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Bridge Organics

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Vicksburg, Michigan, US

About Bridge Organics

Size: 11-50 employees

Bridge Organics Company is a contract research and chemical manufacturing company specializing in multi-step synthesis of complex organic compounds and developing chemical processes for scale up. Our team is comprised of chemists with extensive experience in the areas of:

  • Steroid, Heterocyclic, Prostaglandin, and Peptide Research
  • Ozonolysis
  • Stable isotope-labeled chemicals
  • Pressure reactions
  • Analytical reference standards

Bridge Organics occupies a 20,500 sq.ft facility with 8 fully equipped R&D labs, a dedicated pressure reactions lab, a kilo lab, and a 3200 sq.ft pilot lab. We have a proven record with large pharmaceutical and biotechnology companies. Our company offers competitive pricing and lead times as well as a detailed analytical characterization.

Our Services (26)


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Manufacturing Services

Price on request

We provide non-GMP laboratory or pilot scale research chemicals of interest to the pharmaceutical and biotechnology industries from milligram to >250 kg quantities with typical purities of 98%.


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Chemical Synthesis

Price on request

Bridge Organics chemists have considerable experience in the preparation and analysis (NMR, mass spec) of 2H and 13C compounds. The process involves designing a synthetic route amenable to incorporation of the label(s), carrying out the preparation “cold”, and once well worked out, running the chemistry with the appropriate labeled compounds. Bridge Organics chemists could readily apply this expertise to other stable isotopes.

Stable labels such as deuterium have been incorporated into target molecules by several different methods at Bridge. These include catalytic hydrogenations with D2, chemical reductions with LiAlD4, and replacement of exchangeable hydrogens using D2O. Likewise, 13C labeling can be carried out by a variety of methods well known to Bridge chemists.

Ozonolysis

Oxidative cleavage of carbon-carbon multiple bonds is readily achieved through ozonolysis. At Bridge Organics, ozonolyses can be run in either batch or continuous mode. In the latter case at up to 5 moles of substrate/hour can be processed, with the post-ozonolysis reaction stream being directed to a quench tank where various work-ups (oxidative or reductive) can be performed.

Chemical coupling


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Process Consulting

Price on request

Our scientists are specialists in the design, development and engineering of batch and semi-batch chemical processes. We offer this service to those companies who would like to develop new processes or would like to develop or improve their particular manufacturing process. We can also work to increase capacity and/or reduce costs of processes.


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Pressure Analysis

Price on request

Bridge Organics offers an array of pressure reaction capabilities, from screening (Endeavor) to multi-kg preparation and process optimization. We have lab scale glass reactors (Parr shakers) as well as stainless steel stirred autoclaves from 0.5 L to 20 L in volume. Reaction temperatures up to 125ºC, and pressures up to 300 psi can be accommodated during hydrogenations, carbonylations and other pressure reactions.


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Chemical Reference Standards

Price on request

Bridge Organics routinely carries out complex multi-step syntheses to generate high purity analytical reference standards for customers. Frequently, the chemistry used to make these compounds is unknown or poorly developed, and requires substantial investigation.


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Chemistry and Materials

Price on request

Chemistry and Materials Services


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Project Management

Price on request

Project and Process Management Services


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Analytical Chemistry Services

Price on request

Analytical Chemistry Services


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Oil and Gas

Price on request

Oil and Gas Services


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Synthetic Chemistry

Price on request

Synthetic Chemistry Services


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Geological Science & Energy

Price on request

Geological Science & Energy Services


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Geological Sciences

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Geological Sciences Services


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Peptide Synthesis

Price on request
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Retrosynthetic Analysis and Synthetic Route Design

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Structure Determination

Price on request
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Impurity Analysis

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Total Synthesis of Natural Products

Price on request
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Compound Sourcing and Management

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Process and Scale-Up Chemistry

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Separation/Purification Services

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Procurement

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Assay Development

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Chemical Process Consulting

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NMR

Nuclear magnetic resonance spectroscopy
Price on request

NMR Spectroscopy (Non-Conforming Sample)


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Spectroscopy

Price on request

Spectroscopy Services


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Imaging & Spectroscopy

Price on request

Imaging & Spectroscopy Services


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Tom Nanninga

Senior Scientist

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