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Beryllium Discovery

Bedford, Massachusetts, US

Our mission is to provide best-in-class lead discovery solutions. Our proven teams of drug discovery professionals are passionate about unlocking the therapeutic potential of both genetically- and clinically-validated drug targets, and in developing new therapeutic modalities. We work in partnership with our clients to address the most difficult scientific and business challenges facing drug discovery, and to ultimately enable transformational health care outcomes.

Our integrated drug discovery services platform enables us to work across the entire pre-clinical research process. Our collaborations range from modular projects such as molecular engineering, biophysical screening, phenotypic screening or gene-to-structure as well as integrated drug-discovery programs where our partners utilize the full capability of the platform to develop drugs for challenging drug targets.

Our research team is diverse and deeply... Show more »

Our mission is to provide best-in-class lead discovery solutions. Our proven teams of drug discovery professionals are passionate about unlocking the therapeutic potential of both genetically- and clinically-validated drug targets, and in developing new therapeutic modalities. We work in partnership with our clients to address the most difficult scientific and business challenges facing drug discovery, and to ultimately enable transformational health care outcomes.

Our integrated drug discovery services platform enables us to work across the entire pre-clinical research process. Our collaborations range from modular projects such as molecular engineering, biophysical screening, phenotypic screening or gene-to-structure as well as integrated drug-discovery programs where our partners utilize the full capability of the platform to develop drugs for challenging drug targets.

Our research team is diverse and deeply experienced in all aspects of drug discovery. As such, we start the process by hand-picking an internal Beryllium team for every single project – and ensure that the team is populated with the appropriate knowledge and expertise to ensure the success of the project. Depending on the scale, disciplines involved and duration of the project being planned, the team may be small or large, but always built appropriately for success. Our track record speaks for itself in collaborations with academia, virtual start-ups and large biopharma.

Selected Publications

  • Gelinas AD, Davies DR, Janjic N. Embracing proteins: structural themes in aptamer-protein complexes. Current Opinion in Structural Biology 2016, 36: 122-132.
  • Gillespie JJ, Phan IQ, Scheib H, Subramanian S, Edwards TE, Lehman SS, Piitulainen H, Sayeedur Rahman M, Rennoll-Bankert KE, Staker BL, Taira S, Stacy R, Myler PJ, Azad AF, Pulliainen AT. Structural insight into how bacteria prevent interference between multiple divergent type IV secretion systems. MBio 2015, 8, e01867-15.
  • Klumpp K, Lam AM, Lukacs C, Vogel R, Ren S, Espirtu C, Baydo R, Atkins K, Abendroth J, Liao G, Efimov A, Hartman G, Flores OA. High-resolution crystal structure of a hepatitis B virus replication inhibitor bound to the viral core protein. PNAS, 2015, 112, 15196-15201.
  • Oliva Chavez AS, Fairman JW, Felsheim RF, Nelson CM, Herron MJ, Higgins L, Burkhardt NY, Oliver JD, Markowski TW, Kurtti TJ, Edwards TE, Munderloh UG. PLoS Pathogens, 2015, 11, e1005248.
  • Kryshtafovych A, Moult J, Basle A, Burgin A, Craig TK, Edwards RA, Fass D, Hartmann MD, Korycinski M, Lewis RJ, Lorimer D, Lupas AN, Newman J, Peat TS, Piepenbrink KH, Prahlad J, van Raaij MJ, Rower F, Segall AM, Seguritan V, Sundberg EJ, Singh AK, Wilson MA, Schwede T. Some of the most interesting CASP11 targets through the eyes of the authors. Proteins, 2015.
  • Jarvis TC, Davies DD, Hisaminato A, Resnicow DI, Gupta S, Waugh SM, Nagabukuro A, Wadatsu T, Hishigaki H, Gawande B, Zhang C, Wolk SK, Mayfield WS, Nakaishi Y, Burgin AB, Stewart LJ, Edwards TE, Gelinas AD, Schneider DJ, Janjic N. Non-helical DNA triplex forms a unique aptamer scaffold for high affinity recognition of nerve growth factor. Structure, 2015, 23, 1293-12304.
  • Phan IQ, Davies DR, Moretti NS, Shanmugam D, Cestari I, Anupama A, Fairman JW, Edwards TE, Stuart K, Schenkman S, Myler PJ. Iron superoxide dismutases in eukaryotic pathogens: new insights from Apicomplexa and Trypanosoma structures. Acta Cryst 2015 F71, 615-621.
  • Clifton MC, Bruhn JF, Atkins K, Webb TL, Baydo RO, Raymond A, Lorimer DD, Edwards TE, Myler PJ, Saphire EO. High-resolution crystal structure of dimeric VP40 from sudan ebolavirus. J Infect Dis. 2015, 212, S167-S171.
  • Buchko GW, Edwards TE, Hewitt SN, Phan IQ, Van Voorhis WC, Miller SI, Myler PJ. Backbone chemical shift assignments for the sensor domain of the Burkholderia pseudomallei histidine kinase RisS: “missing” resonances at the dimer interface. Biomol NMR Assign. 2015, 9, 381-385.
  • Moen SO, Fairman JW, Barnes SR, Sullivan A, Nakazawa-Hewitt S, Van Voorhis WC, Staker BL, Lorimer DD, Myler PJ, Edwards TE. Structures of prostaglandin F synthase form the protozoa Leishmania major and Trypanosoma cruzi with NADP. Acta Cryst 2015, F71, 609-614.
  • Serbzhinskiy DA, Clifton MC, Sankaran B, Staker BL, Edwards TE, Myler PJ. Structure of an ADP-ribosylation factor, ARF1, from Entamoeba histolytica bound to Mg2+-GDP. Acta Cryst, 2015, F71, 594-599.
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Beryllium Discovery has not listed any services.

Fragment Screening
Price on request

Efficiently sample target structure space

  • Smart pooled commercial and in-house libraries
  • High resolution NMR and X-ray crystallography platforms

Obtain small molecule start points for your drug discovery program

Beryllium has a strong track record doing fragment screens by NMR.

*Screening in-house... Show more »

Efficiently sample target structure space

  • Smart pooled commercial and in-house libraries
  • High resolution NMR and X-ray crystallography platforms

Obtain small molecule start points for your drug discovery program

Beryllium has a strong track record doing fragment screens by NMR.

Screening in-house collections

  • Fragments of Life (FOL™) (>1300 compounds)
  • Bionet Premium (>1000 compounds)
  • Maybridge (>1800 compounds)

Screening external libraries

  • client-provided
  • client-selected commercial libraries
  • custom commercial libraries

Additional services

  • protein-observe (HSQC) as one of our screening methodologies
  • NMR-based compound quality check
  • identity
  • purity
  • solubility
  • Fragment pooling
  • Randomized pooling + deconvolution
  • single screen; target-specific library
  • Design mixtures for optimal throughput
  • multiple screens; all-purpose diversity set
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NMR
Nuclear magnetic resonance spectroscopy
Price on request

Pharma-Grade Facilities and Expertise:

  • Low Sample Concentration Requirement
  • Rapid and Efficient Data Collection
  • High Field NMR Systems (700, 800) w/Cryoprobe

Unleash the power of our NMR facility for superior structural insights

700 MHz Bruker Avance III:

  • Bruker 700 MHz ultra-shielded magnet
  • 3-channel... Show more »

Pharma-Grade Facilities and Expertise:

  • Low Sample Concentration Requirement
  • Rapid and Efficient Data Collection
  • High Field NMR Systems (700, 800) w/Cryoprobe

Unleash the power of our NMR facility for superior structural insights

700 MHz Bruker Avance III:

  • Bruker 700 MHz ultra-shielded magnet
  • 3-channel console with z-axis gradients
  • High-sensitivity 1H/13C/15N-nuclei detection with HCN cryoprobe
  • High-throughput, temperature-controlled
  • SampleJet autosampler (5×96 samples)

500 MHz Varian Unity Inova

  • Oxford 500 MHz ultra-shielded magnet
  • 3-channel console with z-axis gradients
  • 1H/13C/15N-nuclei detection with HCN probe
  • 100 sample capacity (SMS autosampler)
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Molecular Profiling
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Assay Development
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Antibody-Antigen Interaction
Price on request

Unambiguously define your epitope-paratope interactions

  • Improve binding interactions using structural data
  • Obtain data imperative to strengthening patent applications

Accelerate the development of your antibody therapeutic programs

Antibody:Antigen Services

2-4 MOS

Unambiguously define your epitope-paratope interactions

  • Improve binding interactions using structural data
  • Obtain data imperative to strengthening patent applications

Accelerate the development of your antibody therapeutic programs

Antibody:Antigen Services

2-4 MOS

  • Antigen production and Fab generation
  • Formation of stable homogenous antibody:antigen complex
  • Antibody:Antigen complex crystallization
  • X-ray screening and dataset collection
  • Structure determination of Antibody:Antigen complex
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Stable Cell Line Generation
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Structure Determination
Price on request

NMR, X-Ray Crystallography

NMR, X-Ray Crystallography

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Protein Production
Price on request

We utilize our capacity to handle all projects- small and large. We deploy our extensive knowledge of target biology to overcome production challenges with even the most difficult targets. In addition to our experience, our project managers can custom design protocols for different types of protein targets, including specific gene... Show more »

We utilize our capacity to handle all projects- small and large. We deploy our extensive knowledge of target biology to overcome production challenges with even the most difficult targets. In addition to our experience, our project managers can custom design protocols for different types of protein targets, including specific gene families, membrane proteins, and difficult-to-fold proteins. We use a variety with innovative approaches, technologies and tools to enable proper expression, folding, purification, stability, and activity of challenging proteins and routinely achieve industry-leading levels of protein yield and purity needed for crystallization and other structural/functional biology applications.

Expression Modules:

  • E. coli – multiple strains for optimization, paste/periplasmic expression,15N labeling for NMR
  • Baculovirus – cytosolic and secreted expression, Sf9/Sf21/Tni
  • Mammalian – HEK293, CHO paste/secreted

Expression Capacity:

  • 32 L of E. coli
  • 4x10L wave bags for BV
  • 4×2.5L and 10L wave for HEK

Protein/Antibody Processing Capacity:

  • 11 AKTAs
  • 1 Protein Maker (multi-parallel chromatographic processing)
  • 3 Ultracentrifuges
  • 3 Tangential Flow Systems
  • 4 HPLCs
  • Much more
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Project Management
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Clinical Research
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Clinical Laboratory Services
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Clinical Molecular Diagnostics
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Biology
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Cells and Tissues
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Cell and Tissue Culture
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Biochemistry & Molecular Biology
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Protein Services
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Antibody Services
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Imaging & Spectroscopy
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Spectroscopy
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Chemistry and Materials
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Analytical Chemistry Services
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Drug Discovery & Development
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Drug Discovery
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Hit Identification
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