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Biocare Medical LLC

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Concord, California, US

About Biocare Medical LLC

Biocare Medical, LLC is an innovator in developing and supplying world class automated immunohistochemistry instrumentation and reagents for IHC, ISH and FISH testing. Our technical competencies lie within three core areas: (1) Immunohistochemistry and in situ hybridization, both chromogenic and fluorescent,... Show more »

Biocare Medical, LLC is an innovator in developing and supplying world class automated immunohistochemistry instrumentation and reagents for IHC, ISH and FISH testing. Our technical competencies lie within three core areas: (1) Immunohistochemistry and in situ hybridization, both chromogenic and fluorescent, for the analysis of solid tumor samples, (2) FISH probe design and manufacture, for both liquid based and solid tumor samples and (3) “boutique” CRO services.

Biocare is a globally recognized leader in the development of innovative IHC and ISH assays and offers a comprehensive portfolio of IVD reagents and instrumentation for advanced staining. We understand the complex needs of both the research and clinical markets and have the ability to transform our scientific expertise into “real-world” applications designed to address critical diagnostic decision points, thus positively impacting patient outcomes. We have an established portfolio of detection reagents designed specifically for both human tissue (MACH™ detection systems) and animal tissue (promARK™ detection systems) which is used extensively in pharmaceutical research. Our Molecular division specializes in the discovery, development and manufacturing of FISH probes for the detection of genomic aberrations in both liquid based and solid tumor samples.

Given our expert technical knowledge and strong presence in the Pharma/Biotech sector through our commercial products, we have expanded our service offering to include CRO services which we refer to as our Diagnostic Development services. We provide our customers with full service R&D functions from assay development through commercialization on a fee per project basis.

Biocare Medical is headquartered, and has manufacturing facilities, in Concord, Calif., and has a global distribution network.

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Certifications & Qualifications

cGMP CLIA/CAP FDA Inspected GMP ISO 13485

Our Services (100)


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Clinical Biomarkers

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Special Slide Staining

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Staining of slides using dye based histology and histochemistry tests. Cut slides are preferred but paraffin wax block cutting is available at an extra charge . Stains include but are not limited to:
Masson's Trichrome
Periodic Acid Schiff's (PAS)
Toluidine Blue
Gram Stain
Picro Sirius Red

Deliverables:
- stained... Show more »

Staining of slides using dye based histology and histochemistry tests. Cut slides are preferred but paraffin wax block cutting is available at an extra charge . Stains include but are not limited to:
Masson's Trichrome
Periodic Acid Schiff's (PAS)
Toluidine Blue
Gram Stain
Picro Sirius Red

Deliverables:
- stained slides. Note:- whole stained slides can be imaged if requested (extra charge)

Turn around time - 1-2 weeks

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VENTANA Discovery XT

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Histology and Pathology Services

Price on request

Routine tissue processing and section cutting of formalin-fixed tissue, including H&E staining if required
Cryotomy of frozen tissue
Whole slide Imaging of stained slides
Quantitative Image analysis

Deliverables: cut sections, stained slides, slide images, quantitative analytical data or reports

Turnaround time: Typically 1-2 weeks but dependent on project scope

Routine tissue processing and section cutting of formalin-fixed tissue, including H&E staining if required
Cryotomy of frozen tissue
Whole slide Imaging of stained slides
Quantitative Image analysis

Deliverables: cut sections, stained slides, slide images, quantitative analytical data or reports

Turnaround time: Typically 1-2 weeks but dependent on project scope

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VENTANA Discovery XT

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Immunohistochemistry (IHC)

Price on request

In CAP/CLIA accredited facility on frozen and FFPE sections. Sections can be provided directly by the researcher or cut in our lab.
IHC assay optimization including development of antibody cocktails to facilitate multiplex staining.
Micro-polymer based detection chemistries with high sensitivity and specificity optimized for a... Show more »

In CAP/CLIA accredited facility on frozen and FFPE sections. Sections can be provided directly by the researcher or cut in our lab.
IHC assay optimization including development of antibody cocktails to facilitate multiplex staining.
Micro-polymer based detection chemistries with high sensitivity and specificity optimized for a variety of species including human, monkey, rodent, rabbit, dog and cat.

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VENTANA Discovery XT Human Mouse Rat Non-human primates (NHP)

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In situ Hybridization (ISH)

In Situ Hybridization
Price on request

Optimization of ISH assay conditions using your probe or custom Biocare design to your desired target
Complete assay development, implementation and training in your laboratory
Multiplex IHC and ISH assay feasibility and optimization
Combination gene and protein expression assays utilizing simultaneous colorimetric visualization on a single slide

Optimization of ISH assay conditions using your probe or custom Biocare design to your desired target
Complete assay development, implementation and training in your laboratory
Multiplex IHC and ISH assay feasibility and optimization
Combination gene and protein expression assays utilizing simultaneous colorimetric visualization on a single slide

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VENTANA Discovery XT

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Fluorescence in situ Hybridization (FISH)

Price on request

Probe design, assay optimization and FISH staining on FFPE, blood and cytological fluids
DelTect technology available to reduce errors through truncation artifacts
Improved labeling technology and use of CGH and Patient Cohort data results in 'tight and bright' probes designed to reduce both false negatives and false... Show more »

Probe design, assay optimization and FISH staining on FFPE, blood and cytological fluids
DelTect technology available to reduce errors through truncation artifacts
Improved labeling technology and use of CGH and Patient Cohort data results in 'tight and bright' probes designed to reduce both false negatives and false positives

Samples can be sent as FFPE blocks, blood films or cytological preparations of body fluids including urine. Results can be imaged and made available electronically or returned as completed slides for the researchers own interpretation

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VENTANA Discovery XT Human

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Bioconjugation/Chemical Crosslinking

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Fluorescent labeling of primary antibodies utilizing a variety of different wavelength fluors and linker chemistries. Small volume feasibility lots to large volume batches for routine testing. RUO, IUO and IVD manufacture under GMP conditions

Fluorescent labeling of primary antibodies utilizing a variety of different wavelength fluors and linker chemistries. Small volume feasibility lots to large volume batches for routine testing. RUO, IUO and IVD manufacture under GMP conditions

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VENTANA Discovery XT

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Histological Staining

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Hybridoma Screening

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Screening of multiple clones of research antibody to determine optimum titer or target tissue
Sensitivity and specificity testing on multiple tissue and tumor types
Testing of a variety of antibody conditions to meet project requirements
Testing from multiple hostspecies, including rabbit, rodent, human

Screening of multiple clones of research antibody to determine optimum titer or target tissue
Sensitivity and specificity testing on multiple tissue and tumor types
Testing of a variety of antibody conditions to meet project requirements
Testing from multiple hostspecies, including rabbit, rodent, human

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VENTANA Discovery XT

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Biology

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Protein Services

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Immunostaining

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Protein Expression Visualization

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Antibody Services

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Nucleic Acid Services

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DNA Services

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DNA Hybridization

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Biochemistry & Molecular Biology

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Antibody/Antigen Detection Based Testing

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Antibody Production Consulting

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Animal Antiserum Production

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Clinical Validation Services

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Veterinary Research & Diagnostics

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Monoclonal Antibody (mAb) Development

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Multiplex Immunofluorescence

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Antibody Manufacturing

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Multiplex in situ Hybridization (ISH)

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Diagnostic Kit Validation

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TCR Screening and Validation

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High Throughput Antibody Expression

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Antibody Testing

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Multiplex Immunohistochemistry (mIHC)

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Antibody Validation

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Drug Development

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Drug Development Services

Drug Development Services

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Drug Discovery & Development

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Drug Discovery & Development Services

Drug Discovery & Development Services

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Antibody-Drug Conjugate (ADC) Development

Antibody Drug Conjugate Development
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Antibody-Drug Conjugate (ADC) Analysis

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Immunoperoxidase Histochemistry

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Clinical Research

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Manufacturing Services

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Clinical Laboratory Services

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Histopathologic Scoring

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Monoclonal Antibody (mAb) Profiling

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Antibody Sequencing

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Antibody Cloning

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Immunotherapy Screening

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Custom FISH Probes

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Small Scale Antibody Purification

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Hybridoma Development

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Polyclonal Antibody Development

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Llama Antibodies

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Ascites Antibody Production

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In vitro Monoclonal Antibody (mAb) Production

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Monoclonal Antibody (mAb) Production from Plasmids

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Monoclonal Antibody (mAb) Production from Synthetic Peptides

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Quantitative Histology

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Digital Pathology Services

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Anatomic Pathology

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Large Scale Antibody Production from Hybridomas

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Custom Polyclonal Antibody Production

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DNA Subcloning

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Custom Monoclonal Antibody (mAb) Production

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Antigen Detection by Immunofluorescence

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Histopathology Consulting

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Antibody Screening

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Antibody Discovery

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Pathology Reports

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Phospho-Specific Antibody Production

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Membrane Protein Antibody Production

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Antibody Characterization

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Hybridoma Production

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Antibody Condition Optimization

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Regulatory Affairs Services

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Clinical Data Collection, Analysis and Management

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Clinical Trials, Consulting, and Management

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Imaging & Spectroscopy

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Imaging & Spectroscopy Services

Imaging & Spectroscopy Services

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Image Analysis

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Tissue Microarray Consulting

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Cells and Tissues

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Equipment

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Hybridoma Fusion

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Coverslipping

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Histology Control Slides

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Tumor Marker Testing

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Hybridoma Subcloning

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Animal Immunization for Antibody Production

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Cell-Based Assays

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Tissue Microarrays

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Animal Models and Studies

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Antigen Expression and Purification

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Negative Staining

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Immunofluorescence

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Antibody Modification

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Project Management

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Polyclonal Antibody Production

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Antibody Purification

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Monoclonal Antibody (mAb) Production

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Immunocytochemistry

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Clinical and Anatomic Pathology

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Clinical Chemistry

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Susan Johnson

Director of Business Development & Strategic Partnering
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Stephen Jones

Vice President, Clinical Laboratory Services

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