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Atlanchim Pharma

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Saint-Herblain, FR

About Atlanchim Pharma

ATLANCHIM PHARMA is a chemistry-based CRO (Contract Research Organization) conducting confidential custom synthesis of complex molecules tailored to customer specifications. Our team provides multi-step organic synthesis from a milligram to several gram scale.

Our Services (6)


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Separation/Purification Services

Price on request

Purification of a mixture of compounds

AtlanChim Pharma can help you to purify your compound if its purity is inadequate for your application or for characterization.

We can provide you with information such as: 1H NMR, , 13C NMR, mass spectrum, HPLC analysis, infrared spectrum, analysis of the... Show more »

Purification of a mixture of compounds

AtlanChim Pharma can help you to purify your compound if its purity is inadequate for your application or for characterization.

We can provide you with information such as: 1H NMR, , 13C NMR, mass spectrum, HPLC analysis, infrared spectrum, analysis of the water content by Karl Fischer … Numerous methods can be used to purify your compound (Liquid-liquid extraction, purification in normal phase or reversed-phase, semi-preparative HPLC, crystallization) in order to increase the purity and/or remove others products. After this step, we will be able to achieve all the required analyses to assume its characterization and we will deliver you a certificate of analysis (CoA) according to your needs (1H NMR, 13C, mass spectrum, HPLC analysis, infrared spectrum, melting point, water content by Karl Fischer titration…)

 

Isolation of Impurities

From a sample of your mixture or an HPLC analysis, we estimate if we will be able to isolate enough quantity to perform the structural elucidation (about 10 mg). We then prepare a quote for isolation of your impurity with a production time and a cost.

Isolation is accomplished by purification on column chromatography on silica gel (normal phase), by purification by flash or semi preparative chromatography (reverse phase), by preparative CCM …

 

We use various techniques in order to isolate one or more impurities in your compound. Before purification, trials can be undertaken to increase impurities’ proportions by forced degradation reactions. We try various methods to purify or isolate the compound (Liquid-liquid extraction, purification in normal phase or reversed-phase, semi-preparative HPLC, crystallization…) so as to have enough quantity of the impurity (ies). Therefore, we will be able to carry out analyses for their structural elucidation.

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Chemical Synthesis

Price on request

When our customers need a molecule exclusively for them at a certain scale, custom synthesis is done under confidentiality agreements. We can work on a Fee For Services basis (FFS) or on Full time Equivalent (FTE). 

FFS : Reproduction of synthetic pathway described... Show more »

When our customers need a molecule exclusively for them at a certain scale, custom synthesis is done under confidentiality agreements. We can work on a Fee For Services basis (FFS) or on Full time Equivalent (FTE). 

FFS : Reproduction of synthetic pathway described in publications or patents, or use of procedures developed in your lab

FTE : Development of innovative solutions for the synthesis of a compound not described in the literature

Your project in custom chemical synthesis will be handled by one of our Project Manager (PhD in organic chemistry or medicinal chemistry). They will deliver to you the compound that fulfill the requirements established during the quotation stage. 

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Impurity Separation

Price on request

We use various techniques in order to isolate one or more impurities in your compound.

Before purification, trials can be undertaken to increase impurities’ proportions by forced degradation reactions. We try various methods to purify or isolate the compound (Liquid-liquid extraction, purification in normal phase... Show more »

We use various techniques in order to isolate one or more impurities in your compound.

Before purification, trials can be undertaken to increase impurities’ proportions by forced degradation reactions. We try various methods to purify or isolate the compound (Liquid-liquid extraction, purification in normal phase or reversed-phase, semi-preparative HPLC, crystallization…) so as to have enough quantity of the impurity (ies). Therefore, we will be able to carry out analyses for their structural elucidation.

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NMR

Nuclear magnetic resonance spectroscopy
Price on request

For known structure

 

Structural analyses done with a NMR 400MHz, (for proton skeleton, 1H, COSY, TOCSY and for carbon skeleton 13C, DEPT, HSQC, HMBC) enable us to confirm that the structure you proposed is correct.

 

For unknown structure

 

We can also do structure... Show more »

For known structure

 

Structural analyses done with a NMR 400MHz, (for proton skeleton, 1H, COSY, TOCSY and for carbon skeleton 13C, DEPT, HSQC, HMBC) enable us to confirm that the structure you proposed is correct.

 

For unknown structure

 

We can also do structure identification (information such as synthetic scheme, analogues, and precursors … must be provided by our client) using NMR analyses, HRMS, IR …

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Impurity Synthesis

Price on request

Our equipments allow us to achieve the necessary analyses for the determination of the structure of an impurity or of your compound: NMR analyses (1H, 13C, DEPT, COSY, HMBC, HSQC…) HRMS, IR, RX … Thanks to our know-how in laboratory experimentation, we also manage to better understand secondary reactions inducing... Show more »

Our equipments allow us to achieve the necessary analyses for the determination of the structure of an impurity or of your compound: NMR analyses (1H, 13C, DEPT, COSY, HMBC, HSQC…) HRMS, IR, RX … Thanks to our know-how in laboratory experimentation, we also manage to better understand secondary reactions inducing the formation of an impurity.

Moreover, our expertise in organic synthesis allows us, if it is necessary, to synthesize the impurity on a lab scale (from milligram to gram) if a synthetic pathway can be proposed. Synthesis of the compound may be necessary to validate the structure proposed after structural analysis (if there are several hypotheses of structure after structural analysis) or if we are not able to isolate the compound (no method enable us to isolate the impurity), or if you need a larger amount of this compound (up to one gram).

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Stable Isotope Analysis

Price on request

Stable isotope lablling is the introduction of one or several stable isotopes (D, 13C, 15N, 34S) into all types of organic molecules. 

We have developed a huge expertise on that field in AtlanChim Pharma. 

Characteristics:

Stable isotope lablling is the introduction of one or several stable isotopes (D, 13C, 15N, 34S) into all types of organic molecules. 

We have developed a huge expertise on that field in AtlanChim Pharma. 

Characteristics:

  • Site specific and quantitative labeling
  • Labeled molecules are detectable by mass spectrometry (and by NMR)
  • Non-radioactive labeling method
  • Maintains physico-chemical properties introducing only significant isotopic effects
  • Cost effective and easier to use than radioactive labeling metho

 

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Aurelie Moreau

Business Manager

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