1401749114897 245915e6dc23cde150cfe083265a12f8

Buffalo BioLabs

Buffalo, New York, US

Buffalo BioLabs, LLC (BBL) is an experienced contractor offering preclinical research services to academia, biotech and pharmaceutical companies. With a highly skilled and cohesive team of Ph.D. level project directors, research scientists, and management, BBL boasts exceptionally broad multidisciplinary expertise in all areas of drug discovery from hit to lead optimization & mechanistic analysis to toxicity and efficacy studies in numerous small animal models. We maintain a strong track record of successful delivery on even the most challenging projects making BBL the partner of choice for outsourcing preclinical research.
The process of engagement is straightforward – oriented towards maximizing customer convenience, we identify and address risks early in the process and provide a research plan for our clients that will yield the best possible results. BBL not only provides expert contract research services,... Show more »

Buffalo BioLabs, LLC (BBL) is an experienced contractor offering preclinical research services to academia, biotech and pharmaceutical companies. With a highly skilled and cohesive team of Ph.D. level project directors, research scientists, and management, BBL boasts exceptionally broad multidisciplinary expertise in all areas of drug discovery from hit to lead optimization & mechanistic analysis to toxicity and efficacy studies in numerous small animal models. We maintain a strong track record of successful delivery on even the most challenging projects making BBL the partner of choice for outsourcing preclinical research.
The process of engagement is straightforward – oriented towards maximizing customer convenience, we identify and address risks early in the process and provide a research plan for our clients that will yield the best possible results. BBL not only provides expert contract research services, but also establishes a unique partnership with our clients to provide a more personalized experience than some of our larger competitors. BBL will give you the results your program needs to advance as quickly as possible through the drug development pipeline.


Certifications: IACUC


Relevant publications:
- Toll-like receptor-5 agonist Entolimod broadens the therapeutic window of 5-fluorouracil by reducing its toxicity to normal tissues in mice. Kojouharov BM, Brackett CM, Veith JM, Johnson CP, Gitlin II, Toshkov IA, Gleiberman AS, Gudkov AV, Burdelya LG. Oncotarget. 2014 Mar;5(3):802-14.
- Central role of liver in anticancer and radioprotective activities of Toll-like receptor 5 agonist. Burdelya LG, Brackett CM, Kojouharov B, Gitlin II, Leonova KI, Gleiberman AS, Aygun-Sunar S, Veith J, Johnson C, Haderski GJ, Stanhope-Baker P, Allamaneni S, Skitzki J, Zeng M, Martsen E, Medvedev A, Scheblyakov D, Artemicheva NM, Logunov DY, Gintsburg AL, Naroditsky BS, Makarov SS, Gudkov AV. Proc Natl Acad Sci U S A. 2013 May 14;110(20):E1857-66. doi: 10.1073/pnas.1222805110. Epub 2013 Apr 29.
- Cell-based methods for the identification of MYC-inhibitory small molecules. Burkhart CA, Haber M, Norris MD, Gudkov AV, Nikiforov MA. Methods Mol Biol. 2013;1012:255-64. doi: 10.1007/978-1-62703-429-6_18.

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Toxicity animal model
Price on request

With our state-of-the-art animal facility, Buffalo BioLabs offers a variety of animal disease models (e.g., chemical toxicity, cancer, infection, irradiation, etc.) Our team expertly designs and conducts animal studies of the desired scope (toxicity, survival benefit, tumor response, etc.) ,scale (from single to thousands of mice), and treatment type (surgical, various administration routes).

With our state-of-the-art animal facility, Buffalo BioLabs offers a variety of animal disease models (e.g., chemical toxicity, cancer, infection, irradiation, etc.) Our team expertly designs and conducts animal studies of the desired scope (toxicity, survival benefit, tumor response, etc.) ,scale (from single to thousands of mice), and treatment type (surgical, various administration routes).

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Cytotoxicity Assays
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Buffalo BioLabs offers cytotoxicity assays in 96 well format for a broad range of cancer cell lines using methylene blue and resazurin based readout. Serial dilutions of up to 9 doses are used in duplicate or triplicate, depending on the sensitivity of the methodology. IC50s are calculated using GraphPad Prism software on a... Show more »

Buffalo BioLabs offers cytotoxicity assays in 96 well format for a broad range of cancer cell lines using methylene blue and resazurin based readout. Serial dilutions of up to 9 doses are used in duplicate or triplicate, depending on the sensitivity of the methodology. IC50s are calculated using GraphPad Prism software on a minimum of 3 independent experiments. Alternative assays include clonogenic assays on a minimum of 5 drug concentrations and growth in soft agar. Assays can be adapted to client’s cell line(s) of choice.

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Drug Potency and Efficacy Testing
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Buffalo BioLabs specializes in customized drug efficacy studies in a broad range of cancer models, including dozens of rodent models, dogs, pigs and rabbits as well as in the identification/validation of novel pharmacological targets and discovery and preclinical development of drugs that effectively interact with these targets.... Show more »

Buffalo BioLabs specializes in customized drug efficacy studies in a broad range of cancer models, including dozens of rodent models, dogs, pigs and rabbits as well as in the identification/validation of novel pharmacological targets and discovery and preclinical development of drugs that effectively interact with these targets.
The expertise of our research team, which is both broad and deep, has led to successful execution of numerous IND-enabling mechanistic and efficacy studies in a variety of in vitro and in vivo models. We offer a comprehensive range of research services focused on driving drug development from the earliest stages of discovery through advanced preclinical development. These services include development and validation of experimental models and assays and full characterization of novel drugs, spanning both conventional (e.g., efficacy, pharmacology, PK/PD, toxicity, metabolism) and advanced (e.g., systemic effects/side effects, molecular mechanisms, biomarker discovery and validation, target identification) aspects of drug development.
BBL’s success in these types of studies stems from the team’s access to and experience with a rich, customizable research tool set, including:
• cell-based readout and screening systems;
• immunological and other bio-analytical assays;
• clinically relevant animal models of diseases and therapies.
Contact us today to learn how our established infrastructure and expertise to perform early stage and advanced preclinical research studies can produce results in a more timely and cost-effective manner.
We will use our deep knowledge of the preclinical field to develop any custom protocol that fits the client’s tactical goals, and are fully open to adapt emerging practices in collaboration with the academia, as we have done over multiple occasions in the past.

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Histopathological Examination
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BBL has experience with preparation and pathomorphological evaluation of samples from various organs and tissues of avian and rodent species, transgenic mice, non-human primates. We have expertise in assessing changes in sections stained with routine H&E, with special histochemical and immunochemical methods (important... Show more »

BBL has experience with preparation and pathomorphological evaluation of samples from various organs and tissues of avian and rodent species, transgenic mice, non-human primates. We have expertise in assessing changes in sections stained with routine H&E, with special histochemical and immunochemical methods (important metabolitic enzymes and products, viral antigens, markers of cell proliferation and cell death) as well as carrying out morphometric studies. Documentation of observed structural changes and preparation of reports for scientific publications and evaluation of efficacy, toxicity and possible adverse effects of drugs in development could find appropriate application in a wide variety of projects. Our knowledge and experience in detecting early preneoplastic lesions and progression of tumorogenesis in the course of time, in development of local and distant metastases and in signs of suppressed tumor growth and appearance of necrosis and hemorrhage in neoplasia has proven beneficial in studying drugs with anti-cancer applications.

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Immunohistochemistry (IHC)
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Buffalo BioLabs' established infrastructure enables cost effective core immunohistochemistry services including:
• Preparation and analysis of samples from all tissue types for pathology, histomorphology and immunohistochemistry studies
• Application of routine and customized methodology and expert... Show more »

Buffalo BioLabs' established infrastructure enables cost effective core immunohistochemistry services including:
• Preparation and analysis of samples from all tissue types for pathology, histomorphology and immunohistochemistry studies
• Application of routine and customized methodology and expert interpretation of results
• Utilization of high-end histology microscopes, microtomes, cryostats
• Development of sensitive and robust immuno-assays, other bioaffinity assays, screens
• Development of custom diagnostic and therapeutic antibodies
• Protein-based, virus-based and other immunomodulatory drug research

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Maximum Tolerated Dose (MTD) Studies
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Protein Expression Visualization
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Clinical Research
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Protein Services
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Biology
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Immunostaining
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Toxicology
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In vivo Toxicity Testing
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Clinical Laboratory Services
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Pharmacology & Toxicology
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Clinical and Anatomic Pathology
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Biochemistry & Molecular Biology
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