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Cambridge Biomedical Inc.

Boston, Massachusetts, US

Since its establishment in 1997, Cambridge Biomedical has supported sponsors and CRO’s developing customized assays for small and large molecules, biomarkers, diagnostics, and medical devices. Our team has expertise and extensive experience in technology transfer, assay development, optimization, and validation. We are positioned to work with you at preclinical, clinical, and post market stages of drug or device development.

Cambridge Biomedical employs senior scientists at the PhD, MD, and MD/PhD level. Our accomplished staff are experts in complex and custom assay development and validation. Given our technical experience and scientific expertise, Cambridge Biomedical is able to perform across a broad range of therapeutic areas.

Since inception, Cambridge Biomedical has developed, qualified, and validated over 150 assays, with an average of 15-20 additional assays per year. We provide sample analysis on over... Show more »

Since its establishment in 1997, Cambridge Biomedical has supported sponsors and CRO’s developing customized assays for small and large molecules, biomarkers, diagnostics, and medical devices. Our team has expertise and extensive experience in technology transfer, assay development, optimization, and validation. We are positioned to work with you at preclinical, clinical, and post market stages of drug or device development.

Cambridge Biomedical employs senior scientists at the PhD, MD, and MD/PhD level. Our accomplished staff are experts in complex and custom assay development and validation. Given our technical experience and scientific expertise, Cambridge Biomedical is able to perform across a broad range of therapeutic areas.

Since inception, Cambridge Biomedical has developed, qualified, and validated over 150 assays, with an average of 15-20 additional assays per year. We provide sample analysis on over 100,000 samples annually.

Certifications: GLP Compliance, CLIA certified, CAP Accredited

Publications:

"Lab Developed Tests" by Dr. John Reddington Ph.D. D.V.M.

"Luminex Assay Validation" by Dr. Archana Kapoor Ph.D.
"Collaborative Assay Development" by Dr. James Lederer Ph.D.

"A High-Throughput Multiplexed Assay For Super Family-Wide Profiling of Enzyme Activity" by Dr. Dan Bachovchin Ph.D.

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Cambridge Biomedical Inc. has not listed any services.

Clinical Biomarkers
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MSD Assays
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FACS
Fluorescence Activated Cell Sorting
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Immunohistochemistry (IHC)
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qPCR
Quantitative PCR
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Cambridge Biomedical has developed numerous PCR, qPCR, and RT-PCR assays utilizing our fully equipped and dedicated PCR suite with the latest generation of PCR equipment including Applied Biosystems ViiA 7 (96 wells, 384 wells, fast cycle), Taqman Low Density Arrays (TLDA), and the Applied Biosystems Prism 7000.

Our scientific... Show more »

Cambridge Biomedical has developed numerous PCR, qPCR, and RT-PCR assays utilizing our fully equipped and dedicated PCR suite with the latest generation of PCR equipment including Applied Biosystems ViiA 7 (96 wells, 384 wells, fast cycle), Taqman Low Density Arrays (TLDA), and the Applied Biosystems Prism 7000.

Our scientific team brings a wide range of experience in developing, validating and optimizing PCR assays.

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Electrochemiluminescence
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Electrochemiluminescence or electrogenerated chemiluminescence (ECL) is a type of luminescence produced during electrochemical reactions in solution. Cambridge Biomedical uses the MesoScale Discovery (MSD) platform allowing the detection of biomarkers in single and multiplex formats in microplate wells.

Typical applications of... Show more »

Electrochemiluminescence or electrogenerated chemiluminescence (ECL) is a type of luminescence produced during electrochemical reactions in solution. Cambridge Biomedical uses the MesoScale Discovery (MSD) platform allowing the detection of biomarkers in single and multiplex formats in microplate wells.

Typical applications of electrochemiluminescence:

• Cytokines and chemokines
• Cell signaling pathways
• Angiogenesis and hypoxia markers
• Growth and vascular factors
• Metabolic markers
• Immunogenicity
• Cell based assays
• Vaccine/bioproduction

Advantages of ECL over conventional ELISA:

• High sensitivity and low background because the stimulation mechanism (electrical)
is decoupled from the detection signal (light)
• Emission read at 620 nm, eliminates issues revolving around color quenching
• Improved precision from non-separation-based ("no-wash") immunoassays due to the
proximity-based nature of signal generation, where only labels near surfaces of
electrodes are stimulated
• A large assay dynamic range of five logs
• Carbon electrode plate surface has a 10X greater binding capacity than
conventional ELISA microplates
• Multiple analytes can be run in a single well, reducing required sample volume

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Custom Cell-Based Assays
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Cell based assays offer a more accurate representation of a real life model since live cells are used. They also offer the possibility of a dynamic experiment through monitoring the numbers or behavior of live cells. We can recommend strategies and provide contract services for:

• Cell-based assays
• Measuring... Show more »

Cell based assays offer a more accurate representation of a real life model since live cells are used. They also offer the possibility of a dynamic experiment through monitoring the numbers or behavior of live cells. We can recommend strategies and provide contract services for:

• Cell-based assays
• Measuring neutralizing antibodies
• Tissue culture
• Cell culture optimization
• Bioassays including stem cells and protein expression
• systems for large-scale tissue culture

Cambridge Biomedical offers a number of different cell based assay experiments, including assays that measure:

• Cell proliferation
• Toxicity
• Motility
• Production of a measurable product
• Morphology

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Flow Cytometry
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Flow Cytometry is a powerful technique for rapidly analyzing large numbers of cells individually using light-scattering, fluorescence, and absorbance measurements. The use of multiple markers in polychromatic Flow Cytometry has a host of applications in basic research, drug discovery, and the clinical laboratory.

Cambridge... Show more »

Flow Cytometry is a powerful technique for rapidly analyzing large numbers of cells individually using light-scattering, fluorescence, and absorbance measurements. The use of multiple markers in polychromatic Flow Cytometry has a host of applications in basic research, drug discovery, and the clinical laboratory.

Cambridge Biomedical is positioned to assist you with specialized Flow Cytomtery or Fluorescence-Activated Cell Sorting (FACS) assay development, validation, optimization, and sample analysis needs. Our facility operates multiple FACS Canto II systems.

The advantages and applications of Flow Cytometry include:

• Capability to simultaneously analyze multiple parameters for a given cell population
• High throughput cell and particle based screening and analyses
• In depth analysis of complex cellular processes such as oncogenesis, cell cycle regulation,
autophagy, apoptosis, necrosis, senescence, cell proliferation, and functional studies
within phenotypically defined populations, such as calcium flux and phosphorylated proteins
• Intracellular and cytoplasmic antigen analysis, and organelle analysis
• DNA and RNA analysis
• Translocation assays
• Screening for ploidy, immunophenotyping, oncological, and disease-associated
biomarker analysis and monitoring
• Whole cell and receptor binding assays, cell counting, functional G-protein-coupled
receptor screening
• In vitro toxicology, antibody screening, and rare event analysis, such as in dendritic cells,
and stem/progenitor cells

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Biomarker Analysis
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Luminex®/Quantigene® is a fluorescence covalent microbead immunosorbent assay. Up to 500 analytes can be multiplexed in a single well, the most commonly used Luminex® x-MAP technology is a flexible, open architecture design that can be configured to perform a wide range of bio-assays.

The Cambridge Biomedical laboratory operates two Luminex® FLEXMAP 3D systems with xPonent software.

Luminex®/Quantigene® is a fluorescence covalent microbead immunosorbent assay. Up to 500 analytes can be multiplexed in a single well, the most commonly used Luminex® x-MAP technology is a flexible, open architecture design that can be configured to perform a wide range of bio-assays.

The Cambridge Biomedical laboratory operates two Luminex® FLEXMAP 3D systems with xPonent software.

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Luminex
NAb Assays
Neutralizing Antibody Assays
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ELISA
Enzyme-linked immunosorbent assay
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ELISA assays in multiple formats, including—colorimetric, fluorescence, electrochemiluminescence.

ELISA assays in multiple formats, including—colorimetric, fluorescence, electrochemiluminescence.

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Metabolite Profiling
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In support of your discovery work or clinical trials, we bring extensive experience studying metabolic processes and analysis of the metabolites. We can recommend strategies and provide contract services as follows:

• HPLC with UV or fluorescence detectors
• Kinetic and/or end-point enzymatic assays
• Enzyme... Show more »

In support of your discovery work or clinical trials, we bring extensive experience studying metabolic processes and analysis of the metabolites. We can recommend strategies and provide contract services as follows:

• HPLC with UV or fluorescence detectors
• Kinetic and/or end-point enzymatic assays
• Enzyme inhibition studies

Methods and Technologies:
We seamlessly adapt to your needs, bringing experience with technologies including colorometric and fluorescent testing and HPLC.

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Western Blot
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In vivo Immunogenicity Assays
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Immunogenicity testing evaluates drug safety, and as such, these tests are essential components in the development of biotherapeutic drugs.

Cambridge Biomedical has developed and validated many different immunogenicity assays for the purposes of both clinical diagnostics and clinical trials, and against a variety of invading... Show more »

Immunogenicity testing evaluates drug safety, and as such, these tests are essential components in the development of biotherapeutic drugs.

Cambridge Biomedical has developed and validated many different immunogenicity assays for the purposes of both clinical diagnostics and clinical trials, and against a variety of invading microorganisms in patient samples and administered drugs.

We can recommend strategies and provide contract services for assessing immunogenicity utilizing the following technologies:

• ELISA (Enzyme Linked Immunosorbant Assay)
• RIA (Radio Immunoassay)
• MSD (Mesoscale Discovery, Electrochemiluminescence)
• Immunofluorescence
• Binding assays
• Cell based neutralizing assays
• Flow cytometry

Cambridge Biomedical is CLIA certified, CAP accredited, and provides services that support best laboratory practices and GLP compliance. We help you navigate through quality and regulatory requirements from preclinical to phase IV studies.

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Custom Cell-Based Assays
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Our specific areas of expertise include: de novo assay development, assay technology transfer, optimization and validation of novel or commercially available kits. We work with biological matrices from humans or animals as well as both small and large therapeutic molecules.

Our specific areas of expertise include: de novo assay development, assay technology transfer, optimization and validation of novel or commercially available kits. We work with biological matrices from humans or animals as well as both small and large therapeutic molecules.

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Cytokine Analysis
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We can detect and quantify (or semi-quantify) cytokines, chemokines, and their receptors, both cell bound and free. Analysis of any combination of cytokines and chemokines can be done in a variety of body fluids, tissue/cell lysate, and culture supernatant samples. We can recommend strategies and provide contract services for:

... Show more »

We can detect and quantify (or semi-quantify) cytokines, chemokines, and their receptors, both cell bound and free. Analysis of any combination of cytokines and chemokines can be done in a variety of body fluids, tissue/cell lysate, and culture supernatant samples. We can recommend strategies and provide contract services for:

• Multiplex of up to 500 targets utilizing Luminex® technology
• Intracellular cytokine analysis using flow cytometry--up to five at one time
• MesoScale Discovery (MSD) and ELISA
• qPCR using 96 and 384 well plates, or open array card

Methods and Technologies:
We seamlessly adapt to your needs, bringing experience with technologies including: qPCR, ELISA, MSD, RIA, Luminex®, and flow cytometry.

Our technicians average eight years' experience in their platform specializations, assuring your organization of the highest level laboratory work.

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In vitro PK/PD Models
In vitro pharmacokinetics/pharmacodynamics
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Understanding the PK/PD behavior of a drug helps design the dose, route, and schedule of administration to maximize effectiveness while reducing adverse effects.

Bioanalytical testing methods are utilized to determine concentration time profiles of the drug and metabolites in biological fluids, providing information necessary... Show more »

Understanding the PK/PD behavior of a drug helps design the dose, route, and schedule of administration to maximize effectiveness while reducing adverse effects.

Bioanalytical testing methods are utilized to determine concentration time profiles of the drug and metabolites in biological fluids, providing information necessary for PK/PD analysis. High performance liquid chromatography (HPLC) and Immunoassay, MSD and Luminex® technologies are selective and sensitive bioanalytical methods utilized in our laboratory to implement your PK/PD studies.

Our bioanalytical capabilities for PK/PD include:

• Sample preparation (PP, LLE, SPE)
• Derivatization
• HPLC method optimization
• UV-Vis or fluorescence detection
• Customized ELISA bioassays

Our development capabilities are supported by a CLIA certified, CAP accredited laboratory capable of processing 10 or 10,000 samples.

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In vitro Diagnostic Development
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Preclinical
Medical Device Development
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Preclinical
Omics
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Cell-Based Assays
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Immunoassays
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Clinical Chemistry
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Protein Expression Visualization
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Clinical Research
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Protein Services
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Biology
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Immunostaining
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Cells and Tissues
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Protein Quantification
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Proteomics
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Toxicology
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PCR
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Cytometry
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In vivo Toxicity Testing
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Antibody/Antigen Detection Based Testing
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Clinical Laboratory Services
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DNA
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Pharmacology & Toxicology
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Biomarker Discovery
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Bioanalysis
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Biomarkers
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ADME and DMPK Studies
Drug Metabolism and Pharmacokinetics
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Functional & Cell Type Specific Assays
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Immune Cell Assays
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Specialized Cell-Based Assays
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Biochemistry & Molecular Biology
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Metabolomics
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Nucleic Acid Services
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Medical Devices & Diagnostics
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