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Bio-Mimetic Chromatography Ltd

1 Order Completed
Stevenage, GB

About Bio-Mimetic Chromatography Ltd

Bio-Mimetic Chromatography Ltd (BMC ) is a consultancy set up to provide advice, training and physchem measurements to clients. We hope to support drug discovery projects and spread the use of HPLC for biomimetic property measurements.

 

We offer HPLC based measurements of lipophilicity at 3 pHs, human serum albumin (HSA) and alpha-1-acidglycoprotein (AGP) binding, immobilized artificial membrane partition (IAM) measurements of drug discovery compounds. Based on the 6 measured data we estimate the compounds' in vivo distribution, such as volume of distribution, tissue binding, brain tissue binding, brain to plasma ratio, lung tissue binding, skin absorption. The models are based on the data of over hundred marketed drugs and fully validated and published. K. Valko Physicochemical and biomimetic properties in drug discovery - Chromatographic techniques for lead optimization. Wiley 2014.

Our Services (3)


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Process Consulting

Starting at £100.00 per hour

We provide consultation for setting up biomimetic HPLC measurements, such as chromatographic lipophilicity determination, phospholipid binding measurements using IAM chromatography, protein binding measurements using chiral albumin and alpha-1-acid glycoprotein HPLC columns.


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HPLC

High Performance Liquid Chromatography
Starting at £300.00 per sample

We offer HPLC based measurements of lipophilicity at 3 pHs, human serum albumin (HSA) and alpha-1-acidglycoprotein (AGP) binding, immobilized artificial membrane partition (IAM) measurements of drug discovery compounds. Based on the 6 measured data we estimate the compounds' in vivo distribution, such as volume of distribution, tissue binding, brain tissue binding, brain to plasma ratio, lung tissue binding, skin absorption. Price per compounds given below for full characterization of a compound and estimation of over 15 in vivo distribution based on published models. The price is negotiable when more than 30 compounds are requested. For full 96-well plate of compounds the price is reduced to £180.00/compound. No structural information is required, only 50 ul 10 mM DMSO solutions are requested.


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Hit to Lead and Lead Optimization

Price on request

With 22 years at GSK as a principal scientist and having supported over 25 neuroscience and respiratory programs; Klara is well placed to support you in the development of lead compounds. This coupled with her extensive experience and knowledge of bio-mimetic chromatography, Klara can help you select and improve the best candidates to achieve your aims.


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  • Positive review for HPLC:

    March 2020

    "Yes. Biomimetic (Klara) has proven to be an excellent partner in terms of expertise in the specific field of this study, efficiency (very quick response) and communication."

Bio-Mimetic Chromatography Ltd has not received any endorsements.