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Callaghan Innovation Biotechnology Group

Lower Hutt, NZ

The Callaghan Innovation Biotechnology Group are a highly skilled and qualified scientific workforce which provides tailored R&D solutions to meet business need.

Core capabilities are expertise in lipid chemistry, proteins and bioactive peptides, natural products and plant chemistry, molecular biology and enzyme technology, fermentation and bioprocessing, supercritical fluid extraction, process development and pilot-scale manufacture, Food Grade processing, and supporting analytical services.

The Biotechnology group is part of Callaghan Innovation, a organisation of about 300 researchers, engineers, scientists, technologists, designers, entrepreneurs, advisors and administrators delivering self-help and on-demand services and tailored programmes. This includes technical expertise for provision of R&D services, access to equipment, facilities & pilot plants, integrated project management to assist... Show more »

The Callaghan Innovation Biotechnology Group are a highly skilled and qualified scientific workforce which provides tailored R&D solutions to meet business need.

Core capabilities are expertise in lipid chemistry, proteins and bioactive peptides, natural products and plant chemistry, molecular biology and enzyme technology, fermentation and bioprocessing, supercritical fluid extraction, process development and pilot-scale manufacture, Food Grade processing, and supporting analytical services.

The Biotechnology group is part of Callaghan Innovation, a organisation of about 300 researchers, engineers, scientists, technologists, designers, entrepreneurs, advisors and administrators delivering self-help and on-demand services and tailored programmes. This includes technical expertise for provision of R&D services, access to equipment, facilities & pilot plants, integrated project management to assist with R&D development, and links into the wider New Zealand and international R&D resources.

http://www.callaghaninnovation.govt.nz/our-areas-expertise/biotechnologies
http://www.callaghaninnovation.govt.nz/technology-and-product-development/our-areas-expertise
https://www.proteinscienceandengineering.nz/

Recent Publications

  • Absolute stereochemistry of 1,2-diols from lipids of thermomicrobia, Lagutin, K., Wong H., Vyssotski M., and MacKenzie A., Lipids, 2016, Volume 51, Issue 3, p.373 - 376, (2016)
  • Archetypes and basic strategies of technology decisions, Lingens, B., Winterhalter S., Krieg L., and Gassmann O., Research Technology Management, 2016, Volume 59, Issue 2, p.36 - 46, (2016)
  • Biotechnological approaches for production of high value compounds from bread waste, Haroon, S., Vinthan A., Negron L., Das S., and Berenjian A., American Journal of Biochemistry and Biotechnology, 2016, Volume 12, Issue 2, p.102 - 109, (2016)
  • Chemoenzymatic Synthesis of a Phosphorylated Glycoprotein, Priyanka, P., Parsons T.B., Miller A., Platt F.M., and Fairbanks A.J. , Angewandte Chemie - International Edition, 2016, Volume 55, Issue 16, p.5058 - 5061, (2016)
  • Development of novel polymer coating for FBG based relative humidity sensing, Swanson, A.J., Raymond S.G., Janssens S., Breukers R.D., Bhuiyan M.D.H., Lovell-Smith J.W., and Waterland M.R., Sensors and Actuators, A: Physical, 2016, Volume 249, p.217 - 224, (2016)
  • Dispersion polymerization of uniform cross-linked polystyrene microspheres in butan-1-ol, Beal, J.H.L., Xu Y., Al-Salim N., and Arnold W.M., Journal of Applied Polymer Science, 2016, Volume 133, Issue 10, (2016)
  • On the Distribution of Detection Delay for Quickest Spectrum Sensing, Hanafi, E., Martin P.A., Smith P.J., and Coulson A.J. , IEEE Transactions on Communications, 2016, Volume 64, Issue 2, p.502 - 510, (2016)
  • The effect of bulky groups on the electro-optic coefficient r33 of a pyridine-donor nonlinear optical chromophore, Quilty, J.W., Thomas D.G., Clarke D.J., and Breukers R.D., Optical Materials, 2016, Volume 54, p.147 - 154, (2016)
  • The effect of drilling fluid and temperature on the cement/rock interaction in wells, Silva, J., and Milestone N.B. , Advances in Cement Research, 2016, Volume 28, Issue 3, p.189 - 201, (2016)
  • The effect of organic retarders on grout thickening and setting during deep borehole disposal of high-level radioactive waste, Collier, N.C., Milestone N.B., Travis K.P., and Gibb F.G.F., Progress in Nuclear Energy, 2016, Volume 90, p.19 - 26, (2016)
  • Engineering properties of cellular Ti-6Al-4V structures fabricated by electron beam melting, Smith, G., Brown I., Kirchner A., Ryan M., McGavin P., and Sharp M. , Key Engineering Materials, 2016, Volume 704, p.318 - 324, (2016)
  • The feasibility of a watt balance based on twin pressure balances, Sutton, C.M., Clarkson M.T., and Kissling W.M., CPEM 2016 - Conference on Precision Electromagnetic Measurements, Conference Digest, 2016, (2016)
  • A free-piston Stirling cryocooler using metal diaphragms, Caughley, A., Sellier M., Gschwendtner M., and Tucker A., Cryogenics, 2016, Volume 80, p.8 - 16, (2016)
  • Generation of half-space sound fields with application to personal sound systems, Poletti, M.A., and Fazi F.M., Journal of the Acoustical Society of America, 2016, Volume 139, Issue 3, p.1294 - 1302, (2016)
  • Identification, library synthesis and anti-vibriosis activity of 2-benzyl-4-chlorophenol from cultures of the marine bacterium Shewanella halifaxensis, Moore, S.L., Berthomier L., Braganza C.D., MacKichan J.K., Ryan J.L., Visnovsky G., and Keyzers R.A., Bioorganic and Medicinal Chemistry Letters, 2016, Volume 26, Issue 13, p.3086 - 3088, (2016)
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Callaghan Innovation Biotechnology Group has not listed any services.

Antibody Fragment Production
Price on request
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Natural Product Analysis
Price on request

Extraction, purification and analysis of bioactives such as anti-inflammatories, flavonoids, pigments, food ingredients/fortifiers and antioxidants.

Extraction, purification and analysis of bioactives such as anti-inflammatories, flavonoids, pigments, food ingredients/fortifiers and antioxidants.

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Lipid Synthesis
Price on request

Extraction, purification, synthesis, modification, enrichment and advanced analysis of lipids (including complex lipids, e.g. phospholipids and glycolipids).

Extraction, purification, synthesis, modification, enrichment and advanced analysis of lipids (including complex lipids, e.g. phospholipids and glycolipids).

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Lipid Analysis
Price on request

Extraction, purification, synthesis, modification, enrichment and advanced analysis of lipids (including complex lipids, e.g. phospholipids and glycolipids).

Extraction, purification, synthesis, modification, enrichment and advanced analysis of lipids (including complex lipids, e.g. phospholipids and glycolipids).

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Recombinant Protein Expression
Price on request

Cloning, engineering, mutagenesis and expression of proteins.
Protein engineering.
Site-directed mutagenesis
Molecular Cloning
DNA Assembly
In-house modular DNA assembly platform for combinatorial assembly of genes and metabolic pathways
Protein purification
Protein analysis

Protein Expression Platforms:
Gram negative... Show more »

Cloning, engineering, mutagenesis and expression of proteins.
Protein engineering.
Site-directed mutagenesis
Molecular Cloning
DNA Assembly
In-house modular DNA assembly platform for combinatorial assembly of genes and metabolic pathways
Protein purification
Protein analysis

Protein Expression Platforms:
Gram negative (E. coli)
Gram-positive (Bacillus subtilis)
Yeast (Pichia pastoris)
Mammalian (HEK293)

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Mammalian Cell Culture
Price on request

Culture of cell lines and primary cells
Proliferation/Viability assays
Apoptosis assays
Growth factor detection - ELISA
Immunocyctochemistry
Flow cytometry expertise

Culture of cell lines and primary cells
Proliferation/Viability assays
Apoptosis assays
Growth factor detection - ELISA
Immunocyctochemistry
Flow cytometry expertise

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Antibody Engineering Services
Price on request

Antibody engineering for production of:
Recombinant antibodies
Chimeric mouse/human antibodies
Fv and Fab antibody fragments
Recombinant immune complexes and polymeric IgGs

Antibody engineering for production of:
Recombinant antibodies
Chimeric mouse/human antibodies
Fv and Fab antibody fragments
Recombinant immune complexes and polymeric IgGs

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Analytical Chemistry Services
Price on request

Access to a range of instrumentation including
Nuclear magnetic resonance (NMR) spectrometers,
Mass spectrometers (MS),
High performance liquid chromatographs (UPLC/HPLC),
Zetasizer (for product formulation),
UV-vis spectrometers
Time resolved fluorescence
Molecular Weight Determination
Moisture content... Show more »

Access to a range of instrumentation including
Nuclear magnetic resonance (NMR) spectrometers,
Mass spectrometers (MS),
High performance liquid chromatographs (UPLC/HPLC),
Zetasizer (for product formulation),
UV-vis spectrometers
Time resolved fluorescence
Molecular Weight Determination
Moisture content analyser.

Our services include assay development, particle size and rheological property measurement, shape analysis protein purification and characterisation (AKTA systems), molecular weight determination (SEC), fluorescence analysis and time resolved fluorescence for bioassays and enzyme assay work.

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Protein Characterization
Price on request

SDS-PAGE
Immunological assays (ELISA, Western blotting)
Protein quantitation (BCA, Lowry, Bradford)

SDS-PAGE
Immunological assays (ELISA, Western blotting)
Protein quantitation (BCA, Lowry, Bradford)

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Assay Development
Price on request
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Enzyme Assays
Price on request
  • Optimisation of enzymes for industrial applications including biotransformation and chemo-enzymatic synthesis.
  • Full suite of recombinant technologies for the enzyme engineering, including molecular cloning, expression, purification and characterisation of proteins, enzymes and biomolecules.
  • Expression in bacterial, yeast,... Show more »
  • Optimisation of enzymes for industrial applications including biotransformation and chemo-enzymatic synthesis.
  • Full suite of recombinant technologies for the enzyme engineering, including molecular cloning, expression, purification and characterisation of proteins, enzymes and biomolecules.
  • Expression in bacterial, yeast, and mammalian hosts.
  • Scale-up facilities to deliver microbial recombinant expression to 1000L.
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Device Prototyping
Price on request

Access to an extensive network of New Zealand manufacturers to get the best value on prototype builds, and in-house capability means test and rapidly evolve prototypes saving valuable time.

Access to an extensive network of New Zealand manufacturers to get the best value on prototype builds, and in-house capability means test and rapidly evolve prototypes saving valuable time.

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Manufacturing Services
Price on request

Our experts in manufacturing and design can help your business convert your ideas into commercially viable market solutions. We’ll help you solve your complex design challenges throughout the development process – from concept feasibility and testing through to production and commercialisation.

Our experts in manufacturing and design can help your business convert your ideas into commercially viable market solutions. We’ll help you solve your complex design challenges throughout the development process – from concept feasibility and testing through to production and commercialisation.

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Bioprocess Development and Scale-Up
Price on request
  • A range of MPI-registered facility with labs and pilot-scale fermentation from 1L to 1000L.
  • Small molecule and secondary metabolite production, pilot plant micro and ultrafiltration, and continuous centrifuge.
  • EPA approvals for large scale (1000L) new organisms and bacterial/yeast recombinants at PC2 level.
  • A range of MPI-registered facility with labs and pilot-scale fermentation from 1L to 1000L.
  • Small molecule and secondary metabolite production, pilot plant micro and ultrafiltration, and continuous centrifuge.
  • EPA approvals for large scale (1000L) new organisms and bacterial/yeast recombinants at PC2 level.
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Microbial Fermentation and Bioprocessing
Price on request
  • A range of MPI-registered facility with labs and pilot-scale fermentation from 1L to 1000L.
  • Small molecule and secondary metabolite production, pilot plant micro and ultrafiltration, and continuous centrifuge.
  • EPA approvals for large scale (1000L) new organisms and bacterial/yeast recombinants at PC2 level.
  • A range of MPI-registered facility with labs and pilot-scale fermentation from 1L to 1000L.
  • Small molecule and secondary metabolite production, pilot plant micro and ultrafiltration, and continuous centrifuge.
  • EPA approvals for large scale (1000L) new organisms and bacterial/yeast recombinants at PC2 level.
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Process Consulting
Price on request
  • Development and/or evaluation of industrial manufacturing processes for natural products. Process modelling, optimisation, and scale up.
  • Evaluation of unit operations including milling, solvent and supercritical fluid extraction and fractionation, solvent removal/evaporation, filtration, freeze drying, formulation,... Show more »
  • Development and/or evaluation of industrial manufacturing processes for natural products. Process modelling, optimisation, and scale up.
  • Evaluation of unit operations including milling, solvent and supercritical fluid extraction and fractionation, solvent removal/evaporation, filtration, freeze drying, formulation, preparative chromatography, centrifugation, chemical and enzymatic reaction.
  • Pilot to small scale manufacture of trial product, including rated facilities for use of ethanol and other flammable solvents. MPI approved manufacture of selected products.
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Project Management
Price on request
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Product Development Consulting
Price on request

Taking an idea from concept to commercial reality with tailored R&D solutions.

Whether it’s lowering the cost of production or managing changing technologies – the end-to-end support provided by our experienced advisors, researchers, scientists and engineers will help you identify each step to commercialise your... Show more »

Taking an idea from concept to commercial reality with tailored R&D solutions.

Whether it’s lowering the cost of production or managing changing technologies – the end-to-end support provided by our experienced advisors, researchers, scientists and engineers will help you identify each step to commercialise your idea.

Develop your components, products, processes and technology by applying or adapting existing technology, or develop your own ground-breaking research – we have the facilities and expertise to help you research, develop, test, measure, analyse and calibrate your products – from proof of concept to commercialisation.

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Natural Product Isolation and Purification
Price on request

Extraction, purification and analysis of bioactives such as anti-inflammatories, flavonoids, pigments, food ingredients/fortifiers and antioxidants.

Extraction, purification and analysis of bioactives such as anti-inflammatories, flavonoids, pigments, food ingredients/fortifiers and antioxidants.

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Lipid Extraction and Purification
Price on request

Extraction, purification, synthesis, modification, enrichment and advanced analysis of lipids (including complex lipids, e.g. phospholipids and glycolipids).

Extraction, purification, synthesis, modification, enrichment and advanced analysis of lipids (including complex lipids, e.g. phospholipids and glycolipids).

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Biochemical Assays
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Natural Products
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Drug Discovery
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Formulation Services
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Protein Services
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Biochemistry & Molecular Biology
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Protein Production
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Drug Discovery & Development
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Cells and Tissues
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Microbiology
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Device Development
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Engineering and Fabrication
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Antibody Services
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Biology
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Lipid Services
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Chemistry and Materials
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Protein Conjugation
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Product Development, Testing, and Packaging
Price on request

Product Development, Testing, and Packaging Services

Product Development, Testing, and Packaging Services

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Cell and Tissue Culture
Price on request

Cell and Tissue Culture Services

Cell and Tissue Culture Services

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Lipoprotein Analysis
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Antibody Modification
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Protein Expression Optimization
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Protein Formulation
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Lyophilization
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Cell Microfiltration
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Cell Ultrafiltration
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Yeast Culture
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Yeast Strain Construction and Optimization
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Recombinant Antigen Development
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Antimicrobial Activity Testing
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Protein Engineering/Directed Evolution
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Protein PEGylation
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Protein Expression Visualization
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Protein Expression in Yeast
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Protein Sequencing
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Equipment
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Imaging & Spectroscopy
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Yeast Services
Price on request

Yeast Services

Yeast Services

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Protein Modification
Price on request

Protein Modification Services

Protein Modification Services

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