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Bioneer A/S

Hørsholm, DK

Bioneer A/S is a R & D based company with 30 years experience in providing quality service to large- and medium-sized international companies and researchers.

Bioneer is specialized in cell- and molecular biology and can offer services from custom disease- and pathway models, through protein production and drug development, including compound- and formulation characterization and development.

Bioneer works with a flexible mindset to ensure that every project is tailored to your needs.

Bioneer A/S has not listed any services.

Biomarker Analysis
Price on request
A portfolio of Molecular Methods for validating biomarkers and drug targets

Once identified, biomarkers and potential drug targets need to be validated, e.g. to confirm the efficiency of a given drug candidate against its target or to confirm the differential expression of a given biomarker to report a specific disease... Show more »

A portfolio of Molecular Methods for validating biomarkers and drug targets

Once identified, biomarkers and potential drug targets need to be validated, e.g. to confirm the efficiency of a given drug candidate against its target or to confirm the differential expression of a given biomarker to report a specific disease condition or a cellular state. For this purpose Bioneer offers many different opportunities depending on the character of the molecule in question:

  • In situ visualization: FISH, CISH, IHC and combinations thereof
  • Quantitative PCR targeting mRNA, ncRNA and miRNA
  • Traditional Northern and Western blotting methodology
Biomarker Assay Development

Bioneer is capable of developing multiplex assays on e.g. tissue sections, where we combine immunohistochemical detection of protein/peptide biomarkers and in situ hybridization of nucleic acid on the same tissue section. An advanced image processing facility enables us to provide high-resolution spatial localization of the specific signals with a reference to e.g. a routine H&E staining.

In the case where a single molecule such as a microRNA or a protein shows biomarker potential, Bioneer offers:

  • specific assay development and optimization for the reliable and sensitive detection of the biomarker from relevant biological sources
Molecular Methods, Tools and Equipment
  • Efficient extraction procedures: DNA, RNA, Protein
  • Specific detection of nucleic acids: PCR, RT-PCR, qPCR, Southern blotting, Northern blotting
  • DNA-sequencing
  • Global profiling of mRNA/miRNA and proteins in cells, tissue and blood: Microarray technology, Bioinformatic tools, statistical evaluation, data analysis
  • In situ detection of nucleic acids and proteins: FISH, CISH, IHC, H&E, FFPE-sections, cryo-sections, monolayer cultures, bacteria, HistoFlex technology
  • Identification of novel differentially expressed sRNA/ncRNA: Optimized cloning protocols, Subtraction cloning
  • Advanced microscope setting
    Confocal imaging through Apotome accessory
    AxioImager.Z1: Epifluorescence, DIC and Brightfield, Phase contrast
    Axiovert 200: Inverted microscope, Fluorescence, Brightfield, Phase contrast
    Image analysis
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MDCK-MDR1 permeability assay
Price on request

At Bioneer:FARMA we have the scientific expertise to assist our clients evaluate how compounds, including poorly soluble drugs, interact with different barriers of the body through the use of cell-based models. Our services also include assessment of whether drug candidates are substrates or inhibitors of common efflux transporters (e.g. P-glycoprotein and BCRP).

At Bioneer:FARMA we have the scientific expertise to assist our clients evaluate how compounds, including poorly soluble drugs, interact with different barriers of the body through the use of cell-based models. Our services also include assessment of whether drug candidates are substrates or inhibitors of common efflux transporters (e.g. P-glycoprotein and BCRP).

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Caco-2 Cell Permeability Assay
Price on request

Bioneer:FARMA offers permeability assessments of drug candidates using the recognized Caco-2 cell culture. The permeability across Caco-2 cells correlated with known standards will give a satisfactory surrogate measure of the human intestinal permeability.

Bioneer:FARMA offers permeability assessments of drug candidates using the recognized Caco-2 cell culture. The permeability across Caco-2 cells correlated with known standards will give a satisfactory surrogate measure of the human intestinal permeability.

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Blood brain barrier screening platform
Price on request

The IPEC-J2 MDR1 cell line, transfected with human P-glycoprotein (p-gp), forms tight monolayers with transepithelialelectrical resistance values well above values normally measured across cell models such as Caco-2 and MDCK MDR1 cells. The IPEC-J2 MDR1 cell line also features a high expression of functional human P-gptogether... Show more »

The IPEC-J2 MDR1 cell line, transfected with human P-glycoprotein (p-gp), forms tight monolayers with transepithelialelectrical resistance values well above values normally measured across cell models such as Caco-2 and MDCK MDR1 cells. The IPEC-J2 MDR1 cell line also features a high expression of functional human P-gptogether with a low expression of endogenous efflux transport systems. The tightness of the monolayer in combination with high efflux ratio’s for P-gpsubstrates, provides a large dynamic range for investigating affinities for P-gpfor a series of related compounds.

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Biologic Formulation
Price on request

The design of a stable protein formulation is challenging due to the complex stability patterns of proteins. A rational formulation development involves rational screening and selection of suitable solution conditions and excipients, i.e. the type and concentration of, for instance, buffer, salt and surfactant. Bioneer:FARMA can... Show more »

The design of a stable protein formulation is challenging due to the complex stability patterns of proteins. A rational formulation development involves rational screening and selection of suitable solution conditions and excipients, i.e. the type and concentration of, for instance, buffer, salt and surfactant. Bioneer:FARMA can assist you in the selection of excipients for liquid or solid formulations or even in the development of more advanced protein formulations, such as particulate or liposomal formulations.

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Drug Formulation Development
Price on request

Bioneer:FARMA develops conventional pharmaceutical formulations and sophisticated drug delivery systems to accommodate your needs and the characteristics of your compound.

Bioneer:FARMA develops conventional pharmaceutical formulations and sophisticated drug delivery systems to accommodate your needs and the characteristics of your compound.

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Compound Permeability Studies
Price on request

Bioneer:FARMA has strong experience in the study of drug transport over biological barriers. You are welcome to contact Bioneer:FARMA in order to discuss the possibility for absorption studies of your peptide or protein drug candidate.

Bioneer:FARMA has strong experience in the study of drug transport over biological barriers. You are welcome to contact Bioneer:FARMA in order to discuss the possibility for absorption studies of your peptide or protein drug candidate.

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Drug Absorption Models
Price on request

Bioneer:FARMA has a range of barrier models available that can be used to determine the transport of your compound across a biological membrane. These models can help you identify which route of delivery as well as which formulation principle may be the optimal for your drug candidate.

Bioneer:FARMA has a range of barrier models available that can be used to determine the transport of your compound across a biological membrane. These models can help you identify which route of delivery as well as which formulation principle may be the optimal for your drug candidate.

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Small Molecule Bioanalysis
Price on request

Bioneer:FARMA will in collaboration with the client customize an experimental plan that will address the solubility and stability issues and identify possible obstacles in the absorption of the compound. Together with an in-depth evaluation other physico-chemical properties for the compound this (tailormade) experimental plan... Show more »

Bioneer:FARMA will in collaboration with the client customize an experimental plan that will address the solubility and stability issues and identify possible obstacles in the absorption of the compound. Together with an in-depth evaluation other physico-chemical properties for the compound this (tailormade) experimental plan will also provide the information necessary to define a formulations strategy for the compound.

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LDH Release Assay
Lactate Dehydrogenase Release Assay
Starting at $200.00 per sample

Assessment of cytotoxicity of food additives and pharmaceutical ingredients is commonly done using epithelial cell lines in an LDH assay. Bioneer offers assessment of toxigenic potential using VERO cells.

Bioneer has many years experience in mammalian cell handling and with applications in biological assays. Furthermore,... Show more »

Assessment of cytotoxicity of food additives and pharmaceutical ingredients is commonly done using epithelial cell lines in an LDH assay. Bioneer offers assessment of toxigenic potential using VERO cells.

Bioneer has many years experience in mammalian cell handling and with applications in biological assays. Furthermore, Bioneer has a proven track-record of conducting cytotoxic evaluation for large, multi-national clients.

Assays are run in accordance with EFSA guidelines.

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Recombinant Protein Expression
Starting at $5,500.00 per strain

Bioneer has developed an IP-free E. coli system and a proprietary L. lactis expression system and has 20 years operating experience in protein production.

Want to see if your protein can be succesfully expressed in our system(s)? For a first validation study, provide us the AA sequence, we codon optimize and test the... Show more »

Bioneer has developed an IP-free E. coli system and a proprietary L. lactis expression system and has 20 years operating experience in protein production.

Want to see if your protein can be succesfully expressed in our system(s)? For a first validation study, provide us the AA sequence, we codon optimize and test the expression in the system of choice (or both).

Bioneer can assist from feasibility to pre-pilot scale.

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In vitro Neurodegeneration Models
Price on request

Bioneer has extensive experience in developing patient-specific disease models from iPS cells, using gene editing (CRISPR-Cas9) and our know-how in differentiation and handling of iPS and neuronal cells.

Bioneer offers custom in vitro disease model development, specified to your needs.

Bioneer has extensive experience in developing patient-specific disease models from iPS cells, using gene editing (CRISPR-Cas9) and our know-how in differentiation and handling of iPS and neuronal cells.

Bioneer offers custom in vitro disease model development, specified to your needs.

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In vitro Neural Models
Price on request

Bioneer has extensive experience in developing patient-specific disease models from iPS cells, using gene editing (CRISPR-Cas9) and our know-how in differentiation and handling of iPS and neuronal cells.

Bioneer offers custom in vitro disease model development, specified to your needs.

Bioneer has extensive experience in developing patient-specific disease models from iPS cells, using gene editing (CRISPR-Cas9) and our know-how in differentiation and handling of iPS and neuronal cells.

Bioneer offers custom in vitro disease model development, specified to your needs.

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Induced Pluripotent Stem Cell (iPSC) Differentiation
Price on request

Bioneer offers differentiation of iPS cells. Primary experience is with differentiation to progenitor- and neuronal cell types and to hepatocytes.

Bioneer offers differentiation of iPS cells. Primary experience is with differentiation to progenitor- and neuronal cell types and to hepatocytes.

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CRISPR/Cas9 Genome Editing
Price on request

As the main cell line contributor to the European induced pluripotent stem cell bank (EBISC), Bioneer offers (and have extensive experience with) gene editing of pluripotent stem cells and other mammalian cells using the CRISPR-Cas9 technology.

The technology can be used for generation of stable cell lines and insertion of... Show more »

As the main cell line contributor to the European induced pluripotent stem cell bank (EBISC), Bioneer offers (and have extensive experience with) gene editing of pluripotent stem cells and other mammalian cells using the CRISPR-Cas9 technology.

The technology can be used for generation of stable cell lines and insertion of reporter genes, aside from its use in gene correction and induction in development of disease models.

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Cell Line Characterization
Price on request

Bioneer offers full cell line characterization of mammalian- and induced pluripotent stem cells (iPSCs).

For acquried cell lines, Bioneer can validate/authenticate as QC before application.

Service includes DNA/RNA sequencing, fingerprinting, identification of pluripotency markers, karyotyping and much more. Moreover, Bioneer can analyse single-cells on genome- and transcriptome level.

Bioneer offers full cell line characterization of mammalian- and induced pluripotent stem cells (iPSCs).

For acquried cell lines, Bioneer can validate/authenticate as QC before application.

Service includes DNA/RNA sequencing, fingerprinting, identification of pluripotency markers, karyotyping and much more. Moreover, Bioneer can analyse single-cells on genome- and transcriptome level.

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T Cell Activation and Proliferation Assays
Price on request

Bioneer offers screening of immune-modulating compounds in a human DC/Tcell model.

Different types of inflammatory phenotypes (autoimmune, chronic autoimmune, allergic, regulatory/cancer) are induced in Dendritic Cells from healthy human donors. Compounds are tested in a Mixed Lymphocyte Reaction with T-cells.

Read-outs include T-cell-secreted cytokines, proliferation and surface markers.

Bioneer offers screening of immune-modulating compounds in a human DC/Tcell model.

Different types of inflammatory phenotypes (autoimmune, chronic autoimmune, allergic, regulatory/cancer) are induced in Dendritic Cells from healthy human donors. Compounds are tested in a Mixed Lymphocyte Reaction with T-cells.

Read-outs include T-cell-secreted cytokines, proliferation and surface markers.

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Anti-inflammatory screening on stimulated human monocytes
Price on request

Bioneer offers screening of anti-inflammatory effect of compounds in a human Dendritic Cell (DC) model. The assay uses DC's from healthy human donors and inflammation is induced with a cocktail, promoting maturation to different phenotypes. The model is validated with small-molecule drugs (e.g. Dexamethasone) and biological... Show more »

Bioneer offers screening of anti-inflammatory effect of compounds in a human Dendritic Cell (DC) model. The assay uses DC's from healthy human donors and inflammation is induced with a cocktail, promoting maturation to different phenotypes. The model is validated with small-molecule drugs (e.g. Dexamethasone) and biological drugs.

The DC's can be matured towards different phenotypes, incl. autoimmune-like and cancer-like (DC10/DCreg)

Read-outs include maturation surface markers, DC-secreted cytokines and in MLR reactions with lymphocytes, T-cell-secreted cytokines and proliferation.

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Enzyme-linked immunosorbent spot
Price on request

Bioneer offers screening for antigen-specificity in the human plasmablast, memory- or naive B-cell repertoire.

The assay can be used to screen for different antigens that can be recognized by B-cells and investigate the frequency of donors, who will cover individual antigen specificities in question.

Bioneer offers screening for antigen-specificity in the human plasmablast, memory- or naive B-cell repertoire.

The assay can be used to screen for different antigens that can be recognized by B-cells and investigate the frequency of donors, who will cover individual antigen specificities in question.

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Single cell gel electrophoresis
Price on request

Bioneer offers single-cell electrophoresis for detection of specific RNA- and DNA sequences.

Bioneer has extensive experience with molecular detection, offering also Northern Blotting, Southern Blotting, Bacterial FISH, Chromosomal FISH, LCM, qPCR, protein-protein interaction analysis and methylation pattern analysis.

Bioneer offers single-cell electrophoresis for detection of specific RNA- and DNA sequences.

Bioneer has extensive experience with molecular detection, offering also Northern Blotting, Southern Blotting, Bacterial FISH, Chromosomal FISH, LCM, qPCR, protein-protein interaction analysis and methylation pattern analysis.

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Single Cell Gene Expression Analysis
Price on request

Bioneer offers single-cell analysis, including both genomic- and transriptomic analysis.

Bioneer has extensive experience with molecular detection, offering also Northern Blotting, Southern Blotting, Bacterial FISH, Chromosomal FISH, LCM, qPCR, protein-protein interaction analysis and methylation pattern analysis.

Bioneer offers single-cell analysis, including both genomic- and transriptomic analysis.

Bioneer has extensive experience with molecular detection, offering also Northern Blotting, Southern Blotting, Bacterial FISH, Chromosomal FISH, LCM, qPCR, protein-protein interaction analysis and methylation pattern analysis.

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DNA Methylation Analysis
Price on request

Bioneer offers methylation pattern analysis.

Bioneer has extensive experience with molecular detection, offering also Northern Blotting, Southern Blotting, Bacterial FISH, Chromosomal FISH, LCM, qPCR, protein-protein interaction analysis and single-cell analysis (genomic & transcriptomic).

Bioneer offers methylation pattern analysis.

Bioneer has extensive experience with molecular detection, offering also Northern Blotting, Southern Blotting, Bacterial FISH, Chromosomal FISH, LCM, qPCR, protein-protein interaction analysis and single-cell analysis (genomic & transcriptomic).

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Protein-Protein Interaction Analysis
Price on request

Bioneer offers protein-protein interaction analysis.

Bioneer has extensive experience with molecular detection, offering also Northern Blotting, Southern Blotting, Bacterial FISH, Chromosomal FISH, LCM, qPCR, methylation pattern analysis and single-cell analysis (genomic & transcriptomic).

Bioneer offers protein-protein interaction analysis.

Bioneer has extensive experience with molecular detection, offering also Northern Blotting, Southern Blotting, Bacterial FISH, Chromosomal FISH, LCM, qPCR, methylation pattern analysis and single-cell analysis (genomic & transcriptomic).

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Laser Capture Microdissection
Price on request

Bioneer offers Laser-Capture Microdissection and detection of analyte(s) in dissection, e.g. qPCR.

Bioneer has extensive experience with molecular detection, offering also Northern Blotting, Southern Blotting, Bacterial FISH, Chromosomal FISH, qPCR, protein-protein interaction analysis, methylation pattern analysis and single-cell analysis (genomic & transcriptomic).

Bioneer offers Laser-Capture Microdissection and detection of analyte(s) in dissection, e.g. qPCR.

Bioneer has extensive experience with molecular detection, offering also Northern Blotting, Southern Blotting, Bacterial FISH, Chromosomal FISH, qPCR, protein-protein interaction analysis, methylation pattern analysis and single-cell analysis (genomic & transcriptomic).

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qPCR
Quantitative PCR
Price on request

Bioneer offers qPCR on any sample type and analysis of results.

Bioneer has extensive experience with molecular detection, offering also Northern Blotting, Southern Blotting, Bacterial FISH, Chromosomal FISH, LCM, protein-protein interaction analysis, methylation pattern analysis and single-cell analysis (genomic & transcriptomic).

Bioneer offers qPCR on any sample type and analysis of results.

Bioneer has extensive experience with molecular detection, offering also Northern Blotting, Southern Blotting, Bacterial FISH, Chromosomal FISH, LCM, protein-protein interaction analysis, methylation pattern analysis and single-cell analysis (genomic & transcriptomic).

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Fluorescence in situ Hybridization (FISH)
Price on request

Bioneer offers Bacterial- and Chromosomal FISH and analysis of results.

Bioneer has extensive experience with molecular detection, offering also Northern Blotting, Southern Blotting, LCM, qPCR, protein-protein interaction analysis, methylation pattern analysis and single-cell analysis (genomic & transcriptomic).

Bioneer offers Bacterial- and Chromosomal FISH and analysis of results.

Bioneer has extensive experience with molecular detection, offering also Northern Blotting, Southern Blotting, LCM, qPCR, protein-protein interaction analysis, methylation pattern analysis and single-cell analysis (genomic & transcriptomic).

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Southern Blot
Price on request

Bioneer offers Southern Blotting and analysis of results.

Bioneer has extensive experience with molecular detection, offering also Western Blotting, Northern Blotting, Bacterial FISH, Chromosomal FISH, LCM, qPCR, protein-protein interaction analysis, methylation pattern analysis and single-cell analysis (genomic & transcriptomic).

Bioneer offers Southern Blotting and analysis of results.

Bioneer has extensive experience with molecular detection, offering also Western Blotting, Northern Blotting, Bacterial FISH, Chromosomal FISH, LCM, qPCR, protein-protein interaction analysis, methylation pattern analysis and single-cell analysis (genomic & transcriptomic).

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Western Blot
Price on request

Bioneer offers Western Blotting and analysis of results.

Bioneer has extensive experience with molecular detection, offering also Northern Blotting, Southern Blotting, Bacterial FISH, Chromosomal FISH, LCM, qPCR, protein-protein interaction analysis, methylation pattern analysis and single-cell analysis (genomic & transcriptomic).

Bioneer offers Western Blotting and analysis of results.

Bioneer has extensive experience with molecular detection, offering also Northern Blotting, Southern Blotting, Bacterial FISH, Chromosomal FISH, LCM, qPCR, protein-protein interaction analysis, methylation pattern analysis and single-cell analysis (genomic & transcriptomic).

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Northern Blot
Price on request

Bioneer offers Northern Blotting and analysis of results.

Bioneer has extensive experience with molecular detection, offering also Western Blotting, Southern Blotting, Bacterial FISH, Chromosomal FISH, LCM, qPCR, protein-protein interaction analysis, methylation pattern analysis and single-cell analysis (genomic & transcriptomic).

Bioneer offers Northern Blotting and analysis of results.

Bioneer has extensive experience with molecular detection, offering also Western Blotting, Southern Blotting, Bacterial FISH, Chromosomal FISH, LCM, qPCR, protein-protein interaction analysis, methylation pattern analysis and single-cell analysis (genomic & transcriptomic).

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Histology Image Analysis
Price on request

Bioneer can perform IHC, ISH (mRNA, lncRNA, miRNA) on any tissue in a HTS manner. Bioneer can assist in the full project flow from fixation in OCT, staining, through image analysis and data interpretation.

Bioneer can multiplex stainings to offer combined IHC and ISH to achieve semi-quantitive data or relative expression... Show more »

Bioneer can perform IHC, ISH (mRNA, lncRNA, miRNA) on any tissue in a HTS manner. Bioneer can assist in the full project flow from fixation in OCT, staining, through image analysis and data interpretation.

Bioneer can multiplex stainings to offer combined IHC and ISH to achieve semi-quantitive data or relative expression estimates.

We obtain Digital Whole Slides using a Zeiss AxioScan.Z1. The images are analyzed and processed using Visiopharm’s Integrator System. The output parameters include area fractions, relative number of cells, perimeters etc.

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In situ Hybridization (ISH)
In Situ Hybridization
Price on request

Bioneer offers ISH for detection of miRNA, mRNA and lncRNA in human- and mouse tissue samples. The Bioneer ISH service is recognized as an Exiqon Center of Excellence (COE) and holds a license from Exiqon to employ high affinity LNA™ detection probes. Our automated high through-put ISH application use a Tecan system and a... Show more »

Bioneer offers ISH for detection of miRNA, mRNA and lncRNA in human- and mouse tissue samples. The Bioneer ISH service is recognized as an Exiqon Center of Excellence (COE) and holds a license from Exiqon to employ high affinity LNA™ detection probes. Our automated high through-put ISH application use a Tecan system and a Visiopharm microscopy analysis system.

Bioneer can assist in the full project flow from fixation in OCT, staining, through image analysis and data interpretation.

For microRNA in situ hybridization analysis in multiple samples (from 10 to more than a 1000), we submit optimized experimental conditions to an automated platform, which provides highly reproducible data. All processing steps will be performed according to our standard operation procedures. This will allow subsequent semi-quantitative assessment using Image Analysis. Samples can be represented by single sections or duplicates from each block.

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Immunohistochemistry (IHC)
Price on request

Bioneer offers high throughput automated immunohistochemistry (IHC) for chromogenic or fluorescence detection of antigens. Primary antibodies are detected with powerful detection systems.

Bioneer can assist in the full project flow from fixation in OCT, staining, through image analysis and data interpretation.

Bioneer offers high throughput automated immunohistochemistry (IHC) for chromogenic or fluorescence detection of antigens. Primary antibodies are detected with powerful detection systems.

Bioneer can assist in the full project flow from fixation in OCT, staining, through image analysis and data interpretation.

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VENTANA Discovery Ultra
Clinical Biomarkers
Price on request

Bioneer offers a range of services related to the identification, validation and documentation of disease relevant biomarkers and drug targets. These services comprise a toolbox of molecular methods that will facilitate the pre-clinical development of both biomarkers, drug-targets and active compounds, which will be useful in... Show more »

Bioneer offers a range of services related to the identification, validation and documentation of disease relevant biomarkers and drug targets. These services comprise a toolbox of molecular methods that will facilitate the pre-clinical development of both biomarkers, drug-targets and active compounds, which will be useful in diagnostic, prognostic, and therapeutic contexts, and, furthermore, serve as effective means to optimize clinical trial designs.

Bioneer offers solutions for monitoring bio-molecules including nucleic acid and proteins in biological specimens, i.e. biopsies, tissues, blood, cells, bacteria and viruses.

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Drug Development
Price on request

Turning an active compound into a drug product

Pharmaceutical services, covering the field from lead identification to final formulation of the active compound, are provided by Bioneer:FARMA.

Bioneer:FARMA is a business unit of Bioneer established in collaboration with the Faculty of Pharmaceutical Sciences (FARMA), University of Copenhagen, Denmark .

Turning an active compound into a drug product

Pharmaceutical services, covering the field from lead identification to final formulation of the active compound, are provided by Bioneer:FARMA.

Bioneer:FARMA is a business unit of Bioneer established in collaboration with the Faculty of Pharmaceutical Sciences (FARMA), University of Copenhagen, Denmark .

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Protein Expression in Mammalian Cells
Mammalian cell based recombinant protein production
Price on request

We currently use CHO cells and HEK293 cells for construction of mammalian expression systems. With regard to vectors, we can use any standard vector designed for transient or stable expression. We currently work with stable transformation of FreeStyle(TM) CHO-S cells using the Flp-In(TM) system from Invitrogen to achieve... Show more »

We currently use CHO cells and HEK293 cells for construction of mammalian expression systems. With regard to vectors, we can use any standard vector designed for transient or stable expression. We currently work with stable transformation of FreeStyle(TM) CHO-S cells using the Flp-In(TM) system from Invitrogen to achieve single-copy, site-specific integration. Furthermore, we offer clients stable protein expression using the CHEF1 system from CMC Biologics.

Bioneer can provide:

  • The expression vector is constructed from a desired gene which is either isolated from a source organism (cDNA or DNA) or a codon-optimised version of the gene.
  • Stable transformants with a single copy or multiple copies of the desired gene can be isolated.
  • Stable transformants with the desired gene integrated at random or at a specific location can be created.
  • We can offer to create a Research Master Cell Bank based on customer needs.
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Drug Target Validation
Price on request

Bioneer offers a range of services related to the identification, validation and documentation of disease relevant biomarkers and drug targets. These services comprise a toolbox of molecular methods that will facilitate the pre-clinical development of both biomarkers, drug-targets and active compounds, which will be useful in... Show more »

Bioneer offers a range of services related to the identification, validation and documentation of disease relevant biomarkers and drug targets. These services comprise a toolbox of molecular methods that will facilitate the pre-clinical development of both biomarkers, drug-targets and active compounds, which will be useful in diagnostic, prognostic, and therapeutic contexts, and, furthermore, serve as effective means to optimize clinical trial designs.

Bioneer offers solutions for monitoring bio-molecules including nucleic acid and proteins in biological specimens, i.e. biopsies, tissues, blood, cells, bacteria and viruses.

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Immuno-oncology Assays
Price on request

Bioneer offers screening in a human Dendritic Cell model which can be induced to exhibit a regulatory phenotype (DCreg/DC10) for testing of compounds. The model can also be applied i a Mixed Lymphocyte Reaction (MLR) for testing effect on the T-cell level.

Bioneer offers screening in a human Dendritic Cell model which can be induced to exhibit a regulatory phenotype (DCreg/DC10) for testing of compounds. The model can also be applied i a Mixed Lymphocyte Reaction (MLR) for testing effect on the T-cell level.

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Microbial Strain Development
Starting at $5,500.00 per strain

Bioneer has developed an IP-free E. coli system and a proprietary L. lactis expression system and has 20 years operating experience in protein production.

Want to see if your protein can be succesfully expressed in our system(s)? For a first validation study, provide us the AA sequence, we codon optimize and test the... Show more »

Bioneer has developed an IP-free E. coli system and a proprietary L. lactis expression system and has 20 years operating experience in protein production.

Want to see if your protein can be succesfully expressed in our system(s)? For a first validation study, provide us the AA sequence, we codon optimize and test the expression in the system of choice (or both).

Bioneer can assist from feasibility to pre-pilot scale.

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Protein Purification
Price on request

Bioneer can develop a purification protocol for a desired protein with emphasis on ensuring maximal purity and yield of the protein.

Bioneer can develop a purification protocol for a desired protein with emphasis on ensuring maximal purity and yield of the protein.

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Gastrointestinal Disease Animal Models
Price on request

Bioneer offers service on the Dynamic Gastric Model (DGM) - currently the most predictive model of in vivo gastric processing of formulations and foods.

The model replicates fundus- and antral processing in terms of hydrodynamics, acid/enzyme secretion and application of representative sheer forces. The model can be run in... Show more »

Bioneer offers service on the Dynamic Gastric Model (DGM) - currently the most predictive model of in vivo gastric processing of formulations and foods.

The model replicates fundus- and antral processing in terms of hydrodynamics, acid/enzyme secretion and application of representative sheer forces. The model can be run in fasted- and fed state allowing the study of potential food effects.

Samples are ejected at programmed intervals for analysis and also allows for visual inspection of dissolution of formulation. The model can be supplemented with intestinal stages to simulate also intestinal processing.

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Animal Models and Studies
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Animal Models of Disease
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Gastroenterology Animal Models
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Clinical Research
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Clinical Laboratory Services
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Clinical Chemistry
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Antibody/Antigen Detection Based Testing
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Biology
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Cell-Based Assays
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Functional & Cell Type Specific Assays
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Immune Cell Assays
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Cells and Tissues
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Biospecimens
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Tissue Processing
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Tissue Preparation
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Mammalian Cell Culture
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Testing of Cell Lines
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In vitro Disease Models
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Genetic Engineering
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Microbiology, Virology, and Parasitology
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Bacterial Culture
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Biochemistry & Molecular Biology
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Protein Services
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Protein Expression Visualization
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Immunostaining
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Protein Expression
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Protein Quantification
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Protein Purification and Quantification
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Biomolecular Interaction Analysis
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Nucleic Acid Services
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DNA
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DNA Fragment Analysis
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Epigenetic Analysis
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PCR
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DNA Hybridization
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RNA
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