BrainXell, Inc.
About BrainXell, Inc.
BrainXell provides iPSC-derived human neurons to the pharmaceutical industry and other research organizations for CNS drug discovery and development. Utilizing proprietary technology developed over the last two decades by Professor Su-Chun Zhang at the University of Wisconsin-Madison, we generate high-purity,... Show more »
BrainXell provides iPSC-derived human neurons to the pharmaceutical industry and other research organizations for CNS drug discovery and development. Utilizing proprietary technology developed over the last two decades by Professor Su-Chun Zhang at the University of Wisconsin-Madison, we generate high-purity, subtype-specific neurons that rapidly mature. Multiple neuron subtypes relevant to a range of disorders are available. Additionally, any of these neurons can be made in custom batches from 50 million to 10 billion neurons from iPSC or ESC lines selected by the customer.
Publications
- Du ZW et al. (2015) Generation and expansion of highly pure motor neuron progenitors from human pluripotent stem cells. Nat Commun. 6:6626.
- Chen et al. (2014) Modeling ALS with iPSCs reveals that mutant SOD1 misregulates neurofilament balance in motor neurons. Cell Stem Cell 14(6):796-809.
- Liu et al. (2015) Spinal muscular atrophy patient-derived motor neurons exhibit hyperexcitability. Sci Rep. 5:12189.
- Xi J et al. (2012) Specification of Midbrain Dopamine Neurons from Primate Pluripotent Stem Cells. Stem Cells. 30(8):1655-63.
- Chen Y et al. (2016) Chemical Control of Grafted Human PSC-Derived Neurons in a Mouse Model of Parkinson's Disease. Cell Stem Cell. 18(6):817-26.
- Johnson MA et al. (2007) Functional Neural Development from Human Embryonic Stem Cells: Accelerated Synaptic Activity Via Astrocyte Coculture. J Neurosci. 27(12):3069-77.
- Weick JP et al. (2011) Human embryonic stem cell-derived neurons adopt and regulate the activity of an established neural network. Proc Natl Acad Sci U S A. 108(50):20189-94.
- Liu et al. (2013) Directed differentiation of forebrain GABA interneurons from human pluripotent stem cells. Nat Protoc. 8(9):1670-9.
Our Services (21)
Induced Pluripotent Stem Cell (iPSC) Differentiation
Have an iPSC or ESC line relevant to a specific disorder? BrainXell provides custom services to produce neurons from customer-supplied iPSC cell lines. We accelerate your research by rapidly producing desired neuronal subtypes of high purity that can be the basis of a dependable experimental system.
Subtype options include: Motor... Show more »
Have an iPSC or ESC line relevant to a specific disorder? BrainXell provides custom services to produce neurons from customer-supplied iPSC cell lines. We accelerate your research by rapidly producing desired neuronal subtypes of high purity that can be the basis of a dependable experimental system.
Subtype options include: Motor Neurons, Glutamatergic Neurons, GABAergic Neurons, Mixed Cortical Neurons, Dopaminergic Neurons, Serotonergic Neurons, and Astrocytes.
Flexible production scales available: 50 million to 10 billion neurons.
Human Neurons
| Neuron Type | Neuronal Subtype Purity | Time to Use | Catalog Number |
|---|---|---|---|
| Spinal Motor Neurons | >70% | 5 - 10 days | BX-0100 |
| Midbrain Dopaminergic Neurons | >50% | 10 - 14 days | BX-0200 |
| Glutamatergic Neurons | >70% | 7 - 12 days | BX-0300 |
| GABAergic Neurons | >70% | ... Show more » |
| Neuron Type | Neuronal Subtype Purity | Time to Use | Catalog Number |
|---|---|---|---|
| Spinal Motor Neurons | >70% | 5 - 10 days | BX-0100 |
| Midbrain Dopaminergic Neurons | >50% | 10 - 14 days | BX-0200 |
| Glutamatergic Neurons | >70% | 7 - 12 days | BX-0300 |
| GABAergic Neurons | >70% | 7-12 days | BX-0400 |
| Mixed Cortical Neurons | >90% | 7 - 12 days | BX-0500 |
| PV-Enriched GABAergic Neurons | >15%/>70% | 7-12 days | BX-0450 |
| Medium Spiny GABAergic Neurons | >70% | 7-12 days | BX-0700 |
| Serotonergic Neurons | >70% | 7-12 days | BX-0800 |
- Neuronal purity represents the percentage of a specific neuron type out of all neurons. For all types, overall purity of neurons out of all cells is >90%.
- Mixed Cortical Neurons are 80% Glutamatergic and 20% GABAergic.
- All neuron types are available with a ubiquitous GFP reporter upon request.
Cell Culture Media and Reagents
BrainFast Neuronal Maturation Supplement
BrainXell’s BrainFast Neuronal Maturation Supplement is a proprietary combination of small molecules that is used to accelerate the differentiation of neural progenitor cells to mature neurons. It is effective with a variety of neuronal subtypes including, but not limited to, motor... Show more »
BrainFast Neuronal Maturation Supplement
BrainXell’s BrainFast Neuronal Maturation Supplement is a proprietary combination of small molecules that is used to accelerate the differentiation of neural progenitor cells to mature neurons. It is effective with a variety of neuronal subtypes including, but not limited to, motor neurons, glutamatergic neurons, and GABAergic neurons.
- 500 microliters of 1000X supplement included
Neuronal Assays
A range of fluorescence microscopy and plate reader based assays can be incorporated in custom projects to examine viability, toxicity, marker expression and more. Please inquire for assay and model specifics.
A range of fluorescence microscopy and plate reader based assays can be incorporated in custom projects to examine viability, toxicity, marker expression and more. Please inquire for assay and model specifics.
Custom Cell Model Development
Custom production of neurons to fit your research goals.
Have an iPSC or ESC line relevant to a specific disorder? BrainXell provides custom services to produce neurons from customer-supplied iPSC cell lines and perform in-house neuronal assays. We accelerate your research by rapidly producing desired neuronal subtypes of... Show more »
Custom production of neurons to fit your research goals.
Have an iPSC or ESC line relevant to a specific disorder? BrainXell provides custom services to produce neurons from customer-supplied iPSC cell lines and perform in-house neuronal assays. We accelerate your research by rapidly producing desired neuronal subtypes of high purity that can be the basis of a dependable experimental system.
Subtype options include: Motor Neurons, Glutamatergic Neurons, GABAergic Neurons, Mixed Cortical Neurons, Dopaminergic Neurons, Serotonergic Neurons, and Astrocytes.
Flexible production scales available: 50 million to 10 billion neurons
Cell-Based Assays
Functional & Cell Type Specific Assays
Cell-Based Screening Methods
Cell Death Assays
Cell Viability & Proliferation Assays
Drug Discovery & Development
Human Neural Stem Cells
Human Astrocytes
In vitro Disease Models
Mammalian Cell Culture
Cell and Tissue Culture
Stem Cell Assays
Assay Development
Cells and Tissues
Cell Lines
Primary Cell Lines
Not finding what you're looking for?
Get info on this provider's capabilities without requesting a quote.Michael Hendrickson
Project Manager
BrainXell, Inc. has not received any reviews.
BrainXell, Inc. has not received any endorsements.