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BrainXell, Inc.

Madison, Wisconsin, US

BrainXell provides iPSC-derived human neurons to the pharmaceutical industry and other research organizations for CNS drug discovery and development. Utilizing proprietary technology developed over the last two decades by Professor Su-Chun Zhang at the University of Wisconsin-Madison, we generate high-purity, subtype-specific neurons that rapidly mature. Multiple neuron subtypes relevant to a range of disorders are available. Additionally, any of these neurons can be made in custom batches from 50 million to 10 billion neurons from iPSC or ESC lines selected by the customer.

Publications

  • Du ZW et al. (2015) Generation and expansion of highly pure motor neuron progenitors from human pluripotent stem cells. Nat Commun. 6:6626.
  • Chen et al. (2014) Modeling ALS with iPSCs reveals that mutant SOD1 misregulates neurofilament balance in motor neurons. Cell Stem Cell 14(6):796-809.
  • Liu et al. (2015)... Show more »

BrainXell provides iPSC-derived human neurons to the pharmaceutical industry and other research organizations for CNS drug discovery and development. Utilizing proprietary technology developed over the last two decades by Professor Su-Chun Zhang at the University of Wisconsin-Madison, we generate high-purity, subtype-specific neurons that rapidly mature. Multiple neuron subtypes relevant to a range of disorders are available. Additionally, any of these neurons can be made in custom batches from 50 million to 10 billion neurons from iPSC or ESC lines selected by the customer.

Publications

  • Du ZW et al. (2015) Generation and expansion of highly pure motor neuron progenitors from human pluripotent stem cells. Nat Commun. 6:6626.
  • Chen et al. (2014) Modeling ALS with iPSCs reveals that mutant SOD1 misregulates neurofilament balance in motor neurons. Cell Stem Cell 14(6):796-809.
  • Liu et al. (2015) Spinal muscular atrophy patient-derived motor neurons exhibit hyperexcitability. Sci Rep. 5:12189.
  • Xi J et al. (2012) Specification of Midbrain Dopamine Neurons from Primate Pluripotent Stem Cells. Stem Cells. 30(8):1655-63.
  • Chen Y et al. (2016) Chemical Control of Grafted Human PSC-Derived Neurons in a Mouse Model of Parkinson's Disease. Cell Stem Cell. 18(6):817-26.
  • Johnson MA et al. (2007) Functional Neural Development from Human Embryonic Stem Cells: Accelerated Synaptic Activity Via Astrocyte Coculture. J Neurosci. 27(12):3069-77.
  • Weick JP et al. (2011) Human embryonic stem cell-derived neurons adopt and regulate the activity of an established neural network. Proc Natl Acad Sci U S A. 108(50):20189-94.
  • Liu et al. (2013) Directed differentiation of forebrain GABA interneurons from human pluripotent stem cells. Nat Protoc. 8(9):1670-9.
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Induced Pluripotent Stem Cell (iPSC) Differentiation
Price on request

Have an iPSC or ESC line relevant to a specific disorder? BrainXell provides custom services to produce neurons from customer-supplied iPSC cell lines. We accelerate your research by rapidly producing desired neuronal subtypes of high purity that can be the basis of a dependable experimental system.
Subtype options include: Motor... Show more »

Have an iPSC or ESC line relevant to a specific disorder? BrainXell provides custom services to produce neurons from customer-supplied iPSC cell lines. We accelerate your research by rapidly producing desired neuronal subtypes of high purity that can be the basis of a dependable experimental system.
Subtype options include: Motor Neurons, Glutamatergic Neurons, GABAergic Neurons, Mixed Cortical Neurons, Dopaminergic Neurons, Serotonergic Neurons, and Astrocytes.
Flexible production scales available: 50 million to 10 billion neurons.

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Human
neurological
neuroscience
neurodegenerative diseases
toxicology
neurotoxcity
Stem Cell Differentiation
Drug development
Neurological Diseases
CNS/neurology
Human Neurons
Price on request
Neuron Type Neuronal Subtype Purity Time to Use Catalog Number
Spinal Motor Neurons >70% 5 - 10 days BX-0100
Midbrain Dopaminergic Neurons >50% 10 - 14 days BX-0200
Glutamatergic Neurons >70% 7 - 12 days BX-0300
GABAergic Neurons ... Show more »
Neuron Type Neuronal Subtype Purity Time to Use Catalog Number
Spinal Motor Neurons >70% 5 - 10 days BX-0100
Midbrain Dopaminergic Neurons >50% 10 - 14 days BX-0200
Glutamatergic Neurons >70% 7 - 12 days BX-0300
GABAergic Neurons >70% 7-12 days BX-0400
Mixed Cortical Neurons >90% 7 - 12 days BX-0500
PV-Enriched GABAergic Neurons >15%/>70% 7-12 days BX-0450
Medium Spiny GABAergic Neurons >70% 7-12 days BX-0700
Serotonergic Neurons >70% 7-12 days BX-0800
  • Neuronal purity represents the percentage of a specific neuron type out of all neurons. For all types, overall purity of neurons out of all cells is >90%.
  • Mixed Cortical Neurons are 80% Glutamatergic and 20% GABAergic.
  • All neuron types are available with a ubiquitous GFP reporter upon request.
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Cell Culture Media and Reagents
Starting at $125.00 per unit

BrainFast Neuronal Maturation Supplement

BrainXell’s BrainFast Neuronal Maturation Supplement is a proprietary combination of small molecules that is used to accelerate the differentiation of neural progenitor cells to mature neurons. It is effective with a variety of neuronal subtypes including, but not limited to, motor... Show more »

BrainFast Neuronal Maturation Supplement

BrainXell’s BrainFast Neuronal Maturation Supplement is a proprietary combination of small molecules that is used to accelerate the differentiation of neural progenitor cells to mature neurons. It is effective with a variety of neuronal subtypes including, but not limited to, motor neurons, glutamatergic neurons, and GABAergic neurons.

  • 500 microliters of 1000X supplement included
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Neuronal Assays
Price on request

A range of fluorescence microscopy and plate reader based assays can be incorporated in custom projects to examine viability, toxicity, marker expression and more. Please inquire for assay and model specifics.

A range of fluorescence microscopy and plate reader based assays can be incorporated in custom projects to examine viability, toxicity, marker expression and more. Please inquire for assay and model specifics.

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Custom Cell Model Development
Price on request

Custom production of neurons to fit your research goals.

Have an iPSC or ESC line relevant to a specific disorder? BrainXell provides custom services to produce neurons from customer-supplied iPSC cell lines and perform in-house neuronal assays. We accelerate your research by rapidly producing desired neuronal subtypes of... Show more »

Custom production of neurons to fit your research goals.

Have an iPSC or ESC line relevant to a specific disorder? BrainXell provides custom services to produce neurons from customer-supplied iPSC cell lines and perform in-house neuronal assays. We accelerate your research by rapidly producing desired neuronal subtypes of high purity that can be the basis of a dependable experimental system.

Subtype options include: Motor Neurons, Glutamatergic Neurons, GABAergic Neurons, Mixed Cortical Neurons, Dopaminergic Neurons, Serotonergic Neurons, and Astrocytes.

Flexible production scales available: 50 million to 10 billion neurons

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neurodegenerative diseases
neurotoxcity
Drug development
Neurological Diseases
CNS/neurology
Cell-Based Assays
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Functional & Cell Type Specific Assays
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Cell-Based Screening Methods
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Cell Death Assays
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Cell Viability & Proliferation Assays
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Drug Discovery & Development
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Human Neural Stem Cells
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Human Astrocytes
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In vitro Disease Models
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Mammalian Cell Culture
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Cell and Tissue Culture
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Stem Cell Assays
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Assay Development
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Cells and Tissues
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Cell Lines
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Primary Cell Lines
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2018-02-20 09:07:42 -0500

Net Promoter Score of 10 received for Neuronal Assays.

Additional Ratings: satisfaction with deliverable: 10, satisfaction with timeliness: 10.
2017-11-27 15:12:45 -0500

Net Promoter Score of 10 received for Neuronal Assays.

Additional Ratings: satisfaction with deliverable: 10, satisfaction with timeliness: 10.
2017-09-01 13:38:39 -0400

Net Promoter Score of 10 received for Neuronal Assays.

Additional Ratings: satisfaction with deliverable: 10, satisfaction with timeliness: 10.
2017-08-08 16:04:21 -0400

Net Promoter Score of 10 received for Neuronal Assays.

Additional Ratings: satisfaction with deliverable: 9, satisfaction with timeliness: 10.

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