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Axolabs GmbH

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About Axolabs GmbH

Axolabs is located in Kulmbach, Germany. The company is a limited liability corporation (GmbH) wholly owned by LGC.

OUR CLIENTS

The majority of research groups in the field of nucleic acid and oligonucleotide-based therapeutics worldwide belongs to our clients, including >10 Big Pharma enterprises,... Show more »

Axolabs is located in Kulmbach, Germany. The company is a limited liability corporation (GmbH) wholly owned by LGC.

OUR CLIENTS

The majority of research groups in the field of nucleic acid and oligonucleotide-based therapeutics worldwide belongs to our clients, including >10 Big Pharma enterprises, >80 Biotech companies, >30 academic research institutes and Venture Capital firms. Moreover, we have collaborations with academic partners relating to own publically funded research projects.

OUR HISTORY

Historically, the company was started under the name of Ribopharma AG in 2000 as the first company in the world to focus on RNAi therapeutics. In 2003 Ribopharma AG merged with Alnylam Pharmaceuticals Inc. to create the leading RNAi therapeutics company. In 2007 – in frame of a spin-off from Alnylam Europe AG – Roche Kulmbach GmbH was established as Roche's Center of Excellence for RNA Therapeutics and focused on the discovery of novel therapeutics based on oligonucleotides. In November 2011 the management bought out the assets from Roche Kulmbach GmbH and established Axolabs GmbH. In March 2017 Axolabs GmbH was acquired by LGC.

COMPANY

Axolabs is a custom research organization providing high-end preclincal solutions and consultancy in the field of oligonucleotide therapeutics and nucleic acid medicines.
Built on the former Roche Kulmbach RNA Therapeutics unit our expert team has 17+ years of experience in the field of oligonucleotide therapeutics and has access to an excellent infrastructure.

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Our Services (14)


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Synthetic Building Blocks and Intermediates

Price on request

Custom amidites and solid supports for oligonucleotide synthesis (at LGC)

Custom amidites and solid supports for oligonucleotide synthesis (at LGC)

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Medicinal Chemistry

Price on request

Pre-clinical services in the field of oligonucleotide therapeutics and other nucleic acid medicines

Pre-clinical services in the field of oligonucleotide therapeutics and other nucleic acid medicines

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Oligonucleotide Synthesis

Price on request

• High-quality oligonucleotide synthesis – from discovery to pre-clinical and GMP (at LGC Biosearch)
• Custom-tailored process optimisation
• Long RNA/DNA, e.g. for CRISPR/Cas applications
• Chemically modified oligonucleotides and conjugates
• Potency and stability improvement
• Regulatory documentation
• Impurity markers and reference standards
• Lipid synthesis

• High-quality oligonucleotide synthesis – from discovery to pre-clinical and GMP (at LGC Biosearch)
• Custom-tailored process optimisation
• Long RNA/DNA, e.g. for CRISPR/Cas applications
• Chemically modified oligonucleotides and conjugates
• Potency and stability improvement
• Regulatory documentation
• Impurity markers and reference standards
• Lipid synthesis

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RNA Synthesis

Price on request

• High-quality oligonucleotide synthesis – from discovery to pre-clinical and GMP (at LGC Biosearch)
• Custom-tailored process optimisation
• Long RNA/DNA, e.g. for CRISPR/Cas applications
• Chemically modified oligonucleotides and conjugates
• Potency and stability improvement
• Regulatory documentation
• Impurity markers and reference standards

• High-quality oligonucleotide synthesis – from discovery to pre-clinical and GMP (at LGC Biosearch)
• Custom-tailored process optimisation
• Long RNA/DNA, e.g. for CRISPR/Cas applications
• Chemically modified oligonucleotides and conjugates
• Potency and stability improvement
• Regulatory documentation
• Impurity markers and reference standards

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Biochemistry & Molecular Biology

Price on request

Biological and pharmacological tests and analyses of oligonucleotide therapeutics
• Safety analyses
• Cell-based assays for cell function, proliferation and toxicity
• Ligand-receptor interaction and uptake studies/histology
• Flow cytometry
• Protein analysis (at LGC)
• Analysis of mRNA up- and downregulation

Platform... Show more »

Biological and pharmacological tests and analyses of oligonucleotide therapeutics
• Safety analyses
• Cell-based assays for cell function, proliferation and toxicity
• Ligand-receptor interaction and uptake studies/histology
• Flow cytometry
• Protein analysis (at LGC)
• Analysis of mRNA up- and downregulation

Platform for functional cell type-specific delivery of oligonucleotides and mRNAs
• In vitro functional analysis and in vivo models
• Rational design tailored for specific delivery systems
• Proprietary lipid nanoparticle formulations

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Drug Discovery & Development

Price on request

Oligonucleotide lead identification
• Bioinformatics assessment for sequence pre-selection
• Drug design and synthesis
• High-throughput in vitro screening
• Lead characterisation and optimisation
• In vivo efficacy and early safety assessment

Oligonucleotide lead identification
• Bioinformatics assessment for sequence pre-selection
• Drug design and synthesis
• High-throughput in vitro screening
• Lead characterisation and optimisation
• In vivo efficacy and early safety assessment

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RNA Services

Price on request

• High-quality oligonucleotide synthesis – from discovery to pre-clinical and GMP (at LGC Biosearch)
• Custom-tailored process optimisation
• Long RNA/DNA, e.g. for CRISPR/Cas applications
• Chemically modified oligonucleotides and conjugates
• Potency and stability improvement
• Regulatory documentation
• Impurity markers and reference standards

• High-quality oligonucleotide synthesis – from discovery to pre-clinical and GMP (at LGC Biosearch)
• Custom-tailored process optimisation
• Long RNA/DNA, e.g. for CRISPR/Cas applications
• Chemically modified oligonucleotides and conjugates
• Potency and stability improvement
• Regulatory documentation
• Impurity markers and reference standards

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Nucleic Acid Services

Price on request

Manufacturing
• High-quality oligonucleotide synthesis – from discovery to pre-clinical and GMP (at LGC Biosearch)
• Custom-tailored process optimisation
• Long RNA/DNA, e.g. for CRISPR/Cas applications
• Chemically modified oligonucleotides and conjugates
• Custom amidites and solid supports
• Potency and stability... Show more »

Manufacturing
• High-quality oligonucleotide synthesis – from discovery to pre-clinical and GMP (at LGC Biosearch)
• Custom-tailored process optimisation
• Long RNA/DNA, e.g. for CRISPR/Cas applications
• Chemically modified oligonucleotides and conjugates
• Custom amidites and solid supports
• Potency and stability improvement
• Regulatory documentation
• Impurity markers and reference standards
• Lipid synthesis

Oligonucleotide and nucleic acid analytics
• Physicochemical and thermodynamic characterisation
• Stability determination in biological matrices
• Identification of metabolites by LC/MS
• mRNA identity
• Characterisation of nucleosides and nucleotides
• Analysis of nucleic acid-protein interactions

Bioanalytical services
• Detection of oligonucleotides from biological matrices
• Quantitative detection of mRNA therapeutics from biological matrices
• GLP-certified test site (also qualified for GCP)
• Small and large molecules (at LGC)
• Biomarkers (at LGC)

Biological and pharmacological tests and analyses
• Safety analyses
• Cell-based assays for cell function, proliferation and toxicity
• Ligand-receptor interaction and uptake studies/histology
• Flow cytometry
• Protein analysis (at LGC)
• Analysis of mRNA up- and downregulation

Platform for functional cell type-specific delivery of oligonucleotides and mRNAs
• In vitro functional analysis and in vivo models
• Rational design tailored for specific delivery systems
• Proprietary lipid nanoparticle formulations

CMC analytical services (at LGC)
• GMP compliant (FDA inspected)
• Broad analytical capabilities
• Materials science

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siRNA Synthesis

Price on request

High-quality oligonucleotide synthesis – from discovery to pre-clinical and GMP (at LGC Biosearch)
• Custom-tailored process optimisation
• Chemically modified oligonucleotides and conjugates
• Potency and stability improvement
• Regulatory documentation
• Impurity markers and reference standards

High-quality oligonucleotide synthesis – from discovery to pre-clinical and GMP (at LGC Biosearch)
• Custom-tailored process optimisation
• Chemically modified oligonucleotides and conjugates
• Potency and stability improvement
• Regulatory documentation
• Impurity markers and reference standards

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DNA Services

Price on request

High-quality oligonucleotide synthesis – from discovery to pre-clinical and GMP (at LGC Biosearch)
• Custom-tailored process optimisation
• Long RNA/DNA, e.g. for CRISPR/Cas applications
• Chemically modified oligonucleotides and conjugates
• Potency and stability improvement
• Regulatory documentation
• Impurity markers and reference standards

High-quality oligonucleotide synthesis – from discovery to pre-clinical and GMP (at LGC Biosearch)
• Custom-tailored process optimisation
• Long RNA/DNA, e.g. for CRISPR/Cas applications
• Chemically modified oligonucleotides and conjugates
• Potency and stability improvement
• Regulatory documentation
• Impurity markers and reference standards

Show less

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Synthetic Chemistry

Price on request

Platform for functional cell type-specific delivery of oligonucleotides and mRNAs
• Rational design tailored for specific delivery systems
• Proprietary lipid nanoparticle formulations

Platform for functional cell type-specific delivery of oligonucleotides and mRNAs
• Rational design tailored for specific delivery systems
• Proprietary lipid nanoparticle formulations

Show less

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Bioinformatics

Price on request

Bioinformatics assessment for sequence pre-selection of oligonucleotide therapeutics

Bioinformatics assessment for sequence pre-selection of oligonucleotide therapeutics

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DNA Synthesis and Probe Development

Price on request

• High-quality oligonucleotide synthesis – from discovery to pre-clinical and GMP (at LGC Biosearch)
• Custom-tailored process optimisation
• Long RNA/DNA, e.g. for CRISPR/Cas applications
• Chemically modified oligonucleotides and conjugates
• Potency and stability improvement
• Regulatory documentation
• Impurity markers and reference standards

• High-quality oligonucleotide synthesis – from discovery to pre-clinical and GMP (at LGC Biosearch)
• Custom-tailored process optimisation
• Long RNA/DNA, e.g. for CRISPR/Cas applications
• Chemically modified oligonucleotides and conjugates
• Potency and stability improvement
• Regulatory documentation
• Impurity markers and reference standards

Show less

ic

Biology

Price on request

Biological and pharmacological tests and analyses of oligonucleotide therapeutics
• Safety analyses
• Cell-based assays for cell function, proliferation and toxicity
• Ligand-receptor interaction and uptake studies/histology
• Flow cytometry
• Protein analysis (at LGC)
• Analysis of mRNA up- and downregulation

Platform... Show more »

Biological and pharmacological tests and analyses of oligonucleotide therapeutics
• Safety analyses
• Cell-based assays for cell function, proliferation and toxicity
• Ligand-receptor interaction and uptake studies/histology
• Flow cytometry
• Protein analysis (at LGC)
• Analysis of mRNA up- and downregulation

Platform for functional cell type-specific delivery of oligonucleotides and mRNAs
• In vitro functional analysis and in vivo models
• Rational design tailored for specific delivery systems
• Proprietary lipid nanoparticle formulations

Show less

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Roland Kreutzer

Managing Director

Axolabs GmbH has not received any reviews.

Axolabs GmbH has not received any endorsements.