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BIOSAXS GmbH

Hamburg, DE

BIOSAXS GmbH utilizes the expertise of the SAXS group of the EMBL Hamburg, a recognized centre of excellence in synchrotron solution X-ray scattering.

Access to the world's most brilliant synchrotron allows us complete sample characterization using 10 μl volumes and dilute concentrations (as low as 0.1 mg/ml).

Our 96-well plate reader as part of the robotic sample changer combined with the automated data analysis pipeline supports high throughput screening.

With our in-line size exclusion chromatography set-up equipped with light scattering, UV-absorption and refractometric detectors we offer a multipronged characterization of the different fractions within a sample.

Our highly competent team offers an in-depth quantitative characterization of the behaviour and structure of biological macromolecules, polymers and nanoparticles in solutions.

Publications

BIOSAXS GmbH utilizes the expertise of the SAXS group of the EMBL Hamburg, a recognized centre of excellence in synchrotron solution X-ray scattering.

Access to the world's most brilliant synchrotron allows us complete sample characterization using 10 μl volumes and dilute concentrations (as low as 0.1 mg/ml).

Our 96-well plate reader as part of the robotic sample changer combined with the automated data analysis pipeline supports high throughput screening.

With our in-line size exclusion chromatography set-up equipped with light scattering, UV-absorption and refractometric detectors we offer a multipronged characterization of the different fractions within a sample.

Our highly competent team offers an in-depth quantitative characterization of the behaviour and structure of biological macromolecules, polymers and nanoparticles in solutions.

Publications

  • Svergun, D. I., Koch, M. H. J., Timmins, P. A., and May, R. P. (2013) Small angle x-ray and neutron scattering from solutions of biological macromolecules, Oxford University Press. 358 pp.
  • Plath F, Ringler P, Graff-Meyer A, Stahlberg H, Lauer ME, Rufer AC, Graewert MA, Svergun D, Gellermann G, Finkler C, Stracke JO, Koulov A, Schnaible V. Characterization of mAb dimers reveals predominant dimer forms common in therapeutic mAbs. MAbs. 2016 Jul;8(5):928-40.
  • Graewert MA, Franke D, Jeffries CM, Blanchet CE, Ruskule D, Kuhle K, Flieger A, Schäfer B, Tartsch B, Meijers R, Svergun DI. Automated pipeline for purification, biophysical and x-ray analysis of biomacromolecular solutions. Sci Rep. 2015 Jun 1;5:10734. doi: 10.1038/srep10734.
  • Kikhney AG, Svergun DI. A practical guide to small angle X-ray scattering (SAXS) of flexible and intrinsically disordered proteins. FEBS Lett. 2015 Sep 14;589(19 Pt A):2570-7.
  • Blanchet CE, Spilotros A, Schwemmer F, Graewert MA, Kikhney A, Jeffries CM, Franke D, Mark D, Zengerle R, Cipriani F, Fiedler S, Roessle M, Svergun DI. Versatile sample environments and automation for biological solution X-ray scattering experiments at the P12 beamline (PETRA III, DESY). J Appl Crystallogr. 2015 Mar 12;48(Pt 2):431-443.
  • Hagelueken G, Clarke BR, Huang H, Tuukkanen A, Danciu I, Svergun DI, Hussain R, Liu H, Whitfield C, Naismith JH. A coiled-coil domain acts as a molecular ruler to regulate O-antigen chain length in lipopolysaccharide. Nat Struct Mol Biol. 2015 Jan;22(1):50-6.
  • Valentini E, Kikhney AG, Previtali G, Jeffries CM, Svergun DI. SASBDB, a repository for biological small-angle scattering data. Nucleic Acids Res. 2015 Jan;43(Database issue):D357-63.
  • Franke D, Jeffries CM, Svergun DI. Correlation Map, a goodness-of-fit test for one-dimensional X-ray scattering spectra. Nat Methods. 2015 May;12(5):419-22.
  • Ribeiro Ede A Jr, Pinotsis N, Ghisleni A, Salmazo A, Konarev PV, Kostan J, Sjöblom B, Schreiner C, Polyansky AA, Gkougkoulia EA, Holt MR, Aachmann FL, Zagrović B, Bordignon E, Pirker KF, Svergun DI, Gautel M, Djinović-Carugo K. The structure and regulation of human muscle α-actinin. Cell. 2014 Dec 4;159(6):1447-60.
  • Tuukkanen AT, Svergun DI. Weak protein-ligand interactions studied by small-angle X-ray scattering. FEBS J. 2014 Apr;281(8):1974-87.
  • Graewert MA, Svergun DI. Impact and progress in small and wide angle X-ray scattering (SAXS and WAXS). Curr Opin Struct Biol. 2013 Oct;23(5):748-54.
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Small Angle X-ray Scattering
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BIOSAXS offers Small Angle X-ray Scattering (SAXS) of macromolecules, chemical compounds and nano particles, including sample preparation, sample measurement at European synchrotron facilities and data analysis.

BIOSAXS offers Small Angle X-ray Scattering (SAXS) of macromolecules, chemical compounds and nano particles, including sample preparation, sample measurement at European synchrotron facilities and data analysis.

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Spectroscopy
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Imaging & Spectroscopy
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Scattering Techniques
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March 29, 2017

Positive review received for Small Angle X-ray Scattering:

"A very thorough and detailed analysis, and very good communication. Would highly recommend. Many thanks! Michael"

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