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BioRxn, LLC

Chapel Hill, North Carolina, US

BioRxn, LLC is a CRO that performs metabolomic analyses on biofluids and tissue extracts, and performs 2D and 3D cultures with flux analysis using 13C-labeled nutrients or xenobiotics added to culture mediums.

Our technology is a fluidized-bed bioreactor that combines alginate-encapsulation with fluidized-bed bioreactor to achieve the world’s densest liver cultures. With diameters of ~400 μm, the alginate-encapsulated tissues mimic the liver to achieve near-in vivo nutrient and oxygen gradients. These preparations can be maintained for months while preserving their Type 1 and Type 2 drug metabolizing functions.

Near tissue density permits physiological concentrations of paracrine factors to accumulate in media, and in conjunction with 31P and 13C NMR can be used to derive physiologically-relevant pharmacokinetic parameters.

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