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Asterand Bioscience, A BioIVT Company

19 Orders Completed
Detroit, Michigan, US

About Asterand Bioscience, A BioIVT Company

Asterand Bioscience, A BioIVT Company, is the leading global provider of high-quality, well-characterized human tissue and human tissue-based research solutions to drug discovery scientists. Our mission is to provide human-based solutions to accelerate the identification and validation of drug targets and enhance the selection of drug candidates with an increased likelihood of clinical success.

Asterand Bioscience, A BioIVT Company, has a well-established human tissue heritage, having been formed in 2006 through the merger of Asterand (founded 2000), a human tissue biorepository and Pharmagene (founded 1996), a human tissue-based drug discovery company. With this background and capability in human tissue procurement, characterization and research tools, we are uniquely positioned to provide a comprehensive approach to meet the research needs of pharmaceutical, biotechnology and diagnostic companies, as well as academia.

For more information about our processes on the regulatory oversight of Human Biological Specimens (HBS), please visit our website, www.bioivt.com, for more information. Specific information related to our quality and ethical assurances can be found here: https://www.bioivt.com/about/quality-assurance/

Our Services (123)


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Human Biobanking

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Non-Hodgkins Lymphoma Human Serum

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Non-Hodgkins Lymphoma Human Plasma

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Bone Marrow Mononuclear Cells

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Lymphoma Human Serum

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Lymphoma Human Plasma

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Lymphoma Human Biofluids

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Pancreatic Cancer Human Serum

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Pancreatic Cancer Human Plasma

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Pancreatic Cancer Human Biofluids

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Esophageal Cancer Human Serum

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Esophageal Cancer Human Plasma

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Sarcoma Human Serum

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Sarcoma Human Plasma

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Sarcoma Human Biofluids

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Psoriasis Human Whole Blood

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Alzheimers Human Whole Blood

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Uterine Cancer Human Serum

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Ovarian Cancer Human Serum

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Thyroid Cancer Human Serum

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Stomach Cancer Human Serum

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Liver Cancer Human Serum

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Cervical Cancer Human Serum

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Prostate Cancer Human Serum

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Lung Cancer Human Serum

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Breast Cancer Human Serum

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Matched Human Plasma and Tumor Tissue Samples

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BioIVT’s clinical specimens now include the ASTERAND Human Tissue Specimens, an invaluable source of high-quality, thoroughly characterized and validated human tissue, which can be used throughout the drug discovery and development process. As the leading provider of high quality human biospecimens and associated clinical information, we use rigorous criteria for the procurement and quality control of biospecimens. BioIVT has a worldwide network of hospitals working exclusively to procure high-quality biological samples for our onsite tissue bank. Our dynamic network of hospital procurement sites makes BioIVT unique in the biobanking industry and allows BioIVT to offer our clients many hard to procure treatment naïve tissue specimens in several formats.
Our extensive repository consists of over 300,000 human tissues with associated biofluids. This bank includes material that is prospectively obtained in a variety of formats including fresh frozen and FFPE as well as biofluids. Standard protocols are used to maintain the BioIVT repository and adhere to the highest standards of sample integrity, including difficult to procure treatment naïve tumor samples. Standard tissue products are generally available for next day shipping to keep your research moving.
Our custom procurement service offers human tissues and clinical data custom collected to meet unique research requirements within a wide range of disease categories. Samples are provided in multiple preserved formats or as fresh and unpreserved biospecimens. As a result, we deliver human tissues, biofluids, and accompanying clinical information in a manner that is most compatible with our client’s experimental design.
BioIVT collects every sample under IRB approved protocols, ensuring that strict ethical guidelines are followed to protect patient confidentiality and safety. Each sample has the patients consent for use in a wide range of research including the development of commercial products or services. The samples are identifiable only by barcodes to ensure an unbiased assessment as well as patient confidentiality.

FFPE tissue Tumor tissue Human

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Psoriasis Human Serum

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Alzheimers Human Serum

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Prostate Cancer Human Plasma

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Human DNA and RNA Samples

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BioIVT provides a wide range of molecular extractions for genomic research including DNA extraction (genomic DNA) and RNA extraction (total RNA and mRNA). Standard protocols can be used to obtain genomic DNA and total RNA. A wide range of commercially available DNA extraction and RNA extraction kits or custom protocols can be utilized to obtain samples for specific projects.

RNA DNA Human

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Lung Cancer Human Plasma

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Preclinical Histology

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BioIVT provides a complete team of Histotechnicians, Histotechnologists and Board Certified Pathologists for all your sectioning, cyro-sectioning, staining and analysis needs.

HISTOLOGY SERVICES
Standard Services

  • Sectioning
  • IHC Staining

Custom Services

  • IHC/Custom Staining
  • Instrumentation Validation
  • Assay Controls
  • Specimen Embedding
  • TMA Creation

Platforms

  • Dako Autostainers
  • Aperio AT2 Slide Scanner
  • Auto Tissue Processors

PATHOLOGY SERVICES
Standard Services

  • H&E with diagnosis confirmation

Custom Services

  • Gross preperation of fresh specimens
  • Identification of key tissue features
  • Specimen marking

Platforms & Fees

  • Aperio AT2 Slide Scanner
  • Fees based on hourly rate

DAKO Autostainer Plus Aperio AT2 cryosectioning frozen sectioning Macro Dissection Sectioning serial sectioning tissue section imaging cryoembedding Paraffin Embedding Specimen Embedding IHC Staining Instrument Validation Pathology Review Show 14 more tags Show less

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Uterine Cancer Human Plasma

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Testicular Cancer Human Plasma

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Ovarian Cancer Human Plasma

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Flow Cytometry

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Flow cytometry is a versatile and powerful technology for drug discovery and development researchers and BioIVT offers a wide-range of flow analysis capabilities and support to help you determine the best strategy for your needs. Our cellular and molecular analysis services are designed to accelerate your immune monitoring, epitope discovery, immunophenotyping or cell isolation projects. With off-the-shelf solutions to customized complex flow analysis, we serve as a strategic resource with extensive capabilities to develop, validate and deploy assays for the unique examination of various parameters.

Clinical development requires a wide range of flow analysis capabilities, each with its own optimization and validation. In order to support your R&D efforts, our flow cytometry services strategically align with specific drug development programs across a wide-range of therapeutic areas. BioIVT analyzes a multitude of specimen types including whole blood, fresh and frozen tumor or normal tissue, and PBMCs/BMMCs from pre-clinical model systems and human clinical trials. Combined with our Custom Tissue Procurement Service, our Flow Cytometry Sample Analysis Service is able to isolate unique and rare primary cell populations and characterize these populations according to your needs.


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Kidney Cancer Human Plasma

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Large Intestine Cancer Human Plasma

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Large Intestine Cancer Human Serum

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Stomach Cancer Human Plasma

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Next Generation Sequencing (NGS)

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BioIVT offers mutation services to support assay, diagnostic and drug development needs as well as assay validation. We are able to combine ready access to large cohorts of human tissues with expertise in the design and execution of NGS, qRT-PCR and FISH protocols. We can support the determination of SNVs (single nucleotide variants), Indels (Insertion or deletion of nucleotides), Fusions, and CNV (Copy Number Variants) as well as expression changes. qRT-PCR is an effective approach for determining the status of various somatic mutations in human tissue samples. These data aid in the selection of specific subsets of human tissue samples for future use / applications. We have provided such pre-screening services to enable tissue selections for KRAS and EGFR, among other mutations. Using FISH, we generate data that enable characterization of tissues for specific mutations such as HER2 or cMET gene amplifications or ROS/ALK gene rearrangements.

Features & Benefits

  • Fully managed by in-house specialist
  • Supported by large banked tissue specimen inventory with access to specific cohorts as needed

Access to multiple platforms:

  • qPCR – SNV, Fusion, Expression changes – Tests specific known variants; confirmation of assays
  • Sanger/Pyrosequencing – SNV – Test sections of genes or short genes, confirmation of assays
  • NGS – SNV, CNV, Fusion – Explore large sections of genome, detection from multiple genes, detection of rare variants, information from multiple mutation types in one assay
  • FISH – CNV, Fusion, Expression changes – Detection of specific gene sequences within chromosomes, identification of genomic status of oncology samples, analysis of gene amplification and mutation
  • IHC – Fusion, Expression changes – Specific known variants or expression changes, does not require DNA or RNA to provide information

NGS NGS Panels Mutation Detection Human

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Head and Neck Cancer Human Plasma

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Bladder Cancer Human Plasma

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Diseased Human Peripheral Blood Mononuclear Cells (PBMCs)

Price on request

BioIVT offers a comprehensive portfolio of peripheral blood mononuclear cells (PBMCs) from a variety of animal species. These cells are manufactured with optimized methods to ensure a high quality product with superior viability, purity and functionality. Utilization of our cell products can yield a faster time-to-market as less time will be spent on sample preparation and leaving our clients to focus on more technically challenging end point assays.
Researchers can receive PBMCs and other fresh material less than 24 hours after collection. These cell isolations can either be shipped fresh overnight for immediate use, or cryopreserved for future scheduled work.
-PBMCs can be prepared from a variety of source matrices: vacutainer collection, buffy coat, leukopak and more
-Further processing performed, including RBC lysis, washing, and counting
-Aliquoting by cell count
BioIVT also prospectively collects patient samples that can meet study-specific inclusion and exclusion criteria. All collections are conducted under IRB-approved protocols, and all donors sign informed consent forms where applicable. Samples are fully characterized and come complete with demographic and medical data, as recorded on case report forms at the time of collection.

PBMC's Human

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Human Biofluids

Price on request

Biofluids are available as both banked inventory or custom collection with associated clinical data such as medication, cancer or disease stage, clinical lab values such as cholesterol and liver function, RF value and viral serology. Available matrices include - Whole blood/ Serum / Plasma, Sputum, Synovial fluid, Cerebrospinal fluid (CSF), PAP smears, Bone marrow, Cord blood, Oral swabs/Saliva/Sputum, Tears, Urine, Feces

Customized collections kits:
Donor specifications, protocols, collection containers and more
Repeat donor collections for longitudinal studies
Access to unique or rare patient populations, including pediatric and pregnant donors
Matched sets from individual donors

Plasma Biofluids Stool Blood Bone marrow Human Show 6 more tags Show less

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Breast Cancer Human Plasma

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Human Cerebrospinal Fluid (CSF) Samples

Price on request

Biofluids are available as both banked inventory or custom collection with associated clinical data such as medication, cancer or disease stage, clinical lab values such as cholesterol and liver function, RF value and viral serology.

Customized collections kits:
Donor specifications, protocols, collection containers and more
Matched sets from individual donors

Biofluids Human

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Sepsis Human Plasma

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Human Plasma and Serum

Price on request

Biofluids are available as both banked inventory or custom collection with associated clinical data such as medication, cancer or disease stage, clinical lab values such as cholesterol and liver function, RF value and viral serology. Available matrices include - Whole blood/ Serum / Plasma.
Customized collections kits:
Donor specifications, protocols, collection containers and more
Repeat donor collections for longitudinal studies
Access to unique or rare patient populations, including pediatric and pregnant donors
Matched sets from individual donor

Biofluids Blood Plasma Human

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Chronic Obstructive Pulmonary Disease (COPD) Human Plasma

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Human Urine Samples

Price on request

Urine consists primarily of water, but also contains an assortment of inorganic salts and organic compounds, including proteins, hormones, and a wide range of metabolites. As a sterile, non-invasive biological fluid, urine is becoming a favored sample type for biomarker research. Not only is it being used to detect kidney disease, but scientists have begun to identify urine cancer biomarkers that can be used for early screening and monitoring.

Features & Benefits
-Donor demographics provided for all lots
-Collection protocols can be tailored according to client specification
-Large lot sizes available from individual or pooled donors

Biofluids Human

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Psoriasis Human Plasma

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Normal Human Peripheral Blood Mononuclear Cells (PBMCs)

Price on request

BioIVT offers a comprehensive portfolio of peripheral blood mononuclear cells (PBMCs) from a variety of animal species. These cells are manufactured with optimized methods to ensure a high quality product with superior viability, purity and functionality. Utilization of our cell products can yield a faster time-to-market as less time will be spent on sample preparation and leaving our clients to focus on more technically challenging end point assays.

Researchers can receive PBMCs and other fresh material less than 24 hours after collection. These cell isolations can either be shipped fresh overnight for immediate use, or cryopreserved for future scheduled work.
-PBMCs can be prepared from a variety of source matrices: vacutainer collection, buffy coat, leukopak and more
-Further processing performed, including RBC lysis, washing, and counting
-Aliquoting by cell count

BioIVT also prospectively collects patient samples that can meet study-specific inclusion and exclusion criteria. All collections are conducted under IRB-approved protocols, and all donors sign informed consent forms where applicable. Samples are fully characterized and come complete with demographic and medical data, as recorded on case report forms at the time of collection.

PBMC's

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Alzheimers Human Plasma

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Human Tissue Punch/Biopsy

Price on request

BioIVT has a network of over 200 IRB-approved facilities providing access to a diverse array of specimens. Our growing clinical network is made up of physicians, research groups, hospitals, and reference labs that we work closely with to provide tailored specimen collections to meet your research needs.
Based on diagnosis and standard of care, we are able to provide punch/biopsy samples across a diverse population. Please contact us to find out what is currently in inventory for your specific needs or to design a custom collection process.

FFPE tissue Skin Frozen Tissue

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Human Whole Blood

Price on request

Biofluids are available as both banked inventory or custom collection with associated clinical data such as medication, cancer or disease stage, clinical lab values such as cholesterol and liver function, RF value and viral serology. Available matrices include - Whole blood/ Serum / Plasma,
Customized collections kits:
Donor specifications, protocols, collection containers and more
Repeat donor collections for longitudinal studies
Access to unique or rare patient populations, including pediatric and pregnant donors
Matched sets from individual donors

Blood Human

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Colorectal Cancer Human Biofluids

Price on request
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Human Primary Cells

Price on request

Our clients can access tissue- and blood-derived cell products from patient populations across key disease states. BioIVT offers primary human diseased and normal lung parenchymal and bronchial epithelial cells (huBECs) from COPD, IPF, CF (including genotype), Asthma and other diseased populations as well as primary cancer associated fibroblasts (huCAFS) and epithelial cells from many oncology indications. If the cell product you need isn’t currently in our portfolio, we’ll work with you to develop customized product or cell types to meet your specific requirements. We will tailor our procedures to meet your tissue, donor or product format needs. In addition, our cancer cell lines have the fidelity of primary cells.

Oncology Breast cancer Bladder cancer Colorectal cancer Liver cancer Lung Cancer Prostate Cancer Pancreatic cancer Melanoma Ovarian Cancer Gastric Cancer Asthma Cystic fibrosis Chronic obstructive pulmonary disease (COPD) Pulmonary fibrosis Idiopathic pulmonary fibrosis Rheumatoid Arthritis Primary Cells Show 18 more tags Show less

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Prostate Cancer Human Biofluids

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Human Whole Blood & PBMCs

Price on request

BioIVT offers a comprehensive portfolio of peripheral blood mononuclear cells (PBMCs) from a variety of animal species. These cells are manufactured with optimized methods to ensure a high quality product with superior viability, purity and functionality. Utilization of our cell products can yield a faster time-to-market as less time will be spent on sample preparation and leaving our clients to focus on more technically challenging end point assays.

Researchers can receive PBMCs and other fresh material less than 24 hours after collection. These cell isolations can either be shipped fresh overnight for immediate use, or cryopreserved for future scheduled work.

PBMCs can be prepared from a variety of source matrices: vacutainer collection, buffy coat, leukopak and more
Further processing performed, including RBC lysis, washing, and counting
Aliquoting by cell count
BioIVT also prospectively collects patient samples that can meet study-specific inclusion and exclusion criteria. All collections are conducted under IRB-approved protocols, and all donors sign informed consent forms where applicable. Samples are fully characterized and come complete with demographic and medical data, as recorded on case report forms at the time of collection


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Lung Cancer Human Biofluids

Price on request
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Fixed Human Tissue

Price on request

BioIVT now has a network of over 200 IRB-approved facilities providing access to a diverse array of specimens. Our growing clinical network is made up of physicians, research groups, hospitals, and reference labs that we work closely with to provide tailored specimen collections to meet your research needs.

ASTERAND™ Human Tissue Specimens

  • Over 175,000 tissue samples collected in a standard format, banked and available for immediate shipment
  • Formats: FFPE, frozen, plasma, serum, whole blood and matched sets of donor specimens
    Rigorous QC:
  • Specimens reviewed by board certified pathology to confirm diagnosis and specimen quality
  • Clinical data review of over 200 data points
  • Ethical and regulatory traceability for each case

Oncology Autoimmune disease Dermatology CNS/Neurology Gastroenterology Women's Health and Prenatal Care Metabolism and Endocrinology Musculoskeletal/Orthopedic Cardiovascular Liver Disease Infectious Disease Hematology Ophthalmology Nephrology and Urology FFPE tissue Show 15 more tags Show less

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Breast Cancer Human Biofluids

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Tumor Tissue

Price on request

Available tumors include Solid Tumor Indications (such as adenocarcinoma and squamous cell carcinoma of most organs – Lung, Breast, Colorectal, Prostate, Pancreas, Head & Neck, Gynecological, Urogenital, Brain and Skin), Heme-oncology Indications (such as Lymphoma, Leukemia, Myeloma, and other disorders), and Sarcoma Indications (such as Mesothelioma, GIST, Chondrosarcoma, Osteosarcoma, Rhabdomyosarcoma and others).

BioIVT has the ability to offer tissues in various matrix formats, such as fresh, FFPE, Fresh Frozen or OCT Embedded. In addition, BioIVT has extended capabilities to collect both blood-derived biofluids, with coagulant of choice, and non-blood derived biofluids, including respiratory, reproductive, and gastrointestinal. With the ability to provide matched sets from a single donor, longitudinal time points from a single donor, pre-treatment/Naïve cohorts as well as other client-specific exclusion/inclusion criteria, BioIVT has the specimen you need for your research.

In addition, BioIVT has immortalized cell lines, primary cancer-associated fibroblasts and epithelial cells, dissociated tumor cells, and purified immune cells.

Our PHASEZERO Research Services Team is available to work with you to accelerate your research. Whether you need disease modeling with 2D and 3D cell-based assays drug target validation with immunohistochemistry or in situ hybridization, or safety analysis, our experienced team provides actionable data for you.

Breast cancer Bladder cancer Lung Cancer Gastric Cancer Melanoma Head and neck cancer Uterine Cancer Endometrial diseases Ovarian Cancer Liver cancer Brain cancer Prostate Cancer Pancreatic cancer Colorectal cancer Hematology Kidney Cancer Renal Cancer Cervical Cancer Esophageal cancer Sarcoma Oncology FFPE tissue Frozen Tissue Plasma Biofluids Blood Biopsy tissue Show 27 more tags Show less

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Psoriasis Human Biofluids

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Frozen Human Tissue

Price on request

BioIVT now has a network of over 200 IRB-approved facilities providing access to a diverse array of specimens. Our growing clinical network is made up of physicians, research groups, hospitals, and reference labs that we work closely with to provide tailored specimen collections to meet your research needs.
ASTERAND™ Human Tissue Specimens

  • Over 175,000 tissue samples collected in a standard format, banked and available for immediate shipment
  • Formats: FFPE, frozen, plasma, serum, whole blood and matched sets of donor specimens
    Rigorous QC:
  • Specimens reviewed by board certified pathology to confirm diagnosis and specimen quality
  • Clinical data review of over 200 data points
  • Ethical and regulatory traceability for each case

Autoimmune disease Oncology Gastroenterology Dermatology CNS/Neurology Women's Health and Prenatal Care Musculoskeletal/Orthopedic Nephrology and Urology Liver Disease Frozen Tissue Human Show 11 more tags Show less

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Asthma Human Biofluids

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Fresh Human Tissue

Price on request

BioIVT now has a network of over 200 IRB-approved facilities providing access to a diverse array of specimens. Our growing clinical network is made up of physicians, research groups, hospitals, and reference labs that we work closely with to provide tailored specimen collections to meet your research needs.
ASTERAND™ Human Tissue Specimens

  • Over 175,000 tissue samples collected in a standard format, banked and available for immediate shipment
  • Formats: FFPE, frozen, plasma, serum, whole blood and matched sets of donor specimens
    Rigorous QC:
  • Specimens reviewed by board certified pathology to confirm diagnosis and specimen quality
  • Clinical data review of over 200 data points
  • Ethical and regulatory traceability for each case

Fresh Tissue Tumor tissue

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Chronic Obstructive Pulmonary Disease (COPD) Human Biofluids

Price on request
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Human Tissue Procurement

Price on request

BioIVT’s clinical specimens now include the ASTERAND Human Tissue Specimens, an invaluable source of high-quality, thoroughly characterized and validated human tissue, which can be used throughout the drug discovery and development process. As the leading provider of high quality human biospecimens and associated clinical information, we use rigorous criteria for the procurement and quality control of biospecimens. BioIVT has a worldwide network of hospitals working exclusively to procure high-quality biological samples for our onsite tissue bank. Our dynamic network of hospital procurement sites makes BioIVT unique in the biobanking industry and allows BioIVT to offer our clients many hard to procure treatment naïve tissue specimens in several formats.

Our extensive repository consists of over 300,000 human tissues with associated biofluids. This bank includes material that is prospectively obtained in a variety of formats including fresh frozen and FFPE as well as biofluids. Standard protocols are used to maintain the BioIVT repository and adhere to the highest standards of sample integrity, including difficult to procure treatment naïve tumor samples. Standard tissue products are generally available for next day shipping to keep your research moving.

Our custom procurement service offers human tissues and clinical data custom collected to meet unique research requirements within a wide range of disease categories. Samples are provided in multiple preserved formats or as fresh and unpreserved biospecimens. As a result, we deliver human tissues, biofluids, and accompanying clinical information in a manner that is most compatible with our client’s experimental design.

BioIVT collects every sample under IRB approved protocols, ensuring that strict ethical guidelines are followed to protect patient confidentiality and safety. Each sample has the patients consent for use in a wide range of research including the development of commercial products or services. The samples are identifiable only by barcodes to ensure an unbiased assessment as well as patient confidentiality.

FFPE tissue Frozen Tissue Human tissue Fresh Tissue Tumor tissue Plasma Stool Biofluids Blood Primary Cells Show 10 more tags Show less

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Type 2 Diabetes Human Biofluids

Price on request
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Cancer Cell Line Panels

Price on request

BioIVT’s selection of immortalized cell lines will further your research in the mechanisms of cancer growth and progression. Our cell lines derive directly from freshly isolated solid tumors, including breast and prostate tissues as well as hematological samples. Each cell line purchased includes clinical data delivered with the cell aliquots. Our stringent quality control processes requires authentication including sterility testing, viability, and plating efficiency determined by lot. Immortalized cell lines are cryopreserved in 1 x 106 ampules.

Breast Cell Lines

Through licensing agreements with the University of Michigan and the Karmanos Cancer Institute, BioIVT provides 11 well-characterized human breast cancer cell lines to assist in breast cancer research.

Ten SUM cell lines derived in Steve Ethier’s lab while present at the University of Michigan are available for purchase. Each cell line, from a single patient, represents a different subtype of breast cancer. All of the currently known oncogenes with altered expression patterns in breast cancer, in various combinations, are represented and characterized in the SUM lines. Furthermore, these cell lines have been described in over 50 peer-reviewed publications, describing isolation and growth conditions, gene expression data via Affymetrix GeneChips, and biomolecular markers, such as estrogen receptor and Her2 status.

Prostate Cell Lines **

BioIVT offers three pairs of prostate tumor and normal cell lines. Researchers at the Karmanos Cancer Institute, Onyvax Ltd., and Asterand collaborated to derive these cell lines from tumors and adjacent “normal” tissues obtained at the time of prostatectomy. These prostate cell lines were immortalized via replication-defective retrovirus transferring the transforming HPV16 or HPV18 E6 and E7 genes.

**All prostate cell lines were immortalized were by exposing the cells to a replication-defective retrovirus transferring the transforming HPV16 or HPV18 E6 and E7 genes.

Hematopoietic Malignancies Cell Lines

Through a licensing agreement with the Barbara Ann Karmanos Cancer Institute, BioIVT provides well characterized human cell lines derived from patients with hematopoetic malignancies. These cell lines, developed by Doctors Ayad Al-Katib and Ramzi Mohammad, will be of interest to researchers seeking a cure for lymphoma, leukemia, pancreatic cancer, and macroglobulinema.

Human

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Type 1 Diabetes Human Biofluids

Price on request
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Tissue Slide Preparation

Price on request

BioIVT provides a complete team of Histotechnicians, Histotechnologists and Board Certified Pathologists for all your sectioning, cyro-sectioning, staining and analysis needs.

Histology Services

Standard Services
-Sectioning
-IHC Staining

Custom Services
-IHC/Custom Staining
-Instrumentation Validation
-Assay Controls
-Specimen Embedding
-TMA Creation

Platforms
-Dako Autostainers
-Aperio AT2 Slide Scanner
-Auto Tissue Processors

Pathology Services

Standard Services
-H&E with diagnosis confirmation

Custom Services
-Gross preperation of fresh specimens
-Identification of key tissue features
-Specimen marking

Platforms & Fees
-Aperio AT2 Slide Scanner
-Fees based on hourly rate

DAKO Autostainer Plus Aperio AT2 Automatic Tissue Processors IHC Staining Secdtioning Macro Dissection Specimen Embedding Instrument Validation Frozen Tissue Fresh Tissue FFPE tissue Show 11 more tags Show less

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Cystic Fibrosis (CF) Human Biofluids

Price on request
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Mild Cognitive Impairment (MCI) Human Biofluids

Price on request
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Multiple Sclerosis (MS) Human Biofluids

Price on request
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Alzheimers Human Biofluids

Price on request
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Human Sputum Samples

Price on request
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Tissue Microarrays

Price on request

Tissue Microarrays (TMAs) provide our customer with a screening tool representing multiple donors. TMAs can discover new protein or genetic markers and can be tools in diagnostic development and validation. Tissue arrays can also measure protein, RNA or DNA markers, and are compatible with immunohistochemistry (IHC) staining and potentially in situ hybridization (ISH). Standard human derived TMAs of tumor and normal samples are available for research studies (from FFPE or Frozen tissue). Products are available both as sections as well as whole block. Custom TMAs are available upon request.

BioIVT Tissue Microarrays (TMAs), specifically designed for drug discovery and clinical marker research, can be used in development of diagnostics, therapeutics and for the study of new gene/protein markers. Each TMA is accompanied by a representative map and key that includes clinical and donor demographics. All specimens are collected using consented donors under IRB approval and are pre-reviewed by a board certified pathologist to confirm tissue type and diagnosis.

Our high-density, high-quality oncology and normal tissue FFPE microarrays are currently available in three standard formats:

  • Core4OncArray representing over 120 cases (360 0.6mm cores) of breast, prostate, lung and colon cancer with representative normal tissue from each organ
  • CoreNormArray representing a FDA panel of 36 normal tissues from 3 donors (324 0.6mm cores)
  • CoreOncArray representing 12 different tumor types with associated normal controls with 72 unique samples (144 1.0mm cores)
  • CoreLuFibArray representing IPF (9), PF (4) and normal (4) lung samples, with 34 cores

In addition, the following TMAs are available:

  • fCoreFDAArray representing 36 FDA/EMA cross-reactivity tissues arranged across three separate frozen arrays, each containing 12 non-diseased human tissues in duplicate, from three donors (72 1.5mm cores)
  • Custom designed microarrays are available through our PHASEZERO® services

Features & Benefits

  • All specimens collected using consented donros under IRB approval
  • All specimens are pre-reviewed by a board certified pathologist to confirm tissue type and diagnosis
  • High-density, high-quality with normal tissues on same TMA
  • Map and Key of each TMA available that includes clinical and donor demographics

Idiopathic pulmonary fibrosis Pulmonary fibrosis Breast cancer Lung Cancer Prostate Cancer Colorectal cancer Kidney Cancer Head and neck cancer Bladder cancer Uterine Cancer Ovarian Cancer Cervical Cancer Brain cancer Stomach Cancer Gastric Cancer Skin Cancer Melanoma Human Oncology Respiratory Show 20 more tags Show less

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Human Bone Marrow

Price on request
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Primary Cell Isolation

Price on request

Our scientists provide custom isolations of mammalian fibroblasts from solid tumors, normal tissue or diseased tissue as well as peripheral blood mononucleocytes (PBMCs).

Our scientists provide custom isolations of mammalian fibroblasts from solid tumors, normal tissue or diseased tissue as well as peripheral blood mononucleocytes (PBMCs).
Primary Cells
-Available Primary Cells
Cancer Associated Fibroblasts (HuCAFs)
Lung Epithelial Cells (HuBECs)
Pulmonary Fibroblasts
Chondrocytes
Synovial Fibroblasts

-Custom Services
Isolation of Cells from:
Whole Blood
Tissue
Bone Marrow Aspirates
Synovial Fluids

Methods & Techniques
Tissue Dissociation
Density Gradient

Primary Cells

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Histology and Pathology Services

Price on request

BioIVT provides a complete team of Histotechnicians, Histotechnologists and Board Certified Pathologists for all your sectioning, cyro-sectioning, staining and analysis needs.

HISTOLOGY SERVICES
Standard Services

  • Sectioning
  • IHC Staining

Custom Services

  • IHC/Custom Staining
  • Instrumentation Validation
  • Assay Controls
  • Specimen Embedding
  • TMA Creation

Platforms

  • Dako Autostainers
  • Aperio AT2 Slide Scanner
  • Auto Tissue Processors

PATHOLOGY SERVICES
Standard Services

  • H&E with diagnosis confirmation

Custom Services

  • Gross preperation of fresh specimens
  • Identification of key tissue features
  • Specimen marking

Platforms & Fees

  • Aperio AT2 Slide Scanner
  • Fees based on hourly rate

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Human Synovial Fluid Samples

Price on request
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Mutation Analysis

Price on request

BioIVT offers mutation services to support assay, diagnostic and drug development needs as well as assay validation. We are able to combine ready access to large cohorts of human tissues with expertise in the design and execution of NGS, qRT-PCR and FISH protocols. We can support the determination of SNVs (single nucleotide variants), Indels (Insertion or deletion of nucleotides), Fusions, and CNV (Copy Number Variants) as well as expression changes. qRT-PCR is an effective approach for determining the status of various somatic mutations in human tissue samples. These data aid in the selection of specific subsets of human tissue samples for future use / applications. We have provided such pre-screening services to enable tissue selections for KRAS and EGFR, among other mutations. Using FISH, we generate data that enable characterization of tissues for specific mutations such as HER2 or cMET gene amplifications or ROS/ALK gene rearrangements.

Features & Benefits

  • Fully managed by in-house specialist
  • Supported by large banked tissue specimen inventory with access to specific cohorts as needed

Access to multiple platforms:

  • qPCR – SNV, Fusion, Expression changes – Tests specific known variants; confirmation of assays
  • Sanger/Pyrosequencing – SNV – Test sections of genes or short genes, confirmation of assays
  • NGS – SNV, CNV, Fusion – Explore large sections of genome, detection from multiple genes, detection of rare variants, information from multiple mutation types in one assay
  • FISH – CNV, Fusion, Expression changes – Detection of specific gene sequences within chromosomes, identification of genomic status of oncology samples, analysis of gene amplification and mutation
  • IHC – Fusion, Expression changes – Specific known variants or expression changes, does not require DNA or RNA to provide information

Human NGS NGS Panels FISH Fluorescence in situ Hybridization in situ hybridization (ISH) immunohistochemistry RT-qPCR real-time PCR qPCR Show 10 more tags Show less

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Human Primary Cell Isolation

Price on request
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Cell Services

Price on request
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Human Biospecimens

Price on request

The surge in research and development activities focused on personalized medicine coincides with the rapidly decreasing cost of human genome mapping and a greater understanding of disease heterogeneity. As a researcher, you struggle with high attrition rate based on lack of clinical efficacy. It is crucial to your studies to utilize ethically collected, well-characterized human specimens and comprehensive tissue-based research services.

Look to BioIVT for expertise in the processes required for the ethical acquisition of biospecimens that cover a wide range of disease states and the protocols needed for the production of reliable data.

We offer:
• Unparalleled access to over 200 IRB-approved collection sites
• Access to a comprehensive array of biospecimens across multiple sample types and disease indications
• Standardization and quality control coupled with the ability to customize collections to meet your specific criteria and research needs

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Biochemistry & Molecular Biology

Price on request

The PHASEZERO® Research Services team delivers high quality molecular pathology data to support the selection and validation of drug targets and biomarkers in human tissues. In addition, the approaches we provide are ideally suited for diagnostic assay development and testing. Our molecular pathology platforms are used to great effect as endpoints for our human primary cell based assays. This allows changes in the expression of key targets to be determined following treatment of human cells with novel therapeutic agents.

RNA Extraction Genomic DNA extraction qPCR RT-qPCR

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Nucleic Acid Services

Price on request

Our team of scientists offer routine RNA (total RNA and mRNA), DNA (genomic DNA) and protein isolation from flash frozen tissue, FFPE and cells. We also provide mutation analysis on several of our products as well as a custom service.
Standard protocols can be used to obtain genomic DNA and total RNA. A wide range of commercially available DNA extraction and RNA extraction kits or custom protocols can be utilized to obtain samples for specific projects. Each RNA extraction is analyzed on an Agilent 2100 and provided with a quality control report featuring an RNA Integrity Number (RIN). The Agilent 2100 software assigns an integrity number (0-10) to an RNA sample. The Agilent 2100 identifies the presence or absence of degradation of products and interprets the quality of the specimen. DNA quality is analyzed by gel electrophoresis. Quantitation it performed by spectrophotometry (Nanodrop) and fluorometry (Qubit). Careful qualitative and quantitative analysis will guarantee high quality specimens and yield high quality research results.
Protein Lysates are extracted using a Modified RIPA Buffer protocol.

RNA Extraction Genomic DNA extraction qPCR RT-qPCR

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Biospecimens

Price on request

BioIVT is a leading global provider of high-quality biological specimens and value-added services. We specialize in control and disease state samples including human and animal tissues, cell products, blood and other biofluids. Our unmatched portfolio of clinical specimens directly supports precision medicine research and the effort to improve patient outcomes by coupling comprehensive clinical data with donor samples. By combining our technical expertise, exceptional customer service, and unparalleled access to biological specimens, BioIVT serves the research community as a trusted partner in ELEVATING SCIENCE.

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DNA Services

Price on request

Our team of scientists offer routine DNA (genomic DNA) isolation from flash frozen tissue, FFPE and cells. We also provide mutation analysis on several of our products as well as a custom service.

Standard protocols can be used to obtain genomic DNA. A wide range of commercially available DNA extraction kits or custom protocols can be utilized to obtain samples for specific projects. DNA quality is analyzed by gel electrophoresis. Quantitation it performed by spectrophotometry (Nanodrop) and fluorometry (Qubit). Careful qualitative and quantitative analysis will guarantee high quality specimens and yield high quality research results.

NanoDrop 8000 spectrophotometer Qubit 2.0 fluorometer DNA gDNA

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Anatomic Pathology

Price on request
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Primary Cell Culture

Price on request

Our scientists provide custom isolations of mammalian fibroblasts from solid tumors, normal tissue or diseased tissue as well as peripheral blood mononucleocytes (PBMCs).

Primary Cells
-Available Primary Cells
Cancer Associated Fibroblasts (HuCAFs)
Lung Epithelial Cells (HuBECs)
Pulmonary Fibroblasts
Chondrocytes
Synovial Fibroblasts
-Custom Services
Isolation of Cells from:
Whole Blood
Tissue
Bone Marrow Aspirates
Synovial Fluids

Methods & Techniques
Tissue Dissociation
Density Gradient
Magnetic Separation
Flow Cytometry

Primary Cells Human

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Cell Products

Price on request
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Human Biospecimen Collection

Price on request

The surge in research and development activities focused on personalized medicine coincides with the rapidly decreasing cost of human genome mapping and a greater understanding of disease heterogeneity. As a researcher, you struggle with high attrition rate based on lack of clinical efficacy. It is crucial to your studies to utilize ethically collected, well-characterized human specimens and comprehensive tissue-based research services.
Look to BioIVT for expertise in the processes required for the ethical acquisition of biospecimens that cover a wide range of disease states and the protocols needed for the production of reliable data.

We offer:

BioIVT now has a network of over 200 IRB-approved facilities providing access to a diverse array of specimens. Our growing clinical network is made up of physicians, research groups, hospitals, and reference labs that we work closely with to provide tailored specimen collections to meet your research needs.

ASTERAND Human Tissue Specimens
Over 175,000 tissue samples collected in a standard format, banked and available for immediate shipment
Formats: FFPE, frozen, plasma, serum, whole blood and matched sets of donor specimens
Rigorous QC:

  • Specimens reviewed by board certified pathology to confirm diagnosis and specimen quality
  • Clinical data review of over 200 data points
  • Ethical and regulatory traceability for each case
  • Biofluid Specimens

Biofluids are available as both banked inventory or custom collection with associated clinical data such as medication, cancer or disease stage, clinical lab values such as cholesterol and liver function, RF value and viral serology. Available matrices include - Whole blood/ Serum / Plasma, Sputum, Synovial fluid, Cerebrospinal fluid (CSF), PAP smears, Bone marrow, Cord blood, Oral swabs/Saliva/Sputum, Tears, Urine, Feces

Customized collections kits:

  • Donor specifications, protocols, collection containers and more
  • Repeat donor collections for longitudinal studies
  • Access to unique or rare patient populations, including pediatric and pregnant donors
  • Matched sets from individual donors

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RNA Products

Price on request
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ADME/DMPK Studies

Drug Metabolism and Pharmacokinetics
Price on request

ADME/DMPK Studies Services


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Human Tissue

Price on request

BioIVT’s clinical specimens now include the ASTERAND Human Tissue Specimens, an invaluable source of high-quality, thoroughly characterized and validated human tissue, which can be used throughout the drug discovery and development process. As the leading provider of high quality human biospecimens and associated clinical information, we use rigorous criteria for the procurement and quality control of biospecimens. BioIVT has a worldwide network of hospitals working exclusively to procure high-quality biological samples for our onsite tissue bank. Our dynamic network of hospital procurement sites makes BioIVT unique in the biobanking industry and allows BioIVT to offer our clients many hard to procure treatment naïve tissue specimens in several formats.

Our extensive repository consists of over 300,000 human tissues with associated biofluids. This bank includes material that is prospectively obtained in a variety of formats including fresh frozen and FFPE as well as biofluids. Standard protocols are used to maintain the BioIVT repository and adhere to the highest standards of sample integrity, including difficult to procure treatment naïve tumor samples. Standard tissue products are generally available for next day shipping to keep your research moving.

Our custom procurement service offers human tissues and clinical data custom collected to meet unique research requirements within a wide range of disease categories. Samples are provided in multiple preserved formats or as fresh and unpreserved biospecimens. As a result, we deliver human tissues, biofluids, and accompanying clinical information in a manner that is most compatible with our client’s experimental design.

BioIVT collects every sample under IRB approved protocols, ensuring that strict ethical guidelines are followed to protect patient confidentiality and safety. Each sample has the patients consent for use in a wide range of research including the development of commercial products or services. The samples are identifiable only by barcodes to ensure an unbiased assessment as well as patient confidentiality.

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11b-Hydroxysteroid Dehydrogenase Assay

Price on request
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Histopathological Examination

Price on request

BioIVT provides a complete team of Histotechnicians, Histotechnologists and Board Certified Pathologists for all your sectioning, cyro-sectioning, staining and analysis needs.

PATHOLOGY SERVICES
Standard Services

  • H&E with diagnosis confirmation
    Custom Services
  • Gross preperation of fresh specimens
  • Identification of key tissue features
  • Specimen marking
    Platforms & Fees
  • Aperio AT2 Slide Scanner
  • Fees based on hourly rate

Aperio AT2 DAKO Autostainer Plus Pathology Review Specimen Marking Gross Preparation Identification of Key tissue features Show 6 more tags Show less

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DNA Extraction and Purification

Price on request

Our team of scientists offer routine DNA (genomic DNA) isolation from flash frozen tissue, FFPE and cells. We also provide mutation analysis on several of our products as well as a custom service.

Standard protocols can be used to obtain genomic DNA. A wide range of commercially available DNA extraction kits or custom protocols can be utilized to obtain samples for specific projects. DNA quality is analyzed by gel electrophoresis. Quantitation it performed by spectrophotometry (Nanodrop) and fluorometry (Qubit). Careful qualitative and quantitative analysis will guarantee high quality specimens and yield high quality research results.

NanoDrop 8000 spectrophotometer Qubit 2.0 fluorometer

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Contract Services Directory

Price on request
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In vivo Pharmacology Studies

Price on request
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Tissue Processing

Price on request

BioIVT provides a complete team of Histotechnicians, Histotechnologists and Board Certified Pathologists for all your sectioning, cyro-sectioning, staining and analysis needs.

HISTOLOGY SERVICES
Standard Services

  • Sectioning
  • IHC Staining

Custom Services

  • IHC/Custom Staining
  • Instrumentation Validation
  • Assay Controls
  • Specimen Embedding
  • TMA Creation

Platforms

  • Dako Autostainers
  • Aperio AT2 Slide Scanner
  • Auto Tissue Processors

PATHOLOGY SERVICES

  • Standard Services
  • H&E with diagnosis confirmation

CUSTOM SERVICES

  • Gross preperation of fresh specimens
  • Identification of key tissue features
  • Specimen marking

Platforms & Fees

  • Aperio AT2 Slide Scanner
  • Fees based on hourly rate

DAKO Autostainer Plus Aperio AT2 Sectioning cryosectioning frozen sectioning Macro Dissection serial sectioning tissue section imaging IHC Staining Specimen Embedding Instrument Validation Show 11 more tags Show less

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Cells and Tissues

Price on request

We offer primary isolated cells from oncology and other diseased populations, useful in assay development and the identification of diagnostic and prognostic markers. In addition, we offer specific oncology related cell lines.
• Complete clinical data included with all samples
• Customizable PBMC collections for specific inclusion criteria
• Additional characterization available, including HLA typing

PBMC's Primary Cells Fresh Tissue Tumor tissue

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Cell Lines

Price on request

BioIVT’s selection of immortalized cell lines will further your research in the mechanisms of cancer growth and progression. Our cell lines derive directly from freshly isolated solid tumors, including breast and prostate tissues as well as hematological samples. Each cell line purchased includes clinical data delivered with the cell aliquots. Our stringent quality control processes requires authentication including sterility testing, viability, and plating efficiency determined by lot. Immortalized cell lines are cryopreserved in 1 x 106 ampules.
Breast Cell Lines
Through licensing agreements with the University of Michigan and the Karmanos Cancer Institute, BioIVT provides 11 well-characterized human breast cancer cell lines to assist in breast cancer research.
Ten SUM cell lines derived in Steve Ethier’s lab while present at the University of Michigan are available for purchase. Each cell line, from a single patient, represents a different subtype of breast cancer. All of the currently known oncogenes with altered expression patterns in breast cancer, in various combinations, are represented and characterized in the SUM lines. Furthermore, these cell lines have been described in over 50 peer-reviewed publications, describing isolation and growth conditions, gene expression data via Affymetrix GeneChips, and biomolecular markers, such as estrogen receptor and Her2 status.
Prostate Cell Lines **
BioIVT offers three pairs of prostate tumor and normal cell lines. Researchers at the Karmanos Cancer Institute, Onyvax Ltd., and Asterand collaborated to derive these cell lines from tumors and adjacent “normal” tissues obtained at the time of prostatectomy. These prostate cell lines were immortalized via replication-defective retrovirus transferring the transforming HPV16 or HPV18 E6 and E7 genes.
**All prostate cell lines were immortalized were by exposing the cells to a replication-defective retrovirus transferring the transforming HPV16 or HPV18 E6 and E7 genes.
Hematopoietic Malignancies Cell Lines
Through a licensing agreement with the Barbara Ann Karmanos Cancer Institute, BioIVT provides well characterized human cell lines derived from patients with hematopoetic malignancies. These cell lines, developed by Doctors Ayad Al-Katib and Ramzi Mohammad, will be of interest to researchers seeking a cure for lymphoma, leukemia, pancreatic cancer, and macroglobulinema.

Human

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Mammalian Cell Culture

Price on request

Mammalian Cell Culture Services


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Product Development, Testing, and Packaging

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Immunostaining

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Bioanalysis

Price on request
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Genotyping and Gene Expression Assays

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Cell Culture Media and Reagents

Price on request
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Biospecimen Management and Storage

Price on request
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In vivo PK/PD Studies

Price on request
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In vitro ADME/DMPK Studies

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Product Quality Control

Price on request
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Oxidoreductase Assays

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Biology

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RNA Services

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Pharmacology & Toxicology

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Primary Cell Lines

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