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Calixar

Lyon, FR

CALIXAR, is a French biotech company specialized in the functional and native isolation of complex therapeutic targets and antigens.

As membrane proteins represent more than 60% of pharmaceuticals drug targets, to keep their native conformation during the extraction from membrane cells and solubilization is crucial within the process of targets selection.

Our technological platform preserves the original structure of membrane proteins such as GPCRs, Ion channels, Transporters, Viral targets, enzymes, etc.) acting as drug targets or antigens. As a result, this most accurate targeting helps biotechs, academic teams, pharmaceutical industries to develop highly potential drugs, bio drugs and vaccines and consequently saves significant time and money in further clinical stages.

By using original chemistry and specific approaches designed on demand, we develop new tools and protocols for the identification,... Show more »

CALIXAR, is a French biotech company specialized in the functional and native isolation of complex therapeutic targets and antigens.

As membrane proteins represent more than 60% of pharmaceuticals drug targets, to keep their native conformation during the extraction from membrane cells and solubilization is crucial within the process of targets selection.

Our technological platform preserves the original structure of membrane proteins such as GPCRs, Ion channels, Transporters, Viral targets, enzymes, etc.) acting as drug targets or antigens. As a result, this most accurate targeting helps biotechs, academic teams, pharmaceutical industries to develop highly potential drugs, bio drugs and vaccines and consequently saves significant time and money in further clinical stages.

By using original chemistry and specific approaches designed on demand, we develop new tools and protocols for the identification, expression, extraction, purification and crystallization of these membrane proteins/antigens from cells or from endogenous materials (virus, bacteria, primary cells, organs, etc.).

For structure based drug design approaches, we carry out crystallization tests and structure determination of these native targets starting from their full-length and functional version without any point mutations or deletions.

CALIXAR sets up specific R&D programs with its customers using classical and flexible business model: Fee for service, Risk sharing, Exclusivity option and Licensing out.

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Calixar has not listed any services.

Membrane Protein Isolation
Price on request

We do extraction, purification and stabilization in solution of native and functional membrane proteins including but not limited to GPCRs, Ion Channels, Receptors, Transporters, Viral Proteins, Enzymes, etc.

We do extraction, purification and stabilization in solution of native and functional membrane proteins including but not limited to GPCRs, Ion Channels, Receptors, Transporters, Viral Proteins, Enzymes, etc.

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Membrane Protein Expression
Price on request

We can express all membrane protein families including but not limited to GPCRs, Ion Channels, Receptors, Transporters, Viral Proteins, Enzymes, etc.

Our expression systems can be either endogenous (organ, virus, bacteria and primary cells) or recombinant (E.Coli, Cell Free, Yeast, HEK, CHO, Insect Cells and Baculovirus).

We can express all membrane protein families including but not limited to GPCRs, Ion Channels, Receptors, Transporters, Viral Proteins, Enzymes, etc.

Our expression systems can be either endogenous (organ, virus, bacteria and primary cells) or recombinant (E.Coli, Cell Free, Yeast, HEK, CHO, Insect Cells and Baculovirus).

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Membrane Protein Identification
Price on request

Target identification services

We have a proven experience with all membrane protein families including but not limited to GPCRs, Ion Channels, Receptors, Transporters, Viral Proteins, Enzymes, etc.

Target validation services

We conduct different validation tests during the membrane protein isolation process (see the... Show more »

Target identification services

We have a proven experience with all membrane protein families including but not limited to GPCRs, Ion Channels, Receptors, Transporters, Viral Proteins, Enzymes, etc.

Target validation services

We conduct different validation tests during the membrane protein isolation process (see the non-exhaustive list below).

Standard tests

  • Western blot
  • Coomassie gels
  • Silver stain

Structural tests

  • Fluorescence
  • CD
  • DLS
  • NMR
  • ITC
  • TSA
  • MASS SPEC

Functionality Tests

  • Specific activity
  • Ligand binding
  • ELISA
  • SPR
  • Patch Clamp

Customized Assays

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Membrane Protein Crystallization
Price on request

We provides crystallization trials for your membrane proteins including but not limited to GPCRs, Ion Channels, Receptors, Transporters, Viral Proteins, Enzymes, etc.

We provides crystallization trials for your membrane proteins including but not limited to GPCRs, Ion Channels, Receptors, Transporters, Viral Proteins, Enzymes, etc.

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Customized Detergents for Native Membrane Protein Isolation
Price on request

We design and synthetize new customized and non-denaturing detergents / surfactants that help to extract, solubilize, stabilize membrane proteins incluing but not limited to GPCRs, Ion Channels, Receptors, Transporters, Viral Proteins, Enzymes, etc.

In addition, we also developed additives for the crystallization of membrane... Show more »

We design and synthetize new customized and non-denaturing detergents / surfactants that help to extract, solubilize, stabilize membrane proteins incluing but not limited to GPCRs, Ion Channels, Receptors, Transporters, Viral Proteins, Enzymes, etc.

In addition, we also developed additives for the crystallization of membrane proteins which are available on the market (see The CALIXAR™ v2.0 Additive Kit on Molecular Dimensions website).

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Receptor Deorphanization
Price on request

We identify orphan receptors an/or ligands linked to your membrane protein of interest.

(Read our related article referenced: Nature Communications 6, Article number 8695, 5 - “BAG3 promotes pancreatic ductal adenocarcinoma growth by activating stromal macrophages”, November 2015, http//doi:10.1038/ncomms9695)

We identify orphan receptors an/or ligands linked to your membrane protein of interest.

(Read our related article referenced: Nature Communications 6, Article number 8695, 5 - “BAG3 promotes pancreatic ductal adenocarcinoma growth by activating stromal macrophages”, November 2015, http//doi:10.1038/ncomms9695)

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Protein Production
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Biochemical Assays
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Biochemistry & Molecular Biology
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Protein Services
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Receptor Assays
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Biology
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Protein Characterization
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Protein Characterization Services

Protein Characterization Services

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Recombinant Protein Expression
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Protein Expression in Mammalian Cells
Mammalian cell based recombinant protein production
Price on request
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Protein Expression Optimization
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Protein Formulation
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Protein Purification
Price on request

Protein Purification and Quantification Services

Protein Purification and Quantification Services

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