Biomere, formerly known as Biomedical Research Models, Inc. is a preclinical CRO based in Worcester, MA that offers an extensive portfolio of pre-clinical research services from early discovery and proof-of-concept to discovery toxicology.
Biomere has expertise in a variety of therapeutic areas including particular expertise in autoimmune disease, inflammatory disease, metabolic diseases, PK/PD efficacy, and infectious diseases – virology.
Our team has employed this expertise to test most strategies under development including drugs or small molecules, gene and cell-based therapies, biologics – proteins, antibodies and others.
Our newly renovated, state-of-the-art preclinical CRO facilities include over 55,000 square feet of space including a 22,000 square feet dedicated non-human primate facility equipped with operating suite.
Our small animal program includes a “shower in” barrier facility and dedicated rooms and resources for client’s programs all staffed with outstanding technical and professional teams working in a culture and atmosphere of collaboration focused on customer service.
Our Senior Vice President of Virology/Vaccine specializes in viral pathogenesis research and vaccine development for a series of human viral diseases. In addition to his expertise, Biomere also employs additional fully trained virologists to design and implement a variety of experiments for your in vivo animal studies.
Our expertise includes:
At Biomere, we perform a wide range of non-clinical laboratory studies that support new drug applications (NDAs) for permits regulated by the Food and Drug Administration (FDA). We offer rapid, quality-controlled pharmacokinetic (PK) studies to test the bodily absorption, distribution, metabolism, and excretion of your compound. Biomere can evaluate the effectiveness of your compound using our proprietary research models or other commercially available models.
Biomere specializes in providing preclinical consulting services and early-stage drug discovery and development services in rodent species.
Our customized experiments are personalized to your needs and always include:
At Biomere, we have the expertise and experience to assist you in assessing your novel test material’s therapeutic potential against diabetes, obesity and associated disorders. Biomere offers a number of animal model test systems to facilitate the growth of your drug from discovery to IND. With over 20 years of experience in the diabetic field, Biomere can perform comprehensive evaluations on all test articles.
Animal models available include:
Disease related biomarkers can also be investigated at Biomere using clinical chemistry panels, complete blood counts, ELISA’s and lipid panels. Metabolic cages are available for individual studies.
Inflammation is a vital part of the body’s immune response. It is the body’s attempt to heal itself after an injury; defend itself against foreign invaders, such as viruses and bacteria; and repair damaged tissue. Biomere’s interest in inflammatory disease stems from our expertise in autoimmunity.
We offer models of antigen induced inflammation such as collagen induced arthritis and myelin peptide-induced experimental allergic encephalomyelitis (a model of multiple sclerosis). In addition we offer chemically induced models of inflammatory bowel disease (IBD)/ulcerative colitis as well as rodent models of systemic lupus erythematosus (SLE).
The term autoimmunity refers to a failure of the body’s immune system to recognize its own cells and tissues as “self”. Instead, immune responses are launched against these cells and tissues as if they were foreign or invading bodies.
Animal models are used for the study of a number of human autoimmune diseases, including multiple sclerosis (EAE), type 1 diabetes (IDDM), rheumatoid arthritis (RA), inflammatory bowel disease (IBD) and systemic lupus erythematosus (SLE).
Key models offered at Biomere include:
Induced, spontaneous and genetically manipulated animal models can be purchased, developed and/or validated per request.
Multicolor flow cytometry (cell preparation and analysis)
Biomere has not received any endorsements.