Biomere

At Biomere, we perform a wide range of non-clinical laboratory studies that support new drug applications (NDAs) for permits regulated by the Food and Drug Administration (FDA). We offer rapid, quality-controlled pharmacokinetic (PK) studies to test the bodily absorption, distribution, metabolism, and excretion of your compound. Biomere can evaluate the effectiveness of your compound using our proprietary research models or other commercially available models.

Biomere specializes in providing preclinical consulting services and early-stage drug discovery and development services in rodent species.

Our customized experiments are personalized to your needs and always include:

• Qualified, experienced scientists and technical staff
  
• Protocol development
  
• Twenty-four hour, on call veterinarian service
  
• Non-GLP studies
  
• Use of several animal models including: mouse, rat, guinea pig, hamster, rabbit, marmoset and macaque.
  
• All routine methods of administration.
  

At Biomere, we have the expertise and experience to assist you in assessing your novel test material’s therapeutic potential against diabetes, obesity and associated disorders. Biomere offers a number of animal model test systems to facilitate the growth of your drug from discovery to IND. With over 20 years of experience in the diabetic field, Biomere can perform comprehensive evaluations on all test articles.

Animal models available include:

• Diet-induced obesity (rodent and large animal)
  
• db/db mice
  
• ob/ob mice
  
• BB/Wor rats spontaneous and inducible
  
• Induced models of type 1 diabetes, including STZ
  

Disease related biomarkers can also be investigated at Biomere using clinical chemistry panels, complete blood counts, ELISA’s and lipid panels. Metabolic cages are available for individual studies.

Inflammation is a vital part of the body’s immune response. It is the body’s attempt to heal itself after an injury; defend itself against foreign invaders, such as viruses and bacteria; and repair damaged tissue. Biomere’s interest in inflammatory disease stems from our expertise in autoimmunity.

We offer models of antigen induced inflammation such as collagen induced arthritis and myelin peptide-induced experimental allergic encephalomyelitis (a model of multiple sclerosis). In addition we offer chemically induced models of inflammatory bowel disease (IBD)/ulcerative colitis as well as rodent models of systemic lupus erythematosus (SLE).

The term autoimmunity refers to a failure of the body’s immune system to recognize its own cells and tissues as “self”. Instead, immune responses are launched against these cells and tissues as if they were foreign or invading bodies.

Animal models are used for the study of a number of human autoimmune diseases, including multiple sclerosis (EAE), type 1 diabetes (IDDM), rheumatoid arthritis (RA), inflammatory bowel disease (IBD) and systemic lupus erythematosus (SLE).

Key models offered at Biomere include:

• Induced and Spontaneous IDDM rodent and NHP models.
  
• MOG and PLP Induced models of EAE in rodents and marmosets.
  
• CFA/IFA Induced models of RA in rodents and rabbits.
  
• TNBS and DSS Inducible models of IBD in rodents
  
• Inducible rodent models of SLE in both the NZB/W F1 and MRL/lpr mouse models.
  

Induced, spontaneous and genetically manipulated animal models can be purchased, developed and/or validated per request.

Multicolor flow cytometry (cell preparation and analysis)