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AUM BioTech, LLC

Philadelphia, Pennsylvania, US

AUM BioTech is an American Biotechnology company focused on the development of next generation of innovative genomics tools in the area of gene silencing and regulation for biomedical research. Our next generation genetic research tools are globally being used by biomedical scientists and researchers working on basic, transitional and pre-clinical research.

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FANA Antisense Oligonucleotides
Price on request

AUM's next generation FANA technology provides superior alternatives to CRISPR, siRNA and shRNA approaches.

FANA Antisense Oligonucleotide (FANA – ASO)

  • silence or regulate RNA modalities such as – mRNA, microRNA and long non-coding RNA
  • can be used for target discovery
  • self-deliverable and do not need any... Show more »

AUM's next generation FANA technology provides superior alternatives to CRISPR, siRNA and shRNA approaches.

FANA Antisense Oligonucleotide (FANA – ASO)

  • silence or regulate RNA modalities such as – mRNA, microRNA and long non-coding RNA
  • can be used for target discovery
  • self-deliverable and do not need any transfection reagents
  • help save time, resources and money for researchers all over the world.

FANA oligos can be self-delivered without the use of any delivery agent. FANAs have high intracellular stability as well as high binding affinity to the target RNA forming very stable heteroduplex structures. Unlike conventional technologies, FANAs have high fidelity for the RNA target and highly reduced off target effects (no RISC associated off target effects). These attributes represent a more potent, efficient and cost effective solution in the RNA silencing and regulation space. Next generation FANA RNA silencing and regulation technology can be used to very efficiently knockdown or regulate a variety of genetic modalities, like mRNA, microRNA and long non-coding RNA.

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shRNA-Mediated Gene Knockdown
Price on request

FANA ASO Mediated Knockdown

FANA technology allows simple and efficient delivery into difficult-to-transfect cells and animals without the need of transfection reagents or formulations. FANA oligos can be self-delivered without the use of any delivery agent. Further, as opposed to shRNAs that eventually use the RNAi... Show more »

FANA ASO Mediated Knockdown

FANA technology allows simple and efficient delivery into difficult-to-transfect cells and animals without the need of transfection reagents or formulations. FANA oligos can be self-delivered without the use of any delivery agent. Further, as opposed to shRNAs that eventually use the RNAi pathway (involving RISC), FANAs are single-stranded next generation antisense oligonucleotides that use RNase H to mediate cleavage of the target. This mode is much simpler and does not have RISC associated off-target effects.

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siRNA-Mediated Gene Knockdown
Price on request

FANA ASO Mediated Knockdown

FANA single-stranded antisense oligonucleotides uses RNase H-mediated cleavage. This mode of mRNA knockdown is simpler than siRNA mediated knockdown and eliminates RISC-associated off target effects often observed with siRNA.

Unlike siRNAs that are processed in the cytoplasm, FANA oligos... Show more »

FANA ASO Mediated Knockdown

FANA single-stranded antisense oligonucleotides uses RNase H-mediated cleavage. This mode of mRNA knockdown is simpler than siRNA mediated knockdown and eliminates RISC-associated off target effects often observed with siRNA.

Unlike siRNAs that are processed in the cytoplasm, FANA oligos can go into the nucleus and can be used to target RNA present within in the nucleus

Most importantly FANAs can be self delivered and not need transfection reagents or delivery agents.

FANA ASOs vs siRNA
Not Required Transfection Reagents Required
High Efficiency in Difficult-to-Transfect Cells Low-Moderate
Non-Toxic Toxicity Can be Toxic
Easy One Step Process Transition from Cell Culture to in vivo Models Extensive optimization required
Resistant to Nucleases Stability Moderate
No RISC Associated Off Target Effects Yes
High binding Affinity and specificity to target RNA Specificity siRNA grade binding affinity and specificity
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Morpholino-Based Gene Knockdown
Price on request

FANA ASO Mediated Knockdown

FANA technology allows simple and efficient delivery into difficult-to-transfect cells and animals without the need of transfection reagents or formulations.

FANA ASO Mediated Knockdown

FANA technology allows simple and efficient delivery into difficult-to-transfect cells and animals without the need of transfection reagents or formulations.

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Genome Editing
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CRISPR sgRNA Libraries
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CRISPR/Cas9 Genome Editing
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Custom Gene Synthesis
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Bacterial Plasmid Vector
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Allele Specific Oligonucleotide Probes
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rAAV Genome Editing
Recombinant Adeno-Associated Virus Mediated Genome Editing
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microRNA cDNA Synthesis
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cDNA Synthesis
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Oligonucleotide Annealing
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Gene Synthesis
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DNA Synthesis and Probe Development
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DNA Synthesis and Probe Development Services

DNA Synthesis and Probe Development Services

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Oligonucleotide Synthesis
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ZFN-Mediated Genome Editing
Zinc Finger Nuclease-Mediated Genome Editing
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Genetic Engineering
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Genetic Engineering Services

Genetic Engineering Services

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