1352506245331 405947d4ee4091d86766977474d817ff

Bio-Synthesis

Lewisville, Texas, US

Bio-synthesis Inc., a leading GMP compliant provider for custom synthetic molecules. Through innovative production process, and synthesis know-how, our services are the best in their class, providing you with innovative and trustworthy solutions to accelerate your research.

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BNA Oligos
Bridged Nucleic Acid Oligos
Price on request

3rd Generation Bridged Nucleic Acids (BNA)

Benefit of the BNA Technology
Improved hybridization selectivity and specificity over PNA & LNA
Ideal for the detection of short RNA and DNA targets
Facilitate Tm normalization
Increased thermal duplex stability of duplexes
Increased thermal stability of triplexes
Capable... Show more »

3rd Generation Bridged Nucleic Acids (BNA)

Benefit of the BNA Technology
Improved hybridization selectivity and specificity over PNA & LNA
Ideal for the detection of short RNA and DNA targets
Facilitate Tm normalization
Increased thermal duplex stability of duplexes
Increased thermal stability of triplexes
Capable of single nucleotide discrimination
Resistance to exo- and endonucleases resulting in high biological stability for in vivo and in vitro application
Superior antisense inhibition and potency
Strand invasion enable detection of "hard to access" sample
Flexible probe designs regardless of GC content
Easily adaptable to many DNA or RNA detection system

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BNA Synthesis
Bridged Nucleic Acid Synthesis
Price on request

3rd Generation Bridged Nucleic Acids (BNA)

Benefit of the BNA Technology
Improved hybridization selectivity and specificity over PNA & LNA
Ideal for the detection of short RNA and DNA targets
Facilitate Tm normalization
Increased thermal duplex stability of duplexes
Increased thermal stability of triplexes
Capable... Show more »

3rd Generation Bridged Nucleic Acids (BNA)

Benefit of the BNA Technology
Improved hybridization selectivity and specificity over PNA & LNA
Ideal for the detection of short RNA and DNA targets
Facilitate Tm normalization
Increased thermal duplex stability of duplexes
Increased thermal stability of triplexes
Capable of single nucleotide discrimination
Resistance to exo- and endonucleases resulting in high biological stability for in vivo and in vitro application
Superior antisense inhibition and potency
Strand invasion enable detection of "hard to access" sample
Flexible probe designs regardless of GC content
Easily adaptable to many DNA or RNA detection system

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Peptide Synthesis
Price on request

Peptide-Extremer up to 200 aa
Wide purity range from crude to 99%
Scalable from ug to kg
Single to high throughput peptides
Specialty peptides: Stapled, branched, cyclic, peptoid and others
Peptide post-translational modifications
Chromogenic/fluorogenic substrates
Unusual amino acids and their derivatives
Wide variety of... Show more »

Peptide-Extremer up to 200 aa
Wide purity range from crude to 99%
Scalable from ug to kg
Single to high throughput peptides
Specialty peptides: Stapled, branched, cyclic, peptoid and others
Peptide post-translational modifications
Chromogenic/fluorogenic substrates
Unusual amino acids and their derivatives
Wide variety of modifications and labels
Peptide bioconjugates: biopolymer, small drug molecule, nanoparticles and solid immobilization
Peptide microarray fabrication

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Cell Line Authentication
Starting at $120.00 per sample

Bio-Synthesis offers accredited DNA Genotyping Services, following GLP guidelines for human cell line authentication and mycoplasma detection

Standard Package-DNA Extraction and Unknown Sample Profiling

Premium Package-DNA Extraction, Unknown Sample Profiling, Known Reference Profiling and Comparison Analysis

Gold... Show more »

Bio-Synthesis offers accredited DNA Genotyping Services, following GLP guidelines for human cell line authentication and mycoplasma detection

Standard Package-DNA Extraction and Unknown Sample Profiling

Premium Package-DNA Extraction, Unknown Sample Profiling, Known Reference Profiling and Comparison Analysis

Gold Package- DNA Extraction, Unknown Sample Profiling, Known Reference Profiling, Comparison Analysis, Bioinformatics Data Analysis and Electropherogram & Notarization

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Amino Acid Analysis
Starting at $250.00 per sample

High sensitivity down to low microgram scale
Amino acid testing of all 20 natural amino acids
Comprehensive report delivered within 2-5 days
Non-standard amino acids

Bio-Synthesis offers comprehensive amino acid analysis and amino acid quantification services on biological compounds, foods, tissue, biological fluids, and drug samples.

High sensitivity down to low microgram scale
Amino acid testing of all 20 natural amino acids
Comprehensive report delivered within 2-5 days
Non-standard amino acids

Bio-Synthesis offers comprehensive amino acid analysis and amino acid quantification services on biological compounds, foods, tissue, biological fluids, and drug samples.

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Edman Degradation
Price on request

First 5 amino acids* $600
Additional amino acid beyond first 5 cycles $55
15 amino acid sequencing* $1,100

Results within 10-12 days.

First 5 amino acids* $600
Additional amino acid beyond first 5 cycles $55
15 amino acid sequencing* $1,100

Results within 10-12 days.

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Antibody Modification
Price on request

Antibody Fluorescent Labeling
Antibody Liposome Conjugation
Antibody Enzyme Labeling
Antibody Nanoparticles Labeling
Antibody Oligonucleotide Conjugation
Antibody Fragmentation

Antibody Fluorescent Labeling
Antibody Liposome Conjugation
Antibody Enzyme Labeling
Antibody Nanoparticles Labeling
Antibody Oligonucleotide Conjugation
Antibody Fragmentation

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Antibody Purification
Price on request
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DNA Profiling
Starting at $150.00 per sample

A simple buccal, or oral, swab is all that is needed to generate one's unique DNA profile. In some cases, other types of samples may be used, however, minimally invasive techniques are always used when buccal swabs can not be obtained. Upon receipt of samples, turnaround for DNA profiling is within 5-7 business days.

A simple buccal, or oral, swab is all that is needed to generate one's unique DNA profile. In some cases, other types of samples may be used, however, minimally invasive techniques are always used when buccal swabs can not be obtained. Upon receipt of samples, turnaround for DNA profiling is within 5-7 business days.

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DNA Synthesis and Probe Development
Price on request

Synthetic DNA is deprotected, desalted, lyophilized, Ready-2-Use Quantitated 2x by UV spectrophotometry to provide an accurate measure of yield Synthetic DNA is Quality checked by MALDI-TOF mass spectrometry, purity check by HPLC and/or PAGE Custom preparative and analytical services (optional) Quality Assurance document... Show more »

Synthetic DNA is deprotected, desalted, lyophilized, Ready-2-Use Quantitated 2x by UV spectrophotometry to provide an accurate measure of yield Synthetic DNA is Quality checked by MALDI-TOF mass spectrometry, purity check by HPLC and/or PAGE Custom preparative and analytical services (optional) Quality Assurance document including: yields, TM, MW, μg/OD and more...
Fast delivery with high throughput capacity

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Gene Synthesis
Starting at $299.00 per sample
Request a quote for more information about this service.
Peptide Libraries
Price on request

Peptide Library is a large collection of synthetic peptides with a systematic combination of amino acids. These synthetic peptide library screening tools are used in epitope peptide mapping, peptide library screening for drug target validation and vaccine development. Our synthetic peptide libraries offer a flexible selection of... Show more »

Peptide Library is a large collection of synthetic peptides with a systematic combination of amino acids. These synthetic peptide library screening tools are used in epitope peptide mapping, peptide library screening for drug target validation and vaccine development. Our synthetic peptide libraries offer a flexible selection of peptide purity levels ranging from crude to 98% purity. Each random peptide in the library undergoes rigorous quality control to prevent any cross contaminants before delivery. All purified peptides are delivered with a QC reports of RP-HPLC, MS, and COA to ensure the highest quality.

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RNA Synthesis
Price on request

RNA Synthesis Services
Deprotected, desalted and ready to use Multi-scale capacity Purification by RNase free -PAGE or RP-HPLC upon request QC analysis by MALDI-TOF Mass spectrometry, HPLC, PAGE analysis Package in an inert chemical matrix - inactivate and stabilize during sample handling Fast delivery and high throughput... Show more »

RNA Synthesis Services
Deprotected, desalted and ready to use Multi-scale capacity Purification by RNase free -PAGE or RP-HPLC upon request QC analysis by MALDI-TOF Mass spectrometry, HPLC, PAGE analysis Package in an inert chemical matrix - inactivate and stabilize during sample handling Fast delivery and high throughput capacity

IVT Transcription Services
Sequence design
Gene synthesis
Subcloning
DNA purification and quantification
DNA sequencing verification
Plasmid linearization
IVT reaction followed by DNase I treatment
RNA purification and quantification
RNA size check (denaturing PAGE or agaros gel)
Quality assurance certificate
Formulated in RNaseSAFETM Tube

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MALDI TOF MS
Matrix-assisted laser desorption ionization time-of-flight mass spectrometry
Starting at $250.00 per sample

Matrix-assisted laser desorption ionization time-of-flight mass spectrometry. The price can range from $250-$350

Matrix-assisted laser desorption ionization time-of-flight mass spectrometry. The price can range from $250-$350

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Genomic DNA Extraction
Price on request
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Oligonucleotide Synthesis
Price on request

Since its inception in 1984, Bio-Synthesis is one of the first companies to provide custom DNA synthesis services and has remained over the years a major force in advancing biotechnology research. Bio-Synthesis is a leading developer and supplier of new technologies for unmodified and modified DNA, antisense oligos and DNA... Show more »

Since its inception in 1984, Bio-Synthesis is one of the first companies to provide custom DNA synthesis services and has remained over the years a major force in advancing biotechnology research. Bio-Synthesis is a leading developer and supplier of new technologies for unmodified and modified DNA, antisense oligos and DNA chimera. Researchers often choose BSI as their supplier for DNA oligo synthesis due to our quality standards, delivery speed and high throughput capabilities. Quality is not just a goal, it is a Guarantee, and when it comes to speed, we are able to provide next day delivery in most cases. Through improvement from traditional chemistry to the development of advanced state-of-the-art proprietary instruments, BSI provides economical, high throughput, quality custom DNA synthesis.

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RNA Extraction
Price on request
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qPCR
Quantitative PCR
Price on request
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siRNA Synthesis
Price on request

Large variety of modifications
Deprotected, desalted, annealed, In-vivo quality prep
µg to multi-gram capacity for ASR or cGMP grade
Free online design Sci-Apps tools
Available in duplex or single-stranded format
Standard and advanced QC packages are available

Large variety of modifications
Deprotected, desalted, annealed, In-vivo quality prep
µg to multi-gram capacity for ASR or cGMP grade
Free online design Sci-Apps tools
Available in duplex or single-stranded format
Standard and advanced QC packages are available

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Cell Penetrating Peptides
Price on request
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Non-Coding RNA Synthesis
Price on request
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MicroRNA (miRNA) Synthesis
Price on request
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N-Terminal Sequencing
Price on request

First 5 amino acids* $600
Additional amino acid beyond first 5 cycles $55
15 amino acid sequencing* $1,100

Results within 10-12 days.

First 5 amino acids* $600
Additional amino acid beyond first 5 cycles $55
15 amino acid sequencing* $1,100

Results within 10-12 days.

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Antisense RNA Amplification
Price on request
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Nanoparticle Synthesis
Price on request
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Nanoparticle Conjugation and Functionalization
Price on request
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Chemical Crosslinking/Bioconjugation
Price on request
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Protein Sequencing
Price on request

First 5 amino acids* $600
Additional amino acid beyond first 5 cycles $55
15 amino acid sequencing* $1,100

Results within 10-12 days.

First 5 amino acids* $600
Additional amino acid beyond first 5 cycles $55
15 amino acid sequencing* $1,100

Results within 10-12 days.

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Mass Spectrometry
Price on request
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Peptide Manufacturing
Price on request
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Custom Manufacturing
Price on request
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Biopharmaceutical Manufacturing
Price on request
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Compound Synthesis
Price on request
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Aptazyme Production
Price on request
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Antibody-Drug Conjugate Development
Antibody Drug Conjugate Development
Price on request
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Hapten-Antibody Conjugation
Price on request
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Direct Antibody Labeling
Price on request
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Antibody based Affinity Chromatography
Price on request
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DNA Extraction and Purification
Price on request
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Chromatography
Price on request
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Protein Services
Price on request
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Therapeutic Monoclonal Antibody (mAb) Development
Price on request
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PCR
Price on request
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Synthetic Chemistry
Price on request
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Antibody Services
Price on request
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MALDI Mass Spectrometry Methods
Price on request
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Protein Conjugation
Price on request
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Analytical Chemistry Services
Price on request
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Genotyping Services
Price on request
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Imaging & Spectroscopy
Price on request
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Nucleic Acid Services
Price on request
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Formulation Services
Price on request
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Protein Expression
Price on request

The E. coli expression system is the most widely used expression system for recombinant proteins. Advantages of using E. coli for protein expression are low cost, high expression level, ease of scaling, and a short turnaround time.

Service Highlights:
High Efficiency: Our collection of more than ten host strains and various... Show more »

The E. coli expression system is the most widely used expression system for recombinant proteins. Advantages of using E. coli for protein expression are low cost, high expression level, ease of scaling, and a short turnaround time.

Service Highlights:
High Efficiency: Our collection of more than ten host strains and various proprietary or non-proprietary vectors guarantees the selection of the most efficient expression system.
High Productivity: Multiple fusion tags and our proprietary AIE technology are available in-house to increase protein solubility and production and to decrease purification cost, even for toxic proteins.
Refolding: We have established an effective protein refolding system consisting of 20 refolding buffers optimized with nine parameters to increase the chances of obtaining soluble and bioactive proteins.
Large-Scale Production: We are able to produce up to 500L of E. coli cell culture for gram scale production.
Modifications: Metabolic labeling with stable isotopes (13C and 15N) and biotinylation are available.
Competitive Pricing

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Spectroscopy
Price on request
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Antibody Conjugation
Price on request
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2018-05-03 18:58:04 +0200

Net Promoter Score of 10 received for Peptide Synthesis.

Additional Ratings: satisfaction with deliverable: 10, satisfaction with timeliness: 10.
April 13, 2018

Positive review received for Peptide Synthesis:

"Great service delivered on time. Peptide quality was great and fits requested quality using our own internal QCs."

2018-04-06 15:30:54 +0200

Net Promoter Score of 10 received for Peptide Synthesis.

Additional Ratings: satisfaction with deliverable: 10, satisfaction with timeliness: 10.
2018-03-07 23:45:19 +0100

Net Promoter Score of 10 received for Peptide Synthesis.

Additional Ratings: satisfaction with deliverable: 10, satisfaction with timeliness: 10.
2017-11-09 17:18:04 +0100

Net Promoter Score of 10 received for N-Terminal Sequencing.

Additional Ratings: satisfaction with deliverable: 10, satisfaction with timeliness: 10.
2017-06-26 22:39:16 +0200

Net Promoter Score of 10 received for siRNA Synthesis.

Additional Ratings: satisfaction with deliverable: 8, satisfaction with timeliness: 10.
June 20, 2017

Positive review received for siRNA Synthesis:

"Quick turnaround and excellent communication"

2016-06-21 01:53:41 +0200

Net Promoter Score of 10 received for Peptide Synthesis.

March 7, 2016

Positive review received for Peptide Synthesis:

"Got it done ahead of schedule. Responsive to small post-order request."

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