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Asclepia

Destelbergen, Vlaams Gewest, BE

Asclepia MedChem Solutions' mission is to offer medicinal chemistry oriented research and services by designing innovative, therapeutically relevant, drug-like compounds.

Founded in 2009, Asclepia relies on profound drug discovery expertise, providing exclusive or non-exclusive novel small molecules. We are capable of leading projects through the processes of hit identification, hit-to-lead optimization, lead-to-early development candidate (EDC) optimization and preclinical development. Furthermore, we have profound knowledge in the field of Kinase and Ion Channel modulators.

Knowledge and expertise in the field of Kinase inhibitors:
- Libraries designed as ATP-competitive kinase inhibitors (both general new kinase scaffolds and novel focused compounds)
- The libraries contained >20 novel scaffolds which were synthesized at a CRO. Screening of some representative compounds has identified novel hits with... Show more »

Asclepia MedChem Solutions' mission is to offer medicinal chemistry oriented research and services by designing innovative, therapeutically relevant, drug-like compounds.

Founded in 2009, Asclepia relies on profound drug discovery expertise, providing exclusive or non-exclusive novel small molecules. We are capable of leading projects through the processes of hit identification, hit-to-lead optimization, lead-to-early development candidate (EDC) optimization and preclinical development. Furthermore, we have profound knowledge in the field of Kinase and Ion Channel modulators.

Knowledge and expertise in the field of Kinase inhibitors:
- Libraries designed as ATP-competitive kinase inhibitors (both general new kinase scaffolds and novel focused compounds)
- The libraries contained >20 novel scaffolds which were synthesized at a CRO. Screening of some representative compounds has identified novel hits with IC50s well below 1µM
- Successful hit identification for novel target (STE family)
- Innovative Type II kinase inhibitor library designed for a specific kinase target
- Running 2 different kinase projects through several optimization cycles improving the activity/selectivity profiles, optimizing pharmacokinetic properties and solving identified issues
- One compound delivered at IND stage (ROCK), one at EDC stage (PKC)

Knowledge and expertise in the field of Ion Channel inhibitors:
- Libraries designed as voltage gated potassium channel inhibitors (Kv4.3, Kv1.5 & Kv1.3)
- The libraries contained >20 novel scaffolds. Screening of 2500 compounds has identified novel hits - with IC50s < 30µM (hit rate 6.6%)
- Specific rationale employed to enhance the solubility and the metabolic stability of the compounds
- Running 2 different hit series through several optimization cycles improving the activity/selectivity profiles, optimizing pharmacokinetic properties, solving identified issues
- Having identified 2 compounds as Early Development Candidates (Kv4.3) for the treatment of Atrial Fibrillation

Certifications: GLP compliant

Publication:
In vivo inhibition of RIPK2 kinase alleviates inflammatory disease. DOI: 10.1074/jbc.M114.591388

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Cell-Based Compound Screening
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Compound Synthesis
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Asclepia MedChem Solutions offers synthesis services (both non-GLP and GLP) on small (milligrams to grams) and large (grams to kilograms) scales at competitive prices.

Active input is provided in the planning of the synthesis (synthesis routes).

The synthesis projects are followed-up closely ensuring the timely delivery of... Show more »

Asclepia MedChem Solutions offers synthesis services (both non-GLP and GLP) on small (milligrams to grams) and large (grams to kilograms) scales at competitive prices.

Active input is provided in the planning of the synthesis (synthesis routes).

The synthesis projects are followed-up closely ensuring the timely delivery of the desired final compounds.

Only compounds are delivered that meet the high quality standards.

Reports are provided on the synthesis as well as all analytical data (LC-MS, NMR, melting points etc.).

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Chemistry and Materials
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Synthetic Chemistry
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Hit Identification
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Drug Discovery & Development
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Drug Discovery
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