Default

Calixar

No Reviews Yet
No Completed Orders
Lyon, FR

About Calixar

Founded: 2010 Type: Privately Held Size: 11-50 employees

CALIXAR, is a French biotech company specialized in the functional and native isolation of complex therapeutic targets and antigens.

As membrane proteins represent more than 60% of pharmaceuticals drug targets, to keep their native conformation during the extraction from membrane cells and solubilization is crucial within the process of targets selection.

Our technological platform preserves the original structure of membrane proteins such as GPCRs, Ion channels, Transporters, Viral targets, enzymes, etc.) acting as drug targets or antigens. As a result, this most accurate targeting helps biotechs, academic teams, pharmaceutical industries to develop highly potential drugs, bio drugs and vaccines and consequently saves significant time and money in further clinical stages.

By using original chemistry and specific approaches designed on demand, we develop new tools and protocols for the identification, expression, extraction, purification and crystallization of these membrane proteins/antigens from cells or from endogenous materials (virus, bacteria, primary cells, organs, etc.).

For structure based drug design approaches, we carry out crystallization tests and structure determination of these native targets starting from their full-length and functional version without any point mutations or deletions.

CALIXAR sets up specific R&D programs with its customers using classical and flexible business model: Fee for service, Risk sharing, Exclusivity option and Licensing out.

Diversity Certificates

Small business

Our Services (18)


ic

Membrane Protein Isolation

Price on request

We do extraction, purification and stabilization in solution of native and functional membrane proteins including but not limited to GPCRs, Ion Channels, Receptors, Transporters, Viral Proteins, Enzymes, etc.


ic

Membrane Protein Expression

Price on request

We can express all membrane protein families including but not limited to GPCRs, Ion Channels, Receptors, Transporters, Viral Proteins, Enzymes, etc.

Our expression systems can be either endogenous (organ, virus, bacteria and primary cells) or recombinant (E.Coli, Cell Free, Yeast, HEK, CHO, Insect Cells and Baculovirus).


ic

Membrane Protein Identification

Price on request

Target identification services

We have a proven experience with all membrane protein families including but not limited to GPCRs, Ion Channels, Receptors, Transporters, Viral Proteins, Enzymes, etc.

Target validation services

We conduct different validation tests during the membrane protein isolation process (see the non-exhaustive list below).

Standard tests

  • Western blot
  • Coomassie gels
  • Silver stain

Structural tests

  • Fluorescence
  • CD
  • DLS
  • NMR
  • ITC
  • TSA
  • MASS SPEC

Functionality Tests

  • Specific activity
  • Ligand binding
  • ELISA
  • SPR
  • Patch Clamp

Customized Assays


ic

Membrane Protein Crystallization

Price on request

We provides crystallization trials for your membrane proteins including but not limited to GPCRs, Ion Channels, Receptors, Transporters, Viral Proteins, Enzymes, etc.


ic

Customized Detergents for Native Membrane Protein Isolation

Price on request

We design and synthetize new customized and non-denaturing detergents / surfactants that help to extract, solubilize, stabilize membrane proteins incluing but not limited to GPCRs, Ion Channels, Receptors, Transporters, Viral Proteins, Enzymes, etc.

In addition, we also developed additives for the crystallization of membrane proteins which are available on the market (see The CALIXAR™ v2.0 Additive Kit on Molecular Dimensions website).


ic

Receptor Deorphanization

Price on request

We identify orphan receptors an/or ligands linked to your membrane protein of interest.

(Read our related article referenced: Nature Communications 6, Article number 8695, 5 - “BAG3 promotes pancreatic ductal adenocarcinoma growth by activating stromal macrophages”, November 2015, http//doi:10.1038/ncomms9695)


ic

Protein Production

Price on request
Request a quote for more information about this service.

ic

Biochemical Assays

Price on request
Request a quote for more information about this service.

ic

Biochemistry & Molecular Biology

Price on request
Request a quote for more information about this service.

ic

Protein Services

Price on request
Request a quote for more information about this service.

ic

Receptor Assays

Price on request
Request a quote for more information about this service.

ic

Biology

Price on request
Request a quote for more information about this service.

ic

Protein Characterization

Price on request

Protein Characterization Services


ic

Recombinant Protein Expression

Price on request
Request a quote for more information about this service.

ic

Protein Expression in Mammalian Cells

Mammalian cell based recombinant protein production
Price on request
Request a quote for more information about this service.

ic

Protein Expression Screening and Optimization

Price on request
Request a quote for more information about this service.

ic

Protein Formulation

Price on request
Request a quote for more information about this service.

ic

Protein Purification

Price on request

Protein Purification and Quantification Services


Not finding what you're looking for?

Get info on this provider's capabilities without requesting a quote.
ED

Emmanuel Dejean

Chief Executive Officer
AJ

Anass Jawhari

Chief Scientific Officer

Calixar has not received any reviews.

Calixar has not received any endorsements.