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Biophysical Analysis and High Throughput Screening Facility at ISB3D VCU

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Richmond, Virginia, US

About Biophysical Analysis and High Throughput Screening Facility at ISB3D VCU

The Biophysical Analysis facility and High Throughput Screening Facility consists of multiple instruments available to study macromolecule-ligand interactions, which form a key element of the drug discovery and development operation. Among the biophysics-based instruments available for this purpose include PTI spectrofluorometer, NanoTemper Microscale Thermophoresis, Reichert Surface Plasmon Resonance, Waters UPLC coupled to TQD-ESI-MS, Beckman ultracentrifuge, Olis Circular Dichroism with stopped flow assembly, and dynamic light scattering. We have HT screening instruments like ECHO, Cytation 5, Multidrop combinl, bulk plate washers, flex station, and multiple readers, and chemical libraries (FDA, Diversity).

Our Services (2)


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High Throughput Screening (HTS)

Starting at $384.00 per plate

Screening of FDA library, diversity library and NP library in a 384 well format against a target of your interest. plate based UV-visible or fluorescence end-point assay included. Please contact for cell-based assays

Oncology Heart disease Kidney Cancer Labcyte Echo 525 BioTek Cytation 5 BioTek microplate washer biotek clariostar thermo combi nl Drug Discovery enzyme assays End-point Analysis kinetics HTS Bicarbonate buffer solution Proteins enzymes substrates inhibitors Human Mice Drug Development Fibrinolytic proteins recombinant protein G-protein Procoagulant proteins Infectious Disease Rare Disease Show 27 more tags Show less

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Microscale Thermophoresis

Starting at $100.00 per hour

Nanotemper Monolith NT is available at our facility for biomolecular interaction studies. This technique is based on thermophoresis principle of detecting optically fluorescent molecular binding affinity of different molecules. MST requires low sample volume, label-free options, and detecting changes in hydration shell and charges of biomolecules as well as size changes through the binding events. Assay development, consumables like capillaries and labelling kits and sample analysis is available on service.

Neurodegenerative diseases Alzheimers Disease Oncology thermophoresis Biology Microbiology Antibiotic Development Physics Fluorescence thermal shift HEPES buffer solution Tris Buffered Saline Polysorbate 20 Proteins Antibodies Small molecules Biopharmaceuticals/Biologics Human Rat Mouse Show 20 more tags Show less

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Srinivas Sistla

Core Manager

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Biophysical Analysis and High Throughput Screening Facility at ISB3D VCU has not received any reviews.

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