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Biacore Molecular Interaction Shared Resource (BMISR)

Washington District of Columbia

Georgetown University Medical Center, we provide customized Surface Plasmon Resonance (SPR) services with a Biacore T-200 and a Biacore 4000. The two Biacore machines in our facility utilize SPR technology to study biomolecular binding events on a chip surface. The basic principle involves immobilization of a ligand on a sensor chip followed by delivery of an analyte by a microfluidic system. Any protein, DNA, RNA, lipid, carbohydrate, polysaccharide, cell, virus, drug, drug like molecule (organic or inorganic) can be used as the ligand or analyte. Since the detection system is based on measuring total mass on the sensor chip surface neither ligand nor analyte has to be tagged. In addition to identifying binding partners to a target molecule, SPR also provides quantitative data on:

  • Specificity: How specific is the binding between two molecules?
  • Concentration: How much of a given molecule is present and... Show more »

Georgetown University Medical Center, we provide customized Surface Plasmon Resonance (SPR) services with a Biacore T-200 and a Biacore 4000. The two Biacore machines in our facility utilize SPR technology to study biomolecular binding events on a chip surface. The basic principle involves immobilization of a ligand on a sensor chip followed by delivery of an analyte by a microfluidic system. Any protein, DNA, RNA, lipid, carbohydrate, polysaccharide, cell, virus, drug, drug like molecule (organic or inorganic) can be used as the ligand or analyte. Since the detection system is based on measuring total mass on the sensor chip surface neither ligand nor analyte has to be tagged. In addition to identifying binding partners to a target molecule, SPR also provides quantitative data on:

  • Specificity: How specific is the binding between two molecules?
  • Concentration: How much of a given molecule is present and active?
  • Kinetics: What is the rate of association and dissociation?
  • Affinity: How strong is the binding?
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Biacore Molecular Interaction Shared Resource (BMISR) has not listed any services.

Surface Plasmon Resonance (SPR)
Price on request

The Biacore T-200 instrument can measure direct interactions between two molecules and calculate binding affinities and thermodynamic parameters of the interaction using Surface Plasmon Resonance (SPR). Biacore 4000 is optimized for higher throughput application where a small molecule library, fragment library or large collection... Show more »

The Biacore T-200 instrument can measure direct interactions between two molecules and calculate binding affinities and thermodynamic parameters of the interaction using Surface Plasmon Resonance (SPR). Biacore 4000 is optimized for higher throughput application where a small molecule library, fragment library or large collection of hybridoma clones can be screened for direct binding to target proteins.

User pays the cost of Biacore sensor chips and the following fees:
Academic: $50/h ($400/day max)
For-Profit: $100/h ($1,000/day max)

For large projects we can provide a customized quote to cover the entire study.

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Biacore T-200
Biacore 4000
Cell-Based Compound Screening
Price on request

The Biacore 4000 instrument can perform small molecule or fragment based screening studies to identify direct binders to target proteins. The instrument is also optimized for antibody screening and characterization. Biacore 4000 experiments are priced based on the number of targets, controls and the size of the library. Typical... Show more »

The Biacore 4000 instrument can perform small molecule or fragment based screening studies to identify direct binders to target proteins. The instrument is also optimized for antibody screening and characterization. Biacore 4000 experiments are priced based on the number of targets, controls and the size of the library. Typical small library screens (~1500 compounds) cost ~$4000 for academic institutions ($10,000 for others) .

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Biacore 4000
Antibody Screening
Price on request

The Biacore 4000 instrument is optimized for antibody screening and characterization.

The Biacore 4000 instrument is optimized for antibody screening and characterization.

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Biacore 4000
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2016-04-24 20:45:33 -0700

Net Promoter Score of 10 received for Surface Plasmon Resonance (SPR).

March 23, 2016

Positive review received for Surface Plasmon Resonance (SPR):

"Working with BMISR was a charm. Aykut was so patient while we prepared our samples! Communication was easy and very fast. Highly recommended! Albert Parisien Project Manager Technology Access Centre in Bio-Innovation La Cité Ottawa, Canada"

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