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INOTIV

17 Orders Completed
West Lafayette, Indiana, US

About INOTIV

Founded: 1974 Type: Public Company Size: 201-500 employees

Analyze. Answer. Advance


Answering the right questions on time and with high-quality data is the key to achieving your objectives. At Inotiv, clinical decision support is our focus: We deliver the comprehensive and integrated range of right-size toxicology services, analysis, bioanalysis, and DMPK and consulting solutions essential to your success.


In choosing a laboratory partner, Expect more: more attention, more insight, and a superlative experience. You’ve worked hard to get this far, and you deserve a provider aligned to your needs and goals.


Through scientific leadership and ongoing investments, Inotiv delivers a comprehensive range of nonclinical and analytical services that will exceed your expectations. Benefit from our long and impeccable regulatory history, world-class team of scientists, and track record of providing attentive, decisive service.

Our Services (76)


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Toxicology

Price on request

Studies: Pilot/lead optimization, Acute, Sub-chronic, Chronic
Species: Rodents, Canines, Nonhuman Primates, Swine/Minipigs, Rabbits, Guinea pigs
Routes of Administration: Oral (Gavage, Capsule/tablet), Parenteral (Intramuscular, Intraperitoneal, Intravenous, Subcutaneous, Sublingual, Dermal, Intradermal, Ocular, Intravaginal, Rectal, Intranasal)


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In vivo PK/PD Studies

Price on request
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In vitro Bioavailability/Bioequivalence Studies

Price on request

Inotiv has proven experience and expertise with the FDA guidance documents and regulations on In Vitro Bioequivalence studies. The group's pharmaceutical product testing expertise mixed with the corporation's knowledge of bioequivalence studies and regulations creates the perfect match for our In Vitro services. BASi leverages the FDA guidances and all applicable literature sources to develop a sound scientific, regulatory plan.


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Humanized Mouse Models

Price on request

We have more than 4 years of experience developing and validating pharmacology studies in these models and have successfully executed multiple client sponsored studies. These models have been validated for hepatotropic disease, especially hepatitis. Please contact us to discuss additional applications in liver disease.

Gene Delivery/Gene therapy: We have demonstrated this model’s utility for evaluating gene therapy and gene delivery technology, evaluating expression using in vivo imaging.


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DART Studies

Developmental and Reproductive Toxicology Studies
Price on request
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Rat Mouse Non-human primates (NHP) Dog Pig Minipig Rabbit Guinea pig Show 8 more tags Show less

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Histology and Pathology Services

Price on request

Inotiv pathologists are ACVP board certified and our service is fully GLP compliant. Services Include:

  • GLP Compliant processes, data and reporting systems
  • Rapid and flexible scheduling, fast turnaround times
  • Broad therapeutic expertise
  • Primary review, Peer Review or both for all study types
  • Necropsy participation
  • Reporting

Histology Lab Services:

  • GLP-compliant
  • Robust QC and QA staffing
  • Routine tissue trimming, paraffin embedding, and sectioning
  • H&E staining
  • Non-routine dissections and tissue harvesting
  • Customized trimming and sampling
  • Medical device support
  • Serial sectioning and serial step sectioning
    Special Histology and Pathology Services
  • Frozen sections including serial and step sectioning
  • Plastic embedding and sectioning
  • Immunohistochemistry and immunofluorescence
  • Image analysis (multiple platforms)
  • Stereology (multiple platforms)
  • Electron microscopy

Drug Discovery immunohistochemistry FFPE tissue Frozen Tissue Mouse Rat Rabbit Dog Pig Show 9 more tags Show less

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Hepatitis B Virus (HBV)-Infected Human Serum

Price on request
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LC-MS

Liquid Chromatography-Coupled Mass Spectrometry
Price on request
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Hepatitis B Virus (HBV)-Infected Human Plasma

Price on request
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Assay Development

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Animal Necropsy Services

Price on request
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Rat Mouse Rabbit Pig Dog

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Small Molecule Bioanalysis

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Microscopy

Price on request

Our laboratory provides industry-recognized expertise in quantitative microscopy. Consultation and design-based techniques coupled with broad histochemical/immunohistochemical capabilities and knowledge of various disease states create the best possible quantitative evaluations.
Image Analysis:

  • Computer assisted, high throughput capability
  • Multiple image analysis platforms are used, including Visiomorph™ and Halo™
    Stereology:
  • Unbiased, design-based, using statistically proven principals
  • Multiple stereology platforms are used, including NewCast™
    Examples include:
  • Muscle fiber cross-sectional area and Feret’s diameter
  • Co-expression of markers; double-stain positivity in the cytoplasm or nucleus
  • Area and area ratios; volume and volume ratios (e.g. volume of infarcted tissue, collagen, or mucus in an organ)
  • Membrane marker quantitation
  • Immune cells in tumors
  • Object quantitation (e.g. microvessels, amyloid plaque, glomeruli, islets)
  • Number of cells in a structure or organ
  • Microglial activation
  • Layer thickness
  • Proliferation assays
    Reporting:
  • Interpretive reports with illustrative images are prepared by Inotiv Pathologists

Visiopharm NewCast™ HALO™

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Dermal Toxicity Studies

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Rat Mouse Guinea pig Pig Minipig Dog Rabbit Non-human primates (NHP) Show 8 more tags Show less

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Liquid Chromatography (LC)

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Immunofluorescence

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Pharmacology & Toxicology

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Immunohistochemistry (IHC)

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Storage

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Image Analysis

Price on request
  • Computer assisted, high throughput capability
  • Multiple image analysis platforms are used, including Visiomorph™ and Halo™

Visiopharm HALO™

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Drug Discovery & Development

Price on request
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Animal Surgery

Price on request

FDA-GLP Compliant & Non-GLP Experimental Surgery

  • Minimally Invasive Surgery
  • Electrosurgery
  • GLP & Non-GLP Surgery Models
  • Anesthesia Services
  • Surgeon Training Facilities


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Stereology

Price on request
  • Unbiased, design-based, using statistically proven principals
  • Multiple stereology platforms are used, including NewCast™

NewCast™

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R&D Services

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Medical Imaging Services

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In vivo Toxicity Testing

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In vivo Skin Irritation/Sensitization Testing

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Mouse Rat

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Biochemistry & Molecular Biology

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Preclinical Study Design

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Clinical Laboratory Services

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Animal Model in vivo Analyses

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Small Animal Toxicology Studies

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Rat Mouse Rabbit

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HPLC

High Performance Liquid Chromatography
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Imaging & Spectroscopy

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Dose Range Finding (DRF) Studies

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Drug Discovery

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Discovery Pathology

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Maximum Tolerated Dose (MTD) Studies

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Contract Research

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Project Management

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Osteoarthritis Animal Models

Price on request
  • Dogs and rabbits.
  • Surgically, immunologically or pharmacologically induced.
  • Intra-articular, oral or IV dosing – single, multiple, chronic.
  • Biomarkers – blood, urine, synovial fluid.
  • Orthopedic research diagnostic capabilities that include Kistler force plate data collection and gait analysis.
  • MRI scans and image analysis.
  • Gross and histopathology scoring and evaluation.

Dog Rabbit

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Consulting

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Process Consulting

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Clinical Sample Analysis

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Biology

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Toxicity Animal Models

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Rat Mouse Rabbit Guinea pig Pig Minipig Dog Non-human primates (NHP) Show 8 more tags Show less

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Clinical and Anatomic Pathology

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Biomarker Discovery

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Cells and Tissues

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Biological Testing

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Bioanalytical Assays

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Protein Services

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Bioanalytical Analysis LC/MS/MS

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Bone/Cartilage Animal Models

Price on request

Bone/Cartilage Animal Models Services


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Immunostaining

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Analytical Method Validation

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Animal Models and Studies

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Data Services

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Animal Physiology Analyses

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Animal Physiology Analyses Services


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Mass Spectrometry

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Protein Expression Visualization

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In vitro ADME/DMPK Studies

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Bioanalysis

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Animal Models of Disease

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Chromatography

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Computational Modeling

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Human Plasma and Serum

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Human Plasma and Serum Services


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Biospecimens

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Human Biofluids

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Human Biofluids Services


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Liquid Chromatography Coupled Mass Spectrometry Methods

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Human Biospecimens

Price on request

Human Biospecimens Services


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ADME/DMPK Studies

Drug Metabolism and Pharmacokinetics
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Safety Pharmacology

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Animal Hemodynamics

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Histopathological Examination

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Pharmacology

Price on request

Pharmacology Services


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  • Positive review for Osteoarthritis Animal Models:

    July 2019

    "Excellent study oversight, study implementation, data management, attention to detail, attention to animal welfare, responsiveness to sponsor inquiries, study documentation, and study reporting,"

INOTIV has not received any endorsements.