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Avastus Preclinical Services

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Cambridge, Massachusetts, US

About Avastus Preclinical Services

Avastus Preclinical Services is a Cambridge-based preclinical research service provider that offers an all encompassing approach to pharmacological industry. Avastus provides services for multiple therapeutic areas as well as drug evaluation, making us a cost effective solution to both large and small... Show more »

Avastus Preclinical Services is a Cambridge-based preclinical research service provider that offers an all encompassing approach to pharmacological industry. Avastus provides services for multiple therapeutic areas as well as drug evaluation, making us a cost effective solution to both large and small pharmaceutical or biotechnology companies. As a partner we provide assistance with protocol development, in vivo, in vitro preclinical studies, veterinarian care, and regulatory compliance services. Our Vivarium Services team provides the full complement of care services ranging from husbandry staffing and sanitization to offering research space that includes animal facility rooms with static and ventilated caging and laboratory procedure space.

Avastus Preclinical Services provides OLAW-certified laboratory vivarium space and procedure rooms to our clients in the biotech and pharmaceutical industries. Our comprehensive approach to animal welfare is a key aspect of our business. We work closely with each client, offering flexible rental agreements that allow our clients to adjust coverage to meet workflow needs while significantly reducing their administrative costs.

The Avastus animal husbandry and facility management programs offer full oversight of all vivarium operations at our client’s worksites including: animal husbandry, program development, staff oversight, inventory management, training, project coordination, and conduct/ host audits and inspections. The Avastus management team has worked with more than 30 companies in the New England area and have achieved AAALAC accreditations for many of our clients.

The Avastus regulatory Compliance team holds extensive knowledge in the preclinical field. The services that we offer are: protocol design, IACUC representation (multiple levels), protocol reviews, compliance monitoring, investigator training, grant submittals and more. We are also capable of providing a board certified D.V.M. to conduct veterinary reviews and oversight.

Avastus offers support through all stages of research including in vitro assay development, proof of concept and drug efficacy in many animal models of human disease. Our experienced staff can assist clients in the appropriate selection of animal disease models, study design, and bioanalytical assays to best fit the study requirements.

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Our Services (42)


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ADME/DMPK Studies

Drug Metabolism and Pharmacokinetics
Price on request
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In vitro Drug Efficacy Testing

Price on request
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Patient-Derived Xenograft (PDX)

Price on request
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Orthotopic Tumor Animal Models

Price on request
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Syngeneic (Allograft) Tumor Models

Price on request
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Xenograft Models

Price on request
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Surgical Animal Models

Price on request
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Rodent Breeding

Price on request
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In vitro Antibiotic Testing

Price on request
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Rheumatoid Arthritis Animal Models

Price on request
  • LPS Induced Cytokine Production (In Vivo, In Vitro)
  • Adjuvant induced arthritis (AIA)
  • Experimental autoimmune encephalomyelitis (EAE)
  • Delayed-type hypersensitivity (DTH)
  • Collagen-induced arthritis (CIA)
  • Collagen antibody-induced arthritis model(CAIA)
  • Type III hypersensitivity, Reverse passive Arthus reaction
  • Mouse Colitis model chart
  • LPS Induced Cytokine Production (In Vivo, In Vitro)
  • Adjuvant induced arthritis (AIA)
  • Experimental autoimmune encephalomyelitis (EAE)
  • Delayed-type hypersensitivity (DTH)
  • Collagen-induced arthritis (CIA)
  • Collagen antibody-induced arthritis model(CAIA)
  • Type III hypersensitivity, Reverse passive Arthus reaction
  • Mouse Colitis model chart
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In vivo Drug Efficacy Testing

Price on request

Cancer Efficacy Models

  • Disseminated Mouse and Rat Models
  • Orthotopic Mouse and Rat Models
  • Mouse Subcutaneous Xenograft Models
  • Allograft Mouse and Rat Models
  • Hollow Fiber Models
  • Mammary Fat Pad Models
  • Patient-derived Xenograft (Ovarian, Breast, Mesothelioma)

Cancer Efficacy Models

  • Disseminated Mouse and Rat Models
  • Orthotopic Mouse and Rat Models
  • Mouse Subcutaneous Xenograft Models
  • Allograft Mouse and Rat Models
  • Hollow Fiber Models
  • Mammary Fat Pad Models
  • Patient-derived Xenograft (Ovarian, Breast, Mesothelioma)
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Infectious Disease Animal Models

Price on request
  • Mouse Protection Test
  • Mouse subcutaneous abscess model
  • Rodent Pulmonary models – rat, mouse
  • Rodent kidney infection model
  • Mouse skin infection model
  • Neutropenic models e.g. thigh infection
  • Endocarditis
  • Selected organ infection models – e.g. eye, kidney, skin
  • PK/PD determinations and modeling
  • Bacterial, yeast and fungal infection models
  • Mouse Protection Test
  • Mouse subcutaneous abscess model
  • Rodent Pulmonary models – rat, mouse
  • Rodent kidney infection model
  • Mouse skin infection model
  • Neutropenic models e.g. thigh infection
  • Endocarditis
  • Selected organ infection models – e.g. eye, kidney, skin
  • PK/PD determinations and modeling
  • Bacterial, yeast and fungal infection models
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In vivo Skin Irritation/Sensitization Testing

Price on request
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Diabetes Animal Models

Price on request
  • Diet induced obesity (DIO) Mouse and Rat
  • Hyperlipidemia Hamster, rat, mouse models
  • STZ (streptozotocin) induced diabetic model
  • 5/6 Nephrectomy Rat Model
  • Zucker Fatty Model
  • db/db, ob/ob, db/ob Mouse models -In Vivo Assays for Glucose Metabolism
  • Resting Glucose levels
  • Glucose Tolerance Test (GTT)
  • Cytokine Analysis
  • Diet induced obesity (DIO) Mouse and Rat
  • Hyperlipidemia Hamster, rat, mouse models
  • STZ (streptozotocin) induced diabetic model
  • 5/6 Nephrectomy Rat Model
  • Zucker Fatty Model
  • db/db, ob/ob, db/ob Mouse models -In Vivo Assays for Glucose Metabolism
  • Resting Glucose levels
  • Glucose Tolerance Test (GTT)
  • Cytokine Analysis
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Histology and Pathology Services

Price on request
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Animal Necropsy Services

Price on request
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Antimicrobial Activity Testing

Price on request

Antimicrobial Activity Testing Services

Antimicrobial Activity Testing Services

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Bioanalysis

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Microbiology

Price on request

Microbiology Services

Microbiology Services

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Oncology Animal Models

Price on request

We offer a large catalog of cell lines that can be used to design a variety of efficacy tumor models to support your study needs. Our disease models are designed specifically to meet your study goals, some of the models we offer include:

  • Disseminated Mouse and Rat Models
  • Mouse Subcutaneous Xenograft Models
  • Allograft... Show more »

We offer a large catalog of cell lines that can be used to design a variety of efficacy tumor models to support your study needs. Our disease models are designed specifically to meet your study goals, some of the models we offer include:

  • Disseminated Mouse and Rat Models
  • Mouse Subcutaneous Xenograft Models
  • Allograft Mouse and Rat Models
  • Hollow Fiber Models
  • Mammary Fat Pad Models
  • Patient-derived Xenograft (Ovarian, Breast, Mesothelioma)

Sampling of cell lines:
For a full range of study options contact our oncology department.

  • H841 Xenograft model growth chart
  • H929 Xenograft model growth chart
  • Raji Disseminated model growth chart
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In vivo Toxicity Testing

Price on request

In vivo Toxicity Testing Services

In vivo Toxicity Testing Services

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Toxicology

Price on request

Toxicology Services

Toxicology Services

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Clinical and Anatomic Pathology

Price on request

Clinical and Anatomic Pathology Services

Clinical and Anatomic Pathology Services

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Clinical Laboratory Services

Price on request

Clinical Laboratory Services

Clinical Laboratory Services

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Clinical Research

Price on request

Clinical Research Services

Clinical Research Services

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Discovery Pathology

Price on request

Discovery Pathology Services

Discovery Pathology Services

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Inflammation Animal Models

Price on request

Inflammation Animal Models Services

Inflammation Animal Models Services

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Immunology Animal Models

Price on request

Immunology Animal Models Services

Immunology Animal Models Services

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Animal Models of Disease

Price on request

Animal Models of Disease Services

Animal Models of Disease Services

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In vivo Pharmacology Studies

Price on request

In vivo Pharmacology Studies Services

In vivo Pharmacology Studies Services

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Animal Models and Studies

Price on request

Animal Models and Studies Services

Animal Models and Studies Services

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Pharmacology

Price on request

Pharmacology Services

Pharmacology Services

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Obesity Animal Models

Price on request
  • Diet induced obesity (DIO) Mouse and Rat
  • Hyperlipidemia Hamster, rat, mouse models
  • STZ (streptozotocin) induced diabetic model
  • 5/6 Nephrectomy Rat Model
  • Zucker Fatty Model
  • db/db, ob/ob, db/ob Mouse models -In Vivo Assays for Glucose Metabolism
  • Resting Glucose levels
  • Glucose Tolerance Test (GTT)
  • Cytokine Analysis
  • Diet induced obesity (DIO) Mouse and Rat
  • Hyperlipidemia Hamster, rat, mouse models
  • STZ (streptozotocin) induced diabetic model
  • 5/6 Nephrectomy Rat Model
  • Zucker Fatty Model
  • db/db, ob/ob, db/ob Mouse models -In Vivo Assays for Glucose Metabolism
  • Resting Glucose levels
  • Glucose Tolerance Test (GTT)
  • Cytokine Analysis
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Pharmacology & Toxicology

Price on request

Pharmacology & Toxicology Services

Pharmacology & Toxicology Services

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Biology

Price on request

Biology Services

Biology Services

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Drug Discovery & Development

Price on request

Drug Discovery & Development Services

Drug Discovery & Development Services

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Laboratory Equipment and Facility Management Services

Price on request

Animal Facility Management

Our animal facility management programs offer full oversight of all vivarium operations at our client’s worksites including but not limited to: program development, staff oversight, inventory management, training, project coordination, conduct/ host audits and inspections. The Avastus management... Show more »

Animal Facility Management

Our animal facility management programs offer full oversight of all vivarium operations at our client’s worksites including but not limited to: program development, staff oversight, inventory management, training, project coordination, conduct/ host audits and inspections. The Avastus management team has a vast knowledge in animal facilities. Having collectively worked with over 30 companies in the New England area has given the Avastus Management Team cutting-edge knowledge of the latest industry trends. Through our management assistance we have achieved AAALAC accreditations for many of our clients, and have proven our concept through successful collaborations with our clients.

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In vitro Pharmacology Studies

Price on request

In vitro Pharmacology Studies Services

In vitro Pharmacology Studies Services

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Metabolic Animal Models

Price on request

Metabolic Animal Models Services

Metabolic Animal Models Services

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Hit Identification

Price on request

Hit Identification Services

Hit Identification Services

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Drug Discovery

Price on request

Drug Discovery Services

Drug Discovery Services

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Animal Model Housing and Maintenance

Price on request

Animal Model Housing and Maintenance Services

Animal Model Housing and Maintenance Services

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Dana Tilley

Director Preclinical Services

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