**BioIVT offers biospecimens relevant to COVID-19 research. Submit a quote request containing the word ‘COVID-19’ to receive more details.**
BioIVT, formerly BioreclamationIVT, is a leading global provider of high-quality biological specimens and value-added services. We specialize in control and disease state samples including human and animal tissues, cell products, blood and other biofluids. Our unmatched portfolio of clinical specimens directly supports precision medicine research and the effort to improve patient outcomes by coupling comprehensive clinical data with donor samples. Our Research Services team works collaboratively with clients to provide in vitro hepatic modeling solutions. And as the world’s premier supplier of ADME-toxicology model systems, including hepatocytes and subcellular fractions, BioIVT enables scientists to better understand the pharmacokinetics and drug metabolism of newly discovered compounds and the effects on disease processes. By combining our technical expertise, exceptional customer service, and unparalleled access to biological specimens, BioIVT serves the research community as a trusted partner in ELEVATING SCIENCE.
We design and implement Drug-Drug Interaction (DDI) studies to provide data that our clients use in their lead selection, optimization processes, and regulatory submissions. Our methods comply with regulatory guidelines, including the FDA Draft Guidance. Our programs include:
CYP450 inhibition studies predict if expsoure to a test article will result in decreased synthesis and concentration of liver enzymes.
We design and implement evaluations of hepatotoxicity including the following assessment programs:
Clients use the reports from our toxicity studies in their lead selection and optimization programs, and for determining the dose range in other in vitro programs. We provide numerous models and recommend the optimal approach based on our clients’ research objectives and characteristics of the compound. Our models are available as products and kits, or studies can be conducted in our research facilities.
Predictive toxicology assays use in vitro methodologies to forecast potential toxic effects of a test article.
Based on the study objectives and characteristics of the compounds being investigated we design programs that include the following physiologically-relevant models for predictive tox assessments:
TRANSPORTER CERTIFIED hepatocytes in sandwich culture
Identify CYP isoforms that may be involved in metabolism of a test article.
BioIVT offers over 100 single-transporter assays and multi-transporter models to investigate liver, kidney, intestine, and blood-brain barrier transporters known to be involved in pharmacokinetics, including the 11 transporters typically requested by regulatory agencies.
Using OPTI-EXPRESSION™ Technology, we efficiently express transporters in polarized mammalian cell monolayers, where they are localized to the appropriate membrane (e.g., apical or basolateral). With this technology, transporter expression levels can be controlled in order to mimic those observed in vivo, and new assays can be quickly developed and validated.
Animal matrices are collected at facilities located in the United States, using BioreclamationIVT Standard Operating Procedures. This allows us to customize every order according to your exact specifications, while maintaining the highest level of product quality.
BioreclamationIVT can collect samples that meet your study requirements and protocol. Inclusion and/or exclusion criteria can be specified.
Normal human matrices are collected from consented donors under IRB approved protocols at facilities located in the United States, using BioreclamationIVT Standard Operating Procedures. This allows us to customize every order according to your exact specifications, while maintaining the highest level of product quality.
BioreclamationIVT can collect samples that meet your study requirements. Inclusion and/or exclusion criteria can be specified such as: age, gender, weight, ethnicity, smoking status, etc. Specific questions can also be added to the case report form for further screening.
BioreclamationIVT provides viral negative normal human samples as noted on the Certificate of Analysis included with each shipment. Samples are tested in accordance with FDA regulations and found negative for HBsAG, HIV 1/2 Ab, HCV Ab, HIV-1 RNA, HCV RNA and STS.
Primary cell cultures from many different tissues and/or species
"BioIVT is a great vendor. Very responsive to questions. Was willing to provide Tcells at the concentration requested and number of tubes. Pricing was much better than other vendors. I highly recommend this vendor."
"Because their report was pretty comprehensive and worth for pricing."
"I think Bioreclamation is excellent to work with. They are an easy partner, flexible and very capable of delivering on what they agreed on with. The only thing is price wise they are much higher than my other vendors, so that is something I would like to see to come down a little."
BioIVT, formerly BioreclamationIVT has not received any endorsements.