AUM BioTech, LLC

Silence or regulate mRNA, microRNA or long non-coding RNA. FANA technology provides superior alternatives to CRISPR, siRNA and shRNA approaches.

Key Attributes: FANA Antisense Oligonucleotides (FANA – ASOs)

• Self-deliverable - do not need any formulations, conjugates, transfection or delivery agents.
  
• Ideal for hard to transfect cells like primary cells including immunological cells (like PBMCs, T cells, B cells, macrophages), neuronal cells, endothelial cells etc.
  
• FANAs can be self-delivered into very sensitive primary cells from diseased donors and silence the desired RNA. Such study models can more accurately mimic the biology of the disease.
  
• Ideal for animal studies and can be used via multiple modes of injections including intravenous (IV), intraperitoneal (IP), intradermal (ID), intratumoral (IT), intranasal (IN), intratracheal, hydrodynamic tail injection, inhalation, or local organ delivery.
  
• Ideal for bacterial, viral and fungal research.
  
• Ideal for agriculture and entomology research.
  
• Non-toxic and resistant to degradation by serum and cellular nucleases.
  
• Provide sustained silencing and does not alter the biology of the cells.
  
• Ideal for target discovery.
  
• Ideal for high throughput gene screening.
  
• Single step knockdown will help save time, resources and money for researchers.
  

FANAs have high intracellular stability as well as high binding affinity to the target RNA forming very stable heteroduplex structures. Unlike conventional technologies, FANAs have high fidelity for the RNA target and highly reduced off target effects (no RISC associated off target effects). These attributes represent a more potent, efficient, and cost effective solution in the RNA silencing and regulation space.