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Bright Line Research

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South Pasadena, California, US

About Bright Line Research

Bringing twenty five years of experience (biomedical product development, immunoassays, micro-arraying, label-free analysis and surface science), intellectual curiosity, and a passion for improving lives, we will:

Completely absorb and understand your scientific and commercial goals. Keenly targeted projects provide actionable answers.

Show you label-free real-time imaging of your multiplex arrays and cell-surface interactions.

Deliver the best-working assay products by optimizing every step, not just the amplified endpoint.

Our Services (71)


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Product Development Consulting

Price on request

Full-cycle IVD and research analytical systems Product Development, specializing in repackaging of existing mainframe and "central lab" platform biochemical, immuno, and cell-based assays, into elegant, compact, point-of-use and point-of-care devices and consumables. Mechanical, optical, electrical, and software engineering, assay development and transfer. Adaptation of optics-based metrology methods to biological problem-solving.

As your R&D partner, we'll work with you through the whole process:

Product Concept

Market Requirements & Feasibility

Technical Specification & Planning

Lab Prototype (Alpha)

Engineering Prototype (Beta)

Pilot Product Optimization & Process Engineering

Manufacturing Process Verification & Product Release

Product Performance Review


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In vitro Diagnostic Development

Price on request
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Ellipsometry

Price on request

Imaging ellipsometry of dry samples from 1mm to 25mm square, with sub-angstrom thickness resolution.

Microarray Post-Wash QC to verify and quantify attachment of biomolecules. This assay correlates printing matrices and morphology with activity.

In-situ real-time internal reflection ellipsometry for dynamic systems such as protein microarrays (225 spots in flow-injection, 450 spots in wells) and glycomic microarrays.

Birefringence mapping of glass and transparent plastic with sensitivity >25 times greater than crossed-polarizer tests.


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Autoantibody Testing

Price on request

Research Use Only. Label-free, fluorometric, and enzyme-amplified custom Autoimmune and Allergy Panel Microarrays.


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Glycan Analysis

Price on request

Real-time glycan arrays and glycan-binding (lectin) arrays reveal sub-micromolar and high off-rate interactions lost in wash steps.


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Microarray Experimental Design

Price on request
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Microarray Spotting

Price on request

Microarray spotting, biosensor functionalization, and content loading with the Scienion S1 non-contact piezoelectric microarraying robot.


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Human Allergy Testing

Price on request

Research Use Only. Label-free, fluorometric, and enzyme-amplified custom Autoimmune and Allergy Panel Microarrays.


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Glycan Microarray

Price on request

Real-time label-free glycan arrays and glycan-binding (lectin) arrays reveal sub-micromolar and high off-rate interactions lost in wash steps. Any level of service, from design, prep, printing, assay, to analysis!


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Surface Plasmon Resonance (SPR)

Price on request

Phase-Contrast Imaging Surface Plasmon Resonance, for 25 to 225 spot microarrays, with surface chemistry of your choice. Open well for equilibrium determinations or flow injection for kinetic analysis.

Biacore X standard biophysical characterization service.


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Cell-Based Assays

Price on request

Cell-based assays including GPCR and ion channel screening, motility, apoptosis, wound healing, attachment with classic methods and label-free approaches.


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CD Spectroscopy

Circular dichroism spectroscopy
Price on request
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Mass Spectrometry

Price on request

Coupled to Thin Layer Chromatography


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Thin Layer Chromatography (TLC)

Thin Layer Chromatography
Price on request

Thin Layer Chromatography coupled to Mass Spectrometry


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Total Internal Reflection Microscopy

Price on request
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High Throughput Screening (HTS)

Price on request

Exclusively offered by BLR. Your lipophilic drug candidates (partition coefficient > 2.5) made into screening arrays, allowing up to 125 entities to be screened, at four half-logs, in a single well with less than 20,000 cells.

Screen beyond Lipinski's Rule of 5, harness the big greaseballs for trans-dermal delivery and blood-brain barrier formulation.

Offered as a product, shipped arrays for your in-house use with your imaging system and analysis assistance, or full service.


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UV-Vis-NIR Spectroscopy

Price on request
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Hit Identification

Price on request

Hit Identification Services


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Drug Discovery & Development

Price on request

Drug Discovery & Development Services


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Thin Film Analysis

Price on request

Thin Film Analysis Services including ellipsometry and brewster angle microscopy.


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Microscopy

Price on request

Microscopy Services


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Material Testing Services

Price on request

Material Characterization Services


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Analytical Chemistry Services

Price on request

Analytical Chemistry Services


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Chemistry and Materials

Price on request

Chemistry and Materials Services


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Biomolecular Interaction Analysis

Price on request

Biomolecular Interaction Analysis Services using imaging ellipsometry, imaging SPR, or the Biacore X.


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Biochemistry & Molecular Biology

Price on request

Biochemistry & Molecular Biology Services


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Biology

Price on request

Biology Services


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Spectrophotometry

Price on request

Spectrophotometry Services


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Spectroscopy

Price on request

Spectroscopy Services


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Imaging & Spectroscopy

Price on request

Imaging & Spectroscopy Services


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Non-Contact Piezoelectric Printing

Price on request

Protein microarraying, biosensor content-loading and other micropatterning tasks using non-contact piezoelectric printing. Features as small as 10 microns on articles up to 200 millimeters square.


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Engineering and Fabrication

Price on request

Engineering & Devices Services


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Project Management

Price on request

Project Management & Consulting Services


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Equipment

Price on request

Proof of concept and prototyping.


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Liquid Chromatography (LC)

Price on request

Liquid Chromatography Services


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Fabrication and Materials Processing Services

Price on request

Fabrication Services


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Medical Devices & Diagnostics

Price on request

Medical Devices & Diagnostics Services


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Non-Specific Binding Assay

Price on request
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Label-Free Ligand Binding Assays

Price on request
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Biochemical Compound Screening

Price on request
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Ligand Binding Assays

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Circular Dichroism

Price on request
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Lab-on-Chip Devices

Price on request
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Biosensor Development

Price on request
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Nano-Imaging

Price on request
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Rheumatoid Factor Test

Price on request
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Thin Film Optical Characterization

Price on request
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Image Analysis

Price on request
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Protein-DNA Interaction Analysis

Price on request
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Refractive Index Measurement

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Nanoscale Analysis and Characterization

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Assay Development

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Surface Characterization

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Polymer Characterization

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Sessile Drop Contact Angle Measurement

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Cell-Based Compound Screening

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Equipment Design

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Whole Slide Imaging/Digital Slide Scanning

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Protein-Protein Interaction Analysis

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Fluorescence Spectroscopy

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Medical Device Development Consulting

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Product Quality Control

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DNA Microarrays

Price on request

DNA Microarrays Services


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Nucleic Acid Analysis

Price on request

Nucleic Acid Analysis Services


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Nucleic Acid Services

Price on request

Nucleic Acid Services


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Microarray Scanning

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Glycosylation Analysis

Price on request

Glycosylation Analysis Services


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Protein Characterization

Price on request

Protein Characterization Services


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Protein Services

Price on request

Protein Services


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In vitro Immunogenicity Assays

Price on request
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Post-Translational Modification Analysis

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DR

David Ralin

Principal

FileType/PDF Created with Sketch. 20180914 Bright Line Microarray Report CASE STUDY REDACT.pdf

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FileType/PDF Created with Sketch. 20180918 Bright Line Research Universal Surface Chemistry Initial CASE STUDY REDACT .pdf

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