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Asclepia

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Destelbergen, BE

About Asclepia

Asclepia MedChem Solutions' mission is to offer medicinal chemistry oriented research and services by designing innovative, therapeutically relevant, drug-like compounds.

Founded in 2009, Asclepia relies on profound drug discovery expertise, providing exclusive or non-exclusive novel small molecules. We... Show more »

Asclepia MedChem Solutions' mission is to offer medicinal chemistry oriented research and services by designing innovative, therapeutically relevant, drug-like compounds.

Founded in 2009, Asclepia relies on profound drug discovery expertise, providing exclusive or non-exclusive novel small molecules. We are capable of leading projects through the processes of hit identification, hit-to-lead optimization, lead-to-early development candidate (EDC) optimization and preclinical development. Furthermore, we have profound knowledge in the field of Kinase and Ion Channel modulators.

Knowledge and expertise in the field of Kinase inhibitors:
- Libraries designed as ATP-competitive kinase inhibitors (both general new kinase scaffolds and novel focused compounds)
- The libraries contained >20 novel scaffolds which were synthesized at a CRO. Screening of some representative compounds has identified novel hits with IC50s well below 1µM
- Successful hit identification for novel target (STE family)
- Innovative Type II kinase inhibitor library designed for a specific kinase target
- Running 2 different kinase projects through several optimization cycles improving the activity/selectivity profiles, optimizing pharmacokinetic properties and solving identified issues
- One compound delivered at IND stage (ROCK), one at EDC stage (PKC)

Knowledge and expertise in the field of Ion Channel inhibitors:
- Libraries designed as voltage gated potassium channel inhibitors (Kv4.3, Kv1.5 & Kv1.3)
- The libraries contained >20 novel scaffolds. Screening of 2500 compounds has identified novel hits - with IC50s < 30µM (hit rate 6.6%)
- Specific rationale employed to enhance the solubility and the metabolic stability of the compounds
- Running 2 different hit series through several optimization cycles improving the activity/selectivity profiles, optimizing pharmacokinetic properties, solving identified issues
- Having identified 2 compounds as Early Development Candidates (Kv4.3) for the treatment of Atrial Fibrillation

Certifications: GLP compliant

Publication:
In vivo inhibition of RIPK2 kinase alleviates inflammatory disease. DOI: 10.1074/jbc.M114.591388

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Our Services (106)


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Process and Scale-Up Chemistry

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Chiral Chromatography

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Melting Point Determination

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Patent Searching and Analysis

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Compound Sourcing

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Natural Product Discovery by Microbial Fermentation

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Retrosynthetic Analysis and Synthetic Route Design

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Certified Standards

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Chemicals

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Compound Library Synthesis

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Polymorphism Screening

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Natural Product Screening

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QSAR Studies

Quantitative Structure-Activity Relationship Studies
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Homology Modeling

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Solubility and Dissolution Testing

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LC-MS

Liquid Chromatography-Coupled Mass Spectrometry
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Optical Rotation

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High Resolution Mass Spectrometry

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GC-MS

Gas Chromatography Coupled Mass Spectrometry
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Molecular Docking

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Computational Drug Discovery

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Pharmacophore Modeling

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NMR

Nuclear magnetic resonance spectroscopy
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Chemical Stability Testing

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Impurity Analysis

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Forced Degradation Studies

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Accelerated Stability Testing

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Assay Development Consulting

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In silico Antibody Humanization

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Structure Determination

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Fragment Screening

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Co-Crystallization

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Natural Product Libraries

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Radioisotope Production

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Scientific Sourcing

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Featured Vendor: Asclepia MedChem Solutions

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Medicinal Chemistry

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Particle Analysis and Characterization

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UV-VIS Spectroscopy

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Compound Purification

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Batch Release Testing

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Salt Screening

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Activity Prediction

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Activity Based Compound Libraries

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Elemental Analysis

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Photostability Studies

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Compendial Testing

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Compound Management

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Drug-Excipient Compatibility Studies

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Natural Product Analysis

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Pyrolysis/Thermal Analysis

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LogP/LogD Determination

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Compound Libraries

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Metabolite Generation

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Natural Product Isolation and Purification

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Cryo-Electron Microscopy

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Fragment Libraries

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Synthetic Building Blocks and Intermediates

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Structure Mining

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Cell-Based Compound Screening

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Compound Purification

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Chemical Synthesis

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Asclepia MedChem Solutions offers synthesis services (both non-GLP and GLP) on small (milligrams to grams) and large (grams to kilograms) scales at competitive prices.

Active input is provided in the planning of the synthesis (synthesis routes).

The synthesis projects are followed-up closely ensuring the timely delivery of... Show more »

Asclepia MedChem Solutions offers synthesis services (both non-GLP and GLP) on small (milligrams to grams) and large (grams to kilograms) scales at competitive prices.

Active input is provided in the planning of the synthesis (synthesis routes).

The synthesis projects are followed-up closely ensuring the timely delivery of the desired final compounds.

Only compounds are delivered that meet the high quality standards.

Reports are provided on the synthesis as well as all analytical data (LC-MS, NMR, melting points etc.).

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Radiotracers and Radiopharmaceuticals

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Specialty Mass Spectrometry Methods

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Biochemistry & Molecular Biology

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Natural Products

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Drug Discovery & Development

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Assay Development

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Compound Sourcing and Management

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Spectroscopy

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Thermal Analysis Services

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Hit Identification

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Omics

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DNA Services

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Microscopy

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Chemistry and Materials

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Product Quality Control

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Mass Spectrometry

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Separation/Purification Services

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Electron Microscopy

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Other Mass Spectrometry Methods

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Metabolomics

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Physical Analysis Methods

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Business Development Consulting

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Engineering and Fabrication

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DNA Libraries

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Chiral Resolution

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Computational Chemistry

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Imaging & Spectroscopy

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Pharmacology & Toxicology

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Radiochemistry

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Process Consulting

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Synthetic Chemistry

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Nucleic Acid Services

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Spectrophotometry

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Product Development, Testing, and Packaging

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Analytical Chemistry Services

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Bioanalysis

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Drug Discovery

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Strength Analysis

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Liquid Chromatography Coupled Mass Spectrometry Methods

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Computational Modeling

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Biology

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Formulation Services

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Structural Biology

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Project Management

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