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Biomere

Worcester, Massachusetts, US

Biomere, formerly known as Biomedical Research Models, Inc. is a preclinical CRO based in Worcester, MA that offers an extensive portfolio of pre-clinical research services from early discovery and proof-of-concept to discovery toxicology.

Biomere has expertise in a variety of therapeutic areas including particular expertise in autoimmune disease, inflammatory disease, metabolic diseases, PK/PD efficacy, and infectious diseases – virology.

Our team has employed this expertise to test most strategies under development including drugs or small molecules, gene and cell-based therapies, biologics – proteins, antibodies and others.

Our newly renovated, state-of-the-art preclinical CRO facilities include over 55,000 square feet of space including a 22,000 square feet dedicated non-human primate facility equipped with operating suite.

Our small animal program includes a “shower in” barrier facility and dedicated... Show more »

Biomere, formerly known as Biomedical Research Models, Inc. is a preclinical CRO based in Worcester, MA that offers an extensive portfolio of pre-clinical research services from early discovery and proof-of-concept to discovery toxicology.

Biomere has expertise in a variety of therapeutic areas including particular expertise in autoimmune disease, inflammatory disease, metabolic diseases, PK/PD efficacy, and infectious diseases – virology.

Our team has employed this expertise to test most strategies under development including drugs or small molecules, gene and cell-based therapies, biologics – proteins, antibodies and others.

Our newly renovated, state-of-the-art preclinical CRO facilities include over 55,000 square feet of space including a 22,000 square feet dedicated non-human primate facility equipped with operating suite.

Our small animal program includes a “shower in” barrier facility and dedicated rooms and resources for client’s programs all staffed with outstanding technical and professional teams working in a culture and atmosphere of collaboration focused on customer service.

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Virology
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Our Senior Vice President of Virology/Vaccine specializes in viral pathogenesis research and vaccine development for a series of human viral diseases. In addition to his expertise, Biomere also employs additional fully trained virologists to design and implement a variety of experiments for your in vivo animal studies.

*Our... Show more »

Our Senior Vice President of Virology/Vaccine specializes in viral pathogenesis research and vaccine development for a series of human viral diseases. In addition to his expertise, Biomere also employs additional fully trained virologists to design and implement a variety of experiments for your in vivo animal studies.

Our expertise includes:

  • Herpes viruses, parvoviruses, hepatitis viruses, influenza viruses, vaccinia virus, measles virus, rotaviruses and respiratory synctial viruses.
  • Multiple rat models of virus-induced diabetes which can be provided at any stage of disease development:
    • KRV-induced diabetes in BBDR/Wor
    • KRV-induced diabetes in LEW.1WR1
    • RCMV-induced diabetes in LEW.1WR1
  • Design and perform experiments to test efficacy of client’s compounds in ameliorating the symptoms of diabetes induced by viruses.
  • Attenuated virus vectored vaccine validation studies.
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Drug Potency and Efficacy Testing
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At Biomere, we perform a wide range of non-clinical laboratory studies that support new drug applications (NDAs) for permits regulated by the Food and Drug Administration (FDA). We offer rapid, quality-controlled pharmacokinetic (PK) studies to test the bodily absorption, distribution, metabolism, and excretion of your... Show more »

At Biomere, we perform a wide range of non-clinical laboratory studies that support new drug applications (NDAs) for permits regulated by the Food and Drug Administration (FDA). We offer rapid, quality-controlled pharmacokinetic (PK) studies to test the bodily absorption, distribution, metabolism, and excretion of your compound. Biomere can evaluate the effectiveness of your compound using our proprietary research models or other commercially available models.

Biomere specializes in providing preclinical consulting services and early-stage drug discovery and development services in rodent species.

Our customized experiments are personalized to your needs and always include:

  • Qualified, experienced scientists and technical staff
  • Protocol development
  • Twenty-four hour, on call veterinarian service
  • Non-GLP studies
  • Use of several animal models including: mouse, rat, guinea pig, hamster, rabbit, marmoset and macaque.
  • All routine methods of administration.
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Metabolic Disease Animal Models
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At Biomere, we have the expertise and experience to assist you in assessing your novel test material’s therapeutic potential against diabetes, obesity and associated disorders. Biomere offers a number of animal model test systems to facilitate the growth of your drug from discovery to IND. With over 20 years of experience in... Show more »

At Biomere, we have the expertise and experience to assist you in assessing your novel test material’s therapeutic potential against diabetes, obesity and associated disorders. Biomere offers a number of animal model test systems to facilitate the growth of your drug from discovery to IND. With over 20 years of experience in the diabetic field, Biomere can perform comprehensive evaluations on all test articles.

Animal models available include:

  • Diet-induced obesity (rodent and large animal)
  • db/db mice
  • ob/ob mice
  • BB/Wor rats spontaneous and inducible
  • Induced models of type 1 diabetes, including STZ

Disease related biomarkers can also be investigated at Biomere using clinical chemistry panels, complete blood counts, ELISA’s and lipid panels. Metabolic cages are available for individual studies.

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Inflammation Animal Models
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Inflammation is a vital part of the body’s immune response. It is the body’s attempt to heal itself after an injury; defend itself against foreign invaders, such as viruses and bacteria; and repair damaged tissue. Biomere’s interest in inflammatory disease stems from our expertise in autoimmunity.

We offer models of antigen... Show more »

Inflammation is a vital part of the body’s immune response. It is the body’s attempt to heal itself after an injury; defend itself against foreign invaders, such as viruses and bacteria; and repair damaged tissue. Biomere’s interest in inflammatory disease stems from our expertise in autoimmunity.

We offer models of antigen induced inflammation such as collagen induced arthritis and myelin peptide-induced experimental allergic encephalomyelitis (a model of multiple sclerosis). In addition we offer chemically induced models of inflammatory bowel disease (IBD)/ulcerative colitis as well as rodent models of systemic lupus erythematosus (SLE).

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Autoimmune Disease Animal Models
Price on request

The term autoimmunity refers to a failure of the body’s immune system to recognize its own cells and tissues as “self”. Instead, immune responses are launched against these cells and tissues as if they were foreign or invading bodies.

Animal models are used for the study of a number of human autoimmune diseases, including... Show more »

The term autoimmunity refers to a failure of the body’s immune system to recognize its own cells and tissues as “self”. Instead, immune responses are launched against these cells and tissues as if they were foreign or invading bodies.

Animal models are used for the study of a number of human autoimmune diseases, including multiple sclerosis (EAE), type 1 diabetes (IDDM), rheumatoid arthritis (RA), inflammatory bowel disease (IBD) and systemic lupus erythematosus (SLE).

Key models offered at Biomere include:

  • Induced and Spontaneous IDDM rodent and NHP models.
  • MOG and PLP Induced models of EAE in rodents and marmosets.
  • CFA/IFA Induced models of RA in rodents and rabbits.
  • TNBS and DSS Inducible models of IBD in rodents
  • Inducible rodent models of SLE in both the NZB/W F1 and MRL/lpr mouse models.

Induced, spontaneous and genetically manipulated animal models can be purchased, developed and/or validated per request.

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Flow Cytometry
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Multicolor flow cytometry (cell preparation and analysis)

Multicolor flow cytometry (cell preparation and analysis)

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Osteoarthritis Animal Models
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ALS Animal Models
Amyotrophic Lateral Sclerosis Animal Models
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Graft-Versus-Host Disease (GVHD) Animal Models
Graft-Versus-Host Disease Animal Models
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Multiple Sclerosis Animal Models
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IBS/IBD Animal Models
Irritable Bowel Syndrome/Disease Animal Models
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Lupus Animal Models
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Diabetes Animal Models
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Rheumatoid Arthritis Animal Models
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Assay Development
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Single Cell Isolation
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Complete Blood Count
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ELISpot Assays
Enzyme-Linked ImmunoSpot Assays
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RT-PCR
Reverse transcription polymerase chain reaction
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ELISA
Enzyme-linked immunosorbent assay
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DNA Purification
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Biomarker Analysis
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Genotyping Services
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FACS
Fluorescence Activated Cell Sorting
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DNA Extraction and Purification
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Experimental Design
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Acute Inflammation Animal Models
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Project Management, Consulting, & Support Services
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Animal Models and Studies
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Clinical Research
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Animal Models of Disease
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Protein Services
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Biology
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Viral Production and Assays
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Cells and Tissues
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Protein Quantification
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Microbiology, Virology, and Parasitology
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Cell and Tissue Culture
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PCR
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Cytometry
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Blood Count
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Clinical Laboratory Services
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Metabolic Animal Models
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Bone/Cartilage Animal Models
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CNS/Neurology Animal Models
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Immunology Animal Models
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DNA
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Pharmacology & Toxicology
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Bioanalysis
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Biomarkers
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Gastroenterology Animal Models
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Biochemistry & Molecular Biology
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Nucleic Acid Services
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Clinical Hematology
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2018-05-16 07:08:45 +1200

Net Promoter Score of 9 received for Animal Models and Studies.

Additional Ratings: satisfaction with deliverable: 9, satisfaction with timeliness: 8.

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