Asterand Bioscience, A BioIVT Company
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Detroit, Michigan, US
Asterand Bioscience, A BioIVT Company, is the leading global provider of high-quality, well-characterized human tissue and human tissue-based research solutions to drug discovery scientists. Our mission is to provide human-based solutions to accelerate the identification and validation of drug targets and enhance the selection of drug candidates with an increased likelihood of clinical success.
Asterand Bioscience, A BioIVT Company, has a well-established human tissue heritage, having been formed in 2006 through the merger of Asterand (founded 2000), a human tissue biorepository and Pharmagene (founded 1996), a human tissue-based drug discovery company. With this background and capability in human tissue procurement, characterization and research tools, we are uniquely positioned to provide a comprehensive approach to meet the research needs of pharmaceutical, biotechnology and diagnostic companies, as well as academia.
For more information about our processes on the regulatory oversight of Human Biological Specimens (HBS), please visit our website, www.bioivt.com, for more information. Specific information related to our quality and ethical assurances can be found here: https://www.bioivt.com/about/quality-assurance/.
BioIVT’s clinical specimens now include the ASTERAND Human Tissue Specimens, an invaluable source of high-quality, thoroughly characterized and validated human tissue, which can be used throughout the drug discovery and development process. As the leading provider of high quality human biospecimens and associated clinical information, we use rigorous criteria for the procurement and quality control of biospecimens. BioIVT has a worldwide network of hospitals working exclusively to procure high-quality biological samples for our onsite tissue bank. Our dynamic network of hospital procurement sites makes BioIVT unique in the biobanking industry and allows BioIVT to offer our clients many hard to procure treatment naïve tissue specimens in several formats.
Our extensive repository consists of over 300,000 human tissues with associated biofluids. This bank includes material that is prospectively obtained in a variety of formats including fresh frozen and FFPE as well as biofluids. Standard protocols are used to maintain the BioIVT repository and adhere to the highest standards of sample integrity, including difficult to procure treatment naïve tumor samples. Standard tissue products are generally available for next day shipping to keep your research moving.
Our custom procurement service offers human tissues and clinical data custom collected to meet unique research requirements within a wide range of disease categories. Samples are provided in multiple preserved formats or as fresh and unpreserved biospecimens. As a result, we deliver human tissues, biofluids, and accompanying clinical information in a manner that is most compatible with our client’s experimental design.
BioIVT collects every sample under IRB approved protocols, ensuring that strict ethical guidelines are followed to protect patient confidentiality and safety. Each sample has the patients consent for use in a wide range of research including the development of commercial products or services. The samples are identifiable only by barcodes to ensure an unbiased assessment as well as patient confidentiality.
BioIVT provides a wide range of molecular extractions for genomic research including DNA extraction (genomic DNA) and RNA extraction (total RNA and mRNA). Standard protocols can be used to obtain genomic DNA and total RNA. A wide range of commercially available DNA extraction and RNA extraction kits or custom protocols can be utilized to obtain samples for specific projects.
BioIVT provides a complete team of Histotechnicians, Histotechnologists and Board Certified Pathologists for all your sectioning, cyro-sectioning, staining and analysis needs.
HISTOLOGY SERVICES
Standard Services
Custom Services
Platforms
PATHOLOGY SERVICES
Standard Services
Custom Services
Platforms & Fees
Flow cytometry is a versatile and powerful technology for drug discovery and development researchers and BioIVT offers a wide-range of flow analysis capabilities and support to help you determine the best strategy for your needs. Our cellular and molecular analysis services are designed to accelerate your immune monitoring, epitope discovery, immunophenotyping or cell isolation projects. With off-the-shelf solutions to customized complex flow analysis, we serve as a strategic resource with extensive capabilities to develop, validate and deploy assays for the unique examination of various parameters.
Clinical development requires a wide range of flow analysis capabilities, each with its own optimization and validation. In order to support your R&D efforts, our flow cytometry services strategically align with specific drug development programs across a wide-range of therapeutic areas. BioIVT analyzes a multitude of specimen types including whole blood, fresh and frozen tumor or normal tissue, and PBMCs/BMMCs from pre-clinical model systems and human clinical trials. Combined with our Custom Tissue Procurement Service, our Flow Cytometry Sample Analysis Service is able to isolate unique and rare primary cell populations and characterize these populations according to your needs.
BioIVT offers mutation services to support assay, diagnostic and drug development needs as well as assay validation. We are able to combine ready access to large cohorts of human tissues with expertise in the design and execution of NGS, qRT-PCR and FISH protocols. We can support the determination of SNVs (single nucleotide variants), Indels (Insertion or deletion of nucleotides), Fusions, and CNV (Copy Number Variants) as well as expression changes. qRT-PCR is an effective approach for determining the status of various somatic mutations in human tissue samples. These data aid in the selection of specific subsets of human tissue samples for future use / applications. We have provided such pre-screening services to enable tissue selections for KRAS and EGFR, among other mutations. Using FISH, we generate data that enable characterization of tissues for specific mutations such as HER2 or cMET gene amplifications or ROS/ALK gene rearrangements.
Features & Benefits
Access to multiple platforms:
BioIVT offers a comprehensive portfolio of peripheral blood mononuclear cells (PBMCs) from a variety of animal species. These cells are manufactured with optimized methods to ensure a high quality product with superior viability, purity and functionality. Utilization of our cell products can yield a faster time-to-market as less time will be spent on sample preparation and leaving our clients to focus on more technically challenging end point assays.
Researchers can receive PBMCs and other fresh material less than 24 hours after collection. These cell isolations can either be shipped fresh overnight for immediate use, or cryopreserved for future scheduled work.
-PBMCs can be prepared from a variety of source matrices: vacutainer collection, buffy coat, leukopak and more
-Further processing performed, including RBC lysis, washing, and counting
-Aliquoting by cell count
BioIVT also prospectively collects patient samples that can meet study-specific inclusion and exclusion criteria. All collections are conducted under IRB-approved protocols, and all donors sign informed consent forms where applicable. Samples are fully characterized and come complete with demographic and medical data, as recorded on case report forms at the time of collection.
Biofluids are available as both banked inventory or custom collection with associated clinical data such as medication, cancer or disease stage, clinical lab values such as cholesterol and liver function, RF value and viral serology. Available matrices include - Whole blood/ Serum / Plasma, Sputum, Synovial fluid, Cerebrospinal fluid (CSF), PAP smears, Bone marrow, Cord blood, Oral swabs/Saliva/Sputum, Tears, Urine, Feces
Customized collections kits:
Donor specifications, protocols, collection containers and more
Repeat donor collections for longitudinal studies
Access to unique or rare patient populations, including pediatric and pregnant donors
Matched sets from individual donors
Biofluids are available as both banked inventory or custom collection with associated clinical data such as medication, cancer or disease stage, clinical lab values such as cholesterol and liver function, RF value and viral serology.
Customized collections kits:
Donor specifications, protocols, collection containers and more
Matched sets from individual donors
Biofluids are available as both banked inventory or custom collection with associated clinical data such as medication, cancer or disease stage, clinical lab values such as cholesterol and liver function, RF value and viral serology. Available matrices include - Whole blood/ Serum / Plasma.
Customized collections kits:
Donor specifications, protocols, collection containers and more
Repeat donor collections for longitudinal studies
Access to unique or rare patient populations, including pediatric and pregnant donors
Matched sets from individual donor
Urine consists primarily of water, but also contains an assortment of inorganic salts and organic compounds, including proteins, hormones, and a wide range of metabolites. As a sterile, non-invasive biological fluid, urine is becoming a favored sample type for biomarker research. Not only is it being used to detect kidney disease, but scientists have begun to identify urine cancer biomarkers that can be used for early screening and monitoring.
Features & Benefits
-Donor demographics provided for all lots
-Collection protocols can be tailored according to client specification
-Large lot sizes available from individual or pooled donors
BioIVT offers a comprehensive portfolio of peripheral blood mononuclear cells (PBMCs) from a variety of animal species. These cells are manufactured with optimized methods to ensure a high quality product with superior viability, purity and functionality. Utilization of our cell products can yield a faster time-to-market as less time will be spent on sample preparation and leaving our clients to focus on more technically challenging end point assays.
Researchers can receive PBMCs and other fresh material less than 24 hours after collection. These cell isolations can either be shipped fresh overnight for immediate use, or cryopreserved for future scheduled work.
-PBMCs can be prepared from a variety of source matrices: vacutainer collection, buffy coat, leukopak and more
-Further processing performed, including RBC lysis, washing, and counting
-Aliquoting by cell count
BioIVT also prospectively collects patient samples that can meet study-specific inclusion and exclusion criteria. All collections are conducted under IRB-approved protocols, and all donors sign informed consent forms where applicable. Samples are fully characterized and come complete with demographic and medical data, as recorded on case report forms at the time of collection.
BioIVT has a network of over 200 IRB-approved facilities providing access to a diverse array of specimens. Our growing clinical network is made up of physicians, research groups, hospitals, and reference labs that we work closely with to provide tailored specimen collections to meet your research needs.
Based on diagnosis and standard of care, we are able to provide punch/biopsy samples across a diverse population. Please contact us to find out what is currently in inventory for your specific needs or to design a custom collection process.
Biofluids are available as both banked inventory or custom collection with associated clinical data such as medication, cancer or disease stage, clinical lab values such as cholesterol and liver function, RF value and viral serology. Available matrices include - Whole blood/ Serum / Plasma,
Customized collections kits:
Donor specifications, protocols, collection containers and more
Repeat donor collections for longitudinal studies
Access to unique or rare patient populations, including pediatric and pregnant donors
Matched sets from individual donors
Our clients can access tissue- and blood-derived cell products from patient populations across key disease states. BioIVT offers primary human diseased and normal lung parenchymal and bronchial epithelial cells (huBECs) from COPD, IPF, CF (including genotype), Asthma and other diseased populations as well as primary cancer associated fibroblasts (huCAFS) and epithelial cells from many oncology indications. If the cell product you need isn’t currently in our portfolio, we’ll work with you to develop customized product or cell types to meet your specific requirements. We will tailor our procedures to meet your tissue, donor or product format needs. In addition, our cancer cell lines have the fidelity of primary cells.
BioIVT offers a comprehensive portfolio of peripheral blood mononuclear cells (PBMCs) from a variety of animal species. These cells are manufactured with optimized methods to ensure a high quality product with superior viability, purity and functionality. Utilization of our cell products can yield a faster time-to-market as less time will be spent on sample preparation and leaving our clients to focus on more technically challenging end point assays.
Researchers can receive PBMCs and other fresh material less than 24 hours after collection. These cell isolations can either be shipped fresh overnight for immediate use, or cryopreserved for future scheduled work.
PBMCs can be prepared from a variety of source matrices: vacutainer collection, buffy coat, leukopak and more
Further processing performed, including RBC lysis, washing, and counting
Aliquoting by cell count
BioIVT also prospectively collects patient samples that can meet study-specific inclusion and exclusion criteria. All collections are conducted under IRB-approved protocols, and all donors sign informed consent forms where applicable. Samples are fully characterized and come complete with demographic and medical data, as recorded on case report forms at the time of collection
BioIVT now has a network of over 200 IRB-approved facilities providing access to a diverse array of specimens. Our growing clinical network is made up of physicians, research groups, hospitals, and reference labs that we work closely with to provide tailored specimen collections to meet your research needs.
ASTERAND™ Human Tissue Specimens
Available tumors include Solid Tumor Indications (such as adenocarcinoma and squamous cell carcinoma of most organs – Lung, Breast, Colorectal, Prostate, Pancreas, Head & Neck, Gynecological, Urogenital, Brain and Skin), Heme-oncology Indications (such as Lymphoma, Leukemia, Myeloma, and other disorders), and Sarcoma Indications (such as Mesothelioma, GIST, Chondrosarcoma, Osteosarcoma, Rhabdomyosarcoma and others).
BioIVT has the ability to offer tissues in various matrix formats, such as fresh, FFPE, Fresh Frozen or OCT Embedded. In addition, BioIVT has extended capabilities to collect both blood-derived biofluids, with coagulant of choice, and non-blood derived biofluids, including respiratory, reproductive, and gastrointestinal. With the ability to provide matched sets from a single donor, longitudinal time points from a single donor, pre-treatment/Naïve cohorts as well as other client-specific exclusion/inclusion criteria, BioIVT has the specimen you need for your research.
In addition, BioIVT has immortalized cell lines, primary cancer-associated fibroblasts and epithelial cells, dissociated tumor cells, and purified immune cells.
Our PHASEZERO Research Services Team is available to work with you to accelerate your research. Whether you need disease modeling with 2D and 3D cell-based assays drug target validation with immunohistochemistry or in situ hybridization, or safety analysis, our experienced team provides actionable data for you.
BioIVT now has a network of over 200 IRB-approved facilities providing access to a diverse array of specimens. Our growing clinical network is made up of physicians, research groups, hospitals, and reference labs that we work closely with to provide tailored specimen collections to meet your research needs.
ASTERAND™ Human Tissue Specimens
BioIVT now has a network of over 200 IRB-approved facilities providing access to a diverse array of specimens. Our growing clinical network is made up of physicians, research groups, hospitals, and reference labs that we work closely with to provide tailored specimen collections to meet your research needs.
ASTERAND™ Human Tissue Specimens
BioIVT’s clinical specimens now include the ASTERAND Human Tissue Specimens, an invaluable source of high-quality, thoroughly characterized and validated human tissue, which can be used throughout the drug discovery and development process. As the leading provider of high quality human biospecimens and associated clinical information, we use rigorous criteria for the procurement and quality control of biospecimens. BioIVT has a worldwide network of hospitals working exclusively to procure high-quality biological samples for our onsite tissue bank. Our dynamic network of hospital procurement sites makes BioIVT unique in the biobanking industry and allows BioIVT to offer our clients many hard to procure treatment naïve tissue specimens in several formats.
Our extensive repository consists of over 300,000 human tissues with associated biofluids. This bank includes material that is prospectively obtained in a variety of formats including fresh frozen and FFPE as well as biofluids. Standard protocols are used to maintain the BioIVT repository and adhere to the highest standards of sample integrity, including difficult to procure treatment naïve tumor samples. Standard tissue products are generally available for next day shipping to keep your research moving.
Our custom procurement service offers human tissues and clinical data custom collected to meet unique research requirements within a wide range of disease categories. Samples are provided in multiple preserved formats or as fresh and unpreserved biospecimens. As a result, we deliver human tissues, biofluids, and accompanying clinical information in a manner that is most compatible with our client’s experimental design.
BioIVT collects every sample under IRB approved protocols, ensuring that strict ethical guidelines are followed to protect patient confidentiality and safety. Each sample has the patients consent for use in a wide range of research including the development of commercial products or services. The samples are identifiable only by barcodes to ensure an unbiased assessment as well as patient confidentiality.
BioIVT’s selection of immortalized cell lines will further your research in the mechanisms of cancer growth and progression. Our cell lines derive directly from freshly isolated solid tumors, including breast and prostate tissues as well as hematological samples. Each cell line purchased includes clinical data delivered with the cell aliquots. Our stringent quality control processes requires authentication including sterility testing, viability, and plating efficiency determined by lot. Immortalized cell lines are cryopreserved in 1 x 106 ampules.
Breast Cell Lines
Through licensing agreements with the University of Michigan and the Karmanos Cancer Institute, BioIVT provides 11 well-characterized human breast cancer cell lines to assist in breast cancer research.
Ten SUM cell lines derived in Steve Ethier’s lab while present at the University of Michigan are available for purchase. Each cell line, from a single patient, represents a different subtype of breast cancer. All of the currently known oncogenes with altered expression patterns in breast cancer, in various combinations, are represented and characterized in the SUM lines. Furthermore, these cell lines have been described in over 50 peer-reviewed publications, describing isolation and growth conditions, gene expression data via Affymetrix GeneChips, and biomolecular markers, such as estrogen receptor and Her2 status.
Prostate Cell Lines **
BioIVT offers three pairs of prostate tumor and normal cell lines. Researchers at the Karmanos Cancer Institute, Onyvax Ltd., and Asterand collaborated to derive these cell lines from tumors and adjacent “normal” tissues obtained at the time of prostatectomy. These prostate cell lines were immortalized via replication-defective retrovirus transferring the transforming HPV16 or HPV18 E6 and E7 genes.
**All prostate cell lines were immortalized were by exposing the cells to a replication-defective retrovirus transferring the transforming HPV16 or HPV18 E6 and E7 genes.
Hematopoietic Malignancies Cell Lines
Through a licensing agreement with the Barbara Ann Karmanos Cancer Institute, BioIVT provides well characterized human cell lines derived from patients with hematopoetic malignancies. These cell lines, developed by Doctors Ayad Al-Katib and Ramzi Mohammad, will be of interest to researchers seeking a cure for lymphoma, leukemia, pancreatic cancer, and macroglobulinema.
BioIVT provides a complete team of Histotechnicians, Histotechnologists and Board Certified Pathologists for all your sectioning, cyro-sectioning, staining and analysis needs.
Histology Services
Standard Services
-Sectioning
-IHC Staining
Custom Services
-IHC/Custom Staining
-Instrumentation Validation
-Assay Controls
-Specimen Embedding
-TMA Creation
Platforms
-Dako Autostainers
-Aperio AT2 Slide Scanner
-Auto Tissue Processors
Pathology Services
Standard Services
-H&E with diagnosis confirmation
Custom Services
-Gross preperation of fresh specimens
-Identification of key tissue features
-Specimen marking
Platforms & Fees
-Aperio AT2 Slide Scanner
-Fees based on hourly rate
Tissue Microarrays (TMAs) provide our customer with a screening tool representing multiple donors. TMAs can discover new protein or genetic markers and can be tools in diagnostic development and validation. Tissue arrays can also measure protein, RNA or DNA markers, and are compatible with immunohistochemistry (IHC) staining and potentially in situ hybridization (ISH). Standard human derived TMAs of tumor and normal samples are available for research studies (from FFPE or Frozen tissue). Products are available both as sections as well as whole block. Custom TMAs are available upon request.
BioIVT Tissue Microarrays (TMAs), specifically designed for drug discovery and clinical marker research, can be used in development of diagnostics, therapeutics and for the study of new gene/protein markers. Each TMA is accompanied by a representative map and key that includes clinical and donor demographics. All specimens are collected using consented donors under IRB approval and are pre-reviewed by a board certified pathologist to confirm tissue type and diagnosis.
Our high-density, high-quality oncology and normal tissue FFPE microarrays are currently available in three standard formats:
In addition, the following TMAs are available:
Features & Benefits
Our scientists provide custom isolations of mammalian fibroblasts from solid tumors, normal tissue or diseased tissue as well as peripheral blood mononucleocytes (PBMCs).
Our scientists provide custom isolations of mammalian fibroblasts from solid tumors, normal tissue or diseased tissue as well as peripheral blood mononucleocytes (PBMCs).
Primary Cells
-Available Primary Cells
Cancer Associated Fibroblasts (HuCAFs)
Lung Epithelial Cells (HuBECs)
Pulmonary Fibroblasts
Chondrocytes
Synovial Fibroblasts
-Custom Services
Isolation of Cells from:
Whole Blood
Tissue
Bone Marrow Aspirates
Synovial Fluids
Methods & Techniques
Tissue Dissociation
Density Gradient
BioIVT provides a complete team of Histotechnicians, Histotechnologists and Board Certified Pathologists for all your sectioning, cyro-sectioning, staining and analysis needs.
HISTOLOGY SERVICES
Standard Services
Custom Services
Platforms
PATHOLOGY SERVICES
Standard Services
Custom Services
Platforms & Fees
BioIVT offers mutation services to support assay, diagnostic and drug development needs as well as assay validation. We are able to combine ready access to large cohorts of human tissues with expertise in the design and execution of NGS, qRT-PCR and FISH protocols. We can support the determination of SNVs (single nucleotide variants), Indels (Insertion or deletion of nucleotides), Fusions, and CNV (Copy Number Variants) as well as expression changes. qRT-PCR is an effective approach for determining the status of various somatic mutations in human tissue samples. These data aid in the selection of specific subsets of human tissue samples for future use / applications. We have provided such pre-screening services to enable tissue selections for KRAS and EGFR, among other mutations. Using FISH, we generate data that enable characterization of tissues for specific mutations such as HER2 or cMET gene amplifications or ROS/ALK gene rearrangements.
Features & Benefits
Access to multiple platforms:
The surge in research and development activities focused on personalized medicine coincides with the rapidly decreasing cost of human genome mapping and a greater understanding of disease heterogeneity. As a researcher, you struggle with high attrition rate based on lack of clinical efficacy. It is crucial to your studies to utilize ethically collected, well-characterized human specimens and comprehensive tissue-based research services.
Look to BioIVT for expertise in the processes required for the ethical acquisition of biospecimens that cover a wide range of disease states and the protocols needed for the production of reliable data.
We offer:
• Unparalleled access to over 200 IRB-approved collection sites
• Access to a comprehensive array of biospecimens across multiple sample types and disease indications
• Standardization and quality control coupled with the ability to customize collections to meet your specific criteria and research needs
The PHASEZERO® Research Services team delivers high quality molecular pathology data to support the selection and validation of drug targets and biomarkers in human tissues. In addition, the approaches we provide are ideally suited for diagnostic assay development and testing. Our molecular pathology platforms are used to great effect as endpoints for our human primary cell based assays. This allows changes in the expression of key targets to be determined following treatment of human cells with novel therapeutic agents.
Our team of scientists offer routine RNA (total RNA and mRNA), DNA (genomic DNA) and protein isolation from flash frozen tissue, FFPE and cells. We also provide mutation analysis on several of our products as well as a custom service.
Standard protocols can be used to obtain genomic DNA and total RNA. A wide range of commercially available DNA extraction and RNA extraction kits or custom protocols can be utilized to obtain samples for specific projects. Each RNA extraction is analyzed on an Agilent 2100 and provided with a quality control report featuring an RNA Integrity Number (RIN). The Agilent 2100 software assigns an integrity number (0-10) to an RNA sample. The Agilent 2100 identifies the presence or absence of degradation of products and interprets the quality of the specimen. DNA quality is analyzed by gel electrophoresis. Quantitation it performed by spectrophotometry (Nanodrop) and fluorometry (Qubit). Careful qualitative and quantitative analysis will guarantee high quality specimens and yield high quality research results.
Protein Lysates are extracted using a Modified RIPA Buffer protocol.
BioIVT is a leading global provider of high-quality biological specimens and value-added services. We specialize in control and disease state samples including human and animal tissues, cell products, blood and other biofluids. Our unmatched portfolio of clinical specimens directly supports precision medicine research and the effort to improve patient outcomes by coupling comprehensive clinical data with donor samples. By combining our technical expertise, exceptional customer service, and unparalleled access to biological specimens, BioIVT serves the research community as a trusted partner in ELEVATING SCIENCE.
Our team of scientists offer routine DNA (genomic DNA) isolation from flash frozen tissue, FFPE and cells. We also provide mutation analysis on several of our products as well as a custom service.
Standard protocols can be used to obtain genomic DNA. A wide range of commercially available DNA extraction kits or custom protocols can be utilized to obtain samples for specific projects. DNA quality is analyzed by gel electrophoresis. Quantitation it performed by spectrophotometry (Nanodrop) and fluorometry (Qubit). Careful qualitative and quantitative analysis will guarantee high quality specimens and yield high quality research results.
Our scientists provide custom isolations of mammalian fibroblasts from solid tumors, normal tissue or diseased tissue as well as peripheral blood mononucleocytes (PBMCs).
Primary Cells
-Available Primary Cells
Cancer Associated Fibroblasts (HuCAFs)
Lung Epithelial Cells (HuBECs)
Pulmonary Fibroblasts
Chondrocytes
Synovial Fibroblasts
-Custom Services
Isolation of Cells from:
Whole Blood
Tissue
Bone Marrow Aspirates
Synovial Fluids
Methods & Techniques
Tissue Dissociation
Density Gradient
Magnetic Separation
Flow Cytometry
The surge in research and development activities focused on personalized medicine coincides with the rapidly decreasing cost of human genome mapping and a greater understanding of disease heterogeneity. As a researcher, you struggle with high attrition rate based on lack of clinical efficacy. It is crucial to your studies to utilize ethically collected, well-characterized human specimens and comprehensive tissue-based research services.
Look to BioIVT for expertise in the processes required for the ethical acquisition of biospecimens that cover a wide range of disease states and the protocols needed for the production of reliable data.
We offer:
BioIVT now has a network of over 200 IRB-approved facilities providing access to a diverse array of specimens. Our growing clinical network is made up of physicians, research groups, hospitals, and reference labs that we work closely with to provide tailored specimen collections to meet your research needs.
ASTERAND Human Tissue Specimens
Over 175,000 tissue samples collected in a standard format, banked and available for immediate shipment
Formats: FFPE, frozen, plasma, serum, whole blood and matched sets of donor specimens
Rigorous QC:
Biofluids are available as both banked inventory or custom collection with associated clinical data such as medication, cancer or disease stage, clinical lab values such as cholesterol and liver function, RF value and viral serology. Available matrices include - Whole blood/ Serum / Plasma, Sputum, Synovial fluid, Cerebrospinal fluid (CSF), PAP smears, Bone marrow, Cord blood, Oral swabs/Saliva/Sputum, Tears, Urine, Feces
Customized collections kits:
ADME/DMPK Studies Services
BioIVT’s clinical specimens now include the ASTERAND Human Tissue Specimens, an invaluable source of high-quality, thoroughly characterized and validated human tissue, which can be used throughout the drug discovery and development process. As the leading provider of high quality human biospecimens and associated clinical information, we use rigorous criteria for the procurement and quality control of biospecimens. BioIVT has a worldwide network of hospitals working exclusively to procure high-quality biological samples for our onsite tissue bank. Our dynamic network of hospital procurement sites makes BioIVT unique in the biobanking industry and allows BioIVT to offer our clients many hard to procure treatment naïve tissue specimens in several formats.
Our extensive repository consists of over 300,000 human tissues with associated biofluids. This bank includes material that is prospectively obtained in a variety of formats including fresh frozen and FFPE as well as biofluids. Standard protocols are used to maintain the BioIVT repository and adhere to the highest standards of sample integrity, including difficult to procure treatment naïve tumor samples. Standard tissue products are generally available for next day shipping to keep your research moving.
Our custom procurement service offers human tissues and clinical data custom collected to meet unique research requirements within a wide range of disease categories. Samples are provided in multiple preserved formats or as fresh and unpreserved biospecimens. As a result, we deliver human tissues, biofluids, and accompanying clinical information in a manner that is most compatible with our client’s experimental design.
BioIVT collects every sample under IRB approved protocols, ensuring that strict ethical guidelines are followed to protect patient confidentiality and safety. Each sample has the patients consent for use in a wide range of research including the development of commercial products or services. The samples are identifiable only by barcodes to ensure an unbiased assessment as well as patient confidentiality.
BioIVT provides a complete team of Histotechnicians, Histotechnologists and Board Certified Pathologists for all your sectioning, cyro-sectioning, staining and analysis needs.
PATHOLOGY SERVICES
Standard Services
Our team of scientists offer routine DNA (genomic DNA) isolation from flash frozen tissue, FFPE and cells. We also provide mutation analysis on several of our products as well as a custom service.
Standard protocols can be used to obtain genomic DNA. A wide range of commercially available DNA extraction kits or custom protocols can be utilized to obtain samples for specific projects. DNA quality is analyzed by gel electrophoresis. Quantitation it performed by spectrophotometry (Nanodrop) and fluorometry (Qubit). Careful qualitative and quantitative analysis will guarantee high quality specimens and yield high quality research results.
BioIVT provides a complete team of Histotechnicians, Histotechnologists and Board Certified Pathologists for all your sectioning, cyro-sectioning, staining and analysis needs.
HISTOLOGY SERVICES
Standard Services
Custom Services
Platforms
PATHOLOGY SERVICES
CUSTOM SERVICES
Platforms & Fees
We offer primary isolated cells from oncology and other diseased populations, useful in assay development and the identification of diagnostic and prognostic markers. In addition, we offer specific oncology related cell lines.
• Complete clinical data included with all samples
• Customizable PBMC collections for specific inclusion criteria
• Additional characterization available, including HLA typing
BioIVT’s selection of immortalized cell lines will further your research in the mechanisms of cancer growth and progression. Our cell lines derive directly from freshly isolated solid tumors, including breast and prostate tissues as well as hematological samples. Each cell line purchased includes clinical data delivered with the cell aliquots. Our stringent quality control processes requires authentication including sterility testing, viability, and plating efficiency determined by lot. Immortalized cell lines are cryopreserved in 1 x 106 ampules.
Breast Cell Lines
Through licensing agreements with the University of Michigan and the Karmanos Cancer Institute, BioIVT provides 11 well-characterized human breast cancer cell lines to assist in breast cancer research.
Ten SUM cell lines derived in Steve Ethier’s lab while present at the University of Michigan are available for purchase. Each cell line, from a single patient, represents a different subtype of breast cancer. All of the currently known oncogenes with altered expression patterns in breast cancer, in various combinations, are represented and characterized in the SUM lines. Furthermore, these cell lines have been described in over 50 peer-reviewed publications, describing isolation and growth conditions, gene expression data via Affymetrix GeneChips, and biomolecular markers, such as estrogen receptor and Her2 status.
Prostate Cell Lines **
BioIVT offers three pairs of prostate tumor and normal cell lines. Researchers at the Karmanos Cancer Institute, Onyvax Ltd., and Asterand collaborated to derive these cell lines from tumors and adjacent “normal” tissues obtained at the time of prostatectomy. These prostate cell lines were immortalized via replication-defective retrovirus transferring the transforming HPV16 or HPV18 E6 and E7 genes.
**All prostate cell lines were immortalized were by exposing the cells to a replication-defective retrovirus transferring the transforming HPV16 or HPV18 E6 and E7 genes.
Hematopoietic Malignancies Cell Lines
Through a licensing agreement with the Barbara Ann Karmanos Cancer Institute, BioIVT provides well characterized human cell lines derived from patients with hematopoetic malignancies. These cell lines, developed by Doctors Ayad Al-Katib and Ramzi Mohammad, will be of interest to researchers seeking a cure for lymphoma, leukemia, pancreatic cancer, and macroglobulinema.
Mammalian Cell Culture Services
Asterand Bioscience, A BioIVT Company has not received any reviews.
Asterand Bioscience, A BioIVT Company has not received any endorsements.