Hj509ry3sv65ptne72z6 biovariance

BioVariance GmbH

Munich, DE

BioVariance as premium provider for bioinformatics services generates insights into complex biomedical datasets that lead to testable hypotheses for our customers. We bring your data into the right context by linking DNA, RNA, proteins, metabolites & more with known biological interactions and phenotypes, generating insights to the big picture of human biology and pharmacology. We use this as fundament for our analyses helping our customers to advance projects quicker and more targeted. Our analytis capabilities are supported by biomedical software development capabilities so that we can implement our pipelines very efficiently and also deploy them to our customers.

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DNA Sequencing Data Analysis
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Drug Repositioning
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  • Objective: Find possible new uses for a drugs interacting with a specific target
  • Approach: Literature analysis, Direct genetic associations, Expression: Based on Coexpression analysisPathways (a) based on coexpressed data b) based on literature knowledge), Compound-based: Driven by selective compounds, Plenty of other stuff:... Show more »
  • Objective: Find possible new uses for a drugs interacting with a specific target
  • Approach: Literature analysis, Direct genetic associations, Expression: Based on Coexpression analysisPathways (a) based on coexpressed data b) based on literature knowledge), Compound-based: Driven by selective compounds, Plenty of other stuff: Patents
  • Delivered: 4 new hypotheses linking diseases to particular target, 2 in follow-up now
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Biomarker Discovery
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  • Complex multiomics analysis for target and biomarker discovery
  • Various datasets (>80 cell line test from various providers with expression data)
  • Integrated with pathway and biochemical activity data
  • Proteomics data
  • Sequence data, some mutation data
  • Public information
  • First validation results look promising
  • Complex multiomics analysis for target and biomarker discovery
  • Various datasets (>80 cell line test from various providers with expression data)
  • Integrated with pathway and biochemical activity data
  • Proteomics data
  • Sequence data, some mutation data
  • Public information
  • First validation results look promising
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Proteomics Data Analysis
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Metabolomics Data Analysis
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  • Metabolomic data for 30 oncology patients, 15 responders, 15 non-responders
  • With some pathway info we developed a simple decision tree that relies on only 3 metabolites to distinguish responders vs. non-responders
  • Metabolomic data for 30 oncology patients, 15 responders, 15 non-responders
  • With some pathway info we developed a simple decision tree that relies on only 3 metabolites to distinguish responders vs. non-responders
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SNP Genotyping Data Analysis
Single nucelotide polymorphism genotyping data analysis
Price on request

Develop biological story for patented SNPs as biomarkers

  • ~15 SNPs are linked to response of a drug through statistical means
  • We collected literature data, performed pathway and expression analyses, incorporated external data
  • Developed a sound biological story for statistically linked SNPs

Develop biological story for patented SNPs as biomarkers

  • ~15 SNPs are linked to response of a drug through statistical means
  • We collected literature data, performed pathway and expression analyses, incorporated external data
  • Developed a sound biological story for statistically linked SNPs
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Biomarker Analysis
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Single Cell Gene Expression Analysis
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Gene expression analysis for target finding and resistance

  • Treated/untreated expression data from 4 cancer cell lines (sensitive and resistant)
  • Build and use analysis pipeline
  • Developed both target and resistance hypothesis
  • Target hypothesis validated in experiment

Gene expression analysis for target finding and resistance

  • Treated/untreated expression data from 4 cancer cell lines (sensitive and resistant)
  • Build and use analysis pipeline
  • Developed both target and resistance hypothesis
  • Target hypothesis validated in experiment
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NGS data analysis
Next generation sequencing data analysis
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Bioinformatics
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Data Services
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Protein Sequencing
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Computational Modeling
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Biology
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Biostatistics & Bioinformatics
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Sequencing Data Analysis
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Nucleic Acid Analysis
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Nucleic Acid Data Analysis
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PCR
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Data Visualization
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DNA
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Pharmacology & Toxicology
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Bioanalysis
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Biomarkers
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Biochemistry & Molecular Biology
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Nucleic Acid Services
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