Bxuswl0mqra0gmignmzh screen shot 2014 12 09 at 6.02.29 pm

Asclepia

Destelbergen, BE

Asclepia MedChem Solutions' mission is to offer medicinal chemistry oriented research and services by designing innovative, therapeutically relevant, drug-like compounds.

Founded in 2009, Asclepia relies on profound drug discovery expertise, providing exclusive or non-exclusive novel small molecules. We are capable of leading projects through the processes of hit identification, hit-to-lead optimization, lead-to-early development candidate (EDC) optimization and preclinical development. Furthermore, we have profound knowledge in the field of Kinase and Ion Channel modulators.

Knowledge and expertise in the field of Kinase inhibitors:
- Libraries designed as ATP-competitive kinase inhibitors (both general new kinase scaffolds and novel focused compounds)
- The libraries contained >20 novel scaffolds which were synthesized at a CRO. Screening of some representative compounds has identified novel hits with... Show more »

Asclepia MedChem Solutions' mission is to offer medicinal chemistry oriented research and services by designing innovative, therapeutically relevant, drug-like compounds.

Founded in 2009, Asclepia relies on profound drug discovery expertise, providing exclusive or non-exclusive novel small molecules. We are capable of leading projects through the processes of hit identification, hit-to-lead optimization, lead-to-early development candidate (EDC) optimization and preclinical development. Furthermore, we have profound knowledge in the field of Kinase and Ion Channel modulators.

Knowledge and expertise in the field of Kinase inhibitors:
- Libraries designed as ATP-competitive kinase inhibitors (both general new kinase scaffolds and novel focused compounds)
- The libraries contained >20 novel scaffolds which were synthesized at a CRO. Screening of some representative compounds has identified novel hits with IC50s well below 1µM
- Successful hit identification for novel target (STE family)
- Innovative Type II kinase inhibitor library designed for a specific kinase target
- Running 2 different kinase projects through several optimization cycles improving the activity/selectivity profiles, optimizing pharmacokinetic properties and solving identified issues
- One compound delivered at IND stage (ROCK), one at EDC stage (PKC)

Knowledge and expertise in the field of Ion Channel inhibitors:
- Libraries designed as voltage gated potassium channel inhibitors (Kv4.3, Kv1.5 & Kv1.3)
- The libraries contained >20 novel scaffolds. Screening of 2500 compounds has identified novel hits - with IC50s < 30µM (hit rate 6.6%)
- Specific rationale employed to enhance the solubility and the metabolic stability of the compounds
- Running 2 different hit series through several optimization cycles improving the activity/selectivity profiles, optimizing pharmacokinetic properties, solving identified issues
- Having identified 2 compounds as Early Development Candidates (Kv4.3) for the treatment of Atrial Fibrillation

Certifications: GLP compliant

Publication:
In vivo inhibition of RIPK2 kinase alleviates inflammatory disease. DOI: 10.1074/jbc.M114.591388

« Show less

Asclepia has not listed any services.

Ask A Question Find what you're looking for? If not, you can ask this lab a question:
Process and Scale-Up Chemistry
Price on request
Request a quote for more information about this service.
Chiral Chromatography
Price on request
Request a quote for more information about this service.
Melting Point Determination
Price on request
Request a quote for more information about this service.
Patent Searching and Analysis
Price on request
Request a quote for more information about this service.
API Sourcing
Price on request
Request a quote for more information about this service.
Natural Product Discovery by Microbial Fermentation
Price on request
Request a quote for more information about this service.
Retrosynthetic Analysis and Synthetic Route Design
Price on request
Request a quote for more information about this service.
Certified Standards
Price on request
Request a quote for more information about this service.
Chemicals
Price on request
Request a quote for more information about this service.
Compound Library Synthesis
Price on request
Request a quote for more information about this service.
Polymorphism Screening
Price on request
Request a quote for more information about this service.
Natural Product Screening
Price on request
Request a quote for more information about this service.
QSAR Studies
Quantitative Structure-Activity Relationship Studies
Price on request
Request a quote for more information about this service.
Homology Modeling
Price on request
Request a quote for more information about this service.
Solubility and Dissolution Testing
Price on request
Request a quote for more information about this service.
LC-MS
Liquid Chromatography-Coupled Mass Spectrometry
Price on request
Request a quote for more information about this service.
Optical Rotation
Price on request
Request a quote for more information about this service.
High Resolution Mass Spectrometry
Price on request
Request a quote for more information about this service.
GC-MS
Gas Chromatography Coupled Mass Spectrometry
Price on request
Request a quote for more information about this service.
Molecular Docking
Price on request
Request a quote for more information about this service.
Virtual Screening
Price on request
Request a quote for more information about this service.
Pharmacophore Modeling
Price on request
Request a quote for more information about this service.
NMR
Nuclear magnetic resonance spectroscopy
Price on request
Request a quote for more information about this service.
Chemical Stability Testing
Price on request
Request a quote for more information about this service.
Impurity Analysis
Price on request
Request a quote for more information about this service.
Forced Degradation Studies
Price on request
Request a quote for more information about this service.
Accelerated Stability Testing
Price on request
Request a quote for more information about this service.
Assay Development Consulting
Price on request
Request a quote for more information about this service.
In Silico Antibody Humanization
Price on request
Request a quote for more information about this service.
Structure Determination
Price on request
Request a quote for more information about this service.
Fragment Screening
Price on request
Request a quote for more information about this service.
Co-Crystallization
Price on request
Request a quote for more information about this service.
Natural Product Libraries
Price on request
Request a quote for more information about this service.
Radioisotope Production
Price on request
Request a quote for more information about this service.
Scientific Sourcing
Price on request
Request a quote for more information about this service.
Featured Vendor: Asclepia MedChem Solutions
Price on request
Request a quote for more information about this service.
Medicinal Chemistry
Price on request
Request a quote for more information about this service.
Compound Purchase
Price on request
Request a quote for more information about this service.
Particle Analysis and Characterization
Price on request
Request a quote for more information about this service.
UV-VIS Spectroscopy
Price on request
Request a quote for more information about this service.
Compound Purification
Price on request
Request a quote for more information about this service.
Lot Release Testing
Price on request
Request a quote for more information about this service.
Salt Screening
Price on request
Request a quote for more information about this service.
Activity Prediction
Price on request
Request a quote for more information about this service.
Activity Based Compound Libraries
Price on request
Request a quote for more information about this service.
Elemental Analysis
Price on request
Request a quote for more information about this service.
Photostability Studies
Price on request
Request a quote for more information about this service.
Compendial Testing
Price on request
Request a quote for more information about this service.
Compound Management Services
Price on request
Request a quote for more information about this service.
Drug-Excipient Compatibility Studies
Price on request
Request a quote for more information about this service.
Natural Product Analysis
Price on request
Request a quote for more information about this service.
Pyrolysis/Thermal Analysis
Price on request
Request a quote for more information about this service.
LogP/LogD Determination
Price on request
Request a quote for more information about this service.
Compound Libraries
Price on request
Request a quote for more information about this service.
Metabolite Generation
Price on request
Request a quote for more information about this service.
Natural Product Isolation and Purification
Price on request
Request a quote for more information about this service.
Cryo-Electron Microscopy
Price on request
Request a quote for more information about this service.
Fragment Libraries
Price on request
Request a quote for more information about this service.
Synthetic Building Blocks & Intermediates
Price on request
Request a quote for more information about this service.
Structure Mining
Price on request
Request a quote for more information about this service.
Cell-Based Compound Screening
Price on request
Request a quote for more information about this service.
Compound Purification
Price on request
Request a quote for more information about this service.
Compound Synthesis
Price on request

Asclepia MedChem Solutions offers synthesis services (both non-GLP and GLP) on small (milligrams to grams) and large (grams to kilograms) scales at competitive prices.

Active input is provided in the planning of the synthesis (synthesis routes).

The synthesis projects are followed-up closely ensuring the timely delivery of... Show more »

Asclepia MedChem Solutions offers synthesis services (both non-GLP and GLP) on small (milligrams to grams) and large (grams to kilograms) scales at competitive prices.

Active input is provided in the planning of the synthesis (synthesis routes).

The synthesis projects are followed-up closely ensuring the timely delivery of the desired final compounds.

Only compounds are delivered that meet the high quality standards.

Reports are provided on the synthesis as well as all analytical data (LC-MS, NMR, melting points etc.).

« Show less
Radiotracers and Radiopharmaceuticals
Price on request
Request a quote for more information about this service.
Specialty Mass Spectrometry Methods
Price on request
Request a quote for more information about this service.
Biochemistry & Molecular Biology
Price on request
Request a quote for more information about this service.
Natural Products
Price on request
Request a quote for more information about this service.
Drug Discovery & Development
Price on request
Request a quote for more information about this service.
Experimental Design
Price on request
Request a quote for more information about this service.
Compound Sourcing and Management
Price on request
Request a quote for more information about this service.
Spectroscopy
Price on request
Request a quote for more information about this service.
Thermal Analysis Services
Price on request
Request a quote for more information about this service.
Hit Identification
Price on request
Request a quote for more information about this service.
Omics
Price on request
Request a quote for more information about this service.
DNA
Price on request
Request a quote for more information about this service.
Microscopy
Price on request
Request a quote for more information about this service.
Chemistry and Materials
Price on request
Request a quote for more information about this service.
Product Quality Control
Price on request
Request a quote for more information about this service.
Mass Spectrometry
Price on request
Request a quote for more information about this service.
Purification Services
Price on request
Request a quote for more information about this service.
Electron Microscopy
Price on request
Request a quote for more information about this service.
Other Mass Spectrometry Methods
Price on request
Request a quote for more information about this service.
Metabolomics
Price on request
Request a quote for more information about this service.
Physical Analysis Methods
Price on request
Request a quote for more information about this service.
Business Development Consulting
Price on request
Request a quote for more information about this service.
Engineering
Price on request
Request a quote for more information about this service.
DNA Libraries
Price on request
Request a quote for more information about this service.
Chiral Resolution
Price on request
Request a quote for more information about this service.
Computational Chemistry
Price on request
Request a quote for more information about this service.
Imaging & Spectroscopy
Price on request
Request a quote for more information about this service.
Pharmacology & Toxicology
Price on request
Request a quote for more information about this service.
Radiochemistry
Price on request
Request a quote for more information about this service.
Process Consulting
Price on request
Request a quote for more information about this service.
Synthetic Chemistry
Price on request
Request a quote for more information about this service.
Nucleic Acid Services
Price on request
Request a quote for more information about this service.
Spectrophotometry
Price on request
Request a quote for more information about this service.
Product Development, Testing, and Packaging
Price on request
Request a quote for more information about this service.
Analytical Chemistry Services
Price on request
Request a quote for more information about this service.
Bioanalysis
Price on request
Request a quote for more information about this service.
Drug Discovery
Price on request
Request a quote for more information about this service.
Strength Analysis
Price on request
Request a quote for more information about this service.
Liquid Chromatography Coupled Mass Spectrometry Methods
Price on request
Request a quote for more information about this service.
Computational Modeling
Price on request
Request a quote for more information about this service.
Biology
Price on request
Request a quote for more information about this service.
Formulation Services
Price on request
Request a quote for more information about this service.
Structural Biology
Price on request
Request a quote for more information about this service.
Project Management, Consulting, & Support Services
Price on request
Request a quote for more information about this service.

Asclepia has not received any ratings.

Be the first to endorse Asclepia

Endorse this lab