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Bright Line Research

South Pasadena, California, US

Bringing twenty five years of experience (biomedical product development, immunoassays, micro-arraying, label-free analysis and surface science), intellectual curiosity, and a passion for improving lives, we will:

Completely absorb and understand your scientific and commercial goals. Keenly targeted projects provide actionable answers.

Show you label-free real-time imaging of your multiplex arrays and cell-surface interactions.

Deliver the best-working assay products by optimizing every step, not just the amplified endpoint.

Bright Line Research has not listed any services.

Product Development Consulting
Price on request

Full-cycle IVD and research analytical systems Product Development, specializing in repackaging of existing mainframe and "central lab" platform biochemical, immuno, and cell-based assays, into elegant, compact, point-of-use and point-of-care devices and consumables. Mechanical, optical, electrical, and software... Show more »

Full-cycle IVD and research analytical systems Product Development, specializing in repackaging of existing mainframe and "central lab" platform biochemical, immuno, and cell-based assays, into elegant, compact, point-of-use and point-of-care devices and consumables. Mechanical, optical, electrical, and software engineering, assay development and transfer. Adaptation of optics-based metrology methods to biological problem-solving.

As your R&D partner, we'll work with you through the whole process:

Product Concept

Market Requirements & Feasibility

Technical Specification & Planning

Lab Prototype (Alpha)

Engineering Prototype (Beta)

Pilot Product Optimization & Process Engineering

Manufacturing Process Verification & Product Release

Product Performance Review

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In vitro Diagnostic Development
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Ellipsometry
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Imaging ellipsometry of dry samples from 1mm to 25mm square, with sub-angstrom thickness resolution.

Microarray Post-Wash QC to verify and quantify attachment of biomolecules. This assay correlates printing matrices and morphology with activity.

In-situ real-time internal reflection ellipsometry for dynamic systems such as... Show more »

Imaging ellipsometry of dry samples from 1mm to 25mm square, with sub-angstrom thickness resolution.

Microarray Post-Wash QC to verify and quantify attachment of biomolecules. This assay correlates printing matrices and morphology with activity.

In-situ real-time internal reflection ellipsometry for dynamic systems such as protein microarrays (225 spots in flow-injection, 450 spots in wells) and glycomic microarrays.

Birefringence mapping of glass and transparent plastic with sensitivity >25 times greater than crossed-polarizer tests.

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Autoantibody Testing
Price on request

Research Use Only. Label-free, fluorometric, and enzyme-amplified custom Autoimmune and Allergy Panel Microarrays.

Research Use Only. Label-free, fluorometric, and enzyme-amplified custom Autoimmune and Allergy Panel Microarrays.

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Glycan Analysis
Price on request

Real-time glycan arrays and glycan-binding (lectin) arrays reveal sub-micromolar and high off-rate interactions lost in wash steps.

Real-time glycan arrays and glycan-binding (lectin) arrays reveal sub-micromolar and high off-rate interactions lost in wash steps.

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Microarray Experimental Design
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Microarray Spotting
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Microarray spotting, biosensor functionalization, and content loading with the Scienion S1 non-contact piezoelectric microarraying robot.

Microarray spotting, biosensor functionalization, and content loading with the Scienion S1 non-contact piezoelectric microarraying robot.

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Human Allergy Testing
Price on request

Research Use Only. Label-free, fluorometric, and enzyme-amplified custom Autoimmune and Allergy Panel Microarrays.

Research Use Only. Label-free, fluorometric, and enzyme-amplified custom Autoimmune and Allergy Panel Microarrays.

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Glycan Microarray
Price on request

Real-time label-free glycan arrays and glycan-binding (lectin) arrays reveal sub-micromolar and high off-rate interactions lost in wash steps. Any level of service, from design, prep, printing, assay, to analysis!

Real-time label-free glycan arrays and glycan-binding (lectin) arrays reveal sub-micromolar and high off-rate interactions lost in wash steps. Any level of service, from design, prep, printing, assay, to analysis!

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Surface Plasmon Resonance (SPR)
Price on request

Phase-Contrast Imaging Surface Plasmon Resonance, for 25 to 225 spot microarrays, with surface chemistry of your choice. Open well for equilibrium determinations or flow injection for kinetic analysis.

Biacore X standard biophysical characterization service.

Phase-Contrast Imaging Surface Plasmon Resonance, for 25 to 225 spot microarrays, with surface chemistry of your choice. Open well for equilibrium determinations or flow injection for kinetic analysis.

Biacore X standard biophysical characterization service.

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Cell-Based Assays
Price on request

Cell-based assays including GPCR and ion channel screening, motility, apoptosis, wound healing, attachment with classic methods and label-free approaches.

Cell-based assays including GPCR and ion channel screening, motility, apoptosis, wound healing, attachment with classic methods and label-free approaches.

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CD Spectroscopy
Circular dichroism spectroscopy
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Mass Spectrometry
Price on request

Coupled to Thin Layer Chromatography

Coupled to Thin Layer Chromatography

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TLC
Thin Layer Chromatography
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Thin Layer Chromatography coupled to Mass Spectrometry

Thin Layer Chromatography coupled to Mass Spectrometry

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Total Internal Reflection Microscopy
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High Throughput Screening (HTS)
Price on request

Exclusively offered by BLR. Your lipophilic drug candidates (partition coefficient > 2.5) made into screening arrays, allowing up to 125 entities to be screened, at four half-logs, in a single well with less than 20,000 cells.

Screen beyond Lipinski's Rule of 5, harness the big greaseballs for trans-dermal delivery and... Show more »

Exclusively offered by BLR. Your lipophilic drug candidates (partition coefficient > 2.5) made into screening arrays, allowing up to 125 entities to be screened, at four half-logs, in a single well with less than 20,000 cells.

Screen beyond Lipinski's Rule of 5, harness the big greaseballs for trans-dermal delivery and blood-brain barrier formulation.

Offered as a product, shipped arrays for your in-house use with your imaging system and analysis assistance, or full service.

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UV-Vis-NIR Spectroscopy
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Hit Identification
Price on request

Hit Identification Services

Hit Identification Services

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Drug Discovery & Development
Price on request

Drug Discovery & Development Services

Drug Discovery & Development Services

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Thin Film Analysis
Price on request

Thin Film Analysis Services including ellipsometry and brewster angle microscopy.

Thin Film Analysis Services including ellipsometry and brewster angle microscopy.

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Microscopy
Price on request

Microscopy Services

Microscopy Services

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Material Testing Services
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Material Characterization Services

Material Characterization Services

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Analytical Chemistry Services
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Analytical Chemistry Services

Analytical Chemistry Services

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Chemistry and Materials
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Chemistry and Materials Services

Chemistry and Materials Services

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Biomolecular Interaction Analysis
Price on request

Biomolecular Interaction Analysis Services using imaging ellipsometry, imaging SPR, or the Biacore X.

Biomolecular Interaction Analysis Services using imaging ellipsometry, imaging SPR, or the Biacore X.

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Biochemistry & Molecular Biology
Price on request

Biochemistry & Molecular Biology Services

Biochemistry & Molecular Biology Services

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Biology
Price on request

Biology Services

Biology Services

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Spectrophotometry
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Spectrophotometry Services

Spectrophotometry Services

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Spectroscopy
Price on request

Spectroscopy Services

Spectroscopy Services

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Imaging & Spectroscopy
Price on request

Imaging & Spectroscopy Services

Imaging & Spectroscopy Services

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Non-Contact Piezoelectric Printing
Price on request

Protein microarraying, biosensor content-loading and other micropatterning tasks using non-contact piezoelectric printing. Features as small as 10 microns on articles up to 200 millimeters square.

Protein microarraying, biosensor content-loading and other micropatterning tasks using non-contact piezoelectric printing. Features as small as 10 microns on articles up to 200 millimeters square.

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Experimental Design
Price on request

Experimental Design Services

Experimental Design Services

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Engineering and Fabrication
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Engineering & Devices Services

Engineering & Devices Services

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Project and Process Management
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Project Management & Consulting Services

Project Management & Consulting Services

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Equipment
Price on request

Proof of concept and prototyping.

Proof of concept and prototyping.

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Liquid Chromatography
Price on request

Liquid Chromatography Services

Liquid Chromatography Services

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Fabrication and Materials Processing Services
Price on request

Fabrication Services

Fabrication Services

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Medical Devices & Diagnostics
Price on request

Medical Devices & Diagnostics Services

Medical Devices & Diagnostics Services

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Non-Specific Binding Assay
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Label-Free Ligand Binding Assays
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Biochemical Compound Screening
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Ligand Binding Assays
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Circular Dichroism
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Lab-on-Chip Devices
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Biosensor Development
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Nano-Imaging
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Rheumatoid Factor Test
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Thin Film Optical Characterization
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Image Analysis
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Protein-DNA Interaction Analysis
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Refractive Index Measurement
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Nanoscale Analysis and Characterization
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Assay Development
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Surface Characterization
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Polymer Characterization
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Sessile Drop Contact Angle Measurement
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Cell-Based Compound Screening
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Equipment Design
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Whole Slide Imaging
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Project Management
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Protein-Protein Interaction Analysis
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Fluorescence Spectroscopy
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Medical Device Development Consulting
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Product Quality Control
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DNA Microarrays
Price on request

DNA Microarrays Services

DNA Microarrays Services

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Nucleic Acid Analysis
Price on request

Nucleic Acid Analysis Services

Nucleic Acid Analysis Services

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Nucleic Acid Services
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Nucleic Acid Services

Nucleic Acid Services

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Microarray Scanning
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Glycosylation Analysis
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Glycosylation Analysis Services

Glycosylation Analysis Services

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Protein Characterization
Price on request

Protein Characterization Services

Protein Characterization Services

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Protein Services
Price on request

Protein Services

Protein Services

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