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BioAspect

Toronto, Ontario, CA

Our Mission is to provide our customers with confidence in key decisions at critical stages of drug discovery. Our Vision is to become indispensable to our customers as a trusted partner and provider of high quality drug discovery contract research services and products. We are determined to always offer the most current, relevant, informative, and predictive models of human disease. We are proud to bring a great and versatile collection of reliable research tools to help new ideas grow and discoveries happen.

BioAspect offers preclinical research services – specializing in efficacy and proof-of-principle studies using cellular, transgenic Drosophila, and rodent models of human diseases – to identify health benefits of pharmaceutical, biotechnology, and nutraceutical products. Located right in the heart of the Toronto research district, BioAspect is your neighbourhood biotechnology company.

Established in 2010,... Show more »

Our Mission is to provide our customers with confidence in key decisions at critical stages of drug discovery. Our Vision is to become indispensable to our customers as a trusted partner and provider of high quality drug discovery contract research services and products. We are determined to always offer the most current, relevant, informative, and predictive models of human disease. We are proud to bring a great and versatile collection of reliable research tools to help new ideas grow and discoveries happen.

BioAspect offers preclinical research services – specializing in efficacy and proof-of-principle studies using cellular, transgenic Drosophila, and rodent models of human diseases – to identify health benefits of pharmaceutical, biotechnology, and nutraceutical products. Located right in the heart of the Toronto research district, BioAspect is your neighbourhood biotechnology company.

Established in 2010, BioAspect is the go-to biotech products and research company in the area. We develop and distribute over 500,000 reliable research tools including ELISA kits, recombinant and native proteins, antibodies, competent cells, and PCR products amongst others. For contract research services, we offer drosophila and mouse models of neurodegenerative diseases, ageing, longevity, addiction, obesity, diabetes, cancer, and natural health products, in addition to behavioural testing.

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In vitro Disease Models
Price on request

We offer cell-based in vitro models to use as the first step in biological evaluation of the effects of treatment. These tests are fast, cost-effective and designed for screening of large number of agents. They provide information about efficacy, toxicity, as well as an insight into the mechanism of action.

Our cell-based... Show more »

We offer cell-based in vitro models to use as the first step in biological evaluation of the effects of treatment. These tests are fast, cost-effective and designed for screening of large number of agents. They provide information about efficacy, toxicity, as well as an insight into the mechanism of action.

Our cell-based models use relevant cell types, expressing targeted pathways. Possible readouts include markers of cell metabolic activity and viability, apoptosis, oxidative stress, or other disease-specific endpoints. To gain insight into the mechanism of action, we offer gene and protein expression analysis. We employ qPCR and gene pathway finder arrays. For protein quantification by ELISA we can use any kit from our extensive catalog of more than 200, 000 products.

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Monoclonal Antibody (mAb) Production
Price on request

We offer ELISA-guaranteed mouse monoclonal antibody development (at least two positive clones). Our flexible package may include:

  • Peptide synthesis (includes documentation of peptide synthesis and HPLC analysis)
  • Peptide acetylation and amidation are offered at no additional cost. Biotinylation, phosphotyrosine,... Show more »

We offer ELISA-guaranteed mouse monoclonal antibody development (at least two positive clones). Our flexible package may include:

  • Peptide synthesis (includes documentation of peptide synthesis and HPLC analysis)
  • Peptide acetylation and amidation are offered at no additional cost. Biotinylation, phosphotyrosine, phosphothreonine, phosphoserine, and fluorescein sites can be added for an additional fee
  • Peptide conjugation to carrier protein (KLH/OVA/BSA)
  • Pre-immune sera collection
  • Immunization of mice and immune sera collection
  • Selection of mouse donors for hybridoma generation. Confirmation of serum titer by ELISA.
  • Fusion and hybridoma development
  • Positive clone identification by ELISA
  • Isotype identification
  • Antibody affinity purification (saturated ammonium sulfate precipitation, protein A/G or antigen affinity purification)
  • Antibody labeling with biotin, avidin, streptavidin, reporter enzymes or fluorophores of customer’s choice
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Custom Polyclonal Antibody Production
Price on request

We generate polyclonal antibodies in specific pathogen-free New Zealand rabbits. Our packages are tailored to Customer needs and may include:

  • Antigen design assistance and immunogenicity prediction
  • Peptide antigen synthesis
  • Peptide conjugation with carrier protein (KLH, BSA, OVA)
  • Immunization program tailored to... Show more »

We generate polyclonal antibodies in specific pathogen-free New Zealand rabbits. Our packages are tailored to Customer needs and may include:

  • Antigen design assistance and immunogenicity prediction
  • Peptide antigen synthesis
  • Peptide conjugation with carrier protein (KLH, BSA, OVA)
  • Immunization program tailored to customer requirements
  • Collection of pre-immune and immune sera
  • Confirmation of serum titer by ELISA
  • Production bleeds
  • Antibody purification according to customer specifications (ammonium sulfate precipitation, protein A/G or affinity purification)
  • Antibody labeling with biotin, avidin, streptavidin, reporter enzymes, or fluorophores
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ADME/DMPK Studies
Drug Metabolism and Pharmacokinetics
Price on request

Assessment of the pharmacokinetic (PK) profile and oral bioavailability (for oral drugs) of lead compounds in the early stages of a drug discovery greatly reduces attrition in drug development. For CNS drugs, minimal acceptable brain exposure has to be achieved to make a lead a viable development candidate. Concurrent... Show more »

Assessment of the pharmacokinetic (PK) profile and oral bioavailability (for oral drugs) of lead compounds in the early stages of a drug discovery greatly reduces attrition in drug development. For CNS drugs, minimal acceptable brain exposure has to be achieved to make a lead a viable development candidate. Concurrent optimisation of PK, oral bioavailability, and pharmacological activity is the best strategy to shorten the lead optimisation process and reduce the risk of failure.

We carry out PK studies in rats and mice. We offer any combination of the following:

  • Help with selection of dosing vehicle
  • Solubility testing in selected dosing vehicles
  • Compound stability study in dosing vehicle
  • Compound stability study in animal blood or tissue homogenate
  • Development and validation of analytical methods for determination of compound concentration in plasma/serum, or tissue homogenate
  • Compound dosing by oral, intravenous, or subcutaneous routes
  • Collection of plasma/serum samples or organs
  • Determination of compound concentration in plasma/serum or tissue homogenate
  • Calculation of PK parameters
  • Detailed study protocol and report
  • Expert advice on ways to improve absorption and metabolism, including in silico modelling
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Elevated Plus Maze Animal Anxiety Test
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T Maze Spontaneous Alternation Test
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Morris Water Maze Assay
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Radial Arm Water Maze Test
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Huntington's Disease Animal Models
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Drosophila
Alcohol Addiction Animal Models
Price on request

Alcohol Preferring Rats (P-rats)
High Alcohol Drinking (HAD- rats)

Alcohol Preferring Rats (P-rats)
High Alcohol Drinking (HAD- rats)

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Diabetes Animal Models
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Obesity Animal Models
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Aging Animal Models
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Drosophila
Rodents
ALS Animal Models
Amyotrophic Lateral Sclerosis Animal Models
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Drosophila
Rodents
Alzheimer's Disease Animal Models
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Drosophila
Rodents
Animal Learning, Memory, and Behavior Tests
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Metabolic Animal Models
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Animal Model in vivo Analyses
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Biochemistry & Molecular Biology
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Animal Anxiety and Depression Tests
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Animal Cognition & Behavior Tests
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Animal Models of Disease
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Cells and Tissues
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Biology
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CNS/Neurology Animal Models
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Pharmacology & Toxicology
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Animal Models and Studies
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Antibody Services
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Protein Services
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