays for the purposes of both clinical diagnostics and clinical trials, and against a variety of invading... Show more »

Immunogenicity testing evaluates drug safety, and as such, these tests are essential components in the development of biotherapeutic drugs.

Cambridge Biomedical has developed and validated many different immunogenicity assays for the purposes of both clinical diagnostics and clinical trials, and against a variety of invading microorganisms in patient samples and administered drugs.

We can recommend strategies and provide contract services for assessing immunogenicity utilizing the following technologies:

• ELISA (Enzyme Linked Immunosorbant Assay)
• RIA (Radio Immunoassay)
• MSD (Mesoscale Discovery, Electrochemiluminescence)
• Immunofluorescence
• Binding assays
• Cell based neutralizing assays
• Flow cytometry

Cambridge Biomedical is CLIA certified, CAP accredited, and provides services that support best laboratory practices and GLP compliance. We help you navigate through quality and regulatory requirements from preclinical to phase IV studies.

« Show less
Custom Cell-Based Assays
Price on request

Our specific areas of expertise include: de novo assay development, assay technology transfer, optimization and validation of novel or commercially available kits. We work with biological matrices from humans or animals as well as both small and large therapeutic molecules.

Our specific areas of expertise include: de novo assay development, assay technology transfer, optimization and validation of novel or commercially available kits. We work with biological matrices from humans or animals as well as both small and large therapeutic molecules.

« Show less
Cytokine Analysis
Price on request

We can detect and quantify (or semi-quantify) cytokines, chemokines, and their receptors, both cell bound and free. Analysis of any combination of cytokines and chemokines can be done in a variety of body fluids, tissue/cell lysate, and culture supernatant samples. We can recommend strategies and provide contract services for:

... Show more »

We can detect and quantify (or semi-quantify) cytokines, chemokines, and their receptors, both cell bound and free. Analysis of any combination of cytokines and chemokines can be done in a variety of body fluids, tissue/cell lysate, and culture supernatant samples. We can recommend strategies and provide contract services for:

• Multiplex of up to 500 targets utilizing Luminex® technology
• Intracellular cytokine analysis using flow cytometry--up to five at one time
• MesoScale Discovery (MSD) and ELISA
• qPCR using 96 and 384 well plates, or open array card

Methods and Technologies:
We seamlessly adapt to your needs, bringing experience with technologies including: qPCR, ELISA, MSD, RIA, Luminex®, and flow cytometry.

Our technicians average eight years' experience in their platform specializations, assuring your organization of the highest level laboratory work.

« Show less
In vitro PK/PD Models
In vitro pharmacokinetics/pharmacodynamics
Price on request

Understanding the PK/PD behavior of a drug helps design the dose, route, and schedule of administration to maximize effectiveness while reducing adverse effects.

Bioanalytical testing methods are utilized to determine concentration time profiles of the drug and metabolites in biological fluids, providing information necessary... Show more »

Understanding the PK/PD behavior of a drug helps design the dose, route, and schedule of administration to maximize effectiveness while reducing adverse effects.

Bioanalytical testing methods are utilized to determine concentration time profiles of the drug and metabolites in biological fluids, providing information necessary for PK/PD analysis. High performance liquid chromatography (HPLC) and Immunoassay, MSD and Luminex® technologies are selective and sensitive bioanalytical methods utilized in our laboratory to implement your PK/PD studies.

Our bioanalytical capabilities for PK/PD include:

• Sample preparation (PP, LLE, SPE)
• Derivatization
• HPLC method optimization
• UV-Vis or fluorescence detection
• Customized ELISA bioassays

Our development capabilities are supported by a CLIA certified, CAP accredited laboratory capable of processing 10 or 10,000 samples.

« Show less
In vitro Diagnostic Development
Price on request
Request a quote for more information about this service.
Preclinical
Medical Device Development
Price on request
Request a quote for more information about this service.
Preclinical
Cell Signaling Analyses
Price on request
Request a quote for more information about this service.
Biochemical Assays
Price on request
Request a quote for more information about this service.
PCR
Price on request
Request a quote for more information about this service.
DNA
Price on request
Request a quote for more information about this service.
Product Development, Testing, and Packaging
Price on request
Request a quote for more information about this service.
Clinical Hematology
Price on request
Request a quote for more information about this service.
Lead Identification and Validation
Price on request
Request a quote for more information about this service.
Human Biospecimens
Price on request
Request a quote for more information about this service.
Cell and Tissue Culture
Price on request
Request a quote for more information about this service.
Ploidy Analysis
Price on request
Request a quote for more information about this service.
Clinical Chemistry
Price on request
Request a quote for more information about this service.
Clinical Data Management
Price on request
Request a quote for more information about this service.
Fungal Infection Animal Models
Price on request
Request a quote for more information about this service.
Complete Blood Count
Price on request
Request a quote for more information about this service.
Bioavailability and Bioequivalence Studies
Price on request
Request a quote for more information about this service.
Specialized Cell-Based Assays
Price on request
Request a quote for more information about this service.
Hepatitis Animal Models
Price on request
Request a quote for more information about this service.
Hepatitis B
Nitric Oxide Synthase Assays
Price on request
Request a quote for more information about this service.
Peroxidase Assays
Price on request
Request a quote for more information about this service.
Osteoclasts
Price on request
Request a quote for more information about this service.
Animal Models of Disease
Price on request
Request a quote for more information about this service.
Dehydrogenase Assays
Price on request
Request a quote for more information about this service.
Antivirals
Price on request
Request a quote for more information about this service.
Ubiquitin Ligase Assays
Price on request
Request a quote for more information about this service.
Oligonucleotide Ligation Assays
Price on request
Request a quote for more information about this service.
Cytogenetics
Price on request
Request a quote for more information about this service.
Viral Infection Animal Models
Price on request
Request a quote for more information about this service.
Drug Target Identification
Price on request
Request a quote for more information about this service.
Hit Identification
Price on request
Request a quote for more information about this service.
Clinical and Anatomic Pathology
Price on request
Request a quote for more information about this service.
Bacterial Infection Animal Models
Price on request
Request a quote for more information about this service.
Antibody Detection
Price on request
Request a quote for more information about this service.
Quality Assurance
Price on request
Request a quote for more information about this service.
Preclinical PK/PD Studies
in vivo Pharmacokinetics/Pharmacodynamics
Price on request
Request a quote for more information about this service.
Enzyme Assays
Price on request
Request a quote for more information about this service.
In vivo Pharmacology Studies
Price on request
Request a quote for more information about this service.
Toxicology
Price on request
Request a quote for more information about this service.
Small Molecule Bioanalysis
Price on request
Request a quote for more information about this service.
Large Molecule Bioanalysis
Price on request
Request a quote for more information about this service.
Cellular Ion Channel Assays
Price on request
Request a quote for more information about this service.
Phosphodiesterase (PDE) Assays
Price on request
Request a quote for more information about this service.
Nuclear Receptor Assays
Price on request
Request a quote for more information about this service.
Ion Channel Screening Assays
Price on request
Request a quote for more information about this service.
Monoamine Transporter Assays
Price on request
Request a quote for more information about this service.
Compound Profiling
Price on request
Request a quote for more information about this service.
Drug Discovery & Development
Price on request
Request a quote for more information about this service.
GPCR Assays
G-Protein Coupled Receptor Assay
Price on request
Request a quote for more information about this service.
Regulatory Affairs Consulting
Price on request
Request a quote for more information about this service.
Biomarkers
Price on request
Request a quote for more information about this service.
Antibody Purification
Price on request
Request a quote for more information about this service.
Virology Services
Price on request
Request a quote for more information about this service.
Central Lab Services
Price on request
Request a quote for more information about this service.
Biochemistry & Molecular Biology
Price on request
Request a quote for more information about this service.
RNA Amplification
Price on request
Request a quote for more information about this service.
Cell Culture Consulting
Price on request
Request a quote for more information about this service.
Assay Development Consulting
Price on request
Request a quote for more information about this service.
Coagulation Profile
Price on request
Request a quote for more information about this service.
Kinase Assays
Price on request
Request a quote for more information about this service.
In vitro Reporter Gene Assays
Price on request
Request a quote for more information about this service.
Protease Assays
Price on request
Request a quote for more information about this service.
Inflammation Assays
Price on request
Request a quote for more information about this service.
Cell Cycle Analysis
Price on request
Request a quote for more information about this service.
Infectious Disease Animal Models
Price on request
Request a quote for more information about this service.
Cell Adhesion Assays
Price on request
Request a quote for more information about this service.
In vivo Toxicity Testing
Price on request
Request a quote for more information about this service.
Histology and Pathology Services
Price on request
Request a quote for more information about this service.
Drug Target Validation
Price on request
Request a quote for more information about this service.
Luminex Assay Development
Price on request
Request a quote for more information about this service.
Protein Quantification
Price on request
Request a quote for more information about this service.
Hepatic Animal Models
Price on request
Request a quote for more information about this service.
Cytometry
Price on request
Request a quote for more information about this service.
Immunophenotyping
Price on request
Request a quote for more information about this service.
Biospecimens
Price on request
Request a quote for more information about this service.
Liquid Chromatography
Price on request
Request a quote for more information about this service.
Cells and Tissues
Price on request
Request a quote for more information about this service.
Omics
Price on request
Request a quote for more information about this service.
Signaling Pathway Analysis
Price on request
Request a quote for more information about this service.
Cell-Based Compound Screening
Price on request
Request a quote for more information about this service.
Biosimilar Assay Development
Price on request
Request a quote for more information about this service.
Biochemical Assay Kits
Price on request
Request a quote for more information about this service.
Immune Cell Assays
Price on request
Request a quote for more information about this service.
Antibody Services
Price on request
Request a quote for more information about this service.
Biomarker Assay Development
Price on request
Request a quote for more information about this service.
Assay Development
Price on request
Request a quote for more information about this service.
Bioanalytical Assay Validation
Price on request
Request a quote for more information about this service.
Bioanalytical Assay Development and Optimization
Price on request
Request a quote for more information about this service.
Transfection
Price on request
Request a quote for more information about this service.
BTK Assay Services
Price on request
Request a quote for more information about this service.
Featured Vendor: Cambridge Biomedical
Price on request
Request a quote for more information about this service.
RNA
Price on request
Request a quote for more information about this service.
Genotyping Services
Price on request
Request a quote for more information about this service.
Receptor Assays
Price on request
Request a quote for more information about this service.
Microbiology Services
Price on request
Request a quote for more information about this service.
Bioanalytical Assays
Price on request
Request a quote for more information about this service.
Experimental Design
Price on request
Request a quote for more information about this service.
Animal Models and Studies
Price on request
Request a quote for more information about this service.
Functional Human Tissue Assays
Price on request
Request a quote for more information about this service.
Project and Process Management
Price on request
Request a quote for more information about this service.
Ligase Assays
Price on request
Request a quote for more information about this service.
Transporter & Cell Uptake Assays
Price on request
Request a quote for more information about this service.
Metabolomics
Price on request
Request a quote for more information about this service.
Analytical Chemistry Services
Price on request
Request a quote for more information about this service.
Nucleic Acid Services
Price on request
Request a quote for more information about this service.
Chromosome Analysis
Price on request
Request a quote for more information about this service.
Regulatory Affairs Services
Price on request
Request a quote for more information about this service.
Hydrolase Assays
Price on request
Request a quote for more information about this service.
Cell-Based Assays
Price on request
Request a quote for more information about this service.
Human Primary Cells
Price on request
Request a quote for more information about this service.
Antibody/Antigen Detection Based Testing
Price on request
Request a quote for more information about this service.
In vivo PK/PD Studies
Price on request
  • ocular pharmacokinetics
  • ocular pharmacokinetics
« Show less
Blood Count
Price on request
Request a quote for more information about this service.
Product Quality Control
Price on request
Request a quote for more information about this service.
Biology
Price on request
Request a quote for more information about this service.
Purification Services
Price on request
Request a quote for more information about this service.
Oxidoreductase Assays
Price on request
Request a quote for more information about this service.
Clinical Research
Price on request
Request a quote for more information about this service.
Process Consulting
Price on request
Request a quote for more information about this service.
Clinical Laboratory Services
Price on request
Request a quote for more information about this service.
ADME/DMPK Studies
Drug Metabolism and Pharmacokinetics
Price on request
Request a quote for more information about this service.
Functional & Cell Type Specific Assays
Price on request
Request a quote for more information about this service.
Chemistry and Materials
Price on request
Request a quote for more information about this service.
Medical Devices & Diagnostics
Price on request
Request a quote for more information about this service.
Synthase Assays
Price on request
Request a quote for more information about this service.
Chromatography
Price on request
Request a quote for more information about this service.
Electrophoresis
Price on request
Request a quote for more information about this service.
Clinical Molecular Diagnostics
Price on request
Request a quote for more information about this service.
Pharmacology & Toxicology
Price on request
Request a quote for more information about this service.
Clinical Data Collection, Analysis and Management
Price on request
Request a quote for more information about this service.
Proteomics
Price on request
Request a quote for more information about this service.
Drug Discovery
Price on request
Request a quote for more information about this service.
Biomarker Discovery
Price on request
Request a quote for more information about this service.
Protein Services
Price on request
Request a quote for more information about this service.
Bioanalysis
Price on request
Request a quote for more information about this service.
Protein Purification and Quantification
Price on request
Request a quote for more information about this service.
Immunostaining
Price on request
Request a quote for more information about this service.
Cell Viability & Proliferation Assays
Price on request
Request a quote for more information about this service.
Protein Expression Visualization
Price on request
Request a quote for more information about this service.
Immunoassays
Price on request
Request a quote for more information about this service.

Cambridge Biomedical Inc. has not received any ratings.

Be the first to endorse Cambridge Biomedical Inc.

Endorse this lab