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Biospective Inc.

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Montreal, Quebec, CA

About Biospective Inc.

Biospective is a leading preclinical Contract Research Organization (CRO) specializing in animal models, histopathology/immunohistochemistry, and imaging services. Our unique, state-of-the-art technologies and world-class scientific expertise facilitate the advancement of translational research studies for our... Show more »

Biospective is a leading preclinical Contract Research Organization (CRO) specializing in animal models, histopathology/immunohistochemistry, and imaging services. Our unique, state-of-the-art technologies and world-class scientific expertise facilitate the advancement of translational research studies for our industry and academic sponsors.

Biospective provides industry-leading services in several cores areas: in-house animal models (Parkinson’s disease, Alzheimer’s disease, multiple sclerosis), animal imaging (NIGHTWING™ Platform), histology and quantitative IHC (PERMITS™ Platform); and behavioral testing (gait, sleep, cognition). These platforms represent some of Biospective’s fully-automated, unbiased, and high-throughput technologies that provide sponsors with an unparalleled ability to assess the efficacy of their novel therapeutic agents throughout preclinical drug development.

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Our Services (25)


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CNS/Neurology Animal Models

Price on request

Biospective has substantial experience working with a large range of rodent models, particularly models of CNS diseases. We can utilize in-house, third-party, or client-supplied mouse and rat models for your studies. We provide a full range of preclinical services, including model generation, housing, dosing, imaging, behavioral... Show more »

Biospective has substantial experience working with a large range of rodent models, particularly models of CNS diseases. We can utilize in-house, third-party, or client-supplied mouse and rat models for your studies. We provide a full range of preclinical services, including model generation, housing, dosing, imaging, behavioral testing, and pathology studies.

BIOSPECTIVE'S IN-HOUSE RODENT MODELS:

  • Alzheimer’s Disease and Tauopathies
    • Tau transgenic mice
    • Tau fibril spreading mouse model
  • Parkinson’s Disease and Synucleinopathies
    • Alpha-synuclein transgenic mice
    • Alpha-synuclein fibril spreading model
  • Multiple Sclerosis
    • Cuprizone mouse model
    • EAE mouse models
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Mouse Rat Rodents Experimental autoimmune encephalomyelitis (EAE) Alzheimers Disease Multiple sclerosis (MS) Parkinson's disease (PD) Show 7 more tags Show less

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Animal Behavior Studies

Price on request

Biospective can perform a diversity of behavioral tests to complement our CNS disease models, animal imaging, and histology/IHC services.

BEHAVIORAL TESTING CAPABILITIES:

  • Gait analysis
  • Sleep analysis
  • Olfactory testing
  • Fear & Anxiety
  • Learning & Memory
  • Motor function
  • Reward sensitivity

Biospective can perform a diversity of behavioral tests to complement our CNS disease models, animal imaging, and histology/IHC services.

BEHAVIORAL TESTING CAPABILITIES:

  • Gait analysis
  • Sleep analysis
  • Olfactory testing
  • Fear & Anxiety
  • Learning & Memory
  • Motor function
  • Reward sensitivity
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Rodents

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Dose Range Finding (DRF) Studies

Price on request

Our team has many years of experience performing dosing of experimental therapeutic agents via various routes.

INJECTION SITE CAPABILITIES:

  • Intravenous
  • Intraperitoneal
  • Intramuscular
  • Per os
  • Subcutaneous
  • Intracranial

Our team has many years of experience performing dosing of experimental therapeutic agents via various routes.

INJECTION SITE CAPABILITIES:

  • Intravenous
  • Intraperitoneal
  • Intramuscular
  • Per os
  • Subcutaneous
  • Intracranial
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Rodents Intraperitoneal Intraveneous subcutaneous intramuscular

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Animal in vivo Imaging

Price on request

Biospective is a leading provider of animal imaging services. Our services cover all aspects of the study, including image acquisition, image processing, and statistical analysis. Biospective provides the broadest range of MRI modalities and quantitative measures in the industry. We also excel in PET/CT, SPECT/CT, and digital... Show more »

Biospective is a leading provider of animal imaging services. Our services cover all aspects of the study, including image acquisition, image processing, and statistical analysis. Biospective provides the broadest range of MRI modalities and quantitative measures in the industry. We also excel in PET/CT, SPECT/CT, and digital autoradiography studies. Our fully-automated NIGHTWING™ software represents a quantum leap in processing of animal imaging data. Strict quality control (QC) is an inherent part of all studies.

7T MRI STUDY CAPABILITIES:

  • Diffusion tensor imaging (DTI) and NODDI
  • Magnetization transfer (MT) imaging
  • Arterial spin labeling (ASL) perfusion imaging
  • MR angiography (MRA)
  • MR spectroscopy (MRS)
  • Anatomical imaging
    • Brain cerebral cortical thickness
    • Regional tissue volumes

MOLECULAR IMAGING STUDY CAPABILITIES:

  • PET/CT
  • SPECT/CT
  • Digital autoradiography
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7T MRI Autoradiography PET/CT CT imaging SPECT

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Immunohistochemistry (IHC)

Price on request

Biospective has its own in-house, state-of-the-art histopathology laboratory to provide a full range of pathology services to its clients. We have expertise performing studies using a broad spectrum of tissues (such as brain, lung, tumor) and stains. One of our particular strengths is quantitative image analysis of digitized... Show more »

Biospective has its own in-house, state-of-the-art histopathology laboratory to provide a full range of pathology services to its clients. We have expertise performing studies using a broad spectrum of tissues (such as brain, lung, tumor) and stains. One of our particular strengths is quantitative image analysis of digitized histology/IHC slides using our unique PERMITS™ software. All studies are performed with strict attention to quality control.

COMMONLY REQUESTED STAINS:

  • Histology
  • H&E
  • Cresyl violet
  • Luxol Fast Blue (LFB)
  • Perl’s Iron/Prussian Blue
  • Masson’s Trichrome
  • Periodic acid-Schiff (PAS)
  • Acid Blue 129
  • Immunohistochemistry
  • Beta-amyloid
  • NeuN (neurons)
  • GFAP (astrocytes)
  • IBA-1 (macrophages/microglia)
  • Alpha-synuclein
  • Neurofilament (axons)
  • Synaptophysin (synapses)
  • MBP, PLP (myelin)
  • Collagen IV (vessels)
  • Tau
  • APP/SMI-32 (axonal damage)
  • IgG/Fibrinogen (vasogenic edema)
  • Inflammatory cell markers
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IHC Primary Cells

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Histological Staining

Price on request

Biospective has its own in-house, state-of-the-art histopathology laboratory to provide a full range of pathology services to its clients. We have expertise performing studies using a broad spectrum of tissues (such as brain, lung, tumor) and stains. One of our particular strengths is quantitative image analysis of digitized... Show more »

Biospective has its own in-house, state-of-the-art histopathology laboratory to provide a full range of pathology services to its clients. We have expertise performing studies using a broad spectrum of tissues (such as brain, lung, tumor) and stains. One of our particular strengths is quantitative image analysis of digitized histology/IHC slides using our unique PERMITS™ software. All studies are performed with strict attention to quality control.

COMMONLY REQUESTED STAINS:

  • Histology
    • H&E
    • Cresyl violet
    • Luxol Fast Blue (LFB)
    • Perl’s Iron/Prussian Blue
    • Masson’s Trichrome
    • Periodic acid-Schiff (PAS)
    • Acid Blue 129
  • Immunohistochemistry
    • Beta-amyloid
    • NeuN (neurons)
    • GFAP (astrocytes)
    • IBA-1 (macrophages/microglia)
    • Alpha-synuclein
    • Neurofilament (axons)
    • Synaptophysin (synapses)
    • MBP, PLP (myelin)
    • Collagen IV (vessels)
    • Tau
    • APP/SMI-32 (axonal damage)
    • IgG/Fibrinogen (vasogenic edema)
    • Inflammatory cell markers
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IHC H&E staining Special staining

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Digital Pathology Image Analysis

Price on request

PERMITS™ is Biospective's proprietary and automated software. It has been developed to provide accurate quantification of immunohistochemistry data from digitized tissue sections. It can analyze individual sections from a broad range of tissues, and includes accurate 3D reconstruction of brain tissue sections for correlation of in... Show more »

PERMITS™ is Biospective's proprietary and automated software. It has been developed to provide accurate quantification of immunohistochemistry data from digitized tissue sections. It can analyze individual sections from a broad range of tissues, and includes accurate 3D reconstruction of brain tissue sections for correlation of in vivo imaging and post-mortem histology/IHC data from mouse or rat brain.

QUANTITATIVE IMAGE ANALYSIS CAPABILITIES (PERMITS™):

  • Brain
    • Misfolded protein (beta-amyloid, alpha-synuclein, tau) burden
    • Myelin quantification
    • Neuronal density
    • Neuroinflammation
    • Vascular density
    • MRI-IHC co-registration (3D PERMITS™)
  • Lung
    • Goblet cell hyperplasia
    • Eosinophil quantification
  • Customized applications
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Rodents IHC Biomarker analysis

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Animal Learning, Memory, and Behavior Tests

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Animal Model in vivo Analyses

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Biochemistry & Molecular Biology

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Pharmacology & Toxicology

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ADME/DMPK Studies

Drug Metabolism and Pharmacokinetics
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Animal Cognition & Behavior Tests

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Image Analysis

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Data Services

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Animal Models and Studies

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Clinical and Anatomic Pathology

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Clinical Laboratory Services

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Animal Models of Disease

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Biology

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Protein Services

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Immunostaining

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Protein Expression Visualization

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Clinical Research

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Computational Modeling

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Simone Zehntner

Director of Preclinical and Laboratory Services

FileType/PDF Created with Sketch. Alzheimer Disease Models.pdf

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FileType/PDF Created with Sketch. CNS Preclinical Capabilities.pdf

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FileType/PDF Created with Sketch. Multiple Sclerosis Models.pdf

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FileType/PDF Created with Sketch. Parkinsons Disease Models.pdf

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