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Averica Discovery Services

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Marlborough, Massachusetts, US

About Averica Discovery Services

Averica Discovery is an analytical development CRO, offering chromatography based custom services. Our expert chromatographers develop methods for the purification and analysis of small molecules to support drug discovery and development teams.

Our custom services involve the development and optimization... Show more »

Averica Discovery is an analytical development CRO, offering chromatography based custom services. Our expert chromatographers develop methods for the purification and analysis of small molecules to support drug discovery and development teams.

Our custom services involve the development and optimization of a chromatographic method specific to the project purpose. Services Include: chiral separation, achiral separation, small molecule purification, impurity isolation and identification, method development and validation, and custom assay development.

MEDICINAL CHEMISTRY SERVICES: Drug Target Assays, Drug Discovery Support Services, Compound Purification, Impurity Separation, Impurity Isolation, Impurity Identification, Medicinal Chemistry

ANALYTICAL LABORATORY SERVICES: Chromatography Separation, Chromatography Services, Chiral Resolution, Chiral Chromatography, Impurity Profiling, Discovery Analytical Services, Drug Preformulation Characterization Studies, Analytical Methods Development

NOTE: Averica is not an analytical testing lab, and doesn't not use chromatography systems for testing. Averica cannot handle any type of biologic fluid or material, such as serum or urine.

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Certifications & Qualifications

DEA Schedule I DEA Schedule II DEA Schedule III DEA Schedule IV DEA Schedule V

Diversity Certificates

Small business

Our Services (47)


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ICH Stability Testing

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Chiral Chromatography

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Preparative chromatography is a great solution for a source of purified enantiomer supply of small molecule chiral compounds, during the early and intermediate state of lead drug candidate profiling. We create method that are fast and easy to scale-up, giving you the ability to receive more material as needs change from... Show more »

Preparative chromatography is a great solution for a source of purified enantiomer supply of small molecule chiral compounds, during the early and intermediate state of lead drug candidate profiling. We create method that are fast and easy to scale-up, giving you the ability to receive more material as needs change from milligrams to kilograms.

Preparative chromatography also offers a reliable and cost-effective purification solution. Whether polishing a batch of compound to achieve a hard-to-meet purity standard, producing reference standard material, removing a problematic impurity, or isolating an unknown degradant; we apply the same highly efficient preparative SFC and HPLC technology to solve the problem.

APPLICATIONS
-Purified supply material for mechanistic studies, differential activity, structural biology, in vivo toxicology, or advanced profiling
-Purification of water sensitive, unstable, or difficult to purify compounds
-Purification of compounds with multiple chiral centers
-Targeted purification of a desired enantiomer or isomer.
-“Polishing” compounds to achieve needed enantiomeric excess (ee)

INSTRUMENTATION
Analytical HPLC, Analytical SFC, Analytical Reverse Phase HPLC, Preparative HPLC, Preparative SFC, Preparative Reverse Phase HPLC, Supercritical Fluid Chromatography (SFC), UPC2, UPLC, GC/MS, ELSD, Mass Spec (MS), Accurate Mass MS, CAD Detection, PDA/UV, NMR

AVERICA ADVANTAGE
-Fastest turnaround & highest recovery
-Turnaround in DAYS, not weeks or months - even at larger scale
-DEA Schedule I-V compounds
-Success-oriented and highly responsive team with many years of pharmaceutical experience

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Waters NanoAcuity UPLC Analytical SFC Analytical HPLC UPC2 ELSD CAD Detector PDA/UV Accurate Mass MS Waters UPLC Chiral Chromatography Chiral Purification Chiral Purity Chiral Release Method Chiral Resolution Chiral Separation Chiral Method Development Preparative Scale Separations Preparative Chromatography Enantiomer Separation Large Scale Chromatography Preparative SFC SFC UPLC Mass Spectrometry Reverse Phase HPLC Show 25 more tags Show less

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Impurity Analysis

Price on request

Small molecule impurity isolation and identification offers you critical information on the structure of your impurity.

Preparative Scale Impurity Isolation Applications:
- Structure Elucidation
- Reference Standards
- Toxicology Studies

Averica’s process uses a broad suite of analytical and preparative instrumentation to... Show more »

Small molecule impurity isolation and identification offers you critical information on the structure of your impurity.

Preparative Scale Impurity Isolation Applications:
- Structure Elucidation
- Reference Standards
- Toxicology Studies

Averica’s process uses a broad suite of analytical and preparative instrumentation to rapidly develop a unique isolation strategy for each impurity. Our aim of giving you enough material to get a definitive structure, while creating a scalable method that can deliver material for reference standards or toxicology studies.

INSTRUMENTATION
Analytical HPLC, Analytical SFC, Analytical Reverse Phase HPLC, Preparative HPLC, Preparative SFC, Preparative Reverse Phase HPLC, Supercritical Fluid Chromatography (SFC), UPC2, UPLC, GC/MS, ELSD, Mass Spec (MS), Accurate Mass MS, CAD Detection, PDA/UV, NMR

AVERICA ADVANTAGE
-Trace component isolation 0.01% of bulk
-Batch scale chromatography to 1 kg
-Degradation kinetic studies — Understand Formation, Purge and Fate
-Drug substance or drug product — Solid, liquid, and semi-solid dosage forms
-Impurity method development and optimization
-Fast timelines, as short a week!

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Analytical SFC Analytical HPLC UPC2 ELSD CAD Detector PDA/UV Accurate Mass MS Solubility Studies Impurity Profiling Physical Properties Assay Structure Elucidation Stress Degradation Impurity Analysis Impurity Determination Impurity Identification Impurity Characterization Process Impurity Trace Impurity Impurity Control Reference Standard GC-MS HPLC NMR Preparative HPLC Preparative SFC SFC UPLC Impurity Isolation Mass Spectrometry Reverse Phase HPLC Show 30 more tags Show less

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Analytical Method Development

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Averica offers rugged and robust analytical method development, method qualification, and method validation services specific to your small molecule drug development needs. Our approach considers the requirements of your compound together with the requirements of your method. With a properly developed method – fit to the... Show more »

Averica offers rugged and robust analytical method development, method qualification, and method validation services specific to your small molecule drug development needs. Our approach considers the requirements of your compound together with the requirements of your method. With a properly developed method – fit to the compound and fit for purpose – your decision making will be easier, and your timeline will be shorter.

METHOD DEVELOPMENT SERVICES:
• Purity, potency (assay), and quantify impurities
• Stability indicating methods
• Chiral purity and chiral release testing
• ICH Q11 support, e.g. for qualification of regulated starting materials (RSMs)
• Molecules with unique complexity or physical properties
• Robust methods for fast method transfer

METHOD DEVELOPMENT ATTRIBUTES
System Suitability, Evaluation of Limit of Detection (LOD) & Limit of Quantitation (LOQ), Linearity, Accuracy, Sample Stability, Standard Stability, Evaluation of Range, Mass Balance, Physical properties assays, EPSA – Intramolecular Hydrogen Bonding

INSTRUMENTATION
Analytical HPLC, Analytical SFC, Analytical Reverse Phase HPLC, Preparative HPLC, Preparative SFC, Preparative Reverse Phase HPLC, Supercritical Fluid Chromatography (SFC), UPC2, UPLC, GC/MS, ELSD, Mass Spec (MS), Accurate Mass MS, CAD Detection, PDA/UV, NMR

AVERICA ADVANTAGE
-Emphasis on making sure that a chromatographic method meets your needs, and serves you development effort
-Depth of experience with method development makes us uniquely suited to tough compounds and projects
-Custom assay design and physical properties testing
-Small scale assay development for when material is limited

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Waters NanoAcuity UPLC Analytical SFC Analytical HPLC UPC2 ELSD CAD Detector Accurate Mass MS Waters UPLC Solubility Studies Impurity Analysis Chiral Purity Chiral Release Method GC-MS HPLC NMR Preparative HPLC Preparative SFC SFC UPLC Potency Assay Purity Assay Forced Degradation Mass Balance Linerity Qualification of Regulated Starting Materials (RSM) Mass Spectrometry Reverse Phase HPLC Show 27 more tags Show less

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Engineering and Fabrication

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Thermal Analysis Services

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Project Management

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Physical Analysis Methods

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Synthetic Chemistry

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Assay Development

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X-Ray Powder Diffraction

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Spectrophotometry

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UV-VIS Spectroscopy

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Thermogravimetric Analysis (TGA)

Thermogravimetric Analysis
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R&D Services

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Process and Scale-Up Chemistry

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Contract Services Directory

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Drug Preformulation

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Medicinal Chemistry

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Mass Spectrometry

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Hit to Lead and Lead Optimization

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HPLC

High Performance Liquid Chromatography
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Forced Degradation Studies

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Drug Discovery

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Solubility and Dissolution Testing

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Contract Research

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Chemistry, Manufacturing and Controls (CMC)

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Gas Chromatography (GC)

Gas Chromatography
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Medicinal Chemistry

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Analytical Validation

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Separation/Purification Services

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Accelerated Stability Testing

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Imaging & Spectroscopy

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Chiral Resolution

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Chromatography

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Product Testing Services

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Product Testing Services

Product Testing Services

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Strength Analysis

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Chemistry and Materials

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Lead Identification and Validation

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Formulation Services

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Drug Discovery & Development

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Product Development, Testing, and Packaging

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Analytical Chemistry Services

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Spectroscopy

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Liquid Chromatography (LC)

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Material Testing Services

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Process Consulting

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