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BioDuro LLC

3 Orders Completed
San Diego, California, US

About BioDuro LLC

BioDuro is a full-service provider for integrated drug discovery and development, including discovery support, API synthesis and optimization, formulation development and cGMP manufacture of drug products. From drug substance to drug product, discovery to development, small molecule or biologics, BioDuro is... Show more »

BioDuro is a full-service provider for integrated drug discovery and development, including discovery support, API synthesis and optimization, formulation development and cGMP manufacture of drug products. From drug substance to drug product, discovery to development, small molecule or biologics, BioDuro is your partner for accelerating drug discovery and development and improving efficiency in establishing drug candidate success.

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Our Services (31)


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Topical Formulation

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Taste Masking

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Batch Release Testing

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ICH Stability Testing

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Computational Chemistry

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In collaboration with medicinal chemists, computational chemists at BioDuro play an integral role in identifying and optimizing novel leads against selected therapeutic targets using various computational tools. Our computational team assists in the design of novel scaffolds and warheads for fragment-based screening. We use... Show more »

In collaboration with medicinal chemists, computational chemists at BioDuro play an integral role in identifying and optimizing novel leads against selected therapeutic targets using various computational tools. Our computational team assists in the design of novel scaffolds and warheads for fragment-based screening. We use chemoinformatics and bioinformatics approaches to profile target selectivity and toxicity.

BioDuro Advantage

  • Deep integration with drug discovery teams
  • Problem solving expertise and creativity
  • Sophisticated interpretation of biological data
  • Responsive project management
  • Broad therapeutic disease area expertise
  • Experience in patenting strategies

Services

  • Small molecule modeling
  • Conformational analysis
  • ADME and physiochemical property prediction
  • Homology modeling
  • Library design, enumeration and diversity analysis
  • Ligand-based virtual screening
  • Development of QSAR models for hERG and CYP inhibition
  • Construct design and identification of amino acids for mutagenesis study

Capabilities

  • Linux workstation
  • 3D graphics room
  • Schrödinger modeling suite
  • Pipeline pilot
  • Spotfire
  • Pymol
  • Weblab viewer
  • Wincoot
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Chemical Synthesis

Price on request

BioDuro is proud of its record in synthesizing quality compounds at rapid speed. We are skilled at tackling complex synthetic routes with ease and on scales ranging from milligrams to kilograms. BioDuro has conducted a broad range of chemistry projects ranging from design and synthesis of biologically relevant heterocyclic systems... Show more »

BioDuro is proud of its record in synthesizing quality compounds at rapid speed. We are skilled at tackling complex synthetic routes with ease and on scales ranging from milligrams to kilograms. BioDuro has conducted a broad range of chemistry projects ranging from design and synthesis of biologically relevant heterocyclic systems through asymmetric synthesis, peptide chemistry, nucleoside chemistry and total synthesis of natural products.

BioDuro Advantage

  • Independent route design to complex target molecules and timely execution
  • Problem solving expertise and creativity
  • Responsive project management and seamless communication
  • Broad synthetic and therapeutic area expertise
  • Strong IP protection and strategic planning

Services

  • Organic synthesis
    • Intermediate synthesis
    • Building block synthesis
    • Reference compound synthesis
    • Metabolite synthesis
    • Impurity synthesis
  • Bioorganic synthesis
    • Antibody drug conjugate synthesis
  • Process Discovery and Development
    • Reaction condition optimization
    • Route discovery, selection, and development
    • Impurity characterization and management
    • Reference standard preparation
  • Parallel chemistry
    • Hit expansion
    • SAR exploration
    • Focused libraries
  • Scale-up to non-GMP drug substance
    • Synthesis of up to 5 kg of final product
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gram milligram kilogram

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Impurity Synthesis

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ADME/DMPK Studies

Drug Metabolism and Pharmacokinetics
Price on request

BioDuro provides insightful Drug Metabolism and Pharmacokinetic services through its unique position as a drug discovery and development organization. With strong credentials and experience in chemistry, biology, pharmacology, and formulation development, the DMPK team performs studies with a wide variety of animal models in an... Show more »

BioDuro provides insightful Drug Metabolism and Pharmacokinetic services through its unique position as a drug discovery and development organization. With strong credentials and experience in chemistry, biology, pharmacology, and formulation development, the DMPK team performs studies with a wide variety of animal models in an AAALAC accredited and GLP-like environment.

BioDuro Advantage

  • Integration with drug discovery and drug development teams
  • 5-10 day project turnaround time
  • Custom studies for ADME
  • AAALAC accredited animal facilities
  • GLP-like laboratory environment
  • Dedication to animal welfare

Services

  • In vitro ADME
    • Physicochemical properties
    • In vitro drug metabolism
    • Permeability measurement
    • Drug-Drug Interaction
  • In vivo PK
    • Metabolite identification and quantification
    • Tissue distribution studies
    • Metabolite identification and quantification
    • Formulation development
    • In-life dosing and sampling
    • Bioanalytical method development
    • Bioanalysis

Capabilities

  • PO, IV, SC, IP, IN; IV/PO cassette dosing
  • Multiple dosage routes
  • Multiple cannulation models
  • Liver microsome/hepatocyte stability
  • CYP phenotyping
  • Metabolite ID (phase I and II)
  • Caco-2
  • PAMPA
  • CYP inhibition assay
  • Time dependent inhibition
  • GSH trapping assay
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Metabolic Disease Animal Models

Price on request
  • High fat diet induced obese (DIO) rats/mice
  • Streptozotocin (STZ) induced type 1 diabetic rats/mice
  • High fat diet (HFD) + STZ induced type 2 diabetic rats/mice
  • KKAy mice with NASH, retinopathy, nephropathy
  • ob/ob and db/db mice
  • GK (Goto-Kakizaki ) rats
  • ApoE KO mice
  • Myocardial infarction and reperfusion injury in rats/mice
  • Renal ischemia and reperfusion injury in rats/mice
  • High fat diet induced obese (DIO) rats/mice
  • Streptozotocin (STZ) induced type 1 diabetic rats/mice
  • High fat diet (HFD) + STZ induced type 2 diabetic rats/mice
  • KKAy mice with NASH, retinopathy, nephropathy
  • ob/ob and db/db mice
  • GK (Goto-Kakizaki ) rats
  • ApoE KO mice
  • Myocardial infarction and reperfusion injury in rats/mice
  • Renal ischemia and reperfusion injury in rats/mice
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Inflammation Assays

Price on request
  • LPS-induced cytokine secretion mice model
  • Topical arachidonic acid-induced inflammation mice model
  • Rodent collagen-induced arthritis (CIA) mice/rat models
  • Experimental Autoimmune Encephalomyelitis (EAE) mice models
  • OVA-induced asthma mice model
  • Pristane-Induced Lupus mice model
  • MRL/lpr genetic Lupus mice... Show more »
  • LPS-induced cytokine secretion mice model
  • Topical arachidonic acid-induced inflammation mice model
  • Rodent collagen-induced arthritis (CIA) mice/rat models
  • Experimental Autoimmune Encephalomyelitis (EAE) mice models
  • OVA-induced asthma mice model
  • Pristane-Induced Lupus mice model
  • MRL/lpr genetic Lupus mice model
  • Intestinal Bowel Disease mice/rat model
  • Delayed Type Hypersensitivity (DTH) mice model
  • FITC Induced Dermatitis mice model
  • Imiquimod-induced psoriasis mice model
  • Bleomycin-induced pulmonary fibrosis in mice model
  • Citric Acid Induced Cough in Guinea-pig model
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In vivo Studies

Price on request
  • Oral/intraperitoneal glucose, insulin and pyruvate tolerance tests
  • Glucagon challenge tests
  • Hyperinsulinemic-euglycemia clamp
  • Hyperglycemia clamp
  • Energy expenditure indirect calorimetry system (TSE)
  • Infrared locomotor activity monitoring
  • Food intake and Water intake monitoring
  • Urine and feces collection
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  • Oral/intraperitoneal glucose, insulin and pyruvate tolerance tests
  • Glucagon challenge tests
  • Hyperinsulinemic-euglycemia clamp
  • Hyperglycemia clamp
  • Energy expenditure indirect calorimetry system (TSE)
  • Infrared locomotor activity monitoring
  • Food intake and Water intake monitoring
  • Urine and feces collection
  • Treadmill exercise
  • Body composition analysis (MRI)
  • Grip strength
  • Coordination (Rotarod)
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Cell-Based Assays

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Synthetic Chemistry

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Immune Cell Assays

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Chemistry and Materials

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Pharmacology & Toxicology

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Animal Models and Studies

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Functional & Cell Type Specific Assays

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Oncology Animal Models

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Diabetes Animal Models

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Spray Drying

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In vivo PK/PD Studies

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T Cell Activation and Proliferation Assays

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Analytical Chemistry Services

Price on request

Method evaluation/transfer
Method development
Method qualification/validation
Raw materials testing
Product-specification support
In-process prototype testing
Stability studies
Finished product release testing
ICH stability testing

Method evaluation/transfer
Method development
Method qualification/validation
Raw materials testing
Product-specification support
In-process prototype testing
Stability studies
Finished product release testing
ICH stability testing

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Drug Preformulation

Price on request

Aqueous solubility (neutral, pH dependent)
Thermal stability
Thermal properties (Tg, MP)
Polymorph screening
Structure verification
Solvent/oil solubility
Partitioning (logP, logD)
Permeability measurement (Caco-2, PAMPA)
Excipient compatibility
Particle size, shape and crystallinity

Aqueous solubility (neutral, pH dependent)
Thermal stability
Thermal properties (Tg, MP)
Polymorph screening
Structure verification
Solvent/oil solubility
Partitioning (logP, logD)
Permeability measurement (Caco-2, PAMPA)
Excipient compatibility
Particle size, shape and crystallinity

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Solid Dosage Formulation

Price on request

Immediate release tablets
Coated tablets
Matrix tablets
Blend in capsules
Tablets in capsules
Liquid in capsules
API in a capsule (Xcelodose®)
Pellets in capsule
Coated pellets/beads
Controlled release beads

Immediate release tablets
Coated tablets
Matrix tablets
Blend in capsules
Tablets in capsules
Liquid in capsules
API in a capsule (Xcelodose®)
Pellets in capsule
Coated pellets/beads
Controlled release beads

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Formulation Services

Price on request

Spray Dried Dispersion
Hot Melt Extrusion
Powder granulation (dry, wet, high-shear, melt)
Multiparticulates
Wet-mass extrusion and spheronization
Tablets
Minitablets
Liquid-gel formulations
Coating (power, bead, tablet, capsule)
Aqueous and solvent based coating
Powder in capsule
Liquid in capsule
API powder in capsule (Xcelodose®)
Pediatric dosage forms
Taste-masking

Spray Dried Dispersion
Hot Melt Extrusion
Powder granulation (dry, wet, high-shear, melt)
Multiparticulates
Wet-mass extrusion and spheronization
Tablets
Minitablets
Liquid-gel formulations
Coating (power, bead, tablet, capsule)
Aqueous and solvent based coating
Powder in capsule
Liquid in capsule
API powder in capsule (Xcelodose®)
Pediatric dosage forms
Taste-masking

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Animal Physiology Analyses

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Biology

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Animal Model in vivo Analyses

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Animal Tumor Volume Measurement

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Todd Blewett

Director of Business Development
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Julie Silverio

Sales & Marketing Support

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