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AvantiCell Science

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Ayr, GB

About AvantiCell Science

Founded: 2006 Type: Privately Held Size: 11-50 employees

AvantiCell was founded on the principle that cell-based technologies offer valuable preclinical alternatives to animal testing. As a global provider of primary cell products and cell-based services, we offer the prospect of faster, more efficient progress towards better drugs and personalised medicine research.... Show more »

AvantiCell was founded on the principle that cell-based technologies offer valuable preclinical alternatives to animal testing. As a global provider of primary cell products and cell-based services, we offer the prospect of faster, more efficient progress towards better drugs and personalised medicine research. As experts in primary cell culture, AvantiCell can successfully and ethically procure human tissue and isolate primary cells, with the aim to provide these as valuable tools for use in preclinical research. By incorporating primary cells into novel, tailor-made 3D models, AvantiCell create physiologically-relevant and predictive platforms for preclinical analysis. The 3D printing of our primary cell models, together with their optimised extracellular matrix, provides a superior in vitro model for medium-throughput assay screening and access to more successful preclinical data. The bioengineering of cells and organs is advancing and recent technological developments have allowed the development of human hepatic organoids for use in basic and applied research into drug metabolism and hepatotoxicity testing.

We have dedicated experts immediately available to guide and shape your study - contact us anytime to begin detailed discussions on your research project.

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Our Services (20)


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3D Cell Culture Models

Price on request
  • Customised options incorporating 3D cell models e.g. 3D human primary cancer models
  • Barrier model incorporating human upper or lower respiratory airway primary cells
  • Barrier model incorporating human colonic epithelial primary cells, based upon colonoid precursers (small intestinal model under development)
  • Co-culture... Show more »
  • Customised options incorporating 3D cell models e.g. 3D human primary cancer models
  • Barrier model incorporating human upper or lower respiratory airway primary cells
  • Barrier model incorporating human colonic epithelial primary cells, based upon colonoid precursers (small intestinal model under development)
  • Co-culture systems with dual modalities e.g. intestinal absorption + target cell function
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Human Non-human Oncology Fibrotic Disease Respiratory Hepatology Colorectal cancer Breast cancer Cell culture Primary Cells Show 10 more tags Show less

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In vitro Toxicity Testing

Price on request

Using our exclusive human hepatic organoids, we offer predictive, preclinical toxicity analysis of your candidate compounds in this innovative 3D model. Scalable and flexible.

Using our exclusive human hepatic organoids, we offer predictive, preclinical toxicity analysis of your candidate compounds in this innovative 3D model. Scalable and flexible.

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Human Hepatology Cell culture Cell-based assays 3D culture Primary Cells Show 6 more tags Show less

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Cryopreservation

Price on request
  • The provision of "plug-and-play" cryopreserved products has driven AvantiCell's R&D activities for recent years, with the proprietary Cryotix technology launch in 2017, introducing this technology to the market.
  • This user-friendly 2D cryopreservation technology is successfully applicable to human primary cells, iPSC-derived... Show more »
  • The provision of "plug-and-play" cryopreserved products has driven AvantiCell's R&D activities for recent years, with the proprietary Cryotix technology launch in 2017, introducing this technology to the market.
  • This user-friendly 2D cryopreservation technology is successfully applicable to human primary cells, iPSC-derived cells with differentiated function and cell lines.
  • Although in early development, AvantiCell has made exciting progress in the application of CryotixTM technology to our 3D cell models.
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Human Non-human Cell culture Primary Cells

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Human Primary Cell Isolation

Price on request
  • Client-commissioned production of unusual human primary cell types
  • Contract manufacturing e.g. large-scale production of human frozen cell stocks
  • Client-commissioned production of unusual human primary cell types
  • Contract manufacturing e.g. large-scale production of human frozen cell stocks
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Human Cell culture Primary Cells

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Cell-Based Assays

Price on request
  • Panel of standard 2D assays based upon key human cells and disease targets
  • Analysis measurements ranging from generic indices of cell health to cell-type specific activities at protein or gene expression level
  • Range of analytical readouts based on flourescence or chemiluminescence techniques
  • Analytical targets... Show more »
  • Panel of standard 2D assays based upon key human cells and disease targets
  • Analysis measurements ranging from generic indices of cell health to cell-type specific activities at protein or gene expression level
  • Range of analytical readouts based on flourescence or chemiluminescence techniques
  • Analytical targets customised according to client requirements
  • Scalable delivery, from one sample to hundreds
  • Competitively priced, with rapid turn-around of samples
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Human Cell culture Primary Cells

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Custom Cell Model Development

Price on request
Request a quote for more information about this service.
Human Non-human Cell culture Primary Cells

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Natural Product Screening

Price on request
  • Cell-based analysis platforms adapted for biomaterials derived from the natural environment
  • Sample pre-screening to ensure readout fidelity
  • Analytical capability ranging from crude extracts to purified biomolecules
  • Bioactivity-driven purification of novel bioactivities
  • Experience with materials ranging from marine... Show more »
  • Cell-based analysis platforms adapted for biomaterials derived from the natural environment
  • Sample pre-screening to ensure readout fidelity
  • Analytical capability ranging from crude extracts to purified biomolecules
  • Bioactivity-driven purification of novel bioactivities
  • Experience with materials ranging from marine microbial extracts through tropical and temperate plant extracts to Traditional Chinese Medicines
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Human Cell culture Primary Cells

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In vitro Biosafety Testing

Price on request
  • Applicable in preclinical testing of candidate therapeutics, quality control of production, screening for impact of environmental contaminants
  • Measured as cytotoxic damage to primary human cells relevant to tissues impacted by test materials or by damage to tissue repair mechanisms, using human tissue-relevant [mesenchymal] stem cell-based system
  • Range of target human cell types available
  • Applicable in preclinical testing of candidate therapeutics, quality control of production, screening for impact of environmental contaminants
  • Measured as cytotoxic damage to primary human cells relevant to tissues impacted by test materials or by damage to tissue repair mechanisms, using human tissue-relevant [mesenchymal] stem cell-based system
  • Range of target human cell types available
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Human Cell culture Primary Cells

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In vitro Wound Healing Assay

Price on request
  • Evaluates candidate therapeutic promotion of wound healing activity by measuring cell migration into cleared cell-free “wound” area in vitro
  • Migration assay incorporates human primary epidermal keratinocytes
  • Assay capable of testing small-molecule candidates drugs and also proven in use with complex natural products
  • Evaluates candidate therapeutic promotion of wound healing activity by measuring cell migration into cleared cell-free “wound” area in vitro
  • Migration assay incorporates human primary epidermal keratinocytes
  • Assay capable of testing small-molecule candidates drugs and also proven in use with complex natural products
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Human Cell culture Primary Cells

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In vitro Insulin Secretion Assay

Price on request
  • Evaluates candidate therapeutic potential as enhancer of glucose-sensitive insulin secretion for Type I Diabetes treatment
  • Measures pancreatic β-cell sensitivity in vitro to glucose-stimulated insulin secretion
  • Analytical platform based upon human pancreatic islets exhibiting mobilisation of intracellular insulin stores in... Show more »
  • Evaluates candidate therapeutic potential as enhancer of glucose-sensitive insulin secretion for Type I Diabetes treatment
  • Measures pancreatic β-cell sensitivity in vitro to glucose-stimulated insulin secretion
  • Analytical platform based upon human pancreatic islets exhibiting mobilisation of intracellular insulin stores in response to glucose challenge
  • Test sample effect compared with known insulin secretory stimulants
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Human Metabolism and Endocrinology Diabetes Cell culture Primary Cells

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Glucose Uptake Assays

Price on request
  • Evaluates candidate therapeutic potential in terms of insulin sensitization of peripheral tissues for Type II diabetes treatment
  • Measures glucose uptake as intracellular accumulation of fluorescent non-metabolised glucose analogue
  • Range of insulin-sensitive peripheral cell types available, including human primary... Show more »
  • Evaluates candidate therapeutic potential in terms of insulin sensitization of peripheral tissues for Type II diabetes treatment
  • Measures glucose uptake as intracellular accumulation of fluorescent non-metabolised glucose analogue
  • Range of insulin-sensitive peripheral cell types available, including human primary adipocytes (from pre-adipocyte precursors) and myocytes (from myoblast precursors)
  • Applied successfully to samples ranging from small molecule drug candidates to complex natural products and traditional medicines
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Human Metabolism and Endocrinology Diabetes Cell culture Primary Cells

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Anti-Inflammatory Drug Screening in Human Cells

Price on request
  • Screening for inflammatory impact or anti-inflammatory potential measured as production of reactive oxygen species and/or induction of pro-inflammatory cytokines in human immune cells
  • Analysis options include medium-throughput whole human blood-based screening, human CD14+ monocyte (immune) cells isolated from normal human... Show more »
  • Screening for inflammatory impact or anti-inflammatory potential measured as production of reactive oxygen species and/or induction of pro-inflammatory cytokines in human immune cells
  • Analysis options include medium-throughput whole human blood-based screening, human CD14+ monocyte (immune) cells isolated from normal human blood, human dendritic cell-based tools
  • Single cytokine or multiplexed cytokine bead-based analyses available
  • Applicable to samples ranging from small molecule drug candidates to complex natural products and traditional medicines
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Human Inflammation Cell culture Primary Cells

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Drug Absorption Studies

Price on request
  • Evaluates uptake of drugs, natural products or other materials across mucosal barriers
  • Uptake measured as transport of fluorescently-tagged or biotinylated material across cell monolayers formed on permeable membranes
  • Co-culture option enables dual study of candidate absorption and post-absorption target cell effect
    -... Show more »
  • Evaluates uptake of drugs, natural products or other materials across mucosal barriers
  • Uptake measured as transport of fluorescently-tagged or biotinylated material across cell monolayers formed on permeable membranes
  • Co-culture option enables dual study of candidate absorption and post-absorption target cell effect
  • Range of mucosal options available: lung, colon, small intestine (under development)
  • Absorption across epithelial monolayers also available, including breast epithelium
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Human Gastroenterology Respiratory Cell culture Primary Cells

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Off-Target Drug Effects

Price on request
  • Evaluates candidate therapeutic specificity by comparing on-target effect on diseased cell with off-target effect on proximal-normal cell type(s)
  • Several paired-assay systems available, including breast cancer, lung cancer/COPD, colon cancer; other options in development
  • Applied successfully in preclinical evaluation of... Show more »
  • Evaluates candidate therapeutic specificity by comparing on-target effect on diseased cell with off-target effect on proximal-normal cell type(s)
  • Several paired-assay systems available, including breast cancer, lung cancer/COPD, colon cancer; other options in development
  • Applied successfully in preclinical evaluation of samples ranging from small molecule drug candidates to complex natural products
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Human Colorectal cancer Breast cancer Chronic obstructive pulmonary disease (COPD) Lung Cancer Cell culture Primary Cells Show 7 more tags Show less

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Stem Cell Assays

Price on request
  • Evaluates candidate therapeutic effect on key cell types with pluripotent or multipotent functionality involved in tissue repair
  • Measures toxic potential in terms of proliferation in 2D or 3D cell models
  • Evaluates candidate therapeutic effect on key cell types with pluripotent or multipotent functionality involved in tissue repair
  • Measures toxic potential in terms of proliferation in 2D or 3D cell models
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Human Cell culture Primary Cells

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Nanoscale Analysis and Characterization

Price on request
  • Cell-based analysis platforms adapted for testing of nanoparticles and nano-objects
  • Mammalian cell models based upon barrier tissue models
  • Non-mammalian cell models incorporating immune cells from sentinel marine species
  • Strategic partnerships with nanosafety specialists via EU Horizon 2020 ETN project “PANDORA”
  • Cell-based analysis platforms adapted for testing of nanoparticles and nano-objects
  • Mammalian cell models based upon barrier tissue models
  • Non-mammalian cell models incorporating immune cells from sentinel marine species
  • Strategic partnerships with nanosafety specialists via EU Horizon 2020 ETN project “PANDORA”
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Human Cell culture Primary Cells

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Preclinical Population Studies

Price on request
  • Analytical techniques use optical sectioning and image deconvolution
  • Techniques score cell populations / sub-populations in 3D or other complex culture models in multiwell formats
  • Analytical tools score cells based upon cell-marker, viability, metabolic activity, cell-signal or gene expression based responses
  • Analytical techniques use optical sectioning and image deconvolution
  • Techniques score cell populations / sub-populations in 3D or other complex culture models in multiwell formats
  • Analytical tools score cells based upon cell-marker, viability, metabolic activity, cell-signal or gene expression based responses
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Antifibrotic Activity Assays

Price on request
  • Evaluates test materials for potential to cause tissue damage by induction of fibrosis
  • Analysis based upon fibroblast / myofibroblast conversion by cell population analysis or direct measurement of extracellular matrix deposition by collagen lattice assay
  • Range of fibroblast cell types available representative of human organs with fibrotic susceptibility
  • 3D fibrosis model in development
  • Evaluates test materials for potential to cause tissue damage by induction of fibrosis
  • Analysis based upon fibroblast / myofibroblast conversion by cell population analysis or direct measurement of extracellular matrix deposition by collagen lattice assay
  • Range of fibroblast cell types available representative of human organs with fibrotic susceptibility
  • 3D fibrosis model in development
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Human Fibrotic Disease Cell culture Primary Cells

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In vitro Disease Models

Price on request
Request a quote for more information about this service.
Human Oncology Respiratory Nephrology and Urology Hepatology Breast cancer Chronic obstructive pulmonary disease (COPD) Cell culture Primary Cells Show 9 more tags Show less

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In vitro ADME/DMPK Studies

Price on request

In vitro ADME/PK Studies Services

In vitro ADME/PK Studies Services

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Sisely Parks

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