Biocrates provides the fast track to metabolic biomarker signatures. With targeted metabolomics kits and services for quantitative, reproducible, and high throughput analyses, Biocrates enables researchers in basic and clinical research to acquire comprehensive metabolic information more quickly, and more reliably. Biocrates is the partner of choice for Metabolic Phenotyping. **Selected Publications** - Allalou, A.; Nalla, A.; Prentice, K. J.; et al. A Predictive Metabolic Signature for the Transition from Gestational Diabetes to Type 2 Diabetes. *Diabetes* 2016. doi: 10.2337/db15-1720 - Allam-Ndoul, B.; Guénard, F.; Garneau, V.; et al. Association between Metabolite Profiles, Metabolic Syndrome and Obesity Status. *Nutrients* 2016, 8 (6). DOI: 10.3390/nu8060324. - Ang, J. E.; Pandher, R.; Ang, J. C., et al. Plasma Metabolomic Changes following PI3K Inhibition as Pharmacodynamic Biomarkers: Preclinical Discovery to Phase I Trial Evaluation. *Molecular cancer therapeutics* [Online] 2016. - Athersuch, T. Metabolome analyses in exposome studies: Profiling methods for a vast chemical space. *Archives of biochemistry and biophysics* 589, p 177–186. doi: 10.1016/j.abb.2015.10.007 - Bachlechner, U.; Floegel, A.; Steffen, A.; et al. Associations of anthropometric markers with serum metabolites using a targeted metabolomics approach: results of the EPIC-potsdam study. *Nutrition & diabetes* 2016, 6. doi: 10.1038/nutd.2016.23 - Bahado-Singh, R. O.; Graham, S. F.; Han, B.; et al. Serum metabolomic markers for traumatic brain injury: a mouse model. *Metabolomics* 2016, 12 (6). doi: 10.1007/s11306-016-1044-3. - Bhattacharyya, S.; Pence, L.; Yan, K.; et al. Targeted Metabolomic Profiling Indicates Structure-based Perturbations in Serum Phospholipids in Children with Acetaminophen Overdose. *Toxicology Reports* 2016. doi: 10.1016/j.toxrep.2016.08.004 - Boeck, C.; Koenig, A. M.; Schury, K.; et al. Inflammation in adult women with a history of child maltreatment: The involvement of mitochondrial alterations and oxidative stress. *Mitochondrion* 2016, 197-207. doi: 10.1016/j.mito.2016.08.006 - Bovo, S.; Mazzoni, G.; Galimberti, G.; et al. Metabolomics evidences plasma and serum biomarkers differentiating two heavy pig breeds. *Animal : an international journal of animal bioscience* [Online] 2016, 1–8. - Brahmbhatt, V.; Montoliu, I. Characterization of Selected Metabolic and Immunologic Markers Following Exclusive Enteral Nutrition of Pediatric Crohn’s Disease Patients. *J Gastrointest Dig Syst* 2016, 6 (4). doi: 10.4172/2161-069X.1000466
Satisfying unmet needs with metabolomic biomarkers
Biocrates’ targeted metabolomics technology is a significant contribution to personalized medicine as it incorporates highly specific and sensitive biomarkers.
Biomarker panels, which are commonly regarded as the future of diagnostics and a prerequisite for tailoring treatments to individual needs, can be successfully introduced only with a highly sensitive, accurate and standardized method.
Biocrates’ targeted metabolomics platform fulfils these criteria and, by multiplexing a variety of metabolic products accompanied by sound statistical methods, rather than measuring single parameters, provides a detailed picture of healthy versus diseased states. Thus, diseases can be detected earlier and more accurately. Ideally, identifying deviations and shifts in metabolic signatures will make it possible to diagnose and take action well before a disease is manifested. Finally, companion diagnostics can be applied successfully using metabolomic biomarkers, thus enhancing the efficacy of treatments.
Through our metabolomics services support partners in pharmaceutical, biotech, and life science industries in identifying metabolomic biomarkers relevant to their specific research and development projects.
Biocrates enables quantitative lipid analyses with an unprecedented level of sensitivity and precision
The crucial role of lipids in cell, tissue and organ physiology is demonstrated by many human diseases that involve the disruption of lipid metabolic enzymes and pathways. Examples of lipid-associated disorders include diabetes, obesity, atherosclerosis, Alzheimer's disease, cancer and infectious diseases. Therefore targeted lipidomics will not only provide insights into the specific roles of lipid molecular species in health and disease, but will also assist in identifying potential biomarkers for establishing preventive or therapeutic approaches for human health.
Targeted lipidomics provides quantitative analyses of lipids on the systems-level scale together with their interacting factors. Using a LC–MS/MS approach Biocrates can provide the necessary sensitivity, structural specificity, and quantitative precision with high-throughput for > 300 lipids in small sample quantities.
Lipid classes we can analyse:
Biocrates' targeted metabolomics approach enables immediate identification of more than 630 endogenous metabolites of different classes, measurement of their absolute concentrations and mapping to their respective pathways. At our Metabolic Phenotyping Center (Contract Research) we can help to identify relevant metabolic biomarkers, enhance the understanding of biochemical pathways and provide important information of the metabolic state of a cell, tissue or living organism. We develop customized research assays to suit your specific research requirements.
Our technology platform offers mass spectrometry-based (FIA-, LC-MS/MS and GC-MS) quantification of metabolites through multiple reaction monitoring (MRM) using triple quadrupole state of the art mass spectrometers.
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