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Biobide

Donostia, ES

Biobide is a CRO whose aim is to accelerate R&D process for Pharmaceutical, Chemical, Cosmetic and Nutraceutical companies minimizing risks through zebrafish animal model, adding value to clients R&D&i mainly in preclinical area.

Thanks to our automated and innovative tools, we have developed and validated several fast and cost-effective Toxicity & Efficacy Assays and we are the unique specialist in Zebrafish Technologies and Services working under a Good Laboratory Practice (GLP) environment providing prompt, clear and relevant information to develop products.

We are specialized developing tailor made solutions based on Customer´s requirements, such as disease models generation, target validation as well as customization of validated assays.

  • Target validation with morpholinos
  • Disease models generation
  • Toxicity Assays: Acute Toxicity, Teratogenicity,... Show more »

Biobide is a CRO whose aim is to accelerate R&D process for Pharmaceutical, Chemical, Cosmetic and Nutraceutical companies minimizing risks through zebrafish animal model, adding value to clients R&D&i mainly in preclinical area.

Thanks to our automated and innovative tools, we have developed and validated several fast and cost-effective Toxicity & Efficacy Assays and we are the unique specialist in Zebrafish Technologies and Services working under a Good Laboratory Practice (GLP) environment providing prompt, clear and relevant information to develop products.

We are specialized developing tailor made solutions based on Customer´s requirements, such as disease models generation, target validation as well as customization of validated assays.

  • Target validation with morpholinos
  • Disease models generation
  • Toxicity Assays: Acute Toxicity, Teratogenicity, Cardiotoxicity, Hepatotoxicity, Neurotoxicity, Otic Toxicity, Immunotoxicity, Ecotoxicity.
  • Efficacy Assays: oncology (Angiogenesis Inhibition, …), CNS (Neuroprotection, Epilepsy, Parkinson, Alzheimer...), rare diseases, metabolism, immune system…

http://www.biobide.com/

Publications

  • Transcriptional and Behavioral Responses of Zebrafish Larvae to Microcystin-LR Exposure. Tzima E, Serifi I, Tsikari I, Alzualde A, Leonardos I and Papamarcaki T. Int. J. Mol. Sci 18(2), 365. 2017
  • Open Source Drug Discovery with the Malaria Box Compound Collection for Neglected Diseases and Beyond. Van Voorhis WC, Adams JH, Adelfio R, Ahyong V, Akabas MH, Alano P, Alzualde A, Muriana, A. et al. PLoS Pathog 12(7). 2016.
  • Targeted identification of sialo-glycoproteins in hypoxic endothelial cells and validation in zebrafish reveals roles for proteins in angiogenesis. Nicolas Delcourt, Celia Quevedo, Christelle Nonne, Pierre Fons, Donogh O’Brien, Denis Loyaux, Maria Diez, François Autelitano, Jean-Claude Guillemot, Pascual Ferrara, Arantza Muriana, Carlos Callol, Jean-Pascal Hérault, Jean-Marc Herbert, Guilles Favre and Françoise Bono. JBC . February 2015.
  • Development and validation of an automated high-throughput system for zebrafish in vivo screenings. Letamendia A., Quevedo C., Ibarbia I., Virto JM., Holgado O., Diez M., Izpisua-Belmonte JC., Callol C. PLoS One. 2012.
  • Identification of phosphorylase kinase as a novel therapeutic target through high-throughput screening for anti-angiogenesis compounds in zebrafish. Camus S, Quevedo C, Menéndez S, Paramonov I, Stouten PF, Janssen RA, Rueb S, He S, Snaar-Jagalska BE, Laricchia-Robbio L, Izpisua Belmonte JC. Oncogene. 2011.
  • Xenografts in zebrafish embryos as a rapid functional assay for breast cancer stem-like cell identification. Eguiara A, Holgado O, Beloqui I, Abalde L, Sanchez Y, Callol C, Martin AG. Cell Cycle. 2011.
  • Evaluation of zebrafish as a model to predict human hepatotoxicity. Callol C., Letamendia A., Holgado O., Diez M. Toxicol Lett, vol 196, pp S214-S214, 2010.
  • A new method for detection and quantification of heartbeat parameters in drosophila, zebrafish, and embryonic mouse hearts.Fink M, Callol-Massot C, Chu A, Ruiz-Lozano P, Izpisua Belmonte JC, Giles W, Bodmer R, Ocorr K.Biotechniques. 2009.
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In vivo Teratogenicity Testing
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Zebrafish development toxicity/teratogenicity assay

In order to understand the potential of a drug to induce birth defects in offspring, teratogenic studies must be performed. Reproductive toxicity is a major concern and different guidelines, such as the ICH S5(R2), state the need to assess chemicals safety during the Drug... Show more »

Zebrafish development toxicity/teratogenicity assay

In order to understand the potential of a drug to induce birth defects in offspring, teratogenic studies must be performed. Reproductive toxicity is a major concern and different guidelines, such as the ICH S5(R2), state the need to assess chemicals safety during the Drug Discovery and Development Process or before drug commercialization.

The zebrafish embryo is an emerging model due to it’s inherent properties (ease of manipulation, external fertilization and transparency) together with the need to apply the 3Rs.

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Zebrafish
Drug discovery
Development
Drug Target Validation
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Drug Target Validation in Zebrafish

Drug Target Validation in Zebrafish

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Zebrafish
In vivo Angiogenesis Assays
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Zebrafish Angiogenesis Assays

Biobide has developed a method to detect the capability of a compound to inhibit angiogenesis as part of efficacy pharmacology studies.

In our automated assay, a transgenic zebrafish line with fluorescent (cop-GFP labelled) blood vessels is used in order to facilitate the visualization and analysis of the intersegmental vessels.

Zebrafish Angiogenesis Assays

Biobide has developed a method to detect the capability of a compound to inhibit angiogenesis as part of efficacy pharmacology studies.

In our automated assay, a transgenic zebrafish line with fluorescent (cop-GFP labelled) blood vessels is used in order to facilitate the visualization and analysis of the intersegmental vessels.

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Zebrafish
In vivo Drug Efficacy Testing
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Zebrafish Drug Efficacy Testing

Zebrafish Drug Efficacy Testing

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Zebrafish
Ototoxicity Evaluation
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Zebrafish Ototoxicity Assay

Zebrafish embryos can be used to analyse the ototoxicity induced by a compound.
Biobide has developed a method to detect the capability of a compound to induce ototoxicity as part of safety pharmacology studies.

In addition to the inner ear, zebrafish have superficial mechano-sensory organs,... Show more »

Zebrafish Ototoxicity Assay

Zebrafish embryos can be used to analyse the ototoxicity induced by a compound.
Biobide has developed a method to detect the capability of a compound to induce ototoxicity as part of safety pharmacology studies.

In addition to the inner ear, zebrafish have superficial mechano-sensory organs, called neuromasts, present on the lateral line along the head and body that detect vibrations in the surrounding environment at frequencies from 50 to 200 Hz. Each neuromast contains a ring of supporting cells which surround a central cluster of sensory hair cells. Hair cells in zebrafish neuromasts are similar in structure and function to the inner ear hair cells in mammals .

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Zebrafish
In vivo Hepatotoxicity Testing
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Zebrafish Hepatotoxicity Assay

Because of functional similarities between zebrafish and mammalian livers, the zebrafish model is proposed for prediction of hepatotoxic agents.

  • The expression of different enzymes involved in liver detoxification in zebrafish indicates that this animal model can be used for prediction of... Show more »

Zebrafish Hepatotoxicity Assay

Because of functional similarities between zebrafish and mammalian livers, the zebrafish model is proposed for prediction of hepatotoxic agents.

  • The expression of different enzymes involved in liver detoxification in zebrafish indicates that this animal model can be used for prediction of hepatotoxic agents.
  • Besides necrosis, zebrafish potentiates assessment of other hepatotoxic endpoints described in the “Non-clinical guideline on drug-induced hepatotoxicity” such as steatosis, hepatomegaly and cholestasis.
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Zebrafish
In vivo Cardiotoxicity Screening
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Zebrafish Cardiotoxicity Assay

Zebrafish strain expressing Green Fluorescent Protein obtained from crossing adult zebrafish under strict environmental conditions of temperature and photoperiod is used in this assay.

  • Zebrafish cardiotoxicity study is an alternative, rapid and non-invasive assay with good sensitivity... Show more »

Zebrafish Cardiotoxicity Assay

Zebrafish strain expressing Green Fluorescent Protein obtained from crossing adult zebrafish under strict environmental conditions of temperature and photoperiod is used in this assay.

  • Zebrafish cardiotoxicity study is an alternative, rapid and non-invasive assay with good sensitivity (100%) and specificity (93.3%) that is suitable to be used to early evaluate cardiotoxicity.
  • Zebrafish embryos can be used in drug discovery to provide early screening assays which comply with 3R principle.
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Zebrafish
Cardiovascular
Heart Failure
In vivo Acute Toxicity Studies
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Zebrafish Acute Toxicity Assay

Following the OECD 236 Guideline (Fish Embryo Acute Toxicity Test), a convenient, rapid and inexpensive acute toxicity test has been set up.

  • Zebrafish Acute Toxicity studies are a good tool to evaluate the acute toxicity of potential drugs at an early preclinical phase.
  • Acutetox Assay is... Show more »

Zebrafish Acute Toxicity Assay

Following the OECD 236 Guideline (Fish Embryo Acute Toxicity Test), a convenient, rapid and inexpensive acute toxicity test has been set up.

  • Zebrafish Acute Toxicity studies are a good tool to evaluate the acute toxicity of potential drugs at an early preclinical phase.
  • Acutetox Assay is a cost and time effective assay compared to other currently used assays.
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Zebrafish
Environmental Science
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Ecotoxicity and AquaticToxicity: zebrafish, algae and daphnia studies

  • OECD 201. Algae Growth Inhibition Test
  • OECD 202. Daphnia magna 48 h. Acute immobilization Test
  • OECD 203. Fish Acute Toxicity Test
  • OECD 210. Fish, Early-life Stage Toxicity Test
  • OECD 211. Daphnia magna reproduction Test
  • OECD 212. Fish,... Show more »

Ecotoxicity and AquaticToxicity: zebrafish, algae and daphnia studies

  • OECD 201. Algae Growth Inhibition Test
  • OECD 202. Daphnia magna 48 h. Acute immobilization Test
  • OECD 203. Fish Acute Toxicity Test
  • OECD 210. Fish, Early-life Stage Toxicity Test
  • OECD 211. Daphnia magna reproduction Test
  • OECD 212. Fish, Short-term Toxicity Test on Embryo and Sac-fry Stages
  • OECD 229. Fish Short Term Reproduction Assay
  • OECD 236. Fish Embryo Acute Toxicity (FET) Test
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Zebrafish
Environmental
Endocrine
Daphnia magna
Zebrafish Models
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Zebrafish Disease Models Generation

We develop zebrafish disease models with Knock Out/Knock in by TALENs or CRISPR/Cas9 technology or with overexpression by transgenesis mainly for:

  • Target identification: discovery of downstream genes, regulatory mechanisms,...
  • Screening: find molecules that reduces or reverts the... Show more »

Zebrafish Disease Models Generation

We develop zebrafish disease models with Knock Out/Knock in by TALENs or CRISPR/Cas9 technology or with overexpression by transgenesis mainly for:

  • Target identification: discovery of downstream genes, regulatory mechanisms,...
  • Screening: find molecules that reduces or reverts the observed phenotypes

Oncology disease models: hepatocarcinoma, melanoma, digestive carcinoma, ...
Neurodegenerative disease models: Alzheimer's disease, Parkinson's disease, Epilepsy, ...
Rare Diseases

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Zebrafish
Oncology
cas9
rare disease
CRISPR
CNS/Neurology
In vivo Regeneration Assays
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Regeneration Assay in Zebrafish

Due the high regenerative capacity of the model, the zebrafish is selected to evaluate whether its regenerative potential upon new specific active ingredient or mixes could reach an increase in its regenerative capacity.

Zebrafish can regenerate several organs such as the tail fin, heart,... Show more »

Regeneration Assay in Zebrafish

Due the high regenerative capacity of the model, the zebrafish is selected to evaluate whether its regenerative potential upon new specific active ingredient or mixes could reach an increase in its regenerative capacity.

Zebrafish can regenerate several organs such as the tail fin, heart, central nervous system, and photoreceptors. This property makes it an interesting tool to evaluate the effect of test items, after injury.

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Zebrafish
Melanin Content Assay
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Zebrafish Melanin Quantification Assay

Skin whitening cosmetics are one of the most demanded products in Asia and other continents. Due the impossibility to use animals for cosmetic experimentation, many of researchers are looking for new alternatives. The Zebrafish model appears as an option for replacing superior animal... Show more »

Zebrafish Melanin Quantification Assay

Skin whitening cosmetics are one of the most demanded products in Asia and other continents. Due the impossibility to use animals for cosmetic experimentation, many of researchers are looking for new alternatives. The Zebrafish model appears as an option for replacing superior animal experiments.

Zebrafish pigment pattern provides the opportunity to study melanocyte development and melanin genesis..

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Zebrafish
Animal Behavior Studies
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Zebrafish Behaviour Alteration Assay

Alterations in the mobility pattern of larvae induced by known drugs have been observed to strongly support the zebrafish as a predictive model of neuroactivity in humans. Behavioral profiling in zebrafish reveals relationships between drugs and their targets and demonstrates a conserved... Show more »

Zebrafish Behaviour Alteration Assay

Alterations in the mobility pattern of larvae induced by known drugs have been observed to strongly support the zebrafish as a predictive model of neuroactivity in humans. Behavioral profiling in zebrafish reveals relationships between drugs and their targets and demonstrates a conserved vertebrate neuropharmacology.

Biobide has set up an assay to evaluate general behavioral alterations, based on responses to dark-light changes.

  • Behavioral alteration analysis is an alternative, rapid and non-invasive assay with good sensitivity (75%) and specificity (100%) that is suitable for use in early neuroactive drug screens.
  • Zebrafish Behavioral assay fulfills 3R´s principles
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Zebrafish
neurological
CNS/Neurology
In vivo Immunotoxicity Testing
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Zebrafish Immunotoxicity Testing

We are able to develop assays for evaluating changes observed at the genetic and cellular level on the immune system of the zebrafish larvae after drug exposure.

Zebrafish Immunotoxicity Testing

We are able to develop assays for evaluating changes observed at the genetic and cellular level on the immune system of the zebrafish larvae after drug exposure.

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Zebrafish
Immunology
Morpholino-Based Gene Knockdown
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Morpholino-Based Gene Knockdown in Zebrafish

The objetive is to find genes involved in specific processes and/or check activity of a desired gene in a process.
The common process used for this is the transient inhibition as a consequence of the injection of Morpholinos.

Advantages: fast, stadistically significant and high repeatability.

Morpholino-Based Gene Knockdown in Zebrafish

The objetive is to find genes involved in specific processes and/or check activity of a desired gene in a process.
The common process used for this is the transient inhibition as a consequence of the injection of Morpholinos.

Advantages: fast, stadistically significant and high repeatability.

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Zebrafish
In vivo Toxicity Testing
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Animal Learning, Memory, and Behavior Tests
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Safety Pharmacology & Efficacy Testing
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Bioanalytical Assays
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Experimental Design
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Animal Model in vivo Analyses
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Fish, Reptile, and Amphibian Models
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Model Organisms
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Drug Discovery
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Water Quality Monitoring
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Validation, Services
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R&D; Services
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Contract Services Directory
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Preclinical Efficacy Studies
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Preclinical Study Design
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Nonclinical Research
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Microscopic Analysis
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Hit to Lead and Lead Optimization
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Clinical Imaging Services
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Bioanalysis
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Imaging & Spectroscopy
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High Throughput Screening (HTS)
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Environmental Testing
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Drug Potency and Efficacy Testing
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Scientific Sourcing
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Contract Sales Organizations
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Animal Cognition & Behavior Tests
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Contract Research
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Environmental Health and Safety Consulting
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Bioavailability and Bioequivalence Studies
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Assay Development
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Training and Teaching Services
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Cells and Tissues
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Microscopy
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Drug Discovery & Development
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Functional & Cell Type Specific Assays
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Animal Models and Studies
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In vivo Assays
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Hit Identification
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Lead Identification and Validation
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