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Cambridge Biolabs

Cambridge, MA

Cambridge Biolabs (CBL) is your hit-the-ground-running, local, contract research organization serving the Boston Innovation Supercluster from our convenient Kendall Square location. Our clients are start-up biotechnology companies and venture capitalists who need their scientists to get started producing results immediately.

We know it can take months to find and build out a lab; our team has been through this many times. CBL now offers wet-bench laboratory space for molecular, cellular and microbiology including a cell culture suite and numerous regional partnerships for in vivo work and specialized core capability. Our team brings experience and expertise to the table that will complement your know-how and ability. Our scientists are ready to start moving your company or investment toward important milestones immediately.

Publications

  • Engineered E. coli as Vehicles for Targeted Therapeutics. *Curr Gene... Show more »

Cambridge Biolabs (CBL) is your hit-the-ground-running, local, contract research organization serving the Boston Innovation Supercluster from our convenient Kendall Square location. Our clients are start-up biotechnology companies and venture capitalists who need their scientists to get started producing results immediately.

We know it can take months to find and build out a lab; our team has been through this many times. CBL now offers wet-bench laboratory space for molecular, cellular and microbiology including a cell culture suite and numerous regional partnerships for in vivo work and specialized core capability. Our team brings experience and expertise to the table that will complement your know-how and ability. Our scientists are ready to start moving your company or investment toward important milestones immediately.

Publications

  • Engineered E. coli as Vehicles for Targeted Therapeutics. Curr Gene Ther. 2010 Feb;10(1):27-33.
  • Delivery of short hairpin RNAs by transkingdom RNA interference modulates the classical ABCB1-mediated multidrug-resistant phenotype of cancer cells.
    Cell Cycle. 2009 Oct 15;8(20):3349-3354.
  • Transkingdom RNA interference (tkRNAi as a new delivery tool for therapeutic RNA. Expert Opin Biol Ther. 2009 Dec;9(12):1533-42.
  • Bacterial vectors and delivery systems in cancer therapy. IDrugs, 2010 Oct; 13(10):701-6
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Cambridge Biolabs has not listed any services.

High Throughput Screening
Price on request

The cell culture suite at Cambridge Biolabs is equipped for medium- to high-throughput small molecule and compound screening. Satisfied customers have used our capacity to validate their new compound screening tool, meet milestones and please investors.

Screening Services

The cell culture suite at Cambridge Biolabs is equipped for medium- to high-throughput small molecule and compound screening. Satisfied customers have used our capacity to validate their new compound screening tool, meet milestones and please investors.

Screening Services

  • Compound library management
  • Cell-line maintenance
  • Screening platform validation
  • Compound library screening

Hit validation

  • Toxicology
  • Histology
  • Pharmacokinetics/ADME
  • Pharmacodynamics
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qPCR
Quantitative PCR
Price on request

Scientists at Cambridge Biolabs are experts in Rt-qPCR and RNAi. We have spent years developing RNAi drug delivery systems for multiple companies. This translates to extensive experience with many qPCR systems that can help prove your drug or technology works. ViThera will use whichever platform option our clients prefer.

*RNA... Show more »

Scientists at Cambridge Biolabs are experts in Rt-qPCR and RNAi. We have spent years developing RNAi drug delivery systems for multiple companies. This translates to extensive experience with many qPCR systems that can help prove your drug or technology works. ViThera will use whichever platform option our clients prefer.

RNA isolation and QC

  • Sample submission guidelines
  • Phenol/chloroform extraction
  • Direct-from-cells reverse transcription and amplification

RNA –based assays:

  • RT-qPCR
  • miRNA profiling
  • Northern Blot

RNAi –specific

  • Screening and selection of lead siRNA candidates
  • Assessment of RNAi delivery technologies
  • siRNA/shRNA technology evaluation

Data and analysis

  • Samples run in triplicate
  • Amplification curves and melt curves available where appropriate
  • Raw Ct values provided
  • ΔΔCt analysis provided with error bars
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Nanoscale Analysis and Characterization
Price on request

Cambridge Biolabs brings Izon’s revolutionary qNano scanning ion occlusion sensing (SIOS) platform to the Kendall Square area.

Nanoparticle Sizing

CBL measures single particles for size and size distribution analysis of multimodal sample populations.

Particle Interaction Monitoring

We provide identification and... Show more »

Cambridge Biolabs brings Izon’s revolutionary qNano scanning ion occlusion sensing (SIOS) platform to the Kendall Square area.

Nanoparticle Sizing

CBL measures single particles for size and size distribution analysis of multimodal sample populations.

Particle Interaction Monitoring

We provide identification and analysis of particle-particle, particle-biomolecule, functionalization and aggregation interactions.

Concentration Analysis

CBL’s relationship with Izon brings a state-of-the-art solution for concentration measurement in both biological and synthetic particle samples.

Multimodal Nanoparticle Sizing

qNano enables particle-by-particle collection & assessment of polydisperse mixtures for highly accurate determination of size distribution within a sample.

Particle Interaction Monitoring

Particle-particle interactions can be carried out in situ in the upper fluid cell and the interaction monitored in real-time through changes in SIOS measurement parameters.

Concentration Analysis

The relationship between an applied pressure and the measured frequency of blockade events is linear for a given particle set.

Particle rates are proportional to concentration, allowing the concentrations of two samples to be compared through their measured blockade frequency and gradient response over pressure.

Measurement of a standard at a single applied pressure setting provides a reference against which any other sample can be compared to obtain an accurate absolute concentration value.

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Epigenetic Analysis
Price on request

Cambridge Biolabs provides exclusive access to ultra-sensitive DNA and RNA epigenetic modification testing through a partnership with Trace Bioanalytics. We can identify epigenetic modifications such as DNA methylation.

Cambridge Biolabs provides exclusive access to ultra-sensitive DNA and RNA epigenetic modification testing through a partnership with Trace Bioanalytics. We can identify epigenetic modifications such as DNA methylation.

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DNA Adduct Testing
Price on request

Cambridge Biolabs provides exclusive access to ultra-sensitive DNA adduct testing. DNA adducts are cancer-causing compounds covalently bonded to DNA. Adducts are used as biomarkers of exposure because presence of an adduct demonstrates exposure to the compound.

The pharmaceutical industry currently uses the Ames test to study... Show more »

Cambridge Biolabs provides exclusive access to ultra-sensitive DNA adduct testing. DNA adducts are cancer-causing compounds covalently bonded to DNA. Adducts are used as biomarkers of exposure because presence of an adduct demonstrates exposure to the compound.

The pharmaceutical industry currently uses the Ames test to study the mutagenic effect of a compound but this test suffers from known shortcomings. The use of DNA adduct testing can increase the compound’s safety profile. New and old compounds considered for drug development by the pharmaceutical industry and drugs considered for approval by the FDA should the subject of DNA adduct testing. These compounds should be subjected to DNA adduct testing to elucidate the potential for DNA-binding that may result in mutation and carcinogenesis.

DNA adduct testing is important for compounds that are not intended for human use as well. Organizations like the EPA, for example, have great use for adduct testing on compounds that they are studying and suspect are carcinogenic.

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Mammalian Cell Culture
Price on request

Our scientists are highly skilled in cell culture techniques and maintain an extensive catalogue of cells lines. All of our team members have extensive experience with mammalian cell culture and are ready to care for your unique or proprietary cell line. Our cell culture suite is biosafety level 2 (BSL-2) and is covered under... Show more »

Our scientists are highly skilled in cell culture techniques and maintain an extensive catalogue of cells lines. All of our team members have extensive experience with mammalian cell culture and are ready to care for your unique or proprietary cell line. Our cell culture suite is biosafety level 2 (BSL-2) and is covered under CBL’s recombinant-DNA research license issued by the City of Cambridge.

Our facility offers:

  • siRNA and pDNA transfection
  • High throughput small molecule screening
  • Maintenance of primary and transformed cell lines
  • Evaluation of biologics and drug delivery in cell culture models
  • A wide range of human and murine cell lines available
  • An array of bioluminescent cell-based assays
  • … and more!
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Assay Development
Price on request

The real beauty in using serial biotech entrepreneurs for your outsourced development needs is that each of our individual scientists has felt your pain and been through the same trials you are going through. Our team members can troubleshoot protocols, change direction quickly and develop entirely new assays. Our convenient... Show more »

The real beauty in using serial biotech entrepreneurs for your outsourced development needs is that each of our individual scientists has felt your pain and been through the same trials you are going through. Our team members can troubleshoot protocols, change direction quickly and develop entirely new assays. Our convenient Kendall Square location means you and your scientists can stop by and oversee troubleshooting and development and our BioCloud model means you can do your development yourself, right at a bench in our lab.

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Experimental Design
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Project Management & Consulting Services
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Biology
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Cells and Tissues
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PCR
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Chemistry and Materials
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Material Characterization Services
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DNA
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Pharmacology & Toxicology
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Safety Pharmacology & Efficacy Testing
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Analytical Chemistry Services
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Hit Identification
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Drug Discovery & Development
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Biochemistry & Molecular Biology
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Drug Discovery
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Nucleic Acid Services
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