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Assay.Works

Regensburg, DE

Assay.Works is a private contract research organization (CRO) occupying a 750 m2 state-of-the-art laboratory located in the Regensburg BioPark, the second largest hub of the Bavarian biotech cluster. Our mission is to accelerate our partner’s research programs by developing and executing predictive and scalable assays to quantify the bioactivity of novel chemical and biological entities. We combine scientific rigor with our domain expertise in laboratory automation, informatics, and industry best practices to turn challenging assays into quantitative, reproducible results.

Recent Publications

  • Fan F, Hu R, Munzli A, Chen Y, Dunn RT 2nd, Weikl K, Strauch S, Schwandner R, Afshari CA, Hamadeh H, Nioi P. Utilization of human nuclear receptors as an early counter screen for off-target activity: a case study with a compendium of 615 known drugs. Toxicol Sci. 2015 Jun;145(2):283-95. doi: 10.1093/toxsci/kfv052.... Show more »

Assay.Works is a private contract research organization (CRO) occupying a 750 m2 state-of-the-art laboratory located in the Regensburg BioPark, the second largest hub of the Bavarian biotech cluster. Our mission is to accelerate our partner’s research programs by developing and executing predictive and scalable assays to quantify the bioactivity of novel chemical and biological entities. We combine scientific rigor with our domain expertise in laboratory automation, informatics, and industry best practices to turn challenging assays into quantitative, reproducible results.

Recent Publications

  • Fan F, Hu R, Munzli A, Chen Y, Dunn RT 2nd, Weikl K, Strauch S, Schwandner R, Afshari CA, Hamadeh H, Nioi P. Utilization of human nuclear receptors as an early counter screen for off-target activity: a case study with a compendium of 615 known drugs. Toxicol Sci. 2015 Jun;145(2):283-95. doi: 10.1093/toxsci/kfv052. Epub 2015 Mar 9
  • Xiong Y, Swaminath G, Cao Q, Yang L, Guo Q, Salomonis H, Lu J, Houze JB, Dransfield PJ, Wang Y, Liu JJ, Wong S, Schwandner R, Steger F, Baribault H, Liu L, Coberly S, Miao L, Zhang J, Lin DC, Schwarz M. Activation of FFA1 mediates GLP-1 secretion in mice. Evidence for allosterism at FFA1. Mol Cell Endocrinol. 2013 Apr 30;369(1-2):119-29. doi: 10.1016/j.mce.2013.01.009. Epub 2013 Feb 9.
  • Yu V, Fisch T, Long AM, Tang J, Lee JH, Hierl M, Chen H, Yakowec P, Schwandner R, Emkey R. High-throughput TR-FRET assays for identifying inhibitors of LSD1 and JMJD2C histone lysine demethylases. 2012. J Biomol Screen. Jan;17(1):27-38.
  • Babij C, Zhang Y, Kurzeja RJ, Munzli A, Shehabeldin A, Fernando M, Quon K, Kassner PD, Ruefli-Brasse AA, Watson VJ, Fajardo F, Jackson A, Zondlo J, Sun Y, Ellison AR, Plewa CA, San MT, Robinson J, McCarter J, Schwandner R, Judd T, Carnahan J, Dussault I. STK33 kinase activity is nonessential in KRAS-dependent cancer cells. 2011. Cancer Res. Sep 1;71(17):5818-26.
  • Lee T., Schwandner R., Swaminath G., Weiszmann J., Cardozo M., Greenberg J., Jaeckel P., Ge H., Wang Y., Jiao X., Liu J., Kayser F., Tian H., Li Y. 2008. Identification and functional characterization of allosteric agonists for the G protein-coupled receptor FFA2. Mol Pharmacol. Dec;74(6):1599-609.
  • Beck HP., Kohn T., Rubenstein S., Hedberg C., Schwandner R., Hasslinger K., Dai K., Li C., Liang L., Wesche H., Frank B., An S., Wickramasinghe D., Jaen J., Medina J., Hungate R., Shen W. Discovery of potent LPA2 (EDG4) antagonists as potential anticancer agents. 2008. Bioorg Med Chem Lett. Feb 1;18(3):1037-41.
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Assay.Works has not listed any services.

Stable Cell Line Generation
Price on request

Mammalian cell line engineering and stable cell line generation
- High-throughput functional cell clone selection for superior performance in the actual functional (HTS) Assay. Successful applied for several difficult to express membrane targets.

  • Flow cytometry-based generation of cell clones tailored for optimal surface expression.

Mammalian cell line engineering and stable cell line generation
- High-throughput functional cell clone selection for superior performance in the actual functional (HTS) Assay. Successful applied for several difficult to express membrane targets.

  • Flow cytometry-based generation of cell clones tailored for optimal surface expression.
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BD FACSAria Cell Sorting System
Cybio FeliX
TAP SelecT Robotics
Assay Development
Price on request

Assay development and optimization for biochemical and cell-based assay formats
- De novo design of predictive and quantitative bioactivity assay. Adaption, miniaturization and automation of client-provided assay protocols. Experience spanning major target classes (GPCRs, Phosphotransferase, Ion Channels, Misc. Enzymes,... Show more »

Assay development and optimization for biochemical and cell-based assay formats
- De novo design of predictive and quantitative bioactivity assay. Adaption, miniaturization and automation of client-provided assay protocols. Experience spanning major target classes (GPCRs, Phosphotransferase, Ion Channels, Misc. Enzymes, Transporters, Binding Proteins, Ubiquitin Ligases across indications (Inflammation, Metabolic, Neuroscience, Oncology)).

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Oncology
Neuroscience
Inflammation
Metabolic Disease
High Throughput Screening
Price on request

Hit identification using Assay.Works small molecule diversity set of 150.000 compounds, client-provided libraries or partner libraries. HTS is supported by integrated time- and temperature controlled multi device platform. Hit identification and HTS work flow are based on biopharmaceutical industry standards with a robust set of... Show more »

Hit identification using Assay.Works small molecule diversity set of 150.000 compounds, client-provided libraries or partner libraries. HTS is supported by integrated time- and temperature controlled multi device platform. Hit identification and HTS work flow are based on biopharmaceutical industry standards with a robust set of best practices, skilled staff, sophisticated laboratory and tissue culture automation in place.

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live-cell imaging
Perkin Elmer Operetta
MD FLIPR Tetra
Perkin Elmer EnVision
Cybio integrated multi device robotics
Cybio FeliX
Cytomat 6004
Genedata Screener
RNAi Screening
Price on request

siRNA Screening:

Target identification or pathway validation using Assay.Works 97.000 siRNA sequences targeting the human
druggable genome. Different RNA chemistries and intrinsic redundancy has been built into the collection to statistically identify false hits.

Combination siRNA Screening:

Genetic interaction... Show more »

siRNA Screening:

Target identification or pathway validation using Assay.Works 97.000 siRNA sequences targeting the human
druggable genome. Different RNA chemistries and intrinsic redundancy has been built into the collection to statistically identify false hits.

Combination siRNA Screening:

Genetic interaction and Pharmacological interaction screening using Assay.Works siRNA collection or 4480 small molecules compounds of the phenotypic toolbox collection

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Molecular Devices FLIPR
Oncology
Neuroscience
Inflammation
Drug-Gene Interaction
Metabolic Disease
Hit to Lead and Lead Optimization
Price on request

Invitro bioactivity assessment
- Characterization of screening hits and lead candidates, concentration response experiments to determine potency efficacy, selectivity and mechanism of action. Collection of 120 engineered cell lines covering a broad range of transmembrane targets available for profiling.

Invitro bioactivity assessment
- Characterization of screening hits and lead candidates, concentration response experiments to determine potency efficacy, selectivity and mechanism of action. Collection of 120 engineered cell lines covering a broad range of transmembrane targets available for profiling.

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GPCR
Tecan Freedom EVO platforms
Transporter
Ion Channel
Nuclear Hormone Receptor
Phosphotransferase
Binding Protein
Ubiquitin Ligase
Compound Libraries
Price on request

Assay.ready compound plates
- Gain access to Assay.Works unique small compound collections (seed.74.000, sprout.100.000 and grow. 150.000) optimized for lead-likeness and diversity, free of undesirable chemotypes, verified by LC/UV/MS. Nanoliter dispensing is supported by Assay.Works Labcyte Echo 550® workstation.

Assay.ready compound plates
- Gain access to Assay.Works unique small compound collections (seed.74.000, sprout.100.000 and grow. 150.000) optimized for lead-likeness and diversity, free of undesirable chemotypes, verified by LC/UV/MS. Nanoliter dispensing is supported by Assay.Works Labcyte Echo 550® workstation.

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Labcyte Echo 550 integrated Workstation
Cell and Tissue Culture
Price on request

Automated production of cellular reagents
- Assay.ready cryopreserved cell production, cell banking, subcellular and supernatants supported by TAP SelecT™ Automated Tissue culture system.

  • Preparation of membrane vesicles for SURFE2R electrogenic event reader (label- and radioactive-free analysis of electrogenic transporters and pumps)

Automated production of cellular reagents
- Assay.ready cryopreserved cell production, cell banking, subcellular and supernatants supported by TAP SelecT™ Automated Tissue culture system.

  • Preparation of membrane vesicles for SURFE2R electrogenic event reader (label- and radioactive-free analysis of electrogenic transporters and pumps)
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TAP SelecT Robotics
Research Management
Price on request

Design and implementation of scalable laboratory processes and workflows.
Research data and information management.
Technology evaluation and case studies.
Safety and compliance management.

Design and implementation of scalable laboratory processes and workflows.
Research data and information management.
Technology evaluation and case studies.
Safety and compliance management.

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Nucleic Acid Services
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Biochemistry & Molecular Biology
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RNA
Price on request
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Lead Identification and Validation
Price on request
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Hit Identification
Price on request
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Experimental Design
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Cells and Tissues
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Project Management & Consulting Services
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Biology
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Drug Discovery
Price on request
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Drug Discovery & Development
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Mammalian Cell Culture
Price on request
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