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Asymmetrex, LLC

Boston, Massachusetts, US

Asymmetrex is a life sciences biotechnology company with a focus on innovating adult stem cell medicine technology that will advance the potential of adult tissue stem cells into routine medical practice. Adult tissue stem cells are found in the bodies of children and adults. They are a small fraction of the cells (less than 1 per 1000) that make up organs and tissues like the liver, cornea, skin, muscles, hair, brain, and bone marrow. Despite their small fraction, they are responsible for continuously renewing and repairing the body.

Employing its internationally recognized, special research expertise in unique adult tissue stem cell properties, Asymmetrex has developed several technologies that make it now possible to either count tissue stem cells directly or estimate their number precisely. This adult stem cell medicine technology and innovation provide, for the first time, the means to monitor tissue stem... Show more »

Asymmetrex is a life sciences biotechnology company with a focus on innovating adult stem cell medicine technology that will advance the potential of adult tissue stem cells into routine medical practice. Adult tissue stem cells are found in the bodies of children and adults. They are a small fraction of the cells (less than 1 per 1000) that make up organs and tissues like the liver, cornea, skin, muscles, hair, brain, and bone marrow. Despite their small fraction, they are responsible for continuously renewing and repairing the body.

Employing its internationally recognized, special research expertise in unique adult tissue stem cell properties, Asymmetrex has developed several technologies that make it now possible to either count tissue stem cells directly or estimate their number precisely. This adult stem cell medicine technology and innovation provide, for the first time, the means to monitor tissue stem cell number and quality for applications in regenerative medicine and drug development.

By continuing to discover and develop adult stem cell medicine technology for the production, identification, and quantification of restorative adult tissue stem cells, Asymmetrex will set the direction and pace of modern stem cell biomedicine. In addition to our current focus in developing stem cell toxicology assays for the pharmaceutical industry, we also license technologies for stem cell detection (including cancer stem cells) and stem cell expansion for user-exclusive applications.

Selected Publications

  • Huh, Y.H. and Sherley, J. L.(2014) "Decreased H3K27 and H3K4 Trimethylation on Mortal Chromosomes in Distributed Stem Cells" Cell Death and Disease 5:e1554. doi:10.1038/cddis.2014.522. Published Online 4 December 2014.
  • Sherley, J. L. (2014) "Commentary: Accelerating Progress in Regenerative Medicine by Advancing Distributed Stem Cell-based Normal Human Cell Biomanufacturing," Pharmaceutica Analytica Acta 5:286. doi: 10.4172/2153-2435.1000286. Online Report
  • Sherley, J. L. (2013) “New Cancer Diagnostics and Therapeutics From A 9th “Hallmark Of Cancer”: Symmetric Self-Renewal ByMutated Distributed Stem Cells,” Expert Rev. Mol. Diagn. 13, 797-810. Online Summary
  • Paré, J.-F., and Sherley, J. L. (2013) “Ex vivo Expansion of Human Pancreatic Distributed Stem Cells by Suppression of Asymmetric Cell Kinetics (SACK),” J. Stem Cell Res. Ther. 3: 149. doi:10.4172/2157-7633.1000149. Online Report
  • Huh, Y. H., Cohen, J., and Sherley, J. L. (2013) "Higher 5- hydroxymethylcytosine identifies immortal DNA strand chromosomes in asymmetrically self-renewing distributed stem cells," Proc. Natl. Acad. Sci. USA 110, 16862-16867. (Abstract)
  • Sherley, J. L. (2013) "Advancing renewable normal human cell assays for drug discovery," Drug Devel. Res. doi: 10.1002/ddr.21069.
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Adult Stem Cell Expansion
Price on request

AlphaSTEM can design serial expansion culture parameters and schedules that increase the yield of tissue stem cells at reduced cost and time.
Requirements: total viable cell count data from serial culture expansion procedures
Approximate turnaround time: <1 week
Deliverables: 1. Serial culture expansion parameters project to... Show more »

AlphaSTEM can design serial expansion culture parameters and schedules that increase the yield of tissue stem cells at reduced cost and time.
Requirements: total viable cell count data from serial culture expansion procedures
Approximate turnaround time: <1 week
Deliverables: 1. Serial culture expansion parameters project to increase final expanded stem cell number while reducing costs for material and labor, decreasing expansion time.
2. Estimated specific stem cell count for final product
3. Projected stem cell kinetics properties for final product
Pricing: Negotiated per Expansion Design

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Stem Cell Analysis
Price on request

Asymmetrex's AlphaSTEM Test service can determine the specific count of adult tissue stem cells in complex research and clinical preparations. This capability can be used to determine the dose of stem cells in transplantation preparations, to identify drug candidates that will cause chronic organ failure because of stem cell... Show more »

Asymmetrex's AlphaSTEM Test service can determine the specific count of adult tissue stem cells in complex research and clinical preparations. This capability can be used to determine the dose of stem cells in transplantation preparations, to identify drug candidates that will cause chronic organ failure because of stem cell toxicity, to identify tissue stem cell-active agents, and for general research of the cell kinetics properties of tissue stem cells, committed progenitor cells or transiently amplifying cells, and terminally differentiated cells in diverse mammalian tissues during cell culture.

The following cell kinetics parameters can be determined for the indicated specific tissue cell types in complex tissue cell cultures:

Stem Cell Kinetics Parameters
1. Number vs. time
2. Death rate vs. time
3. Cell cycle time for symmetric self-renewal
4. Cell cycle time for asymmetric self-renewal
5. Symmetric self-renewal rate
6. Asymmetric self-renewal rate
7. Stem cell unit generation number
8. Density-dependence of symmetric self-renewal rate

Non-stem Cycling Cell Kinetics Parameters
1. Number vs. time
2. Death rate vs. time
3. Cell cycle time

Terminally-Arrested Cell Kinetics Parameters
1. Number vs. time
2. Death rate vs. time

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Biology
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Cells and Tissues
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Mammalian Cell Culture
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