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BrainXell, Inc.

Madison, Wisconsin, US

BrainXell, Inc. provides iPSC-derived human neurons to the pharmaceutical industry and other research organizations for CNS drug discovery and development. Utilizing proprietary technology developed over the last two decades by Professor Su-Chun Zhang at the University of Wisconsin, we generate subtype-specific neurons that rapidly mature. Among the neurons offered are spinal motor, cortical glutamatergic, cortical GABAergic, and midbrain dopaminergic. Largescale, high-purity batches of neurons suitable for high-throughput screening can be provided with a short turnaround. The company also offers services for custom projects using iPSC lines selected by the customer.

Publications

  • Du ZW et al. (2015) Generation and expansion of highly pure motor neuron progenitors from human pluripotent stem cells. Nat Commun. 6:6626.
  • Chen et al. (2014) Modeling ALS with iPSCs reveals that mutant SOD1 misregulates... Show more »

BrainXell, Inc. provides iPSC-derived human neurons to the pharmaceutical industry and other research organizations for CNS drug discovery and development. Utilizing proprietary technology developed over the last two decades by Professor Su-Chun Zhang at the University of Wisconsin, we generate subtype-specific neurons that rapidly mature. Among the neurons offered are spinal motor, cortical glutamatergic, cortical GABAergic, and midbrain dopaminergic. Largescale, high-purity batches of neurons suitable for high-throughput screening can be provided with a short turnaround. The company also offers services for custom projects using iPSC lines selected by the customer.

Publications

  • Du ZW et al. (2015) Generation and expansion of highly pure motor neuron progenitors from human pluripotent stem cells. Nat Commun. 6:6626.
  • Chen et al. (2014) Modeling ALS with iPSCs reveals that mutant SOD1 misregulates neurofilament balance in motor neurons. Cell Stem Cell 14(6):796-809.
  • Liu et al. (2015) Spinal muscular atrophy patient-derived motor neurons exhibit hyperexcitability. Sci Rep. 5:12189.
  • Xi J et al. (2012) Specification of Midbrain Dopamine Neurons from Primate Pluripotent Stem Cells. Stem Cells. 30(8):1655-63.
  • Chen Y et al. (2016) Chemical Control of Grafted Human PSC-Derived Neurons in a Mouse Model of Parkinson's Disease. Cell Stem Cell. 18(6):817-26.
  • Johnson MA et al. (2007) Functional Neural Development from Human Embryonic Stem Cells: Accelerated Synaptic Activity Via Astrocyte Coculture. J Neurosci. 27(12):3069-77.
  • Weick JP et al. (2011) Human embryonic stem cell-derived neurons adopt and regulate the activity of an established neural network. Proc Natl Acad Sci U S A. 108(50):20189-94.
    Liu et al. (2013) Directed differentiation of forebrain GABA interneurons from human pluripotent stem cells. Nat Protoc. 8(9):1670-9.
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BrainXell, Inc. has not listed any services.

Neuronal Assays
Price on request

A range of custom assays can be performed on in-house models of two motor neuron diseases, spinal muscular atrophy and amyotrophic lateral sclerosis. Please inquire for assay and model specifics.

A range of custom assays can be performed on in-house models of two motor neuron diseases, spinal muscular atrophy and amyotrophic lateral sclerosis. Please inquire for assay and model specifics.

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Human Neurons
Price on request
Neuron Type Neuronal Purity Time to Use Catalog Number
Currently Available
Spinal Cord Motor Neurons >90% 5 - 10 days BX-0100
Midbrain Dopaminergic Neurons >80% 10 - 18 days BX-0200
Glutamatergic Neurons >90% 7 - 12 days ... Show more »
Neuron Type Neuronal Purity Time to Use Catalog Number
Currently Available
Spinal Cord Motor Neurons >90% 5 - 10 days BX-0100
Midbrain Dopaminergic Neurons >80% 10 - 18 days BX-0200
Glutamatergic Neurons >90% 7 - 12 days BX-0300
GABAergic Neurons >90% 7-12 days BX-0400
Mixed Cortical Neurons >90% 7 - 12 days BX-0500
Under Development
Striatal GABAergic (Medium Spiny) Neurons >50%
Serotonergic Neurons >50%
Basal Forebrain Cholinergic Neurons >30%
Astrocytes
  • Neuronal purity represents the percentage of a specific neuron type out of all neurons. For all types, overall purity of neurons out of all cells is >80%.
  • Mixed Cortical Neurons are 80% Glutamatergic and 20% GABAergic.
  • All neuron types are available with a ubiquitous GFP reporter upon request.
  • Please inquire about the availability of neuron types under development for evaluation.

Neurons from Specific iPSCs

Any of the neuron types listed under Products can be produced from customer-supplied induced pluripotent cells (iPSCs) or embryonic stem cells (ESCs). The iPSCs can be derived from either healthy controls, individuals with a sporadic disease, or individuals with a disease mutation. From the receipt of cells, delivery time is typically two to three months with quantities of up to half a billion neurons.

Large-Scale Production

Large batch sizes of up to two billion neurons are available for all neuron types.

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Cell-Based Assays
Price on request
Request a quote for more information about this service.
Functional & Cell Type Specific Assays
Price on request
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Human Primary Cells
Price on request
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Biospecimens
Price on request
Request a quote for more information about this service.
Human Biospecimens
Price on request
Request a quote for more information about this service.
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2017-11-28 01:42:45 +0530

Net Promoter Score of 10 received for Neuronal Assays.

Additional Ratings: satisfaction with deliverable: 10, satisfaction with timeliness: 10.
2017-09-01 23:08:39 +0530

Net Promoter Score of 10 received for Neuronal Assays.

Additional Ratings: satisfaction with deliverable: 10, satisfaction with timeliness: 10.
2017-08-09 01:34:21 +0530

Net Promoter Score of 10 received for Neuronal Assays.

Additional Ratings: satisfaction with deliverable: 9, satisfaction with timeliness: 10.

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